AR079404A1 - Antagonista dp2 y composicion farmaceutica, uso y proceso de preparacion - Google Patents

Antagonista dp2 y composicion farmaceutica, uso y proceso de preparacion

Info

Publication number
AR079404A1
AR079404A1 ARP100102885A ARP100102885A AR079404A1 AR 079404 A1 AR079404 A1 AR 079404A1 AR P100102885 A ARP100102885 A AR P100102885A AR P100102885 A ARP100102885 A AR P100102885A AR 079404 A1 AR079404 A1 AR 079404A1
Authority
AR
Argentina
Prior art keywords
compound
salt
pharmaceutically acceptable
acceptable salt
formula
Prior art date
Application number
ARP100102885A
Other languages
English (en)
Inventor
Jason Edgard Brittain
Brian Andrew Stearns
Kevin Ross Holme
Christopher David King
Original Assignee
Amira Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amira Pharmaceuticals Inc filed Critical Amira Pharmaceuticals Inc
Publication of AR079404A1 publication Critical patent/AR079404A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/02—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of urea, its salts, complexes or addition compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicacion 1: Se reivindica una sal farmacéuticamente aceptable del ácido [2'-(3-bencil-1-etil-ureidometil)-6-metoxi-4'-trifluorometil-bifenil-3-il]-acético (Compuesto 1), donde la sal farmacéuticamente aceptable es una sal de calcio, sal de potasio, sal de sodio, sal de amonio, sal de L-arginina, sal de L-lisina, o una sal de N-metil-D-glucamina. Reivindicacion 2: La sal farmacéuticamente aceptable de la reivindicacion 1, donde la sal farmacéuticamente aceptable presenta la estructura del compuesto de formula (2). Reivindicacion 5: Una composicion farmacéutica que incluye: (a) ácido [2'-(3-bencil-1-etil-ureidometil)-6-metoxi-4'-trifluorometil-bifenil-3-il]-acético (Compuesto 1) o una sal farmacéuticamente aceptable del Compuesto 1 de acuerdo con cualquiera de las reivindicaciones 1 a 4; y (b) al menos un excipiente farmacéuticamente aceptable. Reivindicacion 14: La utilizacion de una sal farmacéuticamente aceptable de acuerdo con cualquiera de las reivindicaciones 1 a 4 o de una composicion farmacéutica de acuerdo con cualquiera de las reivindicaciones 5 a 13, en el tratamiento o la prevencion de una enfermedad o condicion respiratoria, una enfermedad o condicion inflamatoria o una enfermedad o condicion alérgica, o combinaciones de las mismos, en un mamífero. Reivindicacion 21: Un proceso para la síntesis del ácido [2'-(3-bencil-1-etil-ureidometil)-6-metoxi-4'-trifluorometil-bifenil-3-il]-acético, (Compuesto 1), que incluye los siguientes pasos: (I) la reaccion de un compuesto de la formula (3), o una sal del mismo, donde, R es alquilo C1-6, con (i) isocianato de bencilo, o (ii) fosgeno, seguido por bencilamina, con el objeto de proporcionar un compuesto de la formula (4); (II) la hidrolisis del grupo éster del compuesto de la formula (4) con el objeto de proporcionar el Compuesto 1.
ARP100102885A 2009-08-05 2010-08-05 Antagonista dp2 y composicion farmaceutica, uso y proceso de preparacion AR079404A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23166009P 2009-08-05 2009-08-05

Publications (1)

Publication Number Publication Date
AR079404A1 true AR079404A1 (es) 2012-01-25

Family

ID=43503081

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102885A AR079404A1 (es) 2009-08-05 2010-08-05 Antagonista dp2 y composicion farmaceutica, uso y proceso de preparacion

Country Status (12)

Country Link
US (2) US8815917B2 (es)
EP (1) EP2462110A4 (es)
JP (1) JP2013501052A (es)
KR (1) KR20120047273A (es)
CN (1) CN102596902A (es)
AR (1) AR079404A1 (es)
CA (1) CA2768587A1 (es)
MX (1) MX2012001542A (es)
SG (2) SG10201404662YA (es)
TW (1) TWI403318B (es)
UY (1) UY32833A (es)
WO (1) WO2011017201A2 (es)

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BRPI0913930A2 (pt) 2008-07-03 2015-10-20 Amira Pharmaceuticals Inc antagonistas de receptores de prostaglandinas d2
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JP2013500978A (ja) * 2009-07-31 2013-01-10 パンミラ ファーマシューティカルズ，エルエルシー． Ｄｐ２受容体アンタゴニストの眼の医薬組成物
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US20110034558A1 (en) 2011-02-10
EP2462110A4 (en) 2013-04-03
US9572785B2 (en) 2017-02-21
CN102596902A (zh) 2012-07-18
US8815917B2 (en) 2014-08-26
WO2011017201A2 (en) 2011-02-10
TWI403318B (zh) 2013-08-01
TW201109015A (en) 2011-03-16
UY32833A (es) 2011-01-31
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US20160136119A1 (en) 2016-05-19
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MX2012001542A (es) 2012-06-19
SG178252A1 (en) 2012-03-29

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