AR089360A1 - Derivados de heterociclilo y su uso como moduladores del receptor d₂ de prostaglandina - Google Patents
Derivados de heterociclilo y su uso como moduladores del receptor d₂ de prostaglandinaInfo
- Publication number
- AR089360A1 AR089360A1 ARP120104859A ARP120104859A AR089360A1 AR 089360 A1 AR089360 A1 AR 089360A1 AR P120104859 A ARP120104859 A AR P120104859A AR P120104859 A ARP120104859 A AR P120104859A AR 089360 A1 AR089360 A1 AR 089360A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- substituted
- mono
- alkyl
- alkoxy
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Composiciones farmacéuticas que contienen estos compuestos; y a procesos para su preparación. Reivindicación 1: Un compuesto de la fórmula (1) donde: R¹ representa hidrógeno, alquilo C₁₋₄, alcoxi C₁₋₄, fluoroalquilo C₁₋₄, alquilsulfonilo C₁₋₄, halógeno o ciano; R² representa hidrógeno o halógeno; uno de R³, R⁴ y R⁵ representa carboxi-alquilo C₁₋₃, carboxi-ciclopropilo o carboxi-alcoxi C₁₋₃ y los otros dos representan, de manera independiente entre sí, hidrógeno, alcoxi C₁₋₄ o halógeno; R⁶ representa hidrógeno, alcoxi C₁₋₄ o halógeno; R⁷ representa hidrógeno, alquilo C₁₋₄, alcoxi C₁₋₄, cicloalquilo C₃₋₆-metoxi, cicloalquiloxi C₃₋₆, metoxi-etoxi, di-[alquilo C₁₋₂]-amino, fluoroalquilo C₁₋₄, fluoroalcoxi C₁₋₄, halógeno o alquilsulfonilo C₁₋₄; o R⁶ y R⁷ juntos representan metilendioxi o etilendioxi; R⁸ representa: alquilo C₂₋₅; alquilo C₁₋₅ que está mono- o di-sustituido donde los sustituyentes se seleccionan de manera independiente del grupo que consiste en hidroxi, alcoxi C₁₋₄, oxo, -NR⁹R¹⁰, cicloalquilo C₃₋₆ opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heterociclilo opcionalmente sustituido, ariloxi opcionalmente sustituido, heteroariloxi opcionalmente sustituido o arilo-alcoxi C₁₋₂ opcionalmente sustituido; alquenilo C₃₋₅; alquenilo C₂₋₃ que está mono-sustituido con arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; alquinilo C₃₋₅; cicloalquilo C₃₋₆ que está no sustituido, mono-, di-, tri- o tetra-sustituido con metilo; mono-sustituido con oxo; mono-sustituido con arilo opcionalmente sustituido; o mono-sustituido con heteroarilo opcionalmente sustituido; o heterociclilo que está opcionalmente mono-sustituido con oxo; R⁹ representa alquilo C₁₋₄; R¹⁰ representa difenilmetilo opcionalmente sustituido; n representa 1 ó 2; m representa 1 ó 2; y Z representa -NH-, -O- o un enlace; o una sal de dicho compuesto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2011055866 | 2011-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR089360A1 true AR089360A1 (es) | 2014-08-20 |
Family
ID=47678924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120104859A AR089360A1 (es) | 2011-12-21 | 2012-12-20 | Derivados de heterociclilo y su uso como moduladores del receptor d₂ de prostaglandina |
Country Status (14)
Country | Link |
---|---|
US (1) | US9255090B2 (es) |
EP (1) | EP2794563B1 (es) |
JP (1) | JP6097765B2 (es) |
KR (1) | KR20140107550A (es) |
CN (1) | CN104011021B (es) |
AR (1) | AR089360A1 (es) |
AU (1) | AU2012356076A1 (es) |
BR (1) | BR112014015081A2 (es) |
CA (1) | CA2858328A1 (es) |
ES (1) | ES2624379T3 (es) |
MX (1) | MX2014007688A (es) |
RU (1) | RU2014129613A (es) |
TW (1) | TW201331179A (es) |
WO (1) | WO2013093842A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2876808A1 (en) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
JO3316B1 (ar) | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
Family Cites Families (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB238854A (en) | 1924-08-20 | 1926-02-11 | Walter Martin Cross | Improvements in or relating to turbines |
US5236934A (en) * | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
EP1395590B1 (en) | 2001-05-23 | 2006-09-27 | Merck Frosst Canada & Co. | Dihydropyrrolo¬1,2-a|indole and tetrahydropyrido¬1,2-a|indole derivatives as prostaglandin d2 receptor antagonists |
SE0103644D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
AU2003231509A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Compound exhibiting pgd 2 receptor antagonism |
JPWO2003097042A1 (ja) | 2002-05-16 | 2005-09-15 | 塩野義製薬株式会社 | Pgd2受容体拮抗剤 |
GB2388540A (en) | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
AU2003277285B2 (en) | 2002-10-04 | 2007-12-13 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
EP1413306A1 (en) | 2002-10-21 | 2004-04-28 | Warner-Lambert Company LLC | Tetrahydroquinoline derivatives as CRTH2 antagonists |
AU2003269327A1 (en) | 2002-10-21 | 2004-05-04 | Warner-Lambert Company Llc | Tetrahydroquinoline derivatives as crth2 antagonists |
AU2003297398B2 (en) | 2002-12-20 | 2009-09-24 | Amgen Inc. | Asthma and allergic inflammation modulators |
EP1435356A1 (en) | 2003-01-06 | 2004-07-07 | Warner-Lambert Company LLC | Quinoline derivatives as CRTH2 antagonists |
SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
SE0301009D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
ES2257616T3 (es) | 2003-04-25 | 2006-08-01 | Actimis Pharmaceuticals, Inc. | Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2. |
SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
ZA200605387B (en) | 2004-01-31 | 2008-05-28 | Actimis Pharmaceuticals Inc | Imidazo[1.2-c]pyrimidinylacetic acid derivatives |
US7875631B2 (en) | 2004-03-12 | 2011-01-25 | Analytecon S.A. | Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives as igf-1 r inhibitors |
CN101018770A (zh) | 2004-04-07 | 2007-08-15 | 千禧药品公司 | 炎性疾病治疗用pgd2受体拮抗剂 |
WO2005102338A1 (en) | 2004-04-20 | 2005-11-03 | Pfizer Limited | Method of treating neuropathic pain using a crth2 receptor antagonist |
GB0409921D0 (en) | 2004-05-04 | 2004-06-09 | Novartis Ag | Organic compounds |
EP2336113A1 (en) | 2004-05-29 | 2011-06-22 | 7TM Pharma A/S | CRTH2 Receptor Ligands for Medical Use |
GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
GB0422057D0 (en) | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
GT200500284A (es) | 2004-10-15 | 2006-03-27 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
ATE517085T1 (de) | 2004-11-23 | 2011-08-15 | Astrazeneca Ab | Zur behandlung von atemwegserkrankungen geeignete phenoxyessigsäurederivate |
GB0427381D0 (en) | 2004-12-14 | 2005-01-19 | Novartis Ag | Organic compounds |
DOP2006000016A (es) | 2005-01-26 | 2006-07-31 | Aventis Pharma Inc | 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2. |
UA90706C2 (ru) | 2005-02-24 | 2010-05-25 | Милленниум Фармасьютикалз, Инк. | Антагонисты рецептора pgd2 для лечения воспалительных заболеваний |
GB0510585D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
US7842692B2 (en) | 2005-07-22 | 2010-11-30 | Shionogi & Co., Ltd. | Azaindole derivative having PGD2 receptor antagonistic activity |
JP5072594B2 (ja) | 2005-07-22 | 2012-11-14 | 塩野義製薬株式会社 | Pgd2受容体アンタゴニスト活性を有するインドール誘導体 |
US8143285B2 (en) | 2005-09-06 | 2012-03-27 | Shionogi & Co., Ltd. | Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity |
AU2006296004B2 (en) | 2005-09-27 | 2011-11-17 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
PT1928457E (pt) | 2005-09-30 | 2013-02-19 | Pulmagen Therapeutics Asthma Ltd | Quinolinas e sua utilização terapêutica |
EP1937632A1 (en) | 2005-10-06 | 2008-07-02 | Astra Zeneca AB | Novel compounds |
TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
WO2007052023A2 (en) | 2005-11-05 | 2007-05-10 | Astrazeneca Ab | Novel compounds |
WO2007062678A1 (en) | 2005-11-29 | 2007-06-07 | 7Tm Pharma A/S | Phenoxyacetic acid derivatives as crth2 receptor ligands |
GB0524428D0 (en) | 2005-11-30 | 2006-01-11 | 7Tm Pharma As | Medicinal use of receptor ligands |
US20080004272A1 (en) | 2006-04-10 | 2008-01-03 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
AR060403A1 (es) | 2006-04-12 | 2008-06-11 | Sanofi Aventis | Compuestos de amino- pirimidina 2,6- sustituidos -4- monosustituidos como antagonistas del receptor de prostaglandina d2 |
EA200802417A1 (ru) | 2006-06-09 | 2009-06-30 | Икос Корпорейшн | Замещенные фенилуксусные кислоты как dp-2-антагонисты |
AU2007256597A1 (en) | 2006-06-09 | 2007-12-13 | Icos Corporation | Substituted phenyl acetic acids as DP-2 antagonists |
GB0611781D0 (en) | 2006-06-14 | 2006-07-26 | Argenta Discovery Ltd | 2-Oxo-2H-Chromene Compounds |
TW200848036A (en) | 2006-12-14 | 2008-12-16 | Astellas Pharma Inc | Novel oxycarbonyl compound |
JP2010522731A (ja) | 2007-03-29 | 2010-07-08 | アージェンタ オーラル セラピューティクス リミテッド | Crth2受容体リガンドとしてのキノリン誘導体 |
US8173812B2 (en) | 2007-04-04 | 2012-05-08 | Pulmagen Therapeutics (Asthma) Limited | Quinolines and their therapeutic use |
UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
WO2009061730A2 (en) | 2007-11-05 | 2009-05-14 | Array Biopharma Inc. | 4-heteroaryl-substituted phenoxyphenylacetic acid |
GB0722055D0 (en) | 2007-11-09 | 2007-12-19 | Argenta Discovery Ltd | Compounds |
WO2009089192A1 (en) | 2008-01-07 | 2009-07-16 | Ligand Pharmaceuticals Inc. | 2-phenyl phenoxyacetic acids useful for treating inflammatory disorders |
MX2010008260A (es) * | 2008-02-01 | 2010-12-20 | Amira Pharmaceuticals Inc | Antagonistas n,n-disustituidos de aminoalquilbifenilo de receptores d2 de prostaglandina. |
EP2245002A4 (en) | 2008-02-01 | 2011-08-17 | Amira Pharmaceuticals Inc | AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN |
JP2011512359A (ja) | 2008-02-14 | 2011-04-21 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のアンタゴニストとしての環式ジアリールエーテル化合物 |
US8497381B2 (en) | 2008-02-25 | 2013-07-30 | Panmira Pharmaceuticals, Llc | Antagonists of prostaglandin D2 receptors |
US8426449B2 (en) | 2008-04-02 | 2013-04-23 | Panmira Pharmaceuticals, Llc | Aminoalkylphenyl antagonists of prostaglandin D2 receptors |
US20110144160A1 (en) | 2008-07-03 | 2011-06-16 | Amira Pharmaceuticals, Inc. | Antagonists of Prostaglandin D2 Receptors |
CA2734104A1 (en) | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Substituted aminotetralines |
CN102149676A (zh) | 2008-08-15 | 2011-08-10 | 霍夫曼-拉罗奇有限公司 | 单芳基氨基四氢化萘类 |
EP2321268A2 (en) | 2008-08-15 | 2011-05-18 | F. Hoffmann-La Roche AG | Bi-aryl aminotetralines |
US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
KR101322496B1 (ko) | 2008-11-17 | 2013-10-29 | 에프. 호프만-라 로슈 아게 | 나프틸아세트산 |
JP2012517405A (ja) | 2009-02-09 | 2012-08-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器及び胃腸の疾患の治療のための新規医薬組成物 |
EP2396295A1 (en) | 2009-02-12 | 2011-12-21 | Merck Serono S.A. | Phenoxy acetic acid derivatives |
WO2010102154A2 (en) | 2009-03-05 | 2010-09-10 | Ligand Pharmaceuticals Incorporated | Biaryl oxyacetic acid compounds |
GB0907284D0 (en) * | 2009-04-28 | 2009-06-10 | Queen Mary & Westfield College | Compounds for inducing cellular apoptosis |
WO2011002814A2 (en) | 2009-06-30 | 2011-01-06 | Ligand Pharmaceuticals Inc. | Biaryl oxyacetic acid compounds |
KR20120046762A (ko) | 2009-07-31 | 2012-05-10 | 판미라 파마슈티칼스, 엘엘씨 | Dp2 수용체 길항제의 피부 제형 |
EP2461809A4 (en) | 2009-07-31 | 2013-06-19 | Panmira Pharmaceuticals Llc | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONSITES |
CA2768587A1 (en) | 2009-08-05 | 2011-02-10 | Panmira Pharmaceuticals, Llc | Dp2 antagonist and uses thereof |
WO2011055270A1 (en) | 2009-11-04 | 2011-05-12 | Wyeth Llc | Indole based receptor crth2 antagonists |
TW201201805A (en) | 2010-07-05 | 2012-01-16 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
BR112013015397A2 (pt) | 2010-12-23 | 2016-09-20 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
PL2671869T3 (pl) * | 2011-02-02 | 2016-09-30 | Pochodna tetrahydroizochinoliny | |
AR089653A1 (es) | 2011-10-25 | 2014-09-10 | Shionogi & Co | Derivados heterociclicos que tienen actividad antagonista del receptor de pgd2 |
US8691993B2 (en) | 2011-12-12 | 2014-04-08 | Hoffmann-La Roche Inc. | Piperidinyl naphthylacetic acids |
US9000044B2 (en) | 2012-02-28 | 2015-04-07 | Hoffmann-La Roche Inc. | Substituted naphthylacetic acids |
CA2876808A1 (en) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
-
2012
- 2012-12-20 WO PCT/IB2012/057541 patent/WO2013093842A1/en active Application Filing
- 2012-12-20 TW TW101148812A patent/TW201331179A/zh unknown
- 2012-12-20 CN CN201280062996.8A patent/CN104011021B/zh not_active Expired - Fee Related
- 2012-12-20 ES ES12823031T patent/ES2624379T3/es active Active
- 2012-12-20 EP EP12823031.5A patent/EP2794563B1/en not_active Not-in-force
- 2012-12-20 AU AU2012356076A patent/AU2012356076A1/en not_active Abandoned
- 2012-12-20 US US14/367,823 patent/US9255090B2/en not_active Expired - Fee Related
- 2012-12-20 BR BR112014015081A patent/BR112014015081A2/pt not_active Application Discontinuation
- 2012-12-20 RU RU2014129613A patent/RU2014129613A/ru not_active Application Discontinuation
- 2012-12-20 KR KR1020147020391A patent/KR20140107550A/ko not_active Application Discontinuation
- 2012-12-20 AR ARP120104859A patent/AR089360A1/es unknown
- 2012-12-20 MX MX2014007688A patent/MX2014007688A/es unknown
- 2012-12-20 CA CA2858328A patent/CA2858328A1/en not_active Abandoned
- 2012-12-20 JP JP2014548313A patent/JP6097765B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN104011021B (zh) | 2016-08-24 |
CN104011021A (zh) | 2014-08-27 |
WO2013093842A1 (en) | 2013-06-27 |
EP2794563B1 (en) | 2017-02-22 |
AU2012356076A1 (en) | 2014-08-14 |
BR112014015081A8 (pt) | 2017-06-13 |
MX2014007688A (es) | 2014-07-28 |
US9255090B2 (en) | 2016-02-09 |
BR112014015081A2 (pt) | 2017-06-13 |
JP6097765B2 (ja) | 2017-03-15 |
US20150252036A1 (en) | 2015-09-10 |
CA2858328A1 (en) | 2013-06-27 |
EP2794563A1 (en) | 2014-10-29 |
KR20140107550A (ko) | 2014-09-04 |
ES2624379T3 (es) | 2017-07-14 |
RU2014129613A (ru) | 2016-02-10 |
JP2015502399A (ja) | 2015-01-22 |
TW201331179A (zh) | 2013-08-01 |
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