AR078863A1 - Derivados de espiropiperidina antagonista de receptores orl-1, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la migrana, obesidad y/o depresion. - Google Patents

Derivados de espiropiperidina antagonista de receptores orl-1, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la migrana, obesidad y/o depresion.

Info

Publication number
AR078863A1
AR078863A1 ARP100104035A ARP100104035A AR078863A1 AR 078863 A1 AR078863 A1 AR 078863A1 AR P100104035 A ARP100104035 A AR P100104035A AR P100104035 A ARP100104035 A AR P100104035A AR 078863 A1 AR078863 A1 AR 078863A1
Authority
AR
Argentina
Prior art keywords
ylmethyl
hydrogen
obesity
depression
treatment
Prior art date
Application number
ARP100104035A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR078863A1 publication Critical patent/AR078863A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP100104035A 2009-11-16 2010-11-02 Derivados de espiropiperidina antagonista de receptores orl-1, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la migrana, obesidad y/o depresion. AR078863A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382246 2009-11-16
US29862910P 2010-01-27 2010-01-27

Publications (1)

Publication Number Publication Date
AR078863A1 true AR078863A1 (es) 2011-12-07

Family

ID=41728051

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104035A AR078863A1 (es) 2009-11-16 2010-11-02 Derivados de espiropiperidina antagonista de receptores orl-1, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la migrana, obesidad y/o depresion.

Country Status (34)

Country Link
US (1) US8232289B2 (https=)
EP (1) EP2501703B1 (https=)
JP (1) JP5680101B2 (https=)
KR (1) KR101363830B1 (https=)
CN (1) CN102612520B (https=)
AR (1) AR078863A1 (https=)
AU (1) AU2010319581C1 (https=)
CA (1) CA2796161C (https=)
CO (1) CO6541545A2 (https=)
CR (1) CR20130087A (https=)
DK (1) DK2501703T3 (https=)
DO (1) DOP2012000135A (https=)
EA (1) EA020848B1 (https=)
EC (1) ECSP12011902A (https=)
ES (1) ES2435814T3 (https=)
HN (1) HN2012001011A (https=)
HR (1) HRP20130967T1 (https=)
IL (1) IL219370A (https=)
JO (1) JO2887B1 (https=)
MA (1) MA33751B1 (https=)
ME (1) ME01537B (https=)
MX (1) MX2012005691A (https=)
MY (1) MY160665A (https=)
NZ (1) NZ600006A (https=)
PE (1) PE20121430A1 (https=)
PH (1) PH12012500969A1 (https=)
PL (1) PL2501703T3 (https=)
PT (1) PT2501703E (https=)
RS (1) RS53018B (https=)
SI (1) SI2501703T1 (https=)
TW (1) TWI465453B (https=)
UA (1) UA107943C2 (https=)
WO (1) WO2011060035A1 (https=)
ZA (1) ZA201202967B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201510665WA (en) 2009-12-04 2016-01-28 Sunovion Pharmaceuticals Inc Multicycle Compounds And Pharmaceutical Compositions Useful For The Treatment Of Neurological Disorders
US9394290B2 (en) * 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
TWI582096B (zh) * 2011-12-06 2017-05-11 美國禮來大藥廠 用於酒精依賴及濫用處理之４',５'－二氫螺［哌啶－４,７'－噻吩并[２，３－c]哌喃］化合物
TW201416370A (zh) 2012-07-31 2014-05-01 Lilly Co Eli 用於治療焦慮之ｏｒｌ－１受體拮抗劑
DK2903440T3 (en) 2012-10-02 2017-12-11 Bayer Cropscience Ag THETEROCYCLIC COMPOUNDS AS PESTICIDES
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
JO3638B1 (ar) * 2015-09-09 2020-08-27 Lilly Co Eli مركبات مفيدة في تثبيط ror - جاما- t
MA45795A (fr) 2016-07-29 2019-06-05 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
PT3494119T (pt) 2016-07-29 2024-12-10 Pgi Drug Discovery Llc Compostos e composições e seus usos
MX390141B (es) 2017-02-16 2025-03-20 Sunovion Pharmaceuticals Inc Metodos para tratar esquizofrenia
HUE054483T2 (hu) 2017-03-02 2021-09-28 Lilly Co Eli ROR-gamma-T gátlására alkalmas vegyületek
US10603320B2 (en) * 2017-03-02 2020-03-31 Eli Lilly And Company Compounds useful for inhibiting ROR-gamma-t
CA3070993C (en) 2017-08-02 2025-05-20 Sunovion Pharmaceuticals Inc. ISOCHROMANE COMPOUNDS AND THEIR USES
UA130249C2 (uk) 2018-02-16 2025-12-31 Сумітомо Фарма Америка, Інк. Солі, кристалічні форми і способи їх отримання
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
EP3938045A1 (en) 2019-03-14 2022-01-19 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
CA3180115A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders
CN115867543A (zh) 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1抑制剂的固体形式及其使用方法
CN116547287B (zh) 2020-08-26 2025-09-26 弗特克斯药品有限公司 Apol1的抑制剂及其使用方法
CA3251050A1 (en) * 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES USED AS APOL1 INHIBITORS AND THEIR METHODS OF USE

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
US6686370B2 (en) * 1999-12-06 2004-02-03 Euro-Celtique S.A. Triazospiro compounds having nociceptin receptor affinity
KR100628292B1 (ko) * 2001-04-18 2006-09-27 유로-셀티크 소시에떼 아노뉨 스파이로파이라졸 화합물
WO2002088089A1 (en) 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Spiropiperidine derivatives, nociceptin receptor antagonists containing the same as the active ingredient and medicinal compositions
ATE396995T1 (de) * 2001-07-23 2008-06-15 Banyu Pharma Co Ltd 4-oxoimidazolidin-2-spiro piperidin derivat
BR0307268A (pt) * 2002-01-28 2004-12-14 Pfizer Compostos de espiropiperidina n-substituìda como ligantes para o receptor orl-1
WO2003095427A1 (en) 2002-05-10 2003-11-20 Taisho Pharmaceutical Co.,Ltd. Spiro-ring compound
US6995168B2 (en) * 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
JP4712384B2 (ja) * 2002-09-09 2011-06-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
WO2005016913A1 (en) * 2003-08-19 2005-02-24 Pfizer Japan, Inc. Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
DE10360792A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US7354925B2 (en) * 2004-03-29 2008-04-08 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists
DE102004039382A1 (de) * 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
PT2260042E (pt) * 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos

Also Published As

Publication number Publication date
SI2501703T1 (sl) 2013-11-29
DK2501703T3 (da) 2013-10-14
TWI465453B (zh) 2014-12-21
ZA201202967B (en) 2013-09-25
CN102612520B (zh) 2015-04-08
CR20130087A (es) 2013-04-17
PL2501703T3 (pl) 2014-02-28
EA201290352A1 (ru) 2012-10-30
MA33751B1 (fr) 2012-11-01
DOP2012000135A (es) 2012-08-15
RS53018B (sr) 2014-04-30
AU2010319581A1 (en) 2012-06-07
TW201127841A (en) 2011-08-16
MX2012005691A (es) 2012-06-13
US8232289B2 (en) 2012-07-31
ES2435814T3 (es) 2013-12-23
JO2887B1 (en) 2015-03-15
PH12012500969A1 (en) 2013-01-07
EA020848B1 (ru) 2015-02-27
ME01537B (me) 2014-04-20
PE20121430A1 (es) 2012-10-26
US20110118251A1 (en) 2011-05-19
JP2013510859A (ja) 2013-03-28
AU2010319581B2 (en) 2013-12-19
JP5680101B2 (ja) 2015-03-04
HK1169988A1 (en) 2013-02-15
IL219370A0 (en) 2012-06-28
ECSP12011902A (es) 2012-07-31
EP2501703B1 (en) 2013-09-18
CN102612520A (zh) 2012-07-25
HRP20130967T1 (hr) 2013-11-22
CA2796161C (en) 2015-03-17
PT2501703E (pt) 2013-11-26
WO2011060035A1 (en) 2011-05-19
HN2012001011A (es) 2015-08-31
AU2010319581C1 (en) 2014-05-15
EP2501703A1 (en) 2012-09-26
MY160665A (en) 2017-03-15
UA107943C2 (xx) 2015-03-10
CA2796161A1 (en) 2011-05-19
KR20130026523A (ko) 2013-03-13
KR101363830B1 (ko) 2014-02-14
CO6541545A2 (es) 2012-10-16
IL219370A (en) 2015-01-29
NZ600006A (en) 2014-05-30

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