KR101363830B1 - Ｏｒｌ―１ 수용체 길항제로서의 스피로피페리딘 화합물 - Google Patents

Ｏｒｌ―１ 수용체 길항제로서의 스피로피페리딘 화합물 Download PDF

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Publication number
KR101363830B1
KR101363830B1 KR1020127012498A KR20127012498A KR101363830B1 KR 101363830 B1 KR101363830 B1 KR 101363830B1 KR 1020127012498 A KR1020127012498 A KR 1020127012498A KR 20127012498 A KR20127012498 A KR 20127012498A KR 101363830 B1 KR101363830 B1 KR 101363830B1
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South Korea
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methyl
mmol
pyran
chloro
added
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Korean (ko)
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KR20130026523A (ko
Inventor
안나 벨렌 베니토 콜라도
누리아 디아즈 부에조
알마 마리아 지메네즈-아구아도
셀리아 라푸엔테 블랑코
마리아 안젤레스 마르티네즈-그라우
콘셉시온 페드레갈-테르세로
미구엘 앤젤 톨레도 에스크리바노
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020127012498A 2009-11-16 2010-11-10 Ｏｒｌ―１ 수용체 길항제로서의 스피로피페리딘 화합물 Expired - Fee Related KR101363830B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09382246 2009-11-16
EP09382246.8 2009-11-16
US29862910P 2010-01-27 2010-01-27
US61/298,629 2010-01-27
PCT/US2010/056180 WO2011060035A1 (en) 2009-11-16 2010-11-10 Spiropiperidine compounds as orl-1 receptor antagonists

Publications (2)

Publication Number Publication Date
KR20130026523A KR20130026523A (ko) 2013-03-13
KR101363830B1 true KR101363830B1 (ko) 2014-02-14

Family

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KR1020127012498A Expired - Fee Related KR101363830B1 (ko) 2009-11-16 2010-11-10 Ｏｒｌ―１ 수용체 길항제로서의 스피로피페리딘 화합물

Country Status (34)

Country Link
US (1) US8232289B2 (https=)
EP (1) EP2501703B1 (https=)
JP (1) JP5680101B2 (https=)
KR (1) KR101363830B1 (https=)
CN (1) CN102612520B (https=)
AR (1) AR078863A1 (https=)
AU (1) AU2010319581C1 (https=)
CA (1) CA2796161C (https=)
CO (1) CO6541545A2 (https=)
CR (1) CR20130087A (https=)
DK (1) DK2501703T3 (https=)
DO (1) DOP2012000135A (https=)
EA (1) EA020848B1 (https=)
EC (1) ECSP12011902A (https=)
ES (1) ES2435814T3 (https=)
HN (1) HN2012001011A (https=)
HR (1) HRP20130967T1 (https=)
IL (1) IL219370A (https=)
JO (1) JO2887B1 (https=)
MA (1) MA33751B1 (https=)
ME (1) ME01537B (https=)
MX (1) MX2012005691A (https=)
MY (1) MY160665A (https=)
NZ (1) NZ600006A (https=)
PE (1) PE20121430A1 (https=)
PH (1) PH12012500969A1 (https=)
PL (1) PL2501703T3 (https=)
PT (1) PT2501703E (https=)
RS (1) RS53018B (https=)
SI (1) SI2501703T1 (https=)
TW (1) TWI465453B (https=)
UA (1) UA107943C2 (https=)
WO (1) WO2011060035A1 (https=)
ZA (1) ZA201202967B (https=)

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SG10201510665WA (en) 2009-12-04 2016-01-28 Sunovion Pharmaceuticals Inc Multicycle Compounds And Pharmaceutical Compositions Useful For The Treatment Of Neurological Disorders
US9394290B2 (en) * 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
TWI582096B (zh) * 2011-12-06 2017-05-11 美國禮來大藥廠 用於酒精依賴及濫用處理之４',５'－二氫螺［哌啶－４,７'－噻吩并[２，３－c]哌喃］化合物
TW201416370A (zh) 2012-07-31 2014-05-01 Lilly Co Eli 用於治療焦慮之ｏｒｌ－１受體拮抗劑
DK2903440T3 (en) 2012-10-02 2017-12-11 Bayer Cropscience Ag THETEROCYCLIC COMPOUNDS AS PESTICIDES
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
JO3638B1 (ar) * 2015-09-09 2020-08-27 Lilly Co Eli مركبات مفيدة في تثبيط ror - جاما- t
MA45795A (fr) 2016-07-29 2019-06-05 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
PT3494119T (pt) 2016-07-29 2024-12-10 Pgi Drug Discovery Llc Compostos e composições e seus usos
MX390141B (es) 2017-02-16 2025-03-20 Sunovion Pharmaceuticals Inc Metodos para tratar esquizofrenia
HUE054483T2 (hu) 2017-03-02 2021-09-28 Lilly Co Eli ROR-gamma-T gátlására alkalmas vegyületek
US10603320B2 (en) * 2017-03-02 2020-03-31 Eli Lilly And Company Compounds useful for inhibiting ROR-gamma-t
CA3070993C (en) 2017-08-02 2025-05-20 Sunovion Pharmaceuticals Inc. ISOCHROMANE COMPOUNDS AND THEIR USES
UA130249C2 (uk) 2018-02-16 2025-12-31 Сумітомо Фарма Америка, Інк. Солі, кристалічні форми і способи їх отримання
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
EP3938045A1 (en) 2019-03-14 2022-01-19 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
CA3180115A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders
CN115867543A (zh) 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1抑制剂的固体形式及其使用方法
CN116547287B (zh) 2020-08-26 2025-09-26 弗特克斯药品有限公司 Apol1的抑制剂及其使用方法
CA3251050A1 (en) * 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES USED AS APOL1 INHIBITORS AND THEIR METHODS OF USE

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WO2005016913A1 (en) 2003-08-19 2005-02-24 Pfizer Japan, Inc. Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
WO2005066183A1 (de) 2003-12-23 2005-07-21 Grünenthal GmbH Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor

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IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
US6686370B2 (en) * 1999-12-06 2004-02-03 Euro-Celtique S.A. Triazospiro compounds having nociceptin receptor affinity
KR100628292B1 (ko) * 2001-04-18 2006-09-27 유로-셀티크 소시에떼 아노뉨 스파이로파이라졸 화합물
WO2002088089A1 (en) 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Spiropiperidine derivatives, nociceptin receptor antagonists containing the same as the active ingredient and medicinal compositions
ATE396995T1 (de) * 2001-07-23 2008-06-15 Banyu Pharma Co Ltd 4-oxoimidazolidin-2-spiro piperidin derivat
BR0307268A (pt) * 2002-01-28 2004-12-14 Pfizer Compostos de espiropiperidina n-substituìda como ligantes para o receptor orl-1
WO2003095427A1 (en) 2002-05-10 2003-11-20 Taisho Pharmaceutical Co.,Ltd. Spiro-ring compound
US6995168B2 (en) * 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
JP4712384B2 (ja) * 2002-09-09 2011-06-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
US7354925B2 (en) * 2004-03-29 2008-04-08 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists
DE102004039382A1 (de) * 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
PT2260042E (pt) * 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2005016913A1 (en) 2003-08-19 2005-02-24 Pfizer Japan, Inc. Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
WO2005066183A1 (de) 2003-12-23 2005-07-21 Grünenthal GmbH Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor

Also Published As

Publication number Publication date
SI2501703T1 (sl) 2013-11-29
DK2501703T3 (da) 2013-10-14
TWI465453B (zh) 2014-12-21
ZA201202967B (en) 2013-09-25
CN102612520B (zh) 2015-04-08
CR20130087A (es) 2013-04-17
PL2501703T3 (pl) 2014-02-28
EA201290352A1 (ru) 2012-10-30
MA33751B1 (fr) 2012-11-01
DOP2012000135A (es) 2012-08-15
RS53018B (sr) 2014-04-30
AU2010319581A1 (en) 2012-06-07
TW201127841A (en) 2011-08-16
MX2012005691A (es) 2012-06-13
US8232289B2 (en) 2012-07-31
ES2435814T3 (es) 2013-12-23
JO2887B1 (en) 2015-03-15
PH12012500969A1 (en) 2013-01-07
EA020848B1 (ru) 2015-02-27
ME01537B (me) 2014-04-20
PE20121430A1 (es) 2012-10-26
US20110118251A1 (en) 2011-05-19
JP2013510859A (ja) 2013-03-28
AU2010319581B2 (en) 2013-12-19
JP5680101B2 (ja) 2015-03-04
HK1169988A1 (en) 2013-02-15
IL219370A0 (en) 2012-06-28
ECSP12011902A (es) 2012-07-31
EP2501703B1 (en) 2013-09-18
CN102612520A (zh) 2012-07-25
HRP20130967T1 (hr) 2013-11-22
CA2796161C (en) 2015-03-17
PT2501703E (pt) 2013-11-26
WO2011060035A1 (en) 2011-05-19
HN2012001011A (es) 2015-08-31
AU2010319581C1 (en) 2014-05-15
EP2501703A1 (en) 2012-09-26
MY160665A (en) 2017-03-15
UA107943C2 (xx) 2015-03-10
CA2796161A1 (en) 2011-05-19
AR078863A1 (es) 2011-12-07
KR20130026523A (ko) 2013-03-13
CO6541545A2 (es) 2012-10-16
IL219370A (en) 2015-01-29
NZ600006A (en) 2014-05-30

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