PE20142421A1 - Fenilimidazopirazoles sustituidos y su uso - Google Patents

Fenilimidazopirazoles sustituidos y su uso

Info

Publication number
PE20142421A1
PE20142421A1 PE2014001145A PE2014001145A PE20142421A1 PE 20142421 A1 PE20142421 A1 PE 20142421A1 PE 2014001145 A PE2014001145 A PE 2014001145A PE 2014001145 A PE2014001145 A PE 2014001145A PE 20142421 A1 PE20142421 A1 PE 20142421A1
Authority
PE
Peru
Prior art keywords
methyl
phenylimidazopyrazoles
substituted
sulfanil
pirazol
Prior art date
Application number
PE2014001145A
Other languages
English (en)
Inventor
;Meier Frank Su&
Mario Lobell
Sylvia Grunewald
Michael Harter
Bernd Buchmann
Joachim Telser
;En Hannah Jori&
Melanie Heroult
Antje Kahnert
Klemens Lustig
Niels Lindner
Original Assignee
Bayer Pharma AG
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47594775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142421(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG, Bayer Ip Gmbh filed Critical Bayer Pharma AG
Publication of PE20142421A1 publication Critical patent/PE20142421A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE ARN ES UN AZA-HETEROARILO C5-C6; R1 ES H O F; R2 ES H O ALQUILO (C1-C4); R3 ES H; R4A Y R4B SON INDEPENDIENTEMENTE ENTRE SI, H, F, CL, ENTRE OTROS; R5 ES H, F, CL O METILO; R6 ES H, F, METILO O HIDROXI, Z1 ES C-R7A O N; Z2 ES C-R7B O N; Z3 ES C-R8 O N; Z4 ES C-R9 O N; Z5 ES C-R10 O N; R7A Y R7B SON, INDEPENDIENTEMENTE ENTRE SI, H, F, CL, ENTRE OTROS; R8 ES H, F, CL O METILO; R9 ES H, PENTAFLUOROSULFANILO, ENTRE OTROS; R10 ES H, F, CL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-CIANO-N-{4-METIL-3-[6-(1,3-TIAZOL-5-IL)-1H-IMIDAZOL[1,2-B]PIRAZOL-1-IL]FENIL}-5-(PENTAFLUORO- ?6-SULFANIL)BENZAMIDA; 3-(2-HIDROXIPROPAN-2-IL)-N-{4-METIL-3-[6-(1,3-TIAZOL-5-IL)-1H-IMIDAZO[1,2-B]PIRAZOL-1-IL]FENIL}-5-(PENTAFLUORO- ?6-SULFANIL)BENZAMIDA. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES ANGIOGENICAS.
PE2014001145A 2012-01-25 2013-01-22 Fenilimidazopirazoles sustituidos y su uso PE20142421A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12152515 2012-01-25

Publications (1)

Publication Number Publication Date
PE20142421A1 true PE20142421A1 (es) 2015-01-11

Family

ID=47594775

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001145A PE20142421A1 (es) 2012-01-25 2013-01-22 Fenilimidazopirazoles sustituidos y su uso

Country Status (31)

Country Link
US (2) US20150005288A1 (es)
EP (1) EP2807162B1 (es)
JP (1) JP6101290B2 (es)
KR (1) KR20140117582A (es)
CN (1) CN104411707B (es)
AP (1) AP2014007869A0 (es)
AR (1) AR089788A1 (es)
AU (1) AU2013211707A1 (es)
BR (1) BR112014018450A8 (es)
CA (1) CA2862163A1 (es)
CL (1) CL2014001959A1 (es)
CO (1) CO7101244A2 (es)
CR (1) CR20140362A (es)
CU (1) CU20140096A7 (es)
DO (1) DOP2014000173A (es)
EA (1) EA201491427A1 (es)
EC (1) ECSP14010868A (es)
ES (1) ES2639338T3 (es)
GT (1) GT201400161A (es)
HK (1) HK1203198A1 (es)
IL (1) IL233652A0 (es)
MA (1) MA35877B1 (es)
MX (1) MX2014008893A (es)
PE (1) PE20142421A1 (es)
PH (1) PH12014501687A1 (es)
SG (1) SG11201404118XA (es)
TN (1) TN2014000320A1 (es)
TW (1) TW201343649A (es)
UY (1) UY34590A (es)
WO (1) WO2013110590A1 (es)
ZA (1) ZA201405392B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013110590A1 (de) * 2012-01-25 2013-08-01 Bayer Pharma Aktiengesellschaft Substituierte phenylimidazopyrazole und ihre verwendung
CA3172586A1 (en) 2013-07-31 2015-02-05 Avalyn Pharma Inc. Aerosol imatininb compounds and uses thereof
CN107873027A (zh) 2014-11-06 2018-04-03 巴斯夫欧洲公司 用于防治无脊椎动物害虫的3‑吡啶基杂双环化合物
MX2018004185A (es) * 2015-10-08 2018-11-09 Fmc Corp Pesticidas de azoles biciclicos sustituidos con heterociclos.
UY38366A (es) * 2018-09-13 2020-04-30 Syngenta Participations Ag Compuestos de azol-amida pesticidamente activos
CN109096195A (zh) * 2018-09-27 2018-12-28 上海雅本化学有限公司 一种艾曲波帕的制备方法
WO2021074108A1 (de) * 2019-10-16 2021-04-22 Bayer Aktiengesellschaft Verfahren zur herstellung von 1,1'-disulfandiylbis(4-fluor-2-methyl-5-nitrobenzol)
US20230145003A1 (en) * 2020-01-29 2023-05-11 Foghorn Therapeutics Inc. Compounds and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753730B2 (ja) * 1988-07-26 1995-06-07 三共株式会社 イミダゾピラゾール誘導体
UA80171C2 (en) * 2002-12-19 2007-08-27 Pfizer Prod Inc Pyrrolopyrimidine derivatives
US7419978B2 (en) * 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
KR101061599B1 (ko) * 2008-12-05 2011-09-02 한국과학기술연구원 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물
JP5744859B2 (ja) * 2009-06-15 2015-07-08 ライジェル ファーマシューティカルズ， インコーポレイテッド 脾臓チロシンキナーゼ（ｓｙｋ）の小分子阻害薬
KR101116756B1 (ko) * 2009-10-27 2012-03-13 한국과학기술연구원 단백질 키나아제 저해활성을 갖는 신규의 1,6-치환된 인돌 화합물
WO2013110590A1 (de) * 2012-01-25 2013-08-01 Bayer Pharma Aktiengesellschaft Substituierte phenylimidazopyrazole und ihre verwendung

Also Published As

Publication number Publication date
ES2639338T3 (es) 2017-10-26
DOP2014000173A (es) 2014-08-31
MA35877B1 (fr) 2014-12-01
JP6101290B2 (ja) 2017-03-22
CN104411707B (zh) 2017-03-01
PH12014501687A1 (en) 2014-10-20
EA201491427A1 (ru) 2015-01-30
GT201400161A (es) 2015-03-05
CL2014001959A1 (es) 2014-11-07
CR20140362A (es) 2014-08-21
AU2013211707A1 (en) 2014-08-07
WO2013110590A1 (de) 2013-08-01
US20150005288A1 (en) 2015-01-01
CO7101244A2 (es) 2014-10-31
EP2807162A1 (de) 2014-12-03
MX2014008893A (es) 2014-08-26
JP2015504904A (ja) 2015-02-16
ZA201405392B (en) 2015-12-23
AP2014007869A0 (en) 2014-08-31
CA2862163A1 (en) 2013-08-01
HK1203198A1 (en) 2015-10-23
BR112014018450A2 (es) 2017-06-20
US9394309B2 (en) 2016-07-19
AR089788A1 (es) 2014-09-17
KR20140117582A (ko) 2014-10-07
ECSP14010868A (es) 2015-12-31
SG11201404118XA (en) 2014-10-30
TN2014000320A1 (en) 2015-12-21
BR112014018450A8 (pt) 2017-07-11
CU20140096A7 (es) 2015-02-26
IL233652A0 (en) 2014-08-31
TW201343649A (zh) 2013-11-01
US20130190290A1 (en) 2013-07-25
CN104411707A (zh) 2015-03-11
UY34590A (es) 2013-09-02
EP2807162B1 (de) 2017-06-07

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