AR077819A1 - Compuestos heterociclicos antagonistas de esfingosina -1-fosfato (sip) - Google Patents
Compuestos heterociclicos antagonistas de esfingosina -1-fosfato (sip)Info
- Publication number
- AR077819A1 AR077819A1 ARP100102904A ARP100102904A AR077819A1 AR 077819 A1 AR077819 A1 AR 077819A1 AR P100102904 A ARP100102904 A AR P100102904A AR P100102904 A ARP100102904 A AR P100102904A AR 077819 A1 AR077819 A1 AR 077819A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- crdrd
- haloalkyl
- zero
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 229940122625 Phosphate antagonist Drugs 0.000 title 1
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- -1 -OH Chemical group 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23205409P | 2009-08-07 | 2009-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077819A1 true AR077819A1 (es) | 2011-09-28 |
Family
ID=43029859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102904A AR077819A1 (es) | 2009-08-07 | 2010-08-06 | Compuestos heterociclicos antagonistas de esfingosina -1-fosfato (sip) |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8399451B2 (OSRAM) |
| EP (1) | EP2462139B1 (OSRAM) |
| JP (1) | JP5602230B2 (OSRAM) |
| KR (1) | KR20120108963A (OSRAM) |
| CN (1) | CN102548989A (OSRAM) |
| AR (1) | AR077819A1 (OSRAM) |
| AU (1) | AU2010279354A1 (OSRAM) |
| BR (1) | BR112012002824A2 (OSRAM) |
| CA (1) | CA2770194A1 (OSRAM) |
| CL (1) | CL2012000326A1 (OSRAM) |
| CO (1) | CO6430439A2 (OSRAM) |
| EA (1) | EA201270266A1 (OSRAM) |
| ES (1) | ES2533095T3 (OSRAM) |
| MX (1) | MX2012001160A (OSRAM) |
| PE (1) | PE20120732A1 (OSRAM) |
| SG (1) | SG177691A1 (OSRAM) |
| TW (1) | TW201109323A (OSRAM) |
| WO (1) | WO2011017578A1 (OSRAM) |
| ZA (1) | ZA201200641B (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010507619A (ja) * | 2006-10-25 | 2010-03-11 | ノイロサーチ アクティーゼルスカブ | オキサジアゾール及びチアジアゾール化合物並びにニコチン性アセチルコリン受容体調節物質としてのその使用 |
| WO2011133734A1 (en) * | 2010-04-23 | 2011-10-27 | Bristol-Myers Squibb Company | 4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists |
| CN103124727B (zh) | 2010-07-20 | 2015-03-25 | 百时美施贵宝公司 | 取代的3-苯基-1,2,4-噁二唑化合物 |
| CN103237795B (zh) | 2010-09-24 | 2015-10-21 | 百时美施贵宝公司 | 经取代的噁二唑化合物及其作为s1p1激动剂的用途 |
| EP2635573B1 (en) * | 2010-11-03 | 2014-10-01 | Bristol-Myers Squibb Company | Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases |
| US9115054B2 (en) | 2013-02-21 | 2015-08-25 | Bristol-Myers Squibb Company | Tetrahydronaphthalenyl compounds useful as sipi agonists |
| TWI689487B (zh) | 2014-08-20 | 2020-04-01 | 美商必治妥美雅史谷比公司 | 經取代雙環化合物 |
| UY38367A (es) * | 2018-09-13 | 2020-04-30 | Syngenta Participations Ag | Compuestos de azol-amida pesticidamente activos |
| CN114181276A (zh) * | 2021-12-17 | 2022-03-15 | 安徽大学 | 硫酯肽合成方法 |
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| TW432061B (en) | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
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| AU2003216054B2 (en) | 2002-01-18 | 2007-01-04 | Merck & Co., Inc. | Selective S1P1/Edg1 receptor agonists |
| JP4709488B2 (ja) | 2002-01-18 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｅｄｇ受容体作動薬としてのＮ−（ベンジル）アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類 |
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-
2010
- 2010-08-05 US US12/850,892 patent/US8399451B2/en active Active
- 2010-08-06 TW TW099126390A patent/TW201109323A/zh unknown
- 2010-08-06 SG SG2012003430A patent/SG177691A1/en unknown
- 2010-08-06 KR KR1020127005901A patent/KR20120108963A/ko not_active Withdrawn
- 2010-08-06 EP EP10742067.1A patent/EP2462139B1/en not_active Not-in-force
- 2010-08-06 MX MX2012001160A patent/MX2012001160A/es not_active Application Discontinuation
- 2010-08-06 BR BR112012002824A patent/BR112012002824A2/pt not_active IP Right Cessation
- 2010-08-06 PE PE2012000174A patent/PE20120732A1/es not_active Application Discontinuation
- 2010-08-06 JP JP2012523967A patent/JP5602230B2/ja not_active Expired - Fee Related
- 2010-08-06 AR ARP100102904A patent/AR077819A1/es not_active Application Discontinuation
- 2010-08-06 CA CA2770194A patent/CA2770194A1/en not_active Abandoned
- 2010-08-06 CN CN2010800453726A patent/CN102548989A/zh active Pending
- 2010-08-06 AU AU2010279354A patent/AU2010279354A1/en not_active Abandoned
- 2010-08-06 ES ES10742067.1T patent/ES2533095T3/es active Active
- 2010-08-06 WO PCT/US2010/044627 patent/WO2011017578A1/en not_active Ceased
- 2010-08-06 EA EA201270266A patent/EA201270266A1/ru unknown
-
2012
- 2012-01-24 ZA ZA2012/00641A patent/ZA201200641B/en unknown
- 2012-02-07 CL CL2012000326A patent/CL2012000326A1/es unknown
- 2012-02-16 CO CO12027713A patent/CO6430439A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120108963A (ko) | 2012-10-05 |
| JP2013501729A (ja) | 2013-01-17 |
| CA2770194A1 (en) | 2011-02-10 |
| US8399451B2 (en) | 2013-03-19 |
| EP2462139A1 (en) | 2012-06-13 |
| PE20120732A1 (es) | 2012-06-20 |
| SG177691A1 (en) | 2012-02-28 |
| ES2533095T3 (es) | 2015-04-07 |
| BR112012002824A2 (pt) | 2019-09-24 |
| MX2012001160A (es) | 2012-02-13 |
| CO6430439A2 (es) | 2012-04-30 |
| ZA201200641B (en) | 2013-06-26 |
| US20110190255A1 (en) | 2011-08-04 |
| EP2462139B1 (en) | 2015-01-14 |
| CL2012000326A1 (es) | 2012-10-19 |
| EA201270266A1 (ru) | 2012-07-30 |
| AU2010279354A1 (en) | 2012-02-09 |
| TW201109323A (en) | 2011-03-16 |
| JP5602230B2 (ja) | 2014-10-08 |
| CN102548989A (zh) | 2012-07-04 |
| WO2011017578A1 (en) | 2011-02-10 |
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