AR073880A1 - Un compuesto heterociclico, composicion farmaceutica que lo compone y metodos para inhibir la proteasa ns3/ns4 y para incrementar la funcion hepatica con dichos compuesto y metodo para tratar fibrosis hepatica con los mismos. - Google Patents

Un compuesto heterociclico, composicion farmaceutica que lo compone y metodos para inhibir la proteasa ns3/ns4 y para incrementar la funcion hepatica con dichos compuesto y metodo para tratar fibrosis hepatica con los mismos.

Info

Publication number
AR073880A1
AR073880A1 ARP090103978A ARP090103978A AR073880A1 AR 073880 A1 AR073880 A1 AR 073880A1 AR P090103978 A ARP090103978 A AR P090103978A AR P090103978 A ARP090103978 A AR P090103978A AR 073880 A1 AR073880 A1 AR 073880A1
Authority
AR
Argentina
Prior art keywords
compound
optionally substituted
heterociclical
composes
protease
Prior art date
Application number
ARP090103978A
Other languages
English (en)
Inventor
Antitsa Stoycheva
Scott Seiwert
Leonid Beigelman
Brad Buckman
Vladimir Serebryany
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41346045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR073880(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of AR073880A1 publication Critical patent/AR073880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

También se describen métodos terapéuticos, composiciones, medicamentos y formas d dosificacion relacionados con los mismos. Reivindicacion 1: Un compuesto caracterizado porque se representa por la formula (1) o una sal farmacéuticamente aceptable del mismo, en donde Ar es heteroarilo bicíclico fusionado opcionalmente sustituido, arilo opcionalmente sustituido C6-10 o isoindolinilo opcionalmente sustituido; z es 0 o 1; G es como en los restos de formulas (2) ; B es arilo C6-10 opcionalmente sustituido o heteroarilo opcionalmente sustituido; Ro es H o hidrocarbilo C1-12; D es alquilo C1-10 o NR11R12, en donde R11 y R12 son independientemente H o alquilo C1-5 y en donde R11 y R12 se pueden conectar para formar uno o más anillos; y E es hidrocarbilo C1-6; con la condicion de que el compuesto no sea como en el grupo de formulas (3).
ARP090103978A 2008-10-15 2009-10-15 Un compuesto heterociclico, composicion farmaceutica que lo compone y metodos para inhibir la proteasa ns3/ns4 y para incrementar la funcion hepatica con dichos compuesto y metodo para tratar fibrosis hepatica con los mismos. AR073880A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10574608P 2008-10-15 2008-10-15
US23674109P 2009-08-25 2009-08-25

Publications (1)

Publication Number Publication Date
AR073880A1 true AR073880A1 (es) 2010-12-09

Family

ID=41346045

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103978A AR073880A1 (es) 2008-10-15 2009-10-15 Un compuesto heterociclico, composicion farmaceutica que lo compone y metodos para inhibir la proteasa ns3/ns4 y para incrementar la funcion hepatica con dichos compuesto y metodo para tratar fibrosis hepatica con los mismos.

Country Status (21)

Country Link
US (1) US20100119479A1 (es)
EP (1) EP2358736A1 (es)
JP (1) JP2012505897A (es)
KR (1) KR20110075019A (es)
CN (1) CN102216321A (es)
AP (1) AP2011005695A0 (es)
AR (1) AR073880A1 (es)
AU (1) AU2009303483A1 (es)
CA (1) CA2740728A1 (es)
CL (1) CL2011000846A1 (es)
CO (1) CO6362017A2 (es)
EA (1) EA201170441A1 (es)
EC (1) ECSP11011054A (es)
IL (1) IL212097A0 (es)
MA (1) MA32787B1 (es)
MX (1) MX2011004007A (es)
NI (1) NI201100076A (es)
TN (1) TN2011000172A1 (es)
TW (1) TW201019950A (es)
WO (1) WO2010045266A1 (es)
ZA (1) ZA201102822B (es)

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WO2010045266A1 (en) 2010-04-22
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IL212097A0 (en) 2011-06-30
NI201100076A (es) 2012-03-15
KR20110075019A (ko) 2011-07-05
CA2740728A1 (en) 2010-04-22
CL2011000846A1 (es) 2011-09-30
MA32787B1 (fr) 2011-11-01
ZA201102822B (en) 2011-12-28
AU2009303483A1 (en) 2010-04-22
MX2011004007A (es) 2011-05-19
TN2011000172A1 (en) 2012-12-17
EP2358736A1 (en) 2011-08-24
AP2011005695A0 (en) 2011-06-30
ECSP11011054A (es) 2011-10-31
TW201019950A (en) 2010-06-01
US20100119479A1 (en) 2010-05-13
JP2012505897A (ja) 2012-03-08
CO6362017A2 (es) 2012-01-20

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