AR071881A2 - Pestivirus atenuados - Google Patents
Pestivirus atenuadosInfo
- Publication number
- AR071881A2 AR071881A2 ARP090101843A ARP090101843A AR071881A2 AR 071881 A2 AR071881 A2 AR 071881A2 AR P090101843 A ARP090101843 A AR P090101843A AR P090101843 A ARP090101843 A AR P090101843A AR 071881 A2 AR071881 A2 AR 071881A2
- Authority
- AR
- Argentina
- Prior art keywords
- glycoprotein
- pestivirus
- deletions
- inactivated
- positions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000710778 Pestivirus Species 0.000 title abstract 3
- 102000003886 Glycoproteins Human genes 0.000 abstract 5
- 108090000288 Glycoproteins Proteins 0.000 abstract 5
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 102000006382 Ribonucleases Human genes 0.000 abstract 2
- 108010083644 Ribonucleases Proteins 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 208000004571 Pestivirus Infections Diseases 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 208000025858 pestivirus infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24361—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Adem s se provee un cido nucleico que codifica una glicoprote¡na ERNS que se expresa en un pestivirus, una composicion farmaceutica para la profilaxis y el tratamiento de infecciones de pestivirus en un animal. Reivindicacion 1: Un pestivirus atenuado, caracterizado porque la actividad de RNasa que reside en la glicoprote¡na ERNS est inactivada por deleciones y/o mutaciones de al menos un amino cido de dicha glicoprote¡na, donde dicha actividad de RNasa est inactivada por deleciones y/o mutaciones situadas en los amino cidos en las posiciones 295 a 307 y/o en las posiciones 338 a 357, segun se describe en la figura para la cepa Alfort de VFPC de una manera ejemplar o correspondiente a la misma en otras cepas, de dicha glicoprote¡na, con la condicion de que los amino cidos en la posicion 297 y/o 346 de dicha glicoprote¡na no sean lisina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110356A EP0965639A1 (en) | 1998-06-05 | 1998-06-05 | Attenuated pestiviruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071881A2 true AR071881A2 (es) | 2010-07-21 |
Family
ID=8232074
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102650A Pending AR020084A1 (es) | 1998-06-05 | 1999-06-04 | Pestivirus atenuados |
| ARP090101843A Pending AR071881A2 (es) | 1998-06-05 | 2009-05-22 | Pestivirus atenuados |
| ARP090101842A Suspension/Interruption AR071880A2 (es) | 1998-06-05 | 2009-05-22 | Metodo para marcar de forma detectable pestivirus |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102650A Pending AR020084A1 (es) | 1998-06-05 | 1999-06-04 | Pestivirus atenuados |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101842A Suspension/Interruption AR071880A2 (es) | 1998-06-05 | 2009-05-22 | Metodo para marcar de forma detectable pestivirus |
Country Status (23)
| Country | Link |
|---|---|
| EP (5) | EP0965639A1 (es) |
| JP (3) | JP4632540B2 (es) |
| KR (1) | KR100637940B1 (es) |
| CN (2) | CN101085346A (es) |
| AR (3) | AR020084A1 (es) |
| AT (3) | ATE311193T1 (es) |
| AU (1) | AU769823C (es) |
| BR (2) | BRPI9917787B1 (es) |
| CA (1) | CA2330241C (es) |
| CO (1) | CO5050392A1 (es) |
| CZ (3) | CZ301494B6 (es) |
| DE (3) | DE69928700T2 (es) |
| DK (3) | DK1084251T3 (es) |
| ES (3) | ES2253457T3 (es) |
| HU (3) | HU228469B1 (es) |
| NZ (1) | NZ509228A (es) |
| PE (1) | PE20000552A1 (es) |
| PL (2) | PL202161B1 (es) |
| PT (2) | PT1084251E (es) |
| SI (3) | SI1084251T1 (es) |
| SK (3) | SK287014B6 (es) |
| TR (3) | TR200103666T2 (es) |
| WO (1) | WO1999064604A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7179473B2 (en) | 1998-06-05 | 2007-02-20 | Boehringer Ingelheim Vetmedica Gmbh | Attenuated pestiviruses |
| EP1104676A1 (en) | 1999-11-30 | 2001-06-06 | Boehringer Ingelheim Vetmedica Gmbh | Safe attenuated bovine viral diarrhea viruses for use in pregnant cows |
| PT1149901E (pt) | 2000-04-21 | 2006-08-31 | Akzo Nobel Nv | Mutantes de pestivirus e vacinas contendo os mesmos |
| US7135561B2 (en) | 2001-09-06 | 2006-11-14 | Boehringer Ingelheim Vetmedica Gmbh | Infectious bovine viral diarrhea virus clone |
| UY29915A1 (es) * | 2005-11-15 | 2007-06-29 | Boehringer Ingelheim Vetmed | Vacuna combinada que comprende un virus atenuado de la diarrea viral bovina |
| UY31437A1 (es) | 2007-10-29 | 2009-05-29 | Vacuna de mycoplasma bovis y métodos de uso de la misma | |
| UY31930A (es) | 2008-06-25 | 2010-01-29 | Boheringer Ingelheim Pharma Kg | Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante |
| US8815255B2 (en) | 2008-10-31 | 2014-08-26 | Boehringer Ingelheim Vetmedica, Inc. | Use of Mycoplasma bovis antigen |
| US8846054B2 (en) | 2009-01-09 | 2014-09-30 | Boehringer Ingelheim Vetmedica, Inc. | Method of treating pregnant cows and/or heifers |
| UY32570A (es) | 2009-04-24 | 2010-11-30 | Boehringer Ingelheim Vetmed | Vacuna viva modificada de mycoplasma bovis mejorada |
| CN101915837B (zh) * | 2010-07-28 | 2013-07-03 | 中国兽医药品监察所 | 一种猪瘟兔化弱毒活疫苗效力检验方法 |
| EP2618841B1 (en) | 2010-09-21 | 2016-10-19 | Intervet International B.V. | Bvdv vaccine |
| CN103882051B (zh) * | 2014-03-20 | 2016-04-06 | 北京市农林科学院 | 一种检测猪瘟病毒抗体的elisa方法及检测试剂盒 |
| EP3956439A4 (en) * | 2019-04-18 | 2023-05-03 | Boehringer Ingelheim Vetmedica (China) Co., Ltd. | RECOMBINANT CLASSICAL SWINE FEVER VIRUS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE342996T1 (de) * | 1986-01-27 | 2006-11-15 | Schering Plough Ltd | Attenuierte herpesviren, herpesviren die eine aminosäuresequenz kodierende fremde dna enthalten,und diese enthaltende impfstoffe |
-
1998
- 1998-06-05 EP EP98110356A patent/EP0965639A1/en not_active Withdrawn
-
1999
- 1999-05-26 BR BRPI9917787A patent/BRPI9917787B1/pt active IP Right Grant
- 1999-05-26 AT AT02003407T patent/ATE311193T1/de active
- 1999-05-26 TR TR2001/03666T patent/TR200103666T2/xx unknown
- 1999-05-26 ES ES02003407T patent/ES2253457T3/es not_active Expired - Lifetime
- 1999-05-26 PT PT99926430T patent/PT1084251E/pt unknown
- 1999-05-26 DK DK99926430T patent/DK1084251T3/da active
- 1999-05-26 DE DE69928700T patent/DE69928700T2/de not_active Expired - Lifetime
- 1999-05-26 AT AT99926430T patent/ATE286131T1/de active
- 1999-05-26 HU HU1200536A patent/HU228469B1/hu unknown
- 1999-05-26 SI SI9930746T patent/SI1084251T1/xx unknown
- 1999-05-26 EP EP99926430A patent/EP1084251B1/en not_active Expired - Lifetime
- 1999-05-26 ES ES02003408T patent/ES2257476T3/es not_active Expired - Lifetime
- 1999-05-26 WO PCT/EP1999/003642 patent/WO1999064604A2/en active Application Filing
- 1999-05-26 SK SK1823-2000A patent/SK287014B6/sk not_active IP Right Cessation
- 1999-05-26 DE DE69922953T patent/DE69922953T2/de not_active Expired - Lifetime
- 1999-05-26 BR BRPI9911619-7B1A patent/BR9911619B1/pt active IP Right Grant
- 1999-05-26 EP EP02003408A patent/EP1203813B1/en not_active Expired - Lifetime
- 1999-05-26 PT PT02003408T patent/PT1203813E/pt unknown
- 1999-05-26 AT AT02003408T patent/ATE316380T1/de active
- 1999-05-26 DK DK02003408T patent/DK1203813T3/da active
- 1999-05-26 JP JP2000553594A patent/JP4632540B2/ja not_active Expired - Lifetime
- 1999-05-26 DE DE69929544T patent/DE69929544T2/de not_active Expired - Lifetime
- 1999-05-26 DK DK02003407T patent/DK1203812T3/da active
- 1999-05-26 TR TR2000/03622T patent/TR200003622T2/xx unknown
- 1999-05-26 CZ CZ20004533A patent/CZ301494B6/cs not_active IP Right Cessation
- 1999-05-26 CN CNA2007101042355A patent/CN101085346A/zh active Pending
- 1999-05-26 SI SI9930882T patent/SI1203813T1/sl unknown
- 1999-05-26 HU HU1200537A patent/HU228471B1/hu unknown
- 1999-05-26 CZ CZ20090293A patent/CZ301570B6/cs not_active IP Right Cessation
- 1999-05-26 TR TR2001/03664T patent/TR200103664T2/xx unknown
- 1999-05-26 AU AU43692/99A patent/AU769823C/en not_active Expired
- 1999-05-26 CZ CZ20090294A patent/CZ301569B6/cs not_active IP Right Cessation
- 1999-05-26 SK SK50019-2009A patent/SK287626B6/sk not_active IP Right Cessation
- 1999-05-26 CA CA2330241A patent/CA2330241C/en not_active Expired - Lifetime
- 1999-05-26 PL PL384046A patent/PL202161B1/pl unknown
- 1999-05-26 CN CNB998070521A patent/CN100374563C/zh not_active Expired - Lifetime
- 1999-05-26 ES ES99926430T patent/ES2235488T3/es not_active Expired - Lifetime
- 1999-05-26 SI SI9930860T patent/SI1203812T1/sl unknown
- 1999-05-26 KR KR1020007013757A patent/KR100637940B1/ko not_active IP Right Cessation
- 1999-05-26 HU HU0102707A patent/HU228468B1/hu unknown
- 1999-05-26 PL PL348019A patent/PL202509B1/pl unknown
- 1999-05-26 SK SK50018-2009A patent/SK287625B6/sk not_active IP Right Cessation
- 1999-05-26 EP EP02003407A patent/EP1203812B1/en not_active Expired - Lifetime
- 1999-05-26 NZ NZ509228A patent/NZ509228A/en not_active IP Right Cessation
- 1999-05-26 EP EP05017098A patent/EP1614423A3/en not_active Withdrawn
- 1999-06-01 CO CO99034189A patent/CO5050392A1/es unknown
- 1999-06-03 PE PE1999000472A patent/PE20000552A1/es not_active Application Discontinuation
- 1999-06-04 AR ARP990102650A patent/AR020084A1/es active Pending
-
2009
- 2009-05-22 AR ARP090101843A patent/AR071881A2/es active Pending
- 2009-05-22 AR ARP090101842A patent/AR071880A2/es not_active Suspension/Interruption
-
2010
- 2010-07-26 JP JP2010167518A patent/JP5247770B2/ja not_active Expired - Lifetime
-
2013
- 2013-02-04 JP JP2013019815A patent/JP5755265B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |