AR020084A1 - Pestivirus atenuados - Google Patents
Pestivirus atenuadosInfo
- Publication number
- AR020084A1 AR020084A1 ARP990102650A ARP990102650A AR020084A1 AR 020084 A1 AR020084 A1 AR 020084A1 AR P990102650 A ARP990102650 A AR P990102650A AR P990102650 A ARP990102650 A AR P990102650A AR 020084 A1 AR020084 A1 AR 020084A1
- Authority
- AR
- Argentina
- Prior art keywords
- pestivirus
- glycoprotein
- vaccine
- pestiviruses
- residing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000710778 Pestivirus Species 0.000 title abstract 11
- 238000000034 method Methods 0.000 abstract 6
- 229960005486 vaccine Drugs 0.000 abstract 6
- 102000003886 Glycoproteins Human genes 0.000 abstract 4
- 108090000288 Glycoproteins Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 3
- 102000006382 Ribonucleases Human genes 0.000 abstract 3
- 108010083644 Ribonucleases Proteins 0.000 abstract 3
- 230000002238 attenuated effect Effects 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 101000807236 Human cytomegalovirus (strain AD169) Membrane glycoprotein US3 Proteins 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- 208000004571 Pestivirus Infections Diseases 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 208000025858 pestivirus infectious disease Diseases 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 229940031567 attenuated vaccine Drugs 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 229940124590 live attenuated vaccine Drugs 0.000 abstract 1
- 229940023012 live-attenuated vaccine Drugs 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24361—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Pestivirus específicamente atenuados y marcados en forma detectable para uso como vacunas atenuadas vivas con una elevada con una elevada eficacia para lainduccion de inmunidad que también se pueden distinguir de pestivirus patogenos procedentes delcampo. Una vacuna viva que comprende un pestivirus, en la quela actividad de RNasa que reside en la glicoproteina E(RNS) está inactivada. Un pestivirus para una vacuna, en el que la actividad de RNasa que reside en laglicoproteína E(RNS) estáinactiv ada por deleciones y/o mutaciones de al menos un aminoácido de dicha glicoproteína, con la condicion de que los aminoácidos enla posicion 297 y/o 346 de dicha proteína no sean lisina. Un ácido nucleico que codifica una glicoproteína que seexpresa en un pestivirus, en el que laactividad de RNasa que reside en dicha glicoproteína ERNS está inactivada por deleciones y/o mutaciones de al menos un aminoácido de dicha glicoproteína, conla condicion de que los aminoácidos en la posicion 297y/o 346 de dicha proteína no sean lisina. El empleo de ácidos nucleicos para preparar vacunas denucleotidos y/o vectores. Una composicion farmacéutica que contiene una vacuna, y/o un pestivirus, y/o una secuencia de nucleotidos. Un método paraatenuarpestiviru s destinados a la vacuna, un método para producir una vacuna específicamente atenuada, un método para marcar de forma detectable pestivirus, un métodopara la profilaxis y el tratamiento de infecciones por pestivirus, unprocedimiento para la preparac ion de pestivirus específicamente atenuados y un métodopara distinguir animales infestados por pestivirus de animales vacunados con un pestivirus específicamente atenuado. El uso de la y de la composicionfarmacéuticapara la profilaxis y el tratamien to de infecciones por pestivirus en animales. El uso de un pestivirus y/o una secuencia de nucleotidospara preparar una vacuna o una composicion farmacéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110356A EP0965639A1 (en) | 1998-06-05 | 1998-06-05 | Attenuated pestiviruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020084A1 true AR020084A1 (es) | 2002-04-10 |
Family
ID=8232074
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102650A Pending AR020084A1 (es) | 1998-06-05 | 1999-06-04 | Pestivirus atenuados |
| ARP090101842A Suspension/Interruption AR071880A2 (es) | 1998-06-05 | 2009-05-22 | Metodo para marcar de forma detectable pestivirus |
| ARP090101843A Pending AR071881A2 (es) | 1998-06-05 | 2009-05-22 | Pestivirus atenuados |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101842A Suspension/Interruption AR071880A2 (es) | 1998-06-05 | 2009-05-22 | Metodo para marcar de forma detectable pestivirus |
| ARP090101843A Pending AR071881A2 (es) | 1998-06-05 | 2009-05-22 | Pestivirus atenuados |
Country Status (23)
| Country | Link |
|---|---|
| EP (5) | EP0965639A1 (es) |
| JP (3) | JP4632540B2 (es) |
| KR (1) | KR100637940B1 (es) |
| CN (2) | CN101085346A (es) |
| AR (3) | AR020084A1 (es) |
| AT (3) | ATE316380T1 (es) |
| AU (1) | AU769823C (es) |
| BR (2) | BR9911619B1 (es) |
| CA (1) | CA2330241C (es) |
| CO (1) | CO5050392A1 (es) |
| CZ (3) | CZ301570B6 (es) |
| DE (3) | DE69928700T2 (es) |
| DK (3) | DK1084251T3 (es) |
| ES (3) | ES2253457T3 (es) |
| HU (3) | HU228469B1 (es) |
| NZ (1) | NZ509228A (es) |
| PE (1) | PE20000552A1 (es) |
| PL (2) | PL202509B1 (es) |
| PT (2) | PT1203813E (es) |
| SI (3) | SI1084251T1 (es) |
| SK (3) | SK287626B6 (es) |
| TR (3) | TR200003622T2 (es) |
| WO (1) | WO1999064604A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7179473B2 (en) | 1998-06-05 | 2007-02-20 | Boehringer Ingelheim Vetmedica Gmbh | Attenuated pestiviruses |
| EP1104676A1 (en) | 1999-11-30 | 2001-06-06 | Boehringer Ingelheim Vetmedica Gmbh | Safe attenuated bovine viral diarrhea viruses for use in pregnant cows |
| EP1149901B1 (en) * | 2000-04-21 | 2006-04-05 | Akzo Nobel N.V. | Pestivirus mutants and vaccines containing the same |
| US7135561B2 (en) | 2001-09-06 | 2006-11-14 | Boehringer Ingelheim Vetmedica Gmbh | Infectious bovine viral diarrhea virus clone |
| US20090068223A1 (en) | 2005-11-15 | 2009-03-12 | Boehringer Ingelheim Vetmedica, Inc. | Combination vaccine comprising an attenuated bovine viral diarrhea virus |
| UY31437A1 (es) | 2007-10-29 | 2009-05-29 | Vacuna de mycoplasma bovis y métodos de uso de la misma | |
| UY31930A (es) | 2008-06-25 | 2010-01-29 | Boheringer Ingelheim Pharma Kg | Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante |
| JP2012507537A (ja) | 2008-10-31 | 2012-03-29 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | マイコプラズマ・ボビスの抗原を含む種々の抗原の多価ワクチン組成物における使用 |
| US8846054B2 (en) | 2009-01-09 | 2014-09-30 | Boehringer Ingelheim Vetmedica, Inc. | Method of treating pregnant cows and/or heifers |
| UY32570A (es) | 2009-04-24 | 2010-11-30 | Boehringer Ingelheim Vetmed | Vacuna viva modificada de mycoplasma bovis mejorada |
| CN101915837B (zh) * | 2010-07-28 | 2013-07-03 | 中国兽医药品监察所 | 一种猪瘟兔化弱毒活疫苗效力检验方法 |
| EP2618841B1 (en) | 2010-09-21 | 2016-10-19 | Intervet International B.V. | Bvdv vaccine |
| CN103882051B (zh) * | 2014-03-20 | 2016-04-06 | 北京市农林科学院 | 一种检测猪瘟病毒抗体的elisa方法及检测试剂盒 |
| WO2020211801A1 (en) * | 2019-04-18 | 2020-10-22 | Boehringer Ingelheim Vetmedica (China) Co., Ltd. | Recombinant classical swine fever virus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122007000004I1 (de) * | 1986-01-27 | 2007-05-24 | Schering Plough Ltd | Attenuierte Herpesviren, Herpesviren die eine Aminosäuresequenz kodierende fremde DNA enthalten, unddiese enthaltende Impfstoffe |
-
1998
- 1998-06-05 EP EP98110356A patent/EP0965639A1/en not_active Withdrawn
-
1999
- 1999-05-26 PT PT02003408T patent/PT1203813E/pt unknown
- 1999-05-26 AT AT02003408T patent/ATE316380T1/de active
- 1999-05-26 DK DK99926430T patent/DK1084251T3/da active
- 1999-05-26 DK DK02003408T patent/DK1203813T3/da active
- 1999-05-26 BR BRPI9911619-7B1A patent/BR9911619B1/pt active IP Right Grant
- 1999-05-26 CZ CZ20090293A patent/CZ301570B6/cs not_active IP Right Cessation
- 1999-05-26 ES ES02003407T patent/ES2253457T3/es not_active Expired - Lifetime
- 1999-05-26 KR KR1020007013757A patent/KR100637940B1/ko not_active IP Right Cessation
- 1999-05-26 TR TR2000/03622T patent/TR200003622T2/xx unknown
- 1999-05-26 DK DK02003407T patent/DK1203812T3/da active
- 1999-05-26 CN CNA2007101042355A patent/CN101085346A/zh active Pending
- 1999-05-26 DE DE69928700T patent/DE69928700T2/de not_active Expired - Lifetime
- 1999-05-26 SK SK50019-2009A patent/SK287626B6/sk not_active IP Right Cessation
- 1999-05-26 CA CA2330241A patent/CA2330241C/en not_active Expired - Lifetime
- 1999-05-26 CZ CZ20090294A patent/CZ301569B6/cs not_active IP Right Cessation
- 1999-05-26 DE DE69922953T patent/DE69922953T2/de not_active Expired - Lifetime
- 1999-05-26 TR TR2001/03664T patent/TR200103664T2/xx unknown
- 1999-05-26 ES ES99926430T patent/ES2235488T3/es not_active Expired - Lifetime
- 1999-05-26 ES ES02003408T patent/ES2257476T3/es not_active Expired - Lifetime
- 1999-05-26 HU HU1200536A patent/HU228469B1/hu unknown
- 1999-05-26 PT PT99926430T patent/PT1084251E/pt unknown
- 1999-05-26 EP EP02003407A patent/EP1203812B1/en not_active Expired - Lifetime
- 1999-05-26 HU HU0102707A patent/HU228468B1/hu unknown
- 1999-05-26 JP JP2000553594A patent/JP4632540B2/ja not_active Expired - Lifetime
- 1999-05-26 CZ CZ20004533A patent/CZ301494B6/cs not_active IP Right Cessation
- 1999-05-26 HU HU1200537A patent/HU228471B1/hu unknown
- 1999-05-26 SI SI9930746T patent/SI1084251T1/xx unknown
- 1999-05-26 SI SI9930882T patent/SI1203813T1/sl unknown
- 1999-05-26 AU AU43692/99A patent/AU769823C/en not_active Expired
- 1999-05-26 BR BRPI9917787A patent/BRPI9917787B1/pt active IP Right Grant
- 1999-05-26 PL PL348019A patent/PL202509B1/pl unknown
- 1999-05-26 PL PL384046A patent/PL202161B1/pl unknown
- 1999-05-26 AT AT02003407T patent/ATE311193T1/de active
- 1999-05-26 WO PCT/EP1999/003642 patent/WO1999064604A2/en active Application Filing
- 1999-05-26 AT AT99926430T patent/ATE286131T1/de active
- 1999-05-26 SK SK50018-2009A patent/SK287625B6/sk not_active IP Right Cessation
- 1999-05-26 DE DE69929544T patent/DE69929544T2/de not_active Expired - Lifetime
- 1999-05-26 EP EP05017098A patent/EP1614423A3/en not_active Withdrawn
- 1999-05-26 SI SI9930860T patent/SI1203812T1/sl unknown
- 1999-05-26 TR TR2001/03666T patent/TR200103666T2/xx unknown
- 1999-05-26 EP EP99926430A patent/EP1084251B1/en not_active Expired - Lifetime
- 1999-05-26 SK SK1823-2000A patent/SK287014B6/sk not_active IP Right Cessation
- 1999-05-26 EP EP02003408A patent/EP1203813B1/en not_active Expired - Lifetime
- 1999-05-26 CN CNB998070521A patent/CN100374563C/zh not_active Expired - Lifetime
- 1999-05-26 NZ NZ509228A patent/NZ509228A/en not_active IP Right Cessation
- 1999-06-01 CO CO99034189A patent/CO5050392A1/es unknown
- 1999-06-03 PE PE1999000472A patent/PE20000552A1/es not_active Application Discontinuation
- 1999-06-04 AR ARP990102650A patent/AR020084A1/es active Pending
-
2009
- 2009-05-22 AR ARP090101842A patent/AR071880A2/es not_active Suspension/Interruption
- 2009-05-22 AR ARP090101843A patent/AR071881A2/es active Pending
-
2010
- 2010-07-26 JP JP2010167518A patent/JP5247770B2/ja not_active Expired - Lifetime
-
2013
- 2013-02-04 JP JP2013019815A patent/JP5755265B2/ja not_active Expired - Lifetime
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