AR020084A1 - Pestivirus atenuados - Google Patents
Pestivirus atenuadosInfo
- Publication number
- AR020084A1 AR020084A1 ARP990102650A ARP990102650A AR020084A1 AR 020084 A1 AR020084 A1 AR 020084A1 AR P990102650 A ARP990102650 A AR P990102650A AR P990102650 A ARP990102650 A AR P990102650A AR 020084 A1 AR020084 A1 AR 020084A1
- Authority
- AR
- Argentina
- Prior art keywords
- pestivirus
- glycoprotein
- vaccine
- pestiviruses
- residing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24361—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pestivirus específicamente atenuados y marcados en forma detectable para uso como vacunas atenuadas vivas con una elevada con una elevada eficacia para lainduccion de inmunidad que también se pueden distinguir de pestivirus patogenos procedentes delcampo. Una vacuna viva que comprende un pestivirus, en la quela actividad de RNasa que reside en la glicoproteina E(RNS) está inactivada. Un pestivirus para una vacuna, en el que la actividad de RNasa que reside en laglicoproteína E(RNS) estáinactiv ada por deleciones y/o mutaciones de al menos un aminoácido de dicha glicoproteína, con la condicion de que los aminoácidos enla posicion 297 y/o 346 de dicha proteína no sean lisina. Un ácido nucleico que codifica una glicoproteína que seexpresa en un pestivirus, en el que laactividad de RNasa que reside en dicha glicoproteína ERNS está inactivada por deleciones y/o mutaciones de al menos un aminoácido de dicha glicoproteína, conla condicion de que los aminoácidos en la posicion 297y/o 346 de dicha proteína no sean lisina. El empleo de ácidos nucleicos para preparar vacunas denucleotidos y/o vectores. Una composicion farmacéutica que contiene una vacuna, y/o un pestivirus, y/o una secuencia de nucleotidos. Un método paraatenuarpestiviru s destinados a la vacuna, un método para producir una vacuna específicamente atenuada, un método para marcar de forma detectable pestivirus, un métodopara la profilaxis y el tratamiento de infecciones por pestivirus, unprocedimiento para la preparac ion de pestivirus específicamente atenuados y un métodopara distinguir animales infestados por pestivirus de animales vacunados con un pestivirus específicamente atenuado. El uso de la y de la composicionfarmacéuticapara la profilaxis y el tratamien to de infecciones por pestivirus en animales. El uso de un pestivirus y/o una secuencia de nucleotidospara preparar una vacuna o una composicion farmacéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110356A EP0965639A1 (en) | 1998-06-05 | 1998-06-05 | Attenuated pestiviruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020084A1 true AR020084A1 (es) | 2002-04-10 |
Family
ID=8232074
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102650A AR020084A1 (es) | 1998-06-05 | 1999-06-04 | Pestivirus atenuados |
| ARP090101843A AR071881A2 (es) | 1998-06-05 | 2009-05-22 | Pestivirus atenuados |
| ARP090101842A AR071880A2 (es) | 1998-06-05 | 2009-05-22 | Metodo para marcar de forma detectable pestivirus |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101843A AR071881A2 (es) | 1998-06-05 | 2009-05-22 | Pestivirus atenuados |
| ARP090101842A AR071880A2 (es) | 1998-06-05 | 2009-05-22 | Metodo para marcar de forma detectable pestivirus |
Country Status (23)
| Country | Link |
|---|---|
| EP (5) | EP0965639A1 (es) |
| JP (3) | JP4632540B2 (es) |
| KR (1) | KR100637940B1 (es) |
| CN (2) | CN100374563C (es) |
| AR (3) | AR020084A1 (es) |
| AT (3) | ATE316380T1 (es) |
| AU (1) | AU769823C (es) |
| BR (2) | BRPI9917787B1 (es) |
| CA (1) | CA2330241C (es) |
| CO (1) | CO5050392A1 (es) |
| CZ (3) | CZ301570B6 (es) |
| DE (3) | DE69928700T2 (es) |
| DK (3) | DK1084251T3 (es) |
| ES (3) | ES2235488T3 (es) |
| HU (3) | HU228469B1 (es) |
| NZ (1) | NZ509228A (es) |
| PE (1) | PE20000552A1 (es) |
| PL (2) | PL202161B1 (es) |
| PT (2) | PT1084251E (es) |
| SI (3) | SI1084251T1 (es) |
| SK (3) | SK287626B6 (es) |
| TR (3) | TR200003622T2 (es) |
| WO (1) | WO1999064604A2 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7179473B2 (en) | 1998-06-05 | 2007-02-20 | Boehringer Ingelheim Vetmedica Gmbh | Attenuated pestiviruses |
| EP1104676A1 (en) * | 1999-11-30 | 2001-06-06 | Boehringer Ingelheim Vetmedica Gmbh | Safe attenuated bovine viral diarrhea viruses for use in pregnant cows |
| DE60118456T2 (de) | 2000-04-21 | 2006-08-24 | Akzo Nobel N.V. | Pestvirus Mutanten und diese enthaltende Impfstoffe |
| US7135561B2 (en) | 2001-09-06 | 2006-11-14 | Boehringer Ingelheim Vetmedica Gmbh | Infectious bovine viral diarrhea virus clone |
| UY29915A1 (es) * | 2005-11-15 | 2007-06-29 | Boehringer Ingelheim Vetmed | Vacuna combinada que comprende un virus atenuado de la diarrea viral bovina |
| AR069087A1 (es) | 2007-10-29 | 2009-12-30 | Boehringer Ingelheim Vetmed | Cepa bacteriana de m. bovis atenuada avirulenta obtenida por pases, vacuna de micoplasma boris y metodos de uso de la misma |
| UY31930A (es) | 2008-06-25 | 2010-01-29 | Boheringer Ingelheim Pharma Kg | Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante |
| EP2362780B1 (en) | 2008-10-31 | 2019-12-25 | Boehringer Ingelheim Animal Health USA Inc. | Use of various antigens including antigens from mycoplasma bovis in multivalent vaccine composition |
| US8846054B2 (en) | 2009-01-09 | 2014-09-30 | Boehringer Ingelheim Vetmedica, Inc. | Method of treating pregnant cows and/or heifers |
| UY32570A (es) | 2009-04-24 | 2010-11-30 | Boehringer Ingelheim Vetmed | Vacuna viva modificada de mycoplasma bovis mejorada |
| CN101915837B (zh) * | 2010-07-28 | 2013-07-03 | 中国兽医药品监察所 | 一种猪瘟兔化弱毒活疫苗效力检验方法 |
| ES2606605T3 (es) | 2010-09-21 | 2017-03-24 | Intervet International B.V. | Vacuna para el BVDV |
| CN103882051B (zh) * | 2014-03-20 | 2016-04-06 | 北京市农林科学院 | 一种检测猪瘟病毒抗体的elisa方法及检测试剂盒 |
| DK3146042T3 (da) * | 2014-05-23 | 2019-09-30 | Boehringer Ingelheim Vetmedica Gmbh | Rekombinant klassisk svinepestvirus (CSFV) med substitution i E2-proteinets TAV-epitop |
| PH12021552641A1 (en) * | 2019-04-18 | 2022-07-18 | Boehringer Ingelheim Vetmedica China Co Ltd | Recombinant classical swine fever virus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE342996T1 (de) * | 1986-01-27 | 2006-11-15 | Schering Plough Ltd | Attenuierte herpesviren, herpesviren die eine aminosäuresequenz kodierende fremde dna enthalten,und diese enthaltende impfstoffe |
-
1998
- 1998-06-05 EP EP98110356A patent/EP0965639A1/en not_active Withdrawn
-
1999
- 1999-05-26 CN CNB998070521A patent/CN100374563C/zh not_active Expired - Lifetime
- 1999-05-26 CZ CZ20090293A patent/CZ301570B6/cs not_active IP Right Cessation
- 1999-05-26 TR TR2000/03622T patent/TR200003622T2/xx unknown
- 1999-05-26 JP JP2000553594A patent/JP4632540B2/ja not_active Expired - Lifetime
- 1999-05-26 SK SK50019-2009A patent/SK287626B6/sk not_active IP Right Cessation
- 1999-05-26 CA CA2330241A patent/CA2330241C/en not_active Expired - Lifetime
- 1999-05-26 SI SI9930746T patent/SI1084251T1/xx unknown
- 1999-05-26 CZ CZ20004533A patent/CZ301494B6/cs not_active IP Right Cessation
- 1999-05-26 PT PT99926430T patent/PT1084251E/pt unknown
- 1999-05-26 PT PT02003408T patent/PT1203813E/pt unknown
- 1999-05-26 SK SK50018-2009A patent/SK287625B6/sk not_active IP Right Cessation
- 1999-05-26 AT AT02003408T patent/ATE316380T1/de active
- 1999-05-26 ES ES99926430T patent/ES2235488T3/es not_active Expired - Lifetime
- 1999-05-26 SI SI9930860T patent/SI1203812T1/sl unknown
- 1999-05-26 ES ES02003408T patent/ES2257476T3/es not_active Expired - Lifetime
- 1999-05-26 HU HU1200536A patent/HU228469B1/hu unknown
- 1999-05-26 WO PCT/EP1999/003642 patent/WO1999064604A2/en not_active Ceased
- 1999-05-26 CZ CZ20090294A patent/CZ301569B6/cs not_active IP Right Cessation
- 1999-05-26 DK DK99926430T patent/DK1084251T3/da active
- 1999-05-26 EP EP02003407A patent/EP1203812B1/en not_active Expired - Lifetime
- 1999-05-26 HU HU1200537A patent/HU228471B1/hu unknown
- 1999-05-26 SI SI9930882T patent/SI1203813T1/sl unknown
- 1999-05-26 DK DK02003408T patent/DK1203813T3/da active
- 1999-05-26 CN CNA2007101042355A patent/CN101085346A/zh active Pending
- 1999-05-26 AU AU43692/99A patent/AU769823C/en not_active Expired
- 1999-05-26 KR KR1020007013757A patent/KR100637940B1/ko not_active Expired - Lifetime
- 1999-05-26 TR TR2001/03664T patent/TR200103664T2/xx unknown
- 1999-05-26 EP EP05017098A patent/EP1614423A3/en not_active Withdrawn
- 1999-05-26 TR TR2001/03666T patent/TR200103666T2/xx unknown
- 1999-05-26 ES ES02003407T patent/ES2253457T3/es not_active Expired - Lifetime
- 1999-05-26 BR BRPI9917787A patent/BRPI9917787B1/pt active IP Right Grant
- 1999-05-26 PL PL384046A patent/PL202161B1/pl unknown
- 1999-05-26 EP EP99926430A patent/EP1084251B1/en not_active Expired - Lifetime
- 1999-05-26 DE DE69928700T patent/DE69928700T2/de not_active Expired - Lifetime
- 1999-05-26 DK DK02003407T patent/DK1203812T3/da active
- 1999-05-26 PL PL348019A patent/PL202509B1/pl unknown
- 1999-05-26 DE DE69922953T patent/DE69922953T2/de not_active Expired - Lifetime
- 1999-05-26 EP EP02003408A patent/EP1203813B1/en not_active Expired - Lifetime
- 1999-05-26 SK SK1823-2000A patent/SK287014B6/sk not_active IP Right Cessation
- 1999-05-26 HU HU0102707A patent/HU228468B1/hu unknown
- 1999-05-26 DE DE69929544T patent/DE69929544T2/de not_active Expired - Lifetime
- 1999-05-26 AT AT99926430T patent/ATE286131T1/de active
- 1999-05-26 NZ NZ509228A patent/NZ509228A/en not_active IP Right Cessation
- 1999-05-26 BR BRPI9911619-7B1A patent/BR9911619B1/pt active IP Right Grant
- 1999-05-26 AT AT02003407T patent/ATE311193T1/de active
- 1999-06-01 CO CO99034189A patent/CO5050392A1/es unknown
- 1999-06-03 PE PE1999000472A patent/PE20000552A1/es not_active Application Discontinuation
- 1999-06-04 AR ARP990102650A patent/AR020084A1/es active IP Right Grant
-
2009
- 2009-05-22 AR ARP090101843A patent/AR071881A2/es active IP Right Grant
- 2009-05-22 AR ARP090101842A patent/AR071880A2/es unknown
-
2010
- 2010-07-26 JP JP2010167518A patent/JP5247770B2/ja not_active Expired - Lifetime
-
2013
- 2013-02-04 JP JP2013019815A patent/JP5755265B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |