AR070861A1 - Uso de terapia de combinacion con antagonistas de c-met y egfr - Google Patents
Uso de terapia de combinacion con antagonistas de c-met y egfrInfo
- Publication number
- AR070861A1 AR070861A1 ARP090100815A ARP090100815A AR070861A1 AR 070861 A1 AR070861 A1 AR 070861A1 AR P090100815 A ARP090100815 A AR P090100815A AR P090100815 A ARP090100815 A AR P090100815A AR 070861 A1 AR070861 A1 AR 070861A1
- Authority
- AR
- Argentina
- Prior art keywords
- nr6r6
- alkyl
- halo
- optionally substituted
- independently selected
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Para el tratamiento de afecciones patologicas, como el cáncer. Reivindicacion 1: Uso de una cantidad terapéuticamente efectiva de un antagonista de c-met y un antagonista de EGFR, para la manufactura de un medicamento para el tratamiento de cáncer en un sujeto. Reivindicacion 2: El uso de la reivindicacion 1, en donde el antagonista de EGFR tiene una formula general (1) de acuerdo con US 5.757.498, se incorpora a la presente a modo de referencia, en donde: m es 1, 2 o 3; cada R1 es independientemente seleccionado de un grupo que consiste de hidrogeno, halo, hidroxi, hidroxiamino, carboxi, nitro, guanidino, ureido, ciano, trifluorometil, y -(alquileno C1-4)-W-(fenilo) en donde W es un enlace simple, O, S o NH; o cada R1 es independientemente seleccionado de R9 y alquilo C1-4 sustituido con ciano, en donde R9 se selecciona de un grupo que consiste de R5, -OR6, -NR6R6, -C(O)R7, -NHOR5, -OC(O)R6, ciano, A y -YR5; R5 es alquilo C1-4; R6 es independientemente hidrogeno o R5; R7 es R5, -OR6 o -NR6R6; A se selecciona de piperidino, morfolino, pirrolidino, 4-R6-piperazin-1-ilo, imidazol-1-ilo, 4-piridon-1-ilo, -(alquileno C1-4)(CO2H), fenoxi, fenilo, fenilsulfanilo, alquenilo C2-4, y -(alquileno C1-4)C(O)NR6R6; e Y es S, SO, o SO2; en donde las porciones de alquilo en R5, -OR6 y -NR6R6 están opcionalmente sustituidas con uno a tres sustituyentes halo y las porciones de alquilo en R5, -OR6 y -NR6R6 están opcionalmente sustituidas con 1 o 2 grupos R9, y en donde las porciones de alquilo de dichos sustituyentes opcionales están opcionalmente sustituidas con halo o R9, con la condicion de que dos heteroátomos no estén unidos al mismo átomo de carbono; o cada R1 es independientemente seleccionado de -NHSO2R5, ftalimido-alquil C1-4sulfonilamino, benzamido, bencensulfonilamino, 3-fenilureido, 2-oxopirrolidin-1-ilo, 2,5-dioxopirrolidin-1-ilo, y R10-alcanoilamino C2-4 en donde R10 se selecciona de halo, -OR6, alcanoiloxi C2-4, -C(O)R7, y -NR6R6; y en donde dicho -NHSO2R5, ftalimido-alquil C1-4sulfonilamino, benzamido, bencensulfonilamino, 3-fenilureido, 2-oxopirrolidin-1ilo, 2,5-dioxopirrolidin-1-ilo, y R10-alcanoilamino C2-4 están opcionalmente sustituidos con 1 o 2 sustituyentes independientemente seleccionados de halo, alquilo C1-4, ciano, metansulfonilo y alcoxi C1-4; o dos grupos R1 se toman junto con los carbonos a los que están unidos para formar un anillo de 5 a 8 miembros que incluye 1 o 2 heteroátomos seleccionados de O, S y N; R2 es hidrogeno o alquilo C1-6 opcionalmente sustituido con 1 a 3 sustituyentes independientemente seleccionados de halo, alcoxi C1-4, -NR6R6, y -SO2R5; n es 1 o 2 y cada R3 es independientemente seleccionado de hidrogeno, halo, hidroxi, alquilo C1-6, -NR6R6, y alcoxi C1-4, en donde las porciones de alquilo de dichos grupos R3 están opcionalmente sustituidas con 1 a 3 sustituyentes independientemente seleccionados de halo, alcoxi C1-4, -NR6R6, y -SO2R; y R4 es azido o -(etinilo)-R11 en donde R11 es hidrogeno o alquilo C1-6 opcionalmente sustituido con hidroxi, -OR6, o -NR6R6. Reivindicacion 7: El uso de la reivindicacion 1, en donde el antagonista de c-met es un anticuerpo. Reivindicacion 9: El uso de la reivindicacion 7, en donde el anticuerpo es monovalente y comprende una region Fc, en donde la region Fc comprende un primer y un segundo polipéptido, en donde el primer polipéptido comprende la secuencia de Fc que se muestra en la figura (SEC ID Ns 17) y el segundo polipéptido comprende la secuencia que se muestra en la figura (SEC ID Ns 18).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3444608P | 2008-03-06 | 2008-03-06 | |
US4443808P | 2008-04-11 | 2008-04-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR070861A1 true AR070861A1 (es) | 2010-05-12 |
Family
ID=40688402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100815A AR070861A1 (es) | 2008-03-06 | 2009-03-06 | Uso de terapia de combinacion con antagonistas de c-met y egfr |
Country Status (20)
Country | Link |
---|---|
US (3) | US20090226443A1 (es) |
EP (1) | EP2257293A2 (es) |
JP (1) | JP2011513427A (es) |
KR (2) | KR20160095186A (es) |
CN (1) | CN102014913A (es) |
AR (1) | AR070861A1 (es) |
AU (1) | AU2009221808A1 (es) |
BR (1) | BRPI0906099A2 (es) |
CA (1) | CA2716851A1 (es) |
CL (1) | CL2009000542A1 (es) |
CR (1) | CR11717A (es) |
EC (1) | ECSP10010527A (es) |
IL (1) | IL207777A0 (es) |
MA (1) | MA32177B1 (es) |
MX (1) | MX2010009669A (es) |
RU (1) | RU2601892C2 (es) |
SG (1) | SG188802A1 (es) |
TW (1) | TW200940064A (es) |
WO (1) | WO2009111691A2 (es) |
ZA (1) | ZA201006028B (es) |
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2009
- 2009-03-06 AR ARP090100815A patent/AR070861A1/es unknown
- 2009-03-06 BR BRPI0906099-5A patent/BRPI0906099A2/pt not_active IP Right Cessation
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- 2009-03-06 EP EP09716498A patent/EP2257293A2/en not_active Withdrawn
- 2009-03-06 CN CN2009801164913A patent/CN102014913A/zh active Pending
- 2009-03-06 AU AU2009221808A patent/AU2009221808A1/en not_active Abandoned
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- 2009-03-06 RU RU2010140795/15A patent/RU2601892C2/ru not_active IP Right Cessation
- 2009-03-06 JP JP2010549904A patent/JP2011513427A/ja active Pending
- 2009-03-06 KR KR1020167020709A patent/KR20160095186A/ko not_active Application Discontinuation
- 2009-03-06 MX MX2010009669A patent/MX2010009669A/es not_active Application Discontinuation
- 2009-03-06 WO PCT/US2009/036314 patent/WO2009111691A2/en active Application Filing
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- 2009-03-06 CL CL2009000542A patent/CL2009000542A1/es unknown
- 2009-03-06 TW TW098107445A patent/TW200940064A/zh unknown
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ZA201006028B (en) | 2011-11-30 |
SG188802A1 (en) | 2013-04-30 |
CN102014913A (zh) | 2011-04-13 |
MA32177B1 (fr) | 2011-03-01 |
KR20100135780A (ko) | 2010-12-27 |
ECSP10010527A (es) | 2010-11-30 |
AU2009221808A1 (en) | 2009-09-11 |
RU2010140795A (ru) | 2012-04-20 |
WO2009111691A3 (en) | 2009-11-12 |
CL2009000542A1 (es) | 2010-11-05 |
JP2011513427A (ja) | 2011-04-28 |
BRPI0906099A2 (pt) | 2015-07-21 |
WO2009111691A2 (en) | 2009-09-11 |
IL207777A0 (en) | 2010-12-30 |
US20090226443A1 (en) | 2009-09-10 |
TW200940064A (en) | 2009-10-01 |
MX2010009669A (es) | 2010-09-22 |
US20150056207A1 (en) | 2015-02-26 |
RU2601892C2 (ru) | 2016-11-10 |
US20160303127A1 (en) | 2016-10-20 |
CA2716851A1 (en) | 2009-09-11 |
CR11717A (es) | 2010-11-26 |
KR20160095186A (ko) | 2016-08-10 |
EP2257293A2 (en) | 2010-12-08 |
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