AR031867A1 - Compuestos derivados de fenoxibencilamina como ssri, su uso en la preparacion de medicamentos, procedimiento de preparacion del compuesto e intermediarios utiles - Google Patents
Compuestos derivados de fenoxibencilamina como ssri, su uso en la preparacion de medicamentos, procedimiento de preparacion del compuesto e intermediarios utilesInfo
- Publication number
- AR031867A1 AR031867A1 ARP010104114A ARP010104114A AR031867A1 AR 031867 A1 AR031867 A1 AR 031867A1 AR P010104114 A ARP010104114 A AR P010104114A AR P010104114 A ARP010104114 A AR P010104114A AR 031867 A1 AR031867 A1 AR 031867A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- compounds
- preparation
- heterocyclic ring
- independently substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto derivado de fenoxibencilamina de formula general (1), sus sales, solvatos o polimorfos farmacéuticamente aceptables, donde: R1 y R2, que pueden ser iguales o diferentes, son H, alquilo C1-6 o (CH2)d-cicloalquilo C3-6, donde d es 0, 1, 2 o 3; o R1 y R2 junto con el nitrogeno al que están unidos forman un anillo de azetidina; uno de Z o Y es -SR3 y el otro de Z o Y es halogeno o -R3; donde R3 es independientemente alquilo C1-4 opcionalmente sustituido con fluor; excepto que R3 no es CF3; o Z e Y están unidos de manera que, junto con los átomos de interconexion, Z e Y forman un anillo carbocíclico o heterocíclico de 5 a 7 miembros, condensado, que puede ser saturado, insaturado o aromático, y donde, cuando Z e Y forman un anillo heterocíclico, además de átomos de C, el enlace contiene uno o dos heteroátomos seleccionados independientemente entre oxígeno, azufre y nitrogeno; con la condicion que cuando R5 es fluor y R2 es metilo, entonces el anillo condensado no es 1,3-dioxolano y Z e Y juntos no forman un anillo de fenilo condensado; R4 y R5, que pueden ser iguales o diferentes, son: A-X, donde A es -CH=CH- o -(CH2)p-, donde p es 0, 1 o 2; X es hidrogeno, F, Cl, Br, I, CONR6R7, SO2NR6R7, SO2NHC(=O)R6, OH, alcoxi C1-4, NR8SO2R9, NO2, NR6R11, CN, CO2R10, CHO, SR10, S(O)R9, o SO2R10; R6, R7, R8 y R10, que pueden ser iguales o diferentes, son hidrogeno o alquilo C1-6 opcionalmente sustituido independientemente con uno o más R12; R9 es alquilo C1-6 opcionalmente sustituido independientemente con uno o más R12, R11 es hidrogeno, alquilo C1-6 opcionalmente sustituido independientemente con uno o más R12, C(O)R6, CO2R9, C(O)NHR6 o SO2NR6R7; R12 es F, OH, CO2H, cicloalquilo C3-6, NH2, CONH2, alcoxi C1-6, alcoxi C1-6-carbonilo o un anillo heterocíclico de 5 o 6 miembros que contiene 1, 2 o 3 heteroátomos seleccionados entre N, S y O, opcionalmente sustituido independientemente con uno o más R13; o R6 y R7, junto con el nitrogeno al que están unidos, forman un anillo heterocíclico de 4, 5 o 6 miembros opcionalmente sustituido independientemente con uno o más R13; o un anillo heterocíclico de 5 o 6 miembros que contiene 1, 2 o 3 heteroátomos seleccionados entre N, S y O, opcionalmente sustituido independientemente con uno o más R13; donde R13 es hidroxi, alcoxi C1-4, F, alquilo C1-6, haloalquilo, haloalcoxi, -NH2, -NH(alquilo C1-6) o -N(alquilo C1-6)2. Compuestos de éter difenílico que inhiben la reabsorcion de monoaminas. En particular los compuestos presentan actividad como inhibidores selectivos de la reabsorcion de serotonina (SSRI, del inglés selective serotonin re-uptake inhibitors) y tienen utilidad, por tanto en diversas áreas terapéuticas. Más notablemente, los compuestos de la presente son utiles en el tratamiento o prevencion de diversos trastornos, incluidos aquellos en los que está implicada la regulacion de la funcion de los transportadores de monoaminas, tales como depresion, trastorno de hiperactividad con déficit de atencion, trastorno obsesivo compulsivo, trastorno de estrés post-traumático, trastornos de abuso de sustancias y disfuncion sexual, incluida eyaculacion precoz, y a las formulaciones farmacéuticas que contienen tales compuestos. Se describe también su uso en la preparacion de medicamentos, proceso para la preparacion de los compuestos e intermediarios utiles en su fabricacion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0021593A GB0021593D0 (en) | 2000-08-31 | 2000-08-31 | Diphenyl ether compounds useful in therapy |
| GB0107116A GB0107116D0 (en) | 2001-03-21 | 2001-03-21 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031867A1 true AR031867A1 (es) | 2003-10-08 |
Family
ID=26244953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104114A AR031867A1 (es) | 2000-08-31 | 2001-08-29 | Compuestos derivados de fenoxibencilamina como ssri, su uso en la preparacion de medicamentos, procedimiento de preparacion del compuesto e intermediarios utiles |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1313701A1 (es) |
| JP (1) | JP2004507523A (es) |
| KR (1) | KR20030029889A (es) |
| CN (1) | CN1449380A (es) |
| AP (1) | AP2001002265A0 (es) |
| AR (1) | AR031867A1 (es) |
| AU (1) | AU2001278650A1 (es) |
| BG (1) | BG107544A (es) |
| BR (1) | BR0113610A (es) |
| CA (1) | CA2420969A1 (es) |
| CZ (1) | CZ2003467A3 (es) |
| DO (1) | DOP2001000242A (es) |
| DZ (1) | DZ3414A1 (es) |
| EA (1) | EA200300206A1 (es) |
| EE (1) | EE200300084A (es) |
| HN (1) | HN2001000191A (es) |
| HR (1) | HRP20030141A2 (es) |
| HU (1) | HUP0303385A2 (es) |
| IL (1) | IL154343A0 (es) |
| IS (1) | IS6704A (es) |
| MA (1) | MA26945A1 (es) |
| MX (1) | MXPA03001848A (es) |
| NO (1) | NO20030842L (es) |
| NZ (1) | NZ523951A (es) |
| OA (1) | OA12372A (es) |
| PA (1) | PA8526701A1 (es) |
| PE (1) | PE20020346A1 (es) |
| PL (1) | PL360743A1 (es) |
| SK (1) | SK2012003A3 (es) |
| TN (1) | TNSN01131A1 (es) |
| UY (1) | UY26924A1 (es) |
| WO (1) | WO2002018333A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403597B1 (en) * | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US20020107244A1 (en) * | 2001-02-02 | 2002-08-08 | Howard Harry R. | Combination treatment for depression |
| US20020183306A1 (en) * | 2001-05-30 | 2002-12-05 | Pfizer Inc. | Combination treatment for sleep disorders including sleep apnea |
| GB0318706D0 (en) * | 2003-08-08 | 2003-09-10 | Pfizer Ltd | Selective serotonin reuptake inhibitors in the treatment of disease |
| AP2006003700A0 (en) | 2004-02-13 | 2006-08-31 | Warner Lambert Co | Androgen receptor modulators |
| CA2563291A1 (en) | 2004-04-13 | 2005-10-27 | Warner-Lambert Company Llc | 4-cyano-phenoxy-alkyl carboxyl derivatives as androgen modulators |
| WO2005102990A1 (en) | 2004-04-22 | 2005-11-03 | Warner-Lambert Company Llc | Androgen modulators |
| BRPI0513020A (pt) | 2004-07-08 | 2008-04-22 | Warner Lambert Co | moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação |
| MX2007001993A (es) * | 2004-08-18 | 2007-05-10 | Warner Lambert Co | Moduladores de androgenos. |
| JP2008512438A (ja) * | 2004-09-10 | 2008-04-24 | ファイザー・プロダクツ・インク | 療法用ジフェニルエーテル系リガンド |
| TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| WO2007010350A1 (en) * | 2005-07-19 | 2007-01-25 | Pfizer Products Inc. | Synthesis of therapeutic diphenyl ethers |
| US7939528B2 (en) | 2005-10-13 | 2011-05-10 | Glaxosmithkline Llc | Heterocycle compounds |
| EP1976495A2 (en) * | 2006-01-06 | 2008-10-08 | Aarhus Universitet | Compounds acting on the serotonin transporter |
| US7479493B2 (en) | 2006-06-29 | 2009-01-20 | Janssen Pharmaceutica N.V. | Substituted benzyl amine compounds |
| WO2008002818A1 (en) * | 2006-06-29 | 2008-01-03 | Janssen Pharmaceutica N.V. | Substituted aminomethyl benzamide compounds |
| AU2007265239A1 (en) * | 2006-06-29 | 2008-01-03 | Janssen Pharmaceutica N.V. | Butyl and butynyl benzyl amine compounds |
| US8642583B2 (en) | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| WO2010059390A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| KR101043200B1 (ko) * | 2010-11-08 | 2011-06-21 | 성시민 | 호흡용 공기탱크의 공기 충전장치 |
| GB2501206B (en) | 2011-01-27 | 2019-12-04 | Hewlett Packard Development Co | A computing device to connect to a portable device |
| JP7413346B2 (ja) | 2019-03-06 | 2024-01-15 | 第一三共株式会社 | ピロロピラゾール誘導体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
| SK20396A3 (en) * | 1993-08-19 | 1997-03-05 | Warner Lambert Co | Substituted 2(5h)furanone, 2(5h)thiophenone or 2(5h)pyrrolone derivatives and pharmaceutical compositions on their base |
| CZ293595A3 (cs) * | 1995-11-09 | 1999-12-15 | Farmak A. S. | Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích |
| WO1999047497A2 (en) * | 1998-03-13 | 1999-09-23 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| EA004860B1 (ru) * | 1999-02-23 | 2004-08-26 | Пфайзер Продактс Инк. | Ингибиторы обратного захвата моноаминов для лечения расстройств цнс |
| GB0007884D0 (en) * | 2000-03-31 | 2000-05-17 | Pfizer Ltd | Diphenyl ether compounds useful in therapy |
-
2001
- 2001-08-22 SK SK201-2003A patent/SK2012003A3/sk unknown
- 2001-08-22 CA CA002420969A patent/CA2420969A1/en not_active Abandoned
- 2001-08-22 CZ CZ2003467A patent/CZ2003467A3/cs unknown
- 2001-08-22 MX MXPA03001848A patent/MXPA03001848A/es active IP Right Grant
- 2001-08-22 PL PL36074301A patent/PL360743A1/xx not_active Application Discontinuation
- 2001-08-22 BR BR0113610-0A patent/BR0113610A/pt not_active IP Right Cessation
- 2001-08-22 HU HU0303385A patent/HUP0303385A2/hu unknown
- 2001-08-22 AU AU2001278650A patent/AU2001278650A1/en not_active Abandoned
- 2001-08-22 IL IL15434301A patent/IL154343A0/xx unknown
- 2001-08-22 EA EA200300206A patent/EA200300206A1/ru unknown
- 2001-08-22 DZ DZ013414A patent/DZ3414A1/fr active
- 2001-08-22 JP JP2002523451A patent/JP2004507523A/ja active Pending
- 2001-08-22 CN CN01814846A patent/CN1449380A/zh active Pending
- 2001-08-22 KR KR10-2003-7003011A patent/KR20030029889A/ko not_active Application Discontinuation
- 2001-08-22 AP APAP/P/2001/002265A patent/AP2001002265A0/en unknown
- 2001-08-22 EP EP01956734A patent/EP1313701A1/en not_active Withdrawn
- 2001-08-22 OA OA1200300056A patent/OA12372A/en unknown
- 2001-08-22 EE EEP200300084A patent/EE200300084A/xx unknown
- 2001-08-22 WO PCT/IB2001/001521 patent/WO2002018333A1/en not_active Application Discontinuation
- 2001-08-22 NZ NZ523951A patent/NZ523951A/en unknown
- 2001-08-24 PA PA20018526701A patent/PA8526701A1/es unknown
- 2001-08-28 HN HN2001000191A patent/HN2001000191A/es unknown
- 2001-08-28 PE PE2001000862A patent/PE20020346A1/es not_active Application Discontinuation
- 2001-08-29 AR ARP010104114A patent/AR031867A1/es unknown
- 2001-08-29 DO DO2001000242A patent/DOP2001000242A/es unknown
- 2001-08-30 TN TNTNSN01131A patent/TNSN01131A1/fr unknown
- 2001-08-31 UY UY26924A patent/UY26924A1/es not_active Application Discontinuation
-
2003
- 2003-01-30 IS IS6704A patent/IS6704A/is unknown
- 2003-02-07 BG BG107544A patent/BG107544A/bg unknown
- 2003-02-21 MA MA27049A patent/MA26945A1/fr unknown
- 2003-02-24 NO NO20030842A patent/NO20030842L/no not_active Application Discontinuation
- 2003-02-26 HR HR20030141A patent/HRP20030141A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2420969A1 (en) | 2002-03-07 |
| BR0113610A (pt) | 2003-06-24 |
| MXPA03001848A (es) | 2003-06-04 |
| EA200300206A1 (ru) | 2003-06-26 |
| TNSN01131A1 (fr) | 2005-11-10 |
| NZ523951A (en) | 2004-09-24 |
| DZ3414A1 (fr) | 2002-03-07 |
| IS6704A (is) | 2003-01-30 |
| SK2012003A3 (en) | 2004-06-08 |
| HRP20030141A2 (en) | 2003-04-30 |
| IL154343A0 (en) | 2003-09-17 |
| DOP2001000242A (es) | 2002-05-15 |
| NO20030842L (no) | 2003-04-28 |
| AU2001278650A1 (en) | 2002-03-13 |
| KR20030029889A (ko) | 2003-04-16 |
| PE20020346A1 (es) | 2002-05-08 |
| CN1449380A (zh) | 2003-10-15 |
| CZ2003467A3 (cs) | 2004-04-14 |
| WO2002018333A1 (en) | 2002-03-07 |
| AP2001002265A0 (en) | 2001-09-30 |
| EP1313701A1 (en) | 2003-05-28 |
| MA26945A1 (fr) | 2004-12-20 |
| BG107544A (bg) | 2003-10-31 |
| NO20030842D0 (no) | 2003-02-24 |
| EE200300084A (et) | 2005-02-15 |
| PA8526701A1 (es) | 2003-07-28 |
| HUP0303385A2 (hu) | 2004-03-01 |
| UY26924A1 (es) | 2002-03-22 |
| OA12372A (en) | 2006-04-17 |
| PL360743A1 (en) | 2004-09-20 |
| HN2001000191A (es) | 2002-03-11 |
| JP2004507523A (ja) | 2004-03-11 |
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