AR064921A1 - Pirazol-amidas sustituidas antagonistas de receptores alfa 7 nicotinicos de acetilcolina,composiciones farmaceuticas que las contienen y usos para el tratamiento de enfermedades neurologicas,psiquiatricas e inflamatorias. - Google Patents
Pirazol-amidas sustituidas antagonistas de receptores alfa 7 nicotinicos de acetilcolina,composiciones farmaceuticas que las contienen y usos para el tratamiento de enfermedades neurologicas,psiquiatricas e inflamatorias.Info
- Publication number
- AR064921A1 AR064921A1 ARP080100189A ARP080100189A AR064921A1 AR 064921 A1 AR064921 A1 AR 064921A1 AR P080100189 A ARP080100189 A AR P080100189A AR P080100189 A ARP080100189 A AR P080100189A AR 064921 A1 AR064921 A1 AR 064921A1
- Authority
- AR
- Argentina
- Prior art keywords
- branched
- cyclic
- linear
- diyl
- alkyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88062907P | 2007-01-16 | 2007-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064921A1 true AR064921A1 (es) | 2009-05-06 |
Family
ID=39345157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100189A AR064921A1 (es) | 2007-01-16 | 2008-01-16 | Pirazol-amidas sustituidas antagonistas de receptores alfa 7 nicotinicos de acetilcolina,composiciones farmaceuticas que las contienen y usos para el tratamiento de enfermedades neurologicas,psiquiatricas e inflamatorias. |
Country Status (25)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008000119A1 (es) | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
| US20090264648A1 (en) * | 2008-01-14 | 2009-10-22 | Wyeth | Synthesis of pyrazoles |
| WO2009091813A1 (en) * | 2008-01-14 | 2009-07-23 | Wyeth | Compounds useful as alpha7 nicotinic acetylcholine receptor agonists |
| US20090181953A1 (en) * | 2008-01-14 | 2009-07-16 | Wyeth | Compound forms and uses thereof |
| TW201004941A (en) * | 2008-07-16 | 2010-02-01 | Wyeth Corp | Alpha7 nicotinic acetylcholine receptor inhibitors |
| AU2009282747B2 (en) | 2008-08-22 | 2015-04-02 | Takeda Pharmaceutical Company Limited | Polymeric benzyl carbonate-derivatives |
| EP2406264A4 (en) * | 2009-03-09 | 2012-08-08 | Univ California | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINE AND GABAA RECEPTORS |
| EP2959902A1 (en) * | 2009-07-23 | 2015-12-30 | Novartis AG | Use of azabicycloalkyl derivatives for the treatment or prevention of ataxia |
| TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α７活化劑之用途 |
| MX343905B (es) | 2010-11-03 | 2016-11-28 | Dow Agrosciences Llc | Composiciones pesticidas y procesos relacionados a las mismas. |
| US20130231290A1 (en) * | 2010-11-18 | 2013-09-05 | Dignity Health | Methods of diagnosing and treating neurodegenerative diseases |
| EP2905279A4 (en) * | 2012-10-02 | 2016-04-20 | Sumitomo Dainippon Pharma Co Ltd | imidazole |
| CN105254564A (zh) * | 2015-10-31 | 2016-01-20 | 丁玉琴 | 一种2-甲基-3,4-二硝基-5-(甲氧苯基)吡唑的合成方法 |
| CN105646358B (zh) * | 2016-03-01 | 2018-03-09 | 苏州艾缇克药物化学有限公司 | 一种3‑氨基‑5‑(4‑甲氧苯基)吡唑的合成方法 |
| CN112457255B (zh) * | 2017-11-08 | 2022-08-19 | 北京嘉林药业股份有限公司 | 化合物及其治疗癌症的用途 |
| TWI805699B (zh) | 2018-03-01 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 甲基內醯胺環化合物及其用途 |
| TWI805727B (zh) | 2018-04-04 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 經雜芳基取代之吡唑化合物及其醫藥用途 |
| GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
| CN113925606B (zh) * | 2021-10-25 | 2023-07-07 | 四川大学华西医院 | 一种神经调控导航定位方法、装置和神经调控治疗系统 |
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-
2008
- 2008-01-15 CL CL200800119A patent/CL2008000119A1/es unknown
- 2008-01-15 TW TW097101453A patent/TW200901974A/zh unknown
- 2008-01-16 EP EP08702252.1A patent/EP2118067B1/en active Active
- 2008-01-16 NZ NZ578411A patent/NZ578411A/en not_active IP Right Cessation
- 2008-01-16 ZA ZA200904943A patent/ZA200904943B/xx unknown
- 2008-01-16 PA PA20088766201A patent/PA8766201A1/es unknown
- 2008-01-16 AU AU2008206759A patent/AU2008206759B2/en not_active Ceased
- 2008-01-16 US US12/523,189 patent/US8163729B2/en not_active Expired - Fee Related
- 2008-01-16 KR KR1020097014828A patent/KR20090116707A/ko not_active Application Discontinuation
- 2008-01-16 CN CN200880008464XA patent/CN101679287B/zh not_active Expired - Fee Related
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- 2008-01-16 BR BRPI0806665-5A patent/BRPI0806665A2/pt not_active IP Right Cessation
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- 2008-01-16 JP JP2009546013A patent/JP2010515770A/ja active Pending
- 2008-01-16 SA SA08290018A patent/SA08290018B1/ar unknown
- 2008-01-16 AR ARP080100189A patent/AR064921A1/es not_active Application Discontinuation
- 2008-01-16 UA UAA200907422A patent/UA98317C2/ru unknown
- 2008-01-16 WO PCT/IB2008/000090 patent/WO2008087529A1/en active Application Filing
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2118067A1 (en) | 2009-11-18 |
| AU2008206759A1 (en) | 2008-07-24 |
| EA200900831A1 (ru) | 2010-02-26 |
| SA08290018B1 (ar) | 2013-01-17 |
| BRPI0806665A2 (pt) | 2011-09-06 |
| PA8766201A1 (es) | 2008-11-19 |
| WO2008087529A1 (en) | 2008-07-24 |
| US8163729B2 (en) | 2012-04-24 |
| UA98317C2 (ru) | 2012-05-10 |
| CL2008000119A1 (es) | 2008-05-16 |
| ZA200904943B (en) | 2010-09-29 |
| ECSP099490A (es) | 2009-09-29 |
| TW200901974A (en) | 2009-01-16 |
| MX2009007615A (es) | 2009-07-27 |
| KR20090116707A (ko) | 2009-11-11 |
| EP2118067B1 (en) | 2013-05-08 |
| JP2010515770A (ja) | 2010-05-13 |
| US20100029606A1 (en) | 2010-02-04 |
| IL199889A0 (en) | 2010-04-15 |
| CO6351782A2 (es) | 2011-12-20 |
| AU2008206759B2 (en) | 2013-09-05 |
| NZ578411A (en) | 2011-06-30 |
| CA2675676A1 (en) | 2008-07-24 |
| EA016948B1 (ru) | 2012-08-30 |
| CR10930A (es) | 2013-02-12 |
| CN101679287B (zh) | 2013-03-27 |
| HK1142335A1 (en) | 2010-12-03 |
| CN101679287A (zh) | 2010-03-24 |
| SV2009003334A (es) | 2010-08-09 |
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