AR061064A1 - Inhibicion mediada por arni de afecciones relacionadas con el factor de necrosis tumoral alfa - Google Patents

Inhibicion mediada por arni de afecciones relacionadas con el factor de necrosis tumoral alfa

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Publication number
AR061064A1
AR061064A1 ARP070102199A ARP070102199A AR061064A1 AR 061064 A1 AR061064 A1 AR 061064A1 AR P070102199 A ARP070102199 A AR P070102199A AR P070102199 A ARP070102199 A AR P070102199A AR 061064 A1 AR061064 A1 AR 061064A1
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AR
Argentina
Prior art keywords
sec
tnfalfa
mrna
silencing
composition
Prior art date
Application number
ARP070102199A
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English (en)
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Alcon Mfg Ltd
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Application filed by Alcon Mfg Ltd filed Critical Alcon Mfg Ltd
Publication of AR061064A1 publication Critical patent/AR061064A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Se proporciona una interferencia de ARN para la inhibicion del factor de necrosis tumoral alfa (TNFalfa) silenciando la expresion del ARNm del receptor de superficie celular del TNFalfa, receptor 1 del TNF (TNFR1), o silenciando la expresion del ARNm de la enzima conversora del TNFalfa (TACE/ADAM17). El silenciamiento de dichos blancos del TNFalfa, en particular, es util para tratar pacientes que padecen una afeccion relacionada con el TNFalfa o en riesgo de desarrollar una afeccion relacionada con el TNFalfa, tal como las afecciones oculares de ojo seco, conjuntivitis alérgica o inflamacion ocular, o tales como dermatitis, rinitis o asma, por ejemplo. Reivindicacion 39: Una composicion que comprende un ARN de interferencia con una longitud de 19 a 49 nucleotidos, y que comprende una secuencia de nucleotidos correspondiente a cualquiera de SEC. ID N°:3, SEC. ID N°:14 - SEC. ID N°:58, y SEC. ID N°:155-SEC. ID N°:201, o un complemento de ella; y un portador farmacéuticamente aceptable. Reivindicacion 40: Una composicion que comprende un ARN de interferencia que consiste esencialmente en una secuencia de nucleotidos correspondiente a cualquiera de SEC. ID N°:59 - SEC. ID N°:69, SEC. ID N°:71 - SEC. ID N°:92, y SEC. ID N°:94 - SEC. ID N°:154, o un complemento de ella; y un portador farmacéuticamente aceptable. Reivindicacion 41: La composicion de la reivindicacion 39, en donde el ARN de interferencia es uno de un ARNsh, un ARNsi o un ARNmi.
ARP070102199A 2006-05-19 2007-05-21 Inhibicion mediada por arni de afecciones relacionadas con el factor de necrosis tumoral alfa AR061064A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80178806P 2006-05-19 2006-05-19

Publications (1)

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AR061064A1 true AR061064A1 (es) 2008-07-30

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ID=38702032

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ARP070102199A AR061064A1 (es) 2006-05-19 2007-05-21 Inhibicion mediada por arni de afecciones relacionadas con el factor de necrosis tumoral alfa

Country Status (18)

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US (7) US7732421B2 (es)
EP (1) EP2018426B1 (es)
JP (4) JP2009537566A (es)
KR (2) KR20120093306A (es)
CN (2) CN103285026B (es)
AR (1) AR061064A1 (es)
AU (1) AU2007253776B2 (es)
CA (1) CA2650416A1 (es)
CL (2) CL2007001434A1 (es)
ES (1) ES2413804T3 (es)
HK (1) HK1128090A1 (es)
MX (1) MX2008014260A (es)
PL (1) PL2018426T3 (es)
RU (1) RU2469090C2 (es)
TW (1) TWI472344B (es)
UY (1) UY30361A1 (es)
WO (1) WO2007137129A2 (es)
ZA (1) ZA200809203B (es)

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US20100166676A1 (en) 2010-07-01
CN101448943B (zh) 2013-07-17
US20140357694A1 (en) 2014-12-04
PL2018426T3 (pl) 2013-10-31
CA2650416A1 (en) 2007-11-29
KR20120093306A (ko) 2012-08-22
CN103285026A (zh) 2013-09-11
TWI472344B (zh) 2015-02-11
US9447419B2 (en) 2016-09-20
US20070281901A1 (en) 2007-12-06
WO2007137129A3 (en) 2008-04-10
US20110142767A1 (en) 2011-06-16
AU2007253776B2 (en) 2012-04-26
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CN101448943A (zh) 2009-06-03
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US20160369283A1 (en) 2016-12-22
RU2469090C2 (ru) 2012-12-10
CL2007001434A1 (es) 2008-02-22
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CN103285026B (zh) 2017-08-04
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US20190032061A1 (en) 2019-01-31
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US20130338213A1 (en) 2013-12-19
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JP2013049728A (ja) 2013-03-14
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