UY30361A1 - Inhibición mediada por el arni de las afecciones vinculadas al factor a (alfa) de necrosis tumoral - Google Patents

Inhibición mediada por el arni de las afecciones vinculadas al factor a (alfa) de necrosis tumoral

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Publication number
UY30361A1
UY30361A1 UY30361A UY30361A UY30361A1 UY 30361 A1 UY30361 A1 UY 30361A1 UY 30361 A UY30361 A UY 30361A UY 30361 A UY30361 A UY 30361A UY 30361 A1 UY30361 A1 UY 30361A1
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UY
Uruguay
Prior art keywords
alpha
tnfa
conditions
tumor necrosis
factor
Prior art date
Application number
UY30361A
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English (en)
Inventor
Diane Michelle Senchyna
Jon E Chatterton
Steven T Miller
Daniel A Gamache
John M Yanni
Original Assignee
Alcon Mfg Ltd
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38702032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY30361(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Mfg Ltd filed Critical Alcon Mfg Ltd
Publication of UY30361A1 publication Critical patent/UY30361A1/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

Se ofrece un ARN de interferencia para inhibir el factor a(alfa) de necrosis tumoral (TNFa(alfa)) mediante el silenciamiento de la expresión del ARNm del receptor 1 del factor de necrosis tumorial (TNF) de la superficie de las células TNFa(alfa) o el ARNm de la enzima de conversión de TNFa(alfa) (TACE/ADAM17). El silenciamiento de dichos TNFa(alfa) objetivos es útil para el tratamiento de pacientes con afecciones vinculadas al TNFa(alfa)-o quienes están en riesgo de sufrir afecciones vinculadas al TNFa(alfa) tales como afecciones oculares como ojo seco, conjuntivitis alérgica o inflación ocular, afecciones tales como dermatitis, rinitis o asma, por ejemplo.
UY30361A 2006-05-19 2007-05-22 Inhibición mediada por el arni de las afecciones vinculadas al factor a (alfa) de necrosis tumoral UY30361A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80178806P 2006-05-19 2006-05-19

Publications (1)

Publication Number Publication Date
UY30361A1 true UY30361A1 (es) 2007-08-31

Family

ID=38702032

Family Applications (1)

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UY30361A UY30361A1 (es) 2006-05-19 2007-05-22 Inhibición mediada por el arni de las afecciones vinculadas al factor a (alfa) de necrosis tumoral

Country Status (18)

Country Link
US (7) US7732421B2 (es)
EP (1) EP2018426B1 (es)
JP (4) JP2009537566A (es)
KR (2) KR20090010234A (es)
CN (2) CN101448943B (es)
AR (1) AR061064A1 (es)
AU (1) AU2007253776B2 (es)
CA (1) CA2650416A1 (es)
CL (2) CL2007001434A1 (es)
ES (1) ES2413804T3 (es)
HK (1) HK1128090A1 (es)
MX (1) MX2008014260A (es)
PL (1) PL2018426T3 (es)
RU (1) RU2469090C2 (es)
TW (1) TWI472344B (es)
UY (1) UY30361A1 (es)
WO (1) WO2007137129A2 (es)
ZA (1) ZA200809203B (es)

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CN103285026B (zh) 2017-08-04
US20160369283A1 (en) 2016-12-22
RU2008150324A (ru) 2010-06-27
WO2007137129A2 (en) 2007-11-29
JP2013049728A (ja) 2013-03-14
JP2013049727A (ja) 2013-03-14
US9447419B2 (en) 2016-09-20
PL2018426T3 (pl) 2013-10-31
KR20090010234A (ko) 2009-01-29
EP2018426A2 (en) 2009-01-28
US20110142767A1 (en) 2011-06-16
JP2009537566A (ja) 2009-10-29
CN103285026A (zh) 2013-09-11
TWI472344B (zh) 2015-02-11
CL2010001109A1 (es) 2011-03-11
CL2007001434A1 (es) 2008-02-22
CN101448943A (zh) 2009-06-03
US20140357694A1 (en) 2014-12-04
CN101448943B (zh) 2013-07-17
US20130338213A1 (en) 2013-12-19
RU2469090C2 (ru) 2012-12-10
US20190032061A1 (en) 2019-01-31
MX2008014260A (es) 2008-11-26
EP2018426B1 (en) 2013-05-15
JP2016033153A (ja) 2016-03-10
TW200812623A (en) 2008-03-16
US7732421B2 (en) 2010-06-08
CA2650416A1 (en) 2007-11-29
AU2007253776B2 (en) 2012-04-26
AR061064A1 (es) 2008-07-30
WO2007137129A3 (en) 2008-04-10
AU2007253776A1 (en) 2007-11-29
US20100166676A1 (en) 2010-07-01
US20070281901A1 (en) 2007-12-06
ES2413804T3 (es) 2013-07-17
US8541389B2 (en) 2013-09-24
KR20120093306A (ko) 2012-08-22
HK1128090A1 (en) 2009-10-16
ZA200809203B (en) 2010-02-24

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