HK1128090A1 - Rnai-mediated inhibition of tumor necrosis factor - Google Patents

Rnai-mediated inhibition of tumor necrosis factor

Info

Publication number
HK1128090A1
HK1128090A1 HK09105531.6A HK09105531A HK1128090A1 HK 1128090 A1 HK1128090 A1 HK 1128090A1 HK 09105531 A HK09105531 A HK 09105531A HK 1128090 A1 HK1128090 A1 HK 1128090A1
Authority
HK
Hong Kong
Prior art keywords
rnai
necrosis factor
tumor necrosis
mediated inhibition
mediated
Prior art date
Application number
HK09105531.6A
Other languages
English (en)
Inventor
John M Yanni
Jon E Chatterton
Diane Michelle Senchyna
Daniel A Gamache
Steven T Miller
Original Assignee
Alcon Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38702032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1128090(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Res Ltd filed Critical Alcon Res Ltd
Publication of HK1128090A1 publication Critical patent/HK1128090A1/xx

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/04—Antipruritics
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
HK09105531.6A 2006-05-19 2009-06-19 Rnai-mediated inhibition of tumor necrosis factor HK1128090A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80178806P 2006-05-19 2006-05-19
PCT/US2007/069165 WO2007137129A2 (en) 2006-05-19 2007-05-17 RNAI-MEDIATED INHIBITION OF TUMOR NECROSIS FACTOR α-RELATED CONDITIONS

Publications (1)

Publication Number Publication Date
HK1128090A1 true HK1128090A1 (en) 2009-10-16

Family

ID=38702032

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09105531.6A HK1128090A1 (en) 2006-05-19 2009-06-19 Rnai-mediated inhibition of tumor necrosis factor

Country Status (18)

Country Link
US (7) US7732421B2 (xx)
EP (1) EP2018426B1 (xx)
JP (4) JP2009537566A (xx)
KR (2) KR20120093306A (xx)
CN (2) CN101448943B (xx)
AR (1) AR061064A1 (xx)
AU (1) AU2007253776B2 (xx)
CA (1) CA2650416A1 (xx)
CL (2) CL2007001434A1 (xx)
ES (1) ES2413804T3 (xx)
HK (1) HK1128090A1 (xx)
MX (1) MX2008014260A (xx)
PL (1) PL2018426T3 (xx)
RU (1) RU2469090C2 (xx)
TW (1) TWI472344B (xx)
UY (1) UY30361A1 (xx)
WO (1) WO2007137129A2 (xx)
ZA (1) ZA200809203B (xx)

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AR067786A1 (es) 2007-08-03 2009-10-21 Alcon Mfg Ltd Inhibicion relacionada con arni (arn de interferencia) de senales tnfalfa (factor de necrosis tumoral) para el tratamiento de glaucoma
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WO2009052140A1 (en) * 2007-10-15 2009-04-23 Alcon Research, Ltd. Use of tnf receptor antagonists for treating dry eye
CN102178959B (zh) * 2011-03-15 2013-10-23 清华大学深圳研究生院 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用
EP2746396A1 (en) * 2012-12-20 2014-06-25 PLS-Design GmbH Selective local inhibition of TNFR1-mediated functions at the site of antigen/allergen presentation
WO2014169264A2 (en) 2013-04-11 2014-10-16 The Board Of Trustees Of The University Of Illinois Nanoparticle mediated delivery of sirna
CN104560997B (zh) * 2014-12-25 2018-05-04 中国科学院广州生物医药与健康研究院 抑制ADAMTS-5和ADAM17基因的siRNA组合物及其应用
US10709729B2 (en) 2014-12-25 2020-07-14 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Compositions and methods for inhibiting expression of ADAMTS-5 and ADAM17
CN104560999B (zh) * 2014-12-25 2018-01-09 广州市锐博生物科技有限公司 抑制ADAMTS‑5基因的siRNA及其应用
CN104498498A (zh) * 2014-12-25 2015-04-08 广州市锐博生物科技有限公司 抑制ADAM17基因的siRNA及其应用
CN105349502A (zh) * 2015-12-09 2016-02-24 山西医科大学 Tnfr1基因重组腺病毒及其构建
KR20180032955A (ko) * 2016-09-23 2018-04-02 (주)아모레퍼시픽 Tnfrsf14 억제 물질을 포함하는 피부 미백용 조성물 및 tnfrsf14 억제 물질의 스크리닝 방법
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ZA200809203B (en) 2010-02-24
AU2007253776A1 (en) 2007-11-29
CN103285026B (zh) 2017-08-04
KR20120093306A (ko) 2012-08-22
EP2018426B1 (en) 2013-05-15
US8541389B2 (en) 2013-09-24
ES2413804T3 (es) 2013-07-17
JP2013049727A (ja) 2013-03-14
CN101448943A (zh) 2009-06-03
US20100166676A1 (en) 2010-07-01
RU2008150324A (ru) 2010-06-27
PL2018426T3 (pl) 2013-10-31
US20140357694A1 (en) 2014-12-04
AU2007253776B2 (en) 2012-04-26
RU2469090C2 (ru) 2012-12-10
EP2018426A2 (en) 2009-01-28
US9447419B2 (en) 2016-09-20
CN101448943B (zh) 2013-07-17
WO2007137129A3 (en) 2008-04-10
JP2013049728A (ja) 2013-03-14
JP2009537566A (ja) 2009-10-29
KR20090010234A (ko) 2009-01-29
WO2007137129A2 (en) 2007-11-29
US20130338213A1 (en) 2013-12-19
MX2008014260A (es) 2008-11-26
TW200812623A (en) 2008-03-16
CL2010001109A1 (es) 2011-03-11
CL2007001434A1 (es) 2008-02-22
US20110142767A1 (en) 2011-06-16
JP2016033153A (ja) 2016-03-10
CN103285026A (zh) 2013-09-11
CA2650416A1 (en) 2007-11-29
AR061064A1 (es) 2008-07-30
TWI472344B (zh) 2015-02-11
US20190032061A1 (en) 2019-01-31
UY30361A1 (es) 2007-08-31
US7732421B2 (en) 2010-06-08
US20070281901A1 (en) 2007-12-06
US20160369283A1 (en) 2016-12-22

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