HK1128090A1 - Rnai-mediated inhibition of tumor necrosis factor - Google Patents

Rnai-mediated inhibition of tumor necrosis factor

Info

Publication number
HK1128090A1
HK1128090A1 HK09105531.6A HK09105531A HK1128090A1 HK 1128090 A1 HK1128090 A1 HK 1128090A1 HK 09105531 A HK09105531 A HK 09105531A HK 1128090 A1 HK1128090 A1 HK 1128090A1
Authority
HK
Hong Kong
Prior art keywords
rnai
necrosis factor
tumor necrosis
mediated inhibition
mediated
Prior art date
Application number
HK09105531.6A
Other languages
English (en)
Inventor
John M Yanni
Jon E Chatterton
Diane Michelle Senchyna
Daniel A Gamache
Steven T Miller
Original Assignee
Alcon Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38702032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1128090(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Res Ltd filed Critical Alcon Res Ltd
Publication of HK1128090A1 publication Critical patent/HK1128090A1/xx

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Molecular Biology (AREA)
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  • Biomedical Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
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  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK09105531.6A 2006-05-19 2009-06-19 Rnai-mediated inhibition of tumor necrosis factor HK1128090A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80178806P 2006-05-19 2006-05-19
PCT/US2007/069165 WO2007137129A2 (en) 2006-05-19 2007-05-17 RNAI-MEDIATED INHIBITION OF TUMOR NECROSIS FACTOR α-RELATED CONDITIONS

Publications (1)

Publication Number Publication Date
HK1128090A1 true HK1128090A1 (en) 2009-10-16

Family

ID=38702032

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09105531.6A HK1128090A1 (en) 2006-05-19 2009-06-19 Rnai-mediated inhibition of tumor necrosis factor

Country Status (18)

Country Link
US (7) US7732421B2 (es)
EP (1) EP2018426B1 (es)
JP (4) JP2009537566A (es)
KR (2) KR20120093306A (es)
CN (2) CN103285026B (es)
AR (1) AR061064A1 (es)
AU (1) AU2007253776B2 (es)
CA (1) CA2650416A1 (es)
CL (2) CL2007001434A1 (es)
ES (1) ES2413804T3 (es)
HK (1) HK1128090A1 (es)
MX (1) MX2008014260A (es)
PL (1) PL2018426T3 (es)
RU (1) RU2469090C2 (es)
TW (1) TWI472344B (es)
UY (1) UY30361A1 (es)
WO (1) WO2007137129A2 (es)
ZA (1) ZA200809203B (es)

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CN102178959B (zh) * 2011-03-15 2013-10-23 清华大学深圳研究生院 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用
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CN104560997B (zh) * 2014-12-25 2018-05-04 中国科学院广州生物医药与健康研究院 抑制ADAMTS-5和ADAM17基因的siRNA组合物及其应用
CN104498498A (zh) * 2014-12-25 2015-04-08 广州市锐博生物科技有限公司 抑制ADAM17基因的siRNA及其应用
CN104560999B (zh) * 2014-12-25 2018-01-09 广州市锐博生物科技有限公司 抑制ADAMTS‑5基因的siRNA及其应用
CN105349502A (zh) * 2015-12-09 2016-02-24 山西医科大学 Tnfr1基因重组腺病毒及其构建
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CN114410627B (zh) * 2021-12-20 2023-08-08 硅羿科技（上海）有限公司 一种特异性敲降TNF-α基因表达的siRNA及其应用
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Publication number Publication date
US20100166676A1 (en) 2010-07-01
CN101448943B (zh) 2013-07-17
US20140357694A1 (en) 2014-12-04
PL2018426T3 (pl) 2013-10-31
CA2650416A1 (en) 2007-11-29
KR20120093306A (ko) 2012-08-22
CN103285026A (zh) 2013-09-11
TWI472344B (zh) 2015-02-11
US9447419B2 (en) 2016-09-20
US20070281901A1 (en) 2007-12-06
WO2007137129A3 (en) 2008-04-10
US20110142767A1 (en) 2011-06-16
AU2007253776B2 (en) 2012-04-26
AU2007253776A1 (en) 2007-11-29
JP2013049727A (ja) 2013-03-14
CN101448943A (zh) 2009-06-03
ES2413804T3 (es) 2013-07-17
AR061064A1 (es) 2008-07-30
US20160369283A1 (en) 2016-12-22
RU2469090C2 (ru) 2012-12-10
CL2007001434A1 (es) 2008-02-22
JP2009537566A (ja) 2009-10-29
RU2008150324A (ru) 2010-06-27
MX2008014260A (es) 2008-11-26
CN103285026B (zh) 2017-08-04
US8541389B2 (en) 2013-09-24
TW200812623A (en) 2008-03-16
CL2010001109A1 (es) 2011-03-11
ZA200809203B (en) 2010-02-24
US7732421B2 (en) 2010-06-08
US20190032061A1 (en) 2019-01-31
UY30361A1 (es) 2007-08-31
US20130338213A1 (en) 2013-12-19
EP2018426A2 (en) 2009-01-28
WO2007137129A2 (en) 2007-11-29
JP2013049728A (ja) 2013-03-14
JP2016033153A (ja) 2016-03-10
KR20090010234A (ko) 2009-01-29
EP2018426B1 (en) 2013-05-15

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