CL2008002277A1 - Metodo para tratar un trastorno ocular relacionado con tnf alfa que comprende una molecula de arn interferente que actua en la expresion del arnm de tnfr1 o tace mediante interferencia de arn; molecula de arn interferente; composicion que comprende dicho interferente. - Google Patents

Metodo para tratar un trastorno ocular relacionado con tnf alfa que comprende una molecula de arn interferente que actua en la expresion del arnm de tnfr1 o tace mediante interferencia de arn; molecula de arn interferente; composicion que comprende dicho interferente.

Info

Publication number
CL2008002277A1
CL2008002277A1 CL2008002277A CL2008002277A CL2008002277A1 CL 2008002277 A1 CL2008002277 A1 CL 2008002277A1 CL 2008002277 A CL2008002277 A CL 2008002277A CL 2008002277 A CL2008002277 A CL 2008002277A CL 2008002277 A1 CL2008002277 A1 CL 2008002277A1
Authority
CL
Chile
Prior art keywords
rna molecule
interfering rna
tnfr1
interferer
expression
Prior art date
Application number
CL2008002277A
Other languages
English (en)
Inventor
Jon E Chatterton
Abbot F Clark
David P Bingaman
Martin B Wax
Adrian M Timmers
Original Assignee
Alcon Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Res Ltd filed Critical Alcon Res Ltd
Publication of CL2008002277A1 publication Critical patent/CL2008002277A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/319—Chemical structure of the backbone linked by 2'-5' linkages, i.e. having a free 3'-position
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Método para tratar un trastorno ocular relacionado con tnf alfa que comprende una molécula de arn interferente que actúa en la expresión del arnm de tnfr1 o tace mediante interferencia de arn; molécula de arn interferente; composición que comprende dicho interferente.
CL2008002277A 2007-08-03 2008-08-01 Metodo para tratar un trastorno ocular relacionado con tnf alfa que comprende una molecula de arn interferente que actua en la expresion del arnm de tnfr1 o tace mediante interferencia de arn; molecula de arn interferente; composicion que comprende dicho interferente. CL2008002277A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95382507P 2007-08-03 2007-08-03

Publications (1)

Publication Number Publication Date
CL2008002277A1 true CL2008002277A1 (es) 2009-07-17

Family

ID=40263006

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002277A CL2008002277A1 (es) 2007-08-03 2008-08-01 Metodo para tratar un trastorno ocular relacionado con tnf alfa que comprende una molecula de arn interferente que actua en la expresion del arnm de tnfr1 o tace mediante interferencia de arn; molecula de arn interferente; composicion que comprende dicho interferente.

Country Status (6)

Country Link
US (8) US20090036396A1 (es)
AR (1) AR071146A1 (es)
CL (1) CL2008002277A1 (es)
TW (1) TW200916117A (es)
UY (1) UY31267A1 (es)
WO (2) WO2009020847A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200808360A (en) 2006-04-13 2008-02-16 Alcon Mfg Ltd RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions
WO2009020847A2 (en) 2007-08-03 2009-02-12 Alcon Research, Ltd. Rnai-related inhibition of tnfa signaling pathway for treatment of ocular angiogenesis
BR112013002767B1 (pt) 2010-08-05 2021-09-14 B. Braun Melsungen Ag Conjunto de agulha e método para montar um conjunto de agulha
WO2014174834A1 (ja) * 2013-04-25 2014-10-30 国立大学法人山口大学 神経疾患治療剤
CN104498498A (zh) * 2014-12-25 2015-04-08 广州市锐博生物科技有限公司 抑制ADAM17基因的siRNA及其应用
CN107904239B (zh) * 2014-12-25 2020-11-27 广州市锐博生物科技有限公司 抑制ADAMTS-5基因的siRNA及其应用

Family Cites Families (12)

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US6531128B1 (en) * 2000-02-08 2003-03-11 Pharmacia Corporation Methods for treating glaucoma
AU2001237939A1 (en) * 2000-02-08 2001-08-20 Gulgun Tezel Methods for treating glaucoma
US20050227935A1 (en) * 2001-05-18 2005-10-13 Sirna Therapeutics, Inc. RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA)
WO2003070897A2 (en) * 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR SUPERFAMILY GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
JP3882725B2 (ja) * 2002-03-12 2007-02-21 株式会社デンソー 車両用回転電機
JP2006507841A (ja) * 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
WO2005076998A2 (en) * 2004-02-05 2005-08-25 Intradigm Corporation Rnai therapeutics for treatment of eye neovascularization diseases
US8084599B2 (en) * 2004-03-15 2011-12-27 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
CN101052717A (zh) * 2004-05-11 2007-10-10 α基因株式会社 诱发rna干扰的多核苷酸以及使用该多核苷酸的基因表达抑制方法
WO2007016597A2 (en) * 2005-07-29 2007-02-08 The Regents Of The University Of California Targeting tnf-alpha converting enzyme (tace)-dependent growth factor shedding in cancer therapy
ES2413804T3 (es) * 2006-05-19 2013-07-17 Alcon Research, Ltd. Inhibición mediada por ARNi de estados relacionados con factor de necrosis tumoral-alfa
WO2009020847A2 (en) 2007-08-03 2009-02-12 Alcon Research, Ltd. Rnai-related inhibition of tnfa signaling pathway for treatment of ocular angiogenesis

Also Published As

Publication number Publication date
US8754202B2 (en) 2014-06-17
UY31267A1 (es) 2009-01-05
US9422556B2 (en) 2016-08-23
US20110190376A1 (en) 2011-08-04
AR071146A1 (es) 2010-06-02
US20110257248A1 (en) 2011-10-20
TW200916117A (en) 2009-04-16
US20140357696A1 (en) 2014-12-04
US9139834B2 (en) 2015-09-22
US20100267811A1 (en) 2010-10-21
WO2009020847A2 (en) 2009-02-12
WO2009020894A2 (en) 2009-02-12
US20150344886A1 (en) 2015-12-03
WO2009020847A3 (en) 2009-07-23
WO2009020894A3 (en) 2009-08-27
US20160326533A1 (en) 2016-11-10
US20090036397A1 (en) 2009-02-05
US20090036396A1 (en) 2009-02-05

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