AR051505A2 - Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se lig - Google Patents

Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se lig

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Publication number
AR051505A2
AR051505A2 ARP050104868A ARP050104868A AR051505A2 AR 051505 A2 AR051505 A2 AR 051505A2 AR P050104868 A ARP050104868 A AR P050104868A AR P050104868 A ARP050104868 A AR P050104868A AR 051505 A2 AR051505 A2 AR 051505A2
Authority
AR
Argentina
Prior art keywords
promoter
variant
nucleic acid
composition
expression vector
Prior art date
Application number
ARP050104868A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/667,197 external-priority patent/US7074397B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR051505A2 publication Critical patent/AR051505A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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Abstract

Una composicion que comprende un receptor OB que comprende la secuencia de aminoácidos de la variante 12.1 del receptor OB humano maduro como SEC ID N°. 4 y un vehículo farmacéuticamente aceptable; una molécula de ácido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una célula huésped, un receptor OB quimérico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se liga específicamente a dicho receptor OB.
ARP050104868A 1996-01-08 2005-11-21 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se lig AR051505A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58500596A 1996-01-08 1996-01-08
US08/667,197 US7074397B1 (en) 1996-01-08 1996-06-20 Method for enhancing proliferation or differentiation of a cell using ob protein

Publications (1)

Publication Number Publication Date
AR051505A2 true AR051505A2 (es) 2007-01-17

Family

ID=27079271

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP970100078A AR005397A1 (es) 1996-01-08 1997-01-08 Anticuerpo agonista monoclonal que se liga especificamente al receptor ob, un metodo para mejorar la proliferacion o diferenciacion in vitro de una celula que comprende un receptor ob, el uso de un anticuerpo agonista anti-receptor ob para la preparacion de una dosificacion fisiologicamente aceptable, y metodos para identificar un anticuerpo que se liga o activa al receptor ob que incrementa la proliferacion o diferenciacion de una celula
ARP050104868A AR051505A2 (es) 1996-01-08 2005-11-21 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se lig
ARP060100522A AR052374A2 (es) 1996-01-08 2006-02-14 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunologlubina y anticuerpo agonista monoclonal que se lig

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP970100078A AR005397A1 (es) 1996-01-08 1997-01-08 Anticuerpo agonista monoclonal que se liga especificamente al receptor ob, un metodo para mejorar la proliferacion o diferenciacion in vitro de una celula que comprende un receptor ob, el uso de un anticuerpo agonista anti-receptor ob para la preparacion de una dosificacion fisiologicamente aceptable, y metodos para identificar un anticuerpo que se liga o activa al receptor ob que incrementa la proliferacion o diferenciacion de una celula

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP060100522A AR052374A2 (es) 1996-01-08 2006-02-14 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunologlubina y anticuerpo agonista monoclonal que se lig

Country Status (10)

Country Link
US (1) US20020193571A1 (es)
EP (2) EP1619250B1 (es)
JP (3) JP2000503204A (es)
AR (3) AR005397A1 (es)
AT (2) ATE307887T1 (es)
AU (1) AU721129B2 (es)
CA (1) CA2241564C (es)
DE (2) DE69734443T2 (es)
IL (2) IL125073A0 (es)
WO (1) WO1997025425A1 (es)

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US6451523B1 (en) * 1994-09-14 2002-09-17 Interneuron Pharmaceuticals, Inc. Detection of a leptin receptor variant and methods for regulating obesity
US6482927B1 (en) * 1995-11-27 2002-11-19 Millennium Pharmaceuticals, Inc. Chimeric proteins comprising the extracellular domain of murine Ob receptor
US6977240B1 (en) 1995-11-27 2005-12-20 Millenium Pharmaceuticals, Inc. Methods of using the OB receptor antibodies to treat bodyweight disorders
ES2244990T3 (es) * 1996-01-04 2005-12-16 Amgen Inc. Receptor de la proteina ob y composiciones y metodos relacionados.
CA2241564C (en) * 1996-01-08 2013-09-03 Genentech, Inc. Wsx receptor and ligands
US6541604B1 (en) * 1996-01-08 2003-04-01 Genentech, Inc. Leptin receptor having a WSX motif
US7148004B1 (en) 1997-01-16 2006-12-12 The Rockefeller University Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight
US7063958B1 (en) * 1996-01-16 2006-06-20 The Rockefeller University Nucleic acids db, the receptor for leptin
AU2476301A (en) * 1996-01-16 2001-05-24 Rockefeller University, The DB the receptor for leptin nucleic acids encoding the receptor, and uses thereof
US7084252B1 (en) 1996-01-16 2006-08-01 The Rockefeller University DB, the receptor for leptin
US7619079B2 (en) 1996-02-14 2009-11-17 The Rockefeller University Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
AUPO224696A0 (en) * 1996-09-11 1996-10-03 Amrad Operations Pty. Limited A novel haemopoietin receptor and genetic sequences encoding same
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JPWO2002033072A1 (ja) * 2000-10-20 2004-02-26 中外製薬株式会社 低分子化ｔｐｏアゴニスト抗体
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ATE307887T1 (de) 2005-11-15
AU1574797A (en) 1997-08-01
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US20020193571A1 (en) 2002-12-19
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AR052374A2 (es) 2007-03-14
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