AR005397A1 - Anticuerpo agonista monoclonal que se liga especificamente al receptor ob, un metodo para mejorar la proliferacion o diferenciacion in vitro de una celula que comprende un receptor ob, el uso de un anticuerpo agonista anti-receptor ob para la preparacion de una dosificacion fisiologicamente aceptable, y metodos para identificar un anticuerpo que se liga o activa al receptor ob que incrementa la proliferacion o diferenciacion de una celula - Google Patents

Anticuerpo agonista monoclonal que se liga especificamente al receptor ob, un metodo para mejorar la proliferacion o diferenciacion in vitro de una celula que comprende un receptor ob, el uso de un anticuerpo agonista anti-receptor ob para la preparacion de una dosificacion fisiologicamente aceptable, y metodos para identificar un anticuerpo que se liga o activa al receptor ob que incrementa la proliferacion o diferenciacion de una celula

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Publication number
AR005397A1
AR005397A1 ARP970100078A ARP970100078A AR005397A1 AR 005397 A1 AR005397 A1 AR 005397A1 AR P970100078 A ARP970100078 A AR P970100078A AR P970100078 A ARP970100078 A AR P970100078A AR 005397 A1 AR005397 A1 AR 005397A1
Authority
AR
Argentina
Prior art keywords
receiver
proliferation
differentiation
receptor
agonist
Prior art date
Application number
ARP970100078A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/667,197 external-priority patent/US7074397B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR005397A1 publication Critical patent/AR005397A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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Abstract

Se describe el receptor de WSX y los anticuerpos que se ligan al mismo incluyendo anticuerpos antagonistas y neutralizantes), incluyendo diversos usosde los mismos. LOs usos de los ligandos de WSX ( por ejemplo, anticuerpo agonistascontr a el receptor de WSX o proteína OB) en la hematopoyesis,receptor de WSX, el DEC del receptor, composición que lo comprende, un método para identificar y puificaar una molécula que activa el receptor WSX, unanticuerpo, un fragmento delmismo, uso o d e un anticuerpo y de un ligando de WSX para la preparación de un medicamento, un ácido nucleico aislado, un vector deexpresión, una célula huésped, un proceso para el uso de ácido nucleico, una composición farmacéutica, un artículode fabricac ión y métodos in vitro paraactivar el receptor WSX y realzar la proliferación o diferenciación de una célula.
ARP970100078A 1996-01-08 1997-01-08 Anticuerpo agonista monoclonal que se liga especificamente al receptor ob, un metodo para mejorar la proliferacion o diferenciacion in vitro de una celula que comprende un receptor ob, el uso de un anticuerpo agonista anti-receptor ob para la preparacion de una dosificacion fisiologicamente aceptable, y metodos para identificar un anticuerpo que se liga o activa al receptor ob que incrementa la proliferacion o diferenciacion de una celula AR005397A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58500596A 1996-01-08 1996-01-08
US08/667,197 US7074397B1 (en) 1996-01-08 1996-06-20 Method for enhancing proliferation or differentiation of a cell using ob protein

Publications (1)

Publication Number Publication Date
AR005397A1 true AR005397A1 (es) 1999-04-28

Family

ID=27079271

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP970100078A AR005397A1 (es) 1996-01-08 1997-01-08 Anticuerpo agonista monoclonal que se liga especificamente al receptor ob, un metodo para mejorar la proliferacion o diferenciacion in vitro de una celula que comprende un receptor ob, el uso de un anticuerpo agonista anti-receptor ob para la preparacion de una dosificacion fisiologicamente aceptable, y metodos para identificar un anticuerpo que se liga o activa al receptor ob que incrementa la proliferacion o diferenciacion de una celula
ARP050104868A AR051505A2 (es) 1996-01-08 2005-11-21 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se lig
ARP060100522A AR052374A2 (es) 1996-01-08 2006-02-14 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunologlubina y anticuerpo agonista monoclonal que se lig

Family Applications After (2)

Application Number Title Priority Date Filing Date
ARP050104868A AR051505A2 (es) 1996-01-08 2005-11-21 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se lig
ARP060100522A AR052374A2 (es) 1996-01-08 2006-02-14 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunologlubina y anticuerpo agonista monoclonal que se lig

Country Status (10)

Country Link
US (1) US20020193571A1 (es)
EP (2) EP0885299B1 (es)
JP (3) JP2000503204A (es)
AR (3) AR005397A1 (es)
AT (2) ATE449849T1 (es)
AU (1) AU721129B2 (es)
CA (1) CA2241564C (es)
DE (2) DE69734443T2 (es)
IL (2) IL125073A0 (es)
WO (1) WO1997025425A1 (es)

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US6451523B1 (en) * 1994-09-14 2002-09-17 Interneuron Pharmaceuticals, Inc. Detection of a leptin receptor variant and methods for regulating obesity
US6977240B1 (en) 1995-11-27 2005-12-20 Millenium Pharmaceuticals, Inc. Methods of using the OB receptor antibodies to treat bodyweight disorders
US6482927B1 (en) * 1995-11-27 2002-11-19 Millennium Pharmaceuticals, Inc. Chimeric proteins comprising the extracellular domain of murine Ob receptor
WO1997025424A1 (en) * 1996-01-04 1997-07-17 Amgen Inc. Ob protein receptor and related compositions and methods
AU721129B2 (en) * 1996-01-08 2000-06-22 Genentech Inc. WSX receptor and ligands
US6541604B1 (en) * 1996-01-08 2003-04-01 Genentech, Inc. Leptin receptor having a WSX motif
US7063958B1 (en) * 1996-01-16 2006-06-20 The Rockefeller University Nucleic acids db, the receptor for leptin
US7084252B1 (en) 1996-01-16 2006-08-01 The Rockefeller University DB, the receptor for leptin
US7148004B1 (en) 1997-01-16 2006-12-12 The Rockefeller University Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight
AU2476301A (en) * 1996-01-16 2001-05-24 Rockefeller University, The DB the receptor for leptin nucleic acids encoding the receptor, and uses thereof
US7619079B2 (en) 1996-02-14 2009-11-17 The Rockefeller University Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
AUPO224696A0 (en) * 1996-09-11 1996-10-03 Amrad Operations Pty. Limited A novel haemopoietin receptor and genetic sequences encoding same
WO1998057177A1 (en) * 1997-06-09 1998-12-17 Regeneron Pharmaceuticals, Inc. Assay systems for leptin-enhancing agents
WO1999036433A2 (en) * 1998-01-14 1999-07-22 Morphogenesis, Inc. Materials and methods for treating oncological disease
GB9814383D0 (en) * 1998-07-02 1998-09-02 Cambridge Antibody Tech Improvements relating to antibodies
US7696325B2 (en) * 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
ES2571230T3 (es) 1999-04-09 2016-05-24 Kyowa Hakko Kirin Co Ltd Procedimiento para controlar la actividad de una molécula inmunofuncional
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