DE69028095D1 - M-csf-monoklonale antikörper, die ein neutralisierendes konformationales epitop erkennen - Google Patents

M-csf-monoklonale antikörper, die ein neutralisierendes konformationales epitop erkennen

Info

Publication number
DE69028095D1
DE69028095D1 DE69028095T DE69028095T DE69028095D1 DE 69028095 D1 DE69028095 D1 DE 69028095D1 DE 69028095 T DE69028095 T DE 69028095T DE 69028095 T DE69028095 T DE 69028095T DE 69028095 D1 DE69028095 D1 DE 69028095D1
Authority
DE
Germany
Prior art keywords
monoclonal antibodies
csf
epitop
conformal
neutralizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69028095T
Other languages
English (en)
Other versions
DE69028095T2 (de
Inventor
Robert Halenbeck
Kirston Koths
Joseph Wrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Publication of DE69028095D1 publication Critical patent/DE69028095D1/de
Application granted granted Critical
Publication of DE69028095T2 publication Critical patent/DE69028095T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69028095T 1989-02-10 1990-01-17 M-csf-monoklonale antikörper, die ein neutralisierendes konformationales epitop erkennen Expired - Lifetime DE69028095T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31004289A 1989-02-10 1989-02-10
PCT/US1990/000202 WO1990009400A1 (en) 1989-02-10 1990-01-17 M-csf monoclonal antibodies that recognize a neutralizing conformational epitope

Publications (2)

Publication Number Publication Date
DE69028095D1 true DE69028095D1 (de) 1996-09-19
DE69028095T2 DE69028095T2 (de) 1997-02-06

Family

ID=23200753

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028095T Expired - Lifetime DE69028095T2 (de) 1989-02-10 1990-01-17 M-csf-monoklonale antikörper, die ein neutralisierendes konformationales epitop erkennen

Country Status (9)

Country Link
US (1) US5491065A (de)
EP (1) EP0457804B1 (de)
JP (1) JP3001969B2 (de)
AT (1) ATE141290T1 (de)
CA (1) CA2008817C (de)
DE (1) DE69028095T2 (de)
DK (1) DK0457804T3 (de)
ES (1) ES2091816T3 (de)
WO (1) WO1990009400A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096540A (en) * 1996-09-30 2000-08-01 Becton Dickinson And Company Differentiation of granulocytic and monocytic progenitor cells
US6363129B1 (en) 1998-11-09 2002-03-26 Broadcom Corporation Timing recovery system for a multi-pair gigabit transceiver
WO2001034177A2 (en) * 1999-11-08 2001-05-17 The Government Of The United States Of America, A S Represented By The Secretary, Department Of Hea Lth & Human Services, The National Institutes Of Health Method of treating a viral infection using antagonists of macrophage colony stimulating factor
US7108852B2 (en) 2000-03-20 2006-09-19 Warner-Lambert Company Llc Methods of treating inflammation using antibodies to M-CSF
EP1572106B1 (de) * 2002-11-15 2010-05-05 Novartis Vaccines and Diagnostics, Inc. Methoden zur verhinderung und behandlung von krebs-metastasierung und mit krebs-metastasierung einhergehendem knochenverlust
US20110091451A1 (en) * 2002-11-15 2011-04-21 Kavanaugh William M Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
AR045563A1 (es) * 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
PT2311873T (pt) 2004-01-07 2018-11-20 Novartis Vaccines & Diagnostics Inc Anticorpo monoclonal específico para m-csf e respetivos usos
CA2570296A1 (en) * 2004-06-12 2005-12-29 Oregon Health And Science University Compositions and methods for diagnosis and treatment of orthopoxviruses
EP1858928A2 (de) * 2005-03-08 2007-11-28 Pharmacia & Upjohn Company LLC Anti-m-csf-antikörperzusammensetzungen mit verringerten endotoxinniveaus
EP2311876A3 (de) * 2005-07-28 2011-04-27 Novartis AG M-CSF-spezifischer monoklonaler Antikörper und Verwendungen davon
JP5657862B2 (ja) * 2005-07-28 2015-01-21 ノバルティス アーゲー Ｍ−ｃｓｆに対する抗体の使用
JP5580535B2 (ja) * 2006-01-05 2014-08-27 ノバルティス アーゲー 癌転移および癌転移に関連する骨量減少を予防および処置するための方法
ES2618828T3 (es) 2011-07-18 2017-06-22 The University Of Melbourne Uso de antagonistas de c-Fms
EP2984106B1 (de) 2013-04-12 2019-03-06 MorphoSys AG Gegen m-csf gerichtete antikörper

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504586A (en) * 1983-02-03 1985-03-12 Amgen Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
EP0307402B1 (de) * 1986-05-06 1993-08-11 Genetics Institute, Inc. Herstellung von m-csf
GB8624899D0 (en) * 1986-10-17 1986-11-19 Sandoz Ltd Monoclonal antibodies
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1

Also Published As

Publication number Publication date
JPH04503155A (ja) 1992-06-11
DK0457804T3 (da) 1996-09-23
US5491065A (en) 1996-02-13
WO1990009400A1 (en) 1990-08-23
ATE141290T1 (de) 1996-08-15
ES2091816T3 (es) 1996-11-16
DE69028095T2 (de) 1997-02-06
EP0457804A1 (de) 1991-11-27
EP0457804B1 (de) 1996-08-14
JP3001969B2 (ja) 2000-01-24
CA2008817A1 (en) 1990-08-10
CA2008817C (en) 2000-03-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CHIRON CORP. (N.D.GES.D. STAATES DELAWARE), EMERYV

8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US