ES2091816T3 - Anticuerpos monoclonales del factor estimulador de colonias de macrofagos (m-csf) que reconocen un epitope conformacional neutralizante. - Google Patents
Anticuerpos monoclonales del factor estimulador de colonias de macrofagos (m-csf) que reconocen un epitope conformacional neutralizante.Info
- Publication number
- ES2091816T3 ES2091816T3 ES90902943T ES90902943T ES2091816T3 ES 2091816 T3 ES2091816 T3 ES 2091816T3 ES 90902943 T ES90902943 T ES 90902943T ES 90902943 T ES90902943 T ES 90902943T ES 2091816 T3 ES2091816 T3 ES 2091816T3
- Authority
- ES
- Spain
- Prior art keywords
- monoclonal antibodies
- csf
- conformational epitope
- macrophagus
- recognizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE DESCRIBEN ANTICUERPOS MONOCLONALES, Y SUS METODOS DE UTILIZACION, QUE SE UNEN A UN EPITOPE CONFORMACIONAL APARENTE ASOCIADO CON M-CSF DIMERICO RECOMBINANTE O INNATO CON NEUTRALIZACION CONCOMITANTE DE ACTIVIDAD BIOLOGICA, ESTOS ANTICUERPOS MONOCLONALES SON SUSTANCIALMENTE NO REACTIVOS CON FORMAS INACTIVAS DE M-CSF INCLUYENDO M-CSF DIMERICO DERIVATIZADO QUIMICAMENTE Y MONOMERICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31004289A | 1989-02-10 | 1989-02-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2091816T3 true ES2091816T3 (es) | 1996-11-16 |
Family
ID=23200753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90902943T Expired - Lifetime ES2091816T3 (es) | 1989-02-10 | 1990-01-17 | Anticuerpos monoclonales del factor estimulador de colonias de macrofagos (m-csf) que reconocen un epitope conformacional neutralizante. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5491065A (es) |
EP (1) | EP0457804B1 (es) |
JP (1) | JP3001969B2 (es) |
AT (1) | ATE141290T1 (es) |
CA (1) | CA2008817C (es) |
DE (1) | DE69028095T2 (es) |
DK (1) | DK0457804T3 (es) |
ES (1) | ES2091816T3 (es) |
WO (1) | WO1990009400A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6096540A (en) * | 1996-09-30 | 2000-08-01 | Becton Dickinson And Company | Differentiation of granulocytic and monocytic progenitor cells |
US6363129B1 (en) | 1998-11-09 | 2002-03-26 | Broadcom Corporation | Timing recovery system for a multi-pair gigabit transceiver |
AU1759501A (en) * | 1999-11-08 | 2001-06-06 | Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The | Method of treating a viral infection using antagonists of macrophage colony stimulating factor |
US7108852B2 (en) * | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
US20110091451A1 (en) * | 2002-11-15 | 2011-04-21 | Kavanaugh William M | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
JP4727992B2 (ja) * | 2002-11-15 | 2011-07-20 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 癌転移および癌転移に伴なう骨量減少を予防および処置するための方法 |
AR045563A1 (es) * | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
DK2311873T3 (en) | 2004-01-07 | 2018-11-26 | Novartis Vaccines & Diagnostics Inc | M-CSF-SPECIFIC MONOCLONAL ANTIBODY AND APPLICATIONS THEREOF |
CA2570296A1 (en) * | 2004-06-12 | 2005-12-29 | Oregon Health And Science University | Compositions and methods for diagnosis and treatment of orthopoxviruses |
US20090117103A1 (en) * | 2005-03-08 | 2009-05-07 | Pharmacia & Upjohn Company Llc | M-CSF Antibody compositions Having Reduced Levels of Endotoxin |
EP2311876A3 (en) * | 2005-07-28 | 2011-04-27 | Novartis AG | M-CSF-specific monoclonal antibody and uses thereof |
EP2277916A3 (en) * | 2005-07-28 | 2011-04-27 | Novartis AG | Use of antibody to M-CSF |
EP1984024A2 (en) | 2006-01-05 | 2008-10-29 | Novartis AG | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
US9243066B2 (en) | 2011-07-18 | 2016-01-26 | University Of Melbourne | Use of M-CSF antibodies in the treatment of osteoarthritis or pain |
WO2014167088A1 (en) | 2013-04-12 | 2014-10-16 | Morphosys Ag | Antibodies targeting m-csf |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4504586A (en) * | 1983-02-03 | 1985-03-12 | Amgen | Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1 |
AU588819B2 (en) * | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
MX9203130A (es) * | 1986-05-06 | 1992-07-01 | Genetics Inst | Produccion de m-csf |
GB8624899D0 (en) * | 1986-10-17 | 1986-11-19 | Sandoz Ltd | Monoclonal antibodies |
US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
-
1990
- 1990-01-17 ES ES90902943T patent/ES2091816T3/es not_active Expired - Lifetime
- 1990-01-17 JP JP2503081A patent/JP3001969B2/ja not_active Expired - Fee Related
- 1990-01-17 WO PCT/US1990/000202 patent/WO1990009400A1/en active IP Right Grant
- 1990-01-17 EP EP90902943A patent/EP0457804B1/en not_active Expired - Lifetime
- 1990-01-17 AT AT90902943T patent/ATE141290T1/de not_active IP Right Cessation
- 1990-01-17 DK DK90902943.1T patent/DK0457804T3/da active
- 1990-01-17 DE DE69028095T patent/DE69028095T2/de not_active Expired - Lifetime
- 1990-01-29 CA CA002008817A patent/CA2008817C/en not_active Expired - Lifetime
-
1993
- 1993-11-19 US US08/156,862 patent/US5491065A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0457804B1 (en) | 1996-08-14 |
ATE141290T1 (de) | 1996-08-15 |
CA2008817C (en) | 2000-03-14 |
JP3001969B2 (ja) | 2000-01-24 |
WO1990009400A1 (en) | 1990-08-23 |
JPH04503155A (ja) | 1992-06-11 |
DE69028095D1 (de) | 1996-09-19 |
EP0457804A1 (en) | 1991-11-27 |
DK0457804T3 (da) | 1996-09-23 |
DE69028095T2 (de) | 1997-02-06 |
US5491065A (en) | 1996-02-13 |
CA2008817A1 (en) | 1990-08-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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