AR052374A2 - Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunologlubina y anticuerpo agonista monoclonal que se lig - Google Patents

Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunologlubina y anticuerpo agonista monoclonal que se lig

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Publication number
AR052374A2
AR052374A2 ARP060100522A ARP060100522A AR052374A2 AR 052374 A2 AR052374 A2 AR 052374A2 AR P060100522 A ARP060100522 A AR P060100522A AR P060100522 A ARP060100522 A AR P060100522A AR 052374 A2 AR052374 A2 AR 052374A2
Authority
AR
Argentina
Prior art keywords
receptor
promoter
variant
nucleic acid
composition
Prior art date
Application number
ARP060100522A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/667,197 external-priority patent/US7074397B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR052374A2 publication Critical patent/AR052374A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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Abstract

Una composicion que comprende un receptor OB que comprende la secuencia de aminoácidos de la variante 12.1 del receptor OB humano maduro como SEC ID NO. 4 y un vehículo farmacéuticamente aceptable; una molécula de ácido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una célula huésped, un receptor OB quimérico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se liga específicamente a dicho receptor OB.
ARP060100522A 1996-01-08 2006-02-14 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunologlubina y anticuerpo agonista monoclonal que se lig AR052374A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58500596A 1996-01-08 1996-01-08
US08/667,197 US7074397B1 (en) 1996-01-08 1996-06-20 Method for enhancing proliferation or differentiation of a cell using ob protein

Publications (1)

Publication Number Publication Date
AR052374A2 true AR052374A2 (es) 2007-03-14

Family

ID=27079271

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP970100078A AR005397A1 (es) 1996-01-08 1997-01-08 Anticuerpo agonista monoclonal que se liga especificamente al receptor ob, un metodo para mejorar la proliferacion o diferenciacion in vitro de una celula que comprende un receptor ob, el uso de un anticuerpo agonista anti-receptor ob para la preparacion de una dosificacion fisiologicamente aceptable, y metodos para identificar un anticuerpo que se liga o activa al receptor ob que incrementa la proliferacion o diferenciacion de una celula
ARP050104868A AR051505A2 (es) 1996-01-08 2005-11-21 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se lig
ARP060100522A AR052374A2 (es) 1996-01-08 2006-02-14 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunologlubina y anticuerpo agonista monoclonal que se lig

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP970100078A AR005397A1 (es) 1996-01-08 1997-01-08 Anticuerpo agonista monoclonal que se liga especificamente al receptor ob, un metodo para mejorar la proliferacion o diferenciacion in vitro de una celula que comprende un receptor ob, el uso de un anticuerpo agonista anti-receptor ob para la preparacion de una dosificacion fisiologicamente aceptable, y metodos para identificar un anticuerpo que se liga o activa al receptor ob que incrementa la proliferacion o diferenciacion de una celula
ARP050104868A AR051505A2 (es) 1996-01-08 2005-11-21 Una composicion que comprende un receptor ob variante 12.1, una molecula de acido nucleico que codifica dicho receptor ligado operativamente a un promotor, un vector de expresion, una celula huesped, un receptor ob quimerico fusionado a una inmunoglobulina y anticuerpo agonista monoclonal que se lig

Country Status (10)

Country Link
US (1) US20020193571A1 (es)
EP (2) EP1619250B1 (es)
JP (3) JP2000503204A (es)
AR (3) AR005397A1 (es)
AT (2) ATE449849T1 (es)
AU (1) AU721129B2 (es)
CA (1) CA2241564C (es)
DE (2) DE69734443T2 (es)
IL (2) IL125073A0 (es)
WO (1) WO1997025425A1 (es)

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US6451523B1 (en) * 1994-09-14 2002-09-17 Interneuron Pharmaceuticals, Inc. Detection of a leptin receptor variant and methods for regulating obesity
US6977240B1 (en) 1995-11-27 2005-12-20 Millenium Pharmaceuticals, Inc. Methods of using the OB receptor antibodies to treat bodyweight disorders
US6482927B1 (en) * 1995-11-27 2002-11-19 Millennium Pharmaceuticals, Inc. Chimeric proteins comprising the extracellular domain of murine Ob receptor
NZ534416A (en) * 1996-01-04 2005-12-23 Amgen Inc OB protein receptor and related compositions and methods
US6541604B1 (en) * 1996-01-08 2003-04-01 Genentech, Inc. Leptin receptor having a WSX motif
JP2000503204A (ja) * 1996-01-08 2000-03-21 ジェネンテック インコーポレーテッド Ｗｓｘレセプター及びリガンド類
US7063958B1 (en) * 1996-01-16 2006-06-20 The Rockefeller University Nucleic acids db, the receptor for leptin
US7084252B1 (en) 1996-01-16 2006-08-01 The Rockefeller University DB, the receptor for leptin
AU2476301A (en) * 1996-01-16 2001-05-24 Rockefeller University, The DB the receptor for leptin nucleic acids encoding the receptor, and uses thereof
US7148004B1 (en) 1997-01-16 2006-12-12 The Rockefeller University Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight
US7619079B2 (en) 1996-02-14 2009-11-17 The Rockefeller University Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
AUPO224696A0 (en) * 1996-09-11 1996-10-03 Amrad Operations Pty. Limited A novel haemopoietin receptor and genetic sequences encoding same
WO1998057177A1 (en) * 1997-06-09 1998-12-17 Regeneron Pharmaceuticals, Inc. Assay systems for leptin-enhancing agents
WO1999036433A2 (en) * 1998-01-14 1999-07-22 Morphogenesis, Inc. Materials and methods for treating oncological disease
GB9814383D0 (en) * 1998-07-02 1998-09-02 Cambridge Antibody Tech Improvements relating to antibodies
US7696325B2 (en) * 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
EP2270150B2 (en) 1999-04-09 2019-08-07 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
SE0000597D0 (sv) * 2000-02-24 2000-02-24 Active Biotech Ab Novel antibody
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
CN1308447C (zh) * 2000-10-20 2007-04-04 中外制药株式会社 低分子化的激动剂抗体
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