AR045816A1 - Derivados de carboxamida - Google Patents

Derivados de carboxamida

Info

Publication number
AR045816A1
AR045816A1 ARP040103460A ARP040103460A AR045816A1 AR 045816 A1 AR045816 A1 AR 045816A1 AR P040103460 A ARP040103460 A AR P040103460A AR P040103460 A ARP040103460 A AR P040103460A AR 045816 A1 AR045816 A1 AR 045816A1
Authority
AR
Argentina
Prior art keywords
group
lower alkyl
formula
alkyl group
optionally substituted
Prior art date
Application number
ARP040103460A
Other languages
English (en)
Inventor
Takayuki Kawaguchi
H Akatsuka
Masayuki Morimoto
T Watanabe
T Lijima
J Murakami
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of AR045816A1 publication Critical patent/AR045816A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)

Abstract

Se describen derivados de carboxamida inhibidores de FXa, una composición farmacéutica y un método de tratamiento de trombosis. Reivindicación 1: Un derivado carboxamida del tipo amida caracterizado por que posee la fórmula (1) en donde X es un grupo de la fórmula -N= o la fórmula: -CH=; Y1 y Y2 son iguales o diferentes y cada uno es un grupo seleccionado de un átomo de H, un átomo halógeno, un grupo alquilo inferior, un grupo alcoxilo inferior, un grupo alquilo inferior sustituido por átomo halógeno, un grupo alcoxicarbonilo inferior, un grupo carboxilo, un grupo alquilcarbamoilo inferior y un grupo fenilo; R1 es un átomo de H, un átomo halógeno, un grupo alquilo inferior, o un grupo alcoxilo inferior; R2 es un grupo de la fórmula -CO-R21-R22-, R21 es un grupo alquileno inferior o un grupo cicloalcandiilo, y R22 es un grupo de la fórmula (2) o (3) en donde R23 y R24 son iguales o diferentes y cada uno es un grupo alquilo inferior o un grupo aminoalquilo inferior opcionalmente sustituido por un grupo alquilo inferior; o se combinan entre sí en los extremos para formar un grupo heterocíclico saturado conteniendo N opcionalmente sustituido junto con el grupo adyacente: -N-C(=O)-; R25 y R26 son iguales o diferentes y cada uno es un grupo alquilo inferior o un grupo amino alquilo inferior opcionalmente sustituido por un grupo alquilo inferior, o se combinan entre si con la finalidad de formar un grupo heterocíclico saturado conteniendo N opcionalmente sustituido junto con el átomo de N adyacente; y El anillo A es un hidrocarburo aromático, un anillo heteroaromático monocíclico o un anillo de tiofeno condensado, o una sal farmacéuticamente aceptable del mismo.
ARP040103460A 2003-09-26 2004-09-24 Derivados de carboxamida AR045816A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003334595 2003-09-26

Publications (1)

Publication Number Publication Date
AR045816A1 true AR045816A1 (es) 2005-11-16

Family

ID=34386034

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103460A AR045816A1 (es) 2003-09-26 2004-09-24 Derivados de carboxamida

Country Status (17)

Country Link
US (1) US7375119B2 (es)
EP (1) EP1666455A4 (es)
JP (1) JP4571075B2 (es)
KR (1) KR100740820B1 (es)
CN (1) CN100475777C (es)
AR (1) AR045816A1 (es)
AU (1) AU2004276128B2 (es)
BR (1) BRPI0414460A (es)
CA (1) CA2538072C (es)
IL (1) IL174188A0 (es)
MX (1) MXPA06003382A (es)
NO (1) NO20061832L (es)
NZ (1) NZ546160A (es)
RU (1) RU2307829C2 (es)
TW (1) TW200512181A (es)
WO (1) WO2005030706A1 (es)
ZA (1) ZA200602131B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875627B2 (en) * 2004-12-07 2011-01-25 Abbott Laboratories Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof
TW200734304A (en) 2005-11-08 2007-09-16 Astellas Pharma Inc Benzene derivative or salt thereof
KR20090086081A (ko) * 2006-11-15 2009-08-10 바이로켐 파마 인코포레이티드 플라비바이러스 감염의 치료 또는 예방용 티오펜 유사체
MY153057A (en) 2007-02-02 2014-12-31 Pfizer Prod Inc Tryclic compounds,compositions and methods
EP2070924A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel
EP2070925A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel
EP2070916A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft 2-Aryl-thiazol-4-carbonsäureamid-Derivate, deren Herstellung und Verwendung als Arzneimittel
US8178583B2 (en) * 2008-12-19 2012-05-15 Hoffmann-La Roche Inc. Compounds
US9186349B2 (en) * 2009-05-12 2015-11-17 Mallinckrodt Llc Diaza heterocyclic compounds for phototherapy
WO2012059442A2 (en) * 2010-11-01 2012-05-10 Neurotune Ag Neurotrypsin inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000121A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
CA2315070A1 (en) 1997-12-17 1999-07-01 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
EP0937711A1 (de) 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
US6956988B2 (en) 1998-08-21 2005-10-18 Avanex Corporation Optical interleaver
US6635657B1 (en) 1998-12-23 2003-10-21 Eli Lilly And Company Aromatic amides
WO2001019788A2 (en) * 1999-09-17 2001-03-22 Cor Therapeutics, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
WO2002012189A1 (fr) 2000-08-09 2002-02-14 Mitsubishi Pharma Corporation Composes amide bicycliques condenses et utilisations medicales associees
US7163938B2 (en) * 2000-11-28 2007-01-16 Eli Lilly And Company Substituted carboxamides
ATE368643T1 (de) * 2001-03-30 2007-08-15 Millennium Pharm Inc Faktor xa benzamidin inhibitoren
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
PL204263B1 (pl) * 2001-09-21 2009-12-31 Bristol Myers Squibb Co Pochodna 1H-pirazolo[3,4-c]pirydyny i jej zastosowanie oraz kompozycja farmaceutyczna i jej zastosowanie
WO2003048081A2 (en) * 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
DE60330847D1 (de) * 2002-03-28 2010-02-25 Mitsubishi Tanabe Pharma Corp Benzofuranderivat
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物

Also Published As

Publication number Publication date
KR100740820B1 (ko) 2007-07-19
AU2004276128B2 (en) 2007-11-29
ZA200602131B (en) 2007-02-28
EP1666455A4 (en) 2009-02-25
US20060287329A1 (en) 2006-12-21
WO2005030706A1 (ja) 2005-04-07
RU2006114055A (ru) 2006-09-10
BRPI0414460A (pt) 2006-11-14
CA2538072C (en) 2009-08-25
MXPA06003382A (es) 2006-06-08
JP4571075B2 (ja) 2010-10-27
AU2004276128A1 (en) 2005-04-07
IL174188A0 (en) 2006-08-01
KR20060095982A (ko) 2006-09-05
JPWO2005030706A1 (ja) 2006-12-07
NZ546160A (en) 2008-09-26
NO20061832L (no) 2006-04-25
EP1666455A1 (en) 2006-06-07
TW200512181A (en) 2005-04-01
US7375119B2 (en) 2008-05-20
RU2307829C2 (ru) 2007-10-10
CA2538072A1 (en) 2005-04-07
CN100475777C (zh) 2009-04-08
CN1860097A (zh) 2006-11-08

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