CO5640098A2 - Acidos biariloximetilaren-carboxilicos - Google Patents

Acidos biariloximetilaren-carboxilicos

Info

Publication number
CO5640098A2
CO5640098A2 CO05128644A CO05128644A CO5640098A2 CO 5640098 A2 CO5640098 A2 CO 5640098A2 CO 05128644 A CO05128644 A CO 05128644A CO 05128644 A CO05128644 A CO 05128644A CO 5640098 A2 CO5640098 A2 CO 5640098A2
Authority
CO
Colombia
Prior art keywords
yloxymethyl
biphenyl
compound
acid
furan
Prior art date
Application number
CO05128644A
Other languages
English (en)
Inventor
Chang An Chu
Paul Gillespie
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33556418&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5640098(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5640098A2 publication Critical patent/CO5640098A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

1.- Un compuesto de la fórmula (I)en la que Ar es un anillo carbocíclico o heterocíclico aromático;R1, R2, R3 se eligen con independencia entre sí entre el grupo formado por alquilo inferior, alcoxi inferior, trifluormetilo, halógeno, hidroxi, amino, alquilamino, dialquilamino, ciano y nitro;R4 es hidroxi o un aminoácido unido mediante un átomo de nitrógeno del aminoácido;n es 0, 1, 2, 3, 4 ó 5;m es 0, 1, 2, 3, ó 4 p es 0, 1 ó 2, y s es 0, 1 ó 2;o una sal farmacéuticamente aceptable de los mismos, con la condición de que a) cuando Ar es furanilo, p y s sean cero y el compuesto es no sea el ácido S-1-[5-(bifenil-4-iloximetil)-furano-2-carbonil]-pirrolidina-2-carboxílico ni el ácido 5-(bifenil-4-iloximetil)-furano-2-carboxílico, b) cuando Ar es fenilo, el compuesto no sea el ácido 3-(bifenil-4-iloximetil)-benzoico ni el ácido 2-(bifenil-3-iloximetil)-benzoico y c) cuando Ar es tiofenilo, el compuesto no sea el ácido 5-(bifenil-4-iloximetil)-tiofeno-2-carboxílico.
CO05128644A 2003-06-24 2005-12-21 Acidos biariloximetilaren-carboxilicos CO5640098A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48214703P 2003-06-24 2003-06-24
US48090003P 2003-06-24 2003-06-24
US56935604P 2004-05-07 2004-05-07

Publications (1)

Publication Number Publication Date
CO5640098A2 true CO5640098A2 (es) 2006-05-31

Family

ID=33556418

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05128644A CO5640098A2 (es) 2003-06-24 2005-12-21 Acidos biariloximetilaren-carboxilicos

Country Status (23)

Country Link
US (3) US7355049B2 (es)
EP (1) EP1663936B1 (es)
JP (1) JP4471974B2 (es)
KR (1) KR100809205B1 (es)
AR (1) AR044856A1 (es)
AT (1) ATE383329T1 (es)
AU (1) AU2004251846B2 (es)
BR (1) BRPI0411906A (es)
CA (1) CA2529875A1 (es)
CO (1) CO5640098A2 (es)
DE (1) DE602004011239T2 (es)
DK (1) DK1663936T3 (es)
ES (1) ES2298761T3 (es)
HK (1) HK1093724A1 (es)
IL (1) IL172617A0 (es)
MX (1) MXPA05014082A (es)
MY (1) MY138708A (es)
NO (1) NO20056010L (es)
NZ (1) NZ544150A (es)
PL (1) PL1663936T3 (es)
PT (1) PT1663936E (es)
TW (2) TW200817350A (es)
WO (1) WO2005000781A1 (es)

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US7576052B2 (en) * 2003-10-17 2009-08-18 Joslin Diabetes Center, Inc. Methods and compositions for modulating adipocyte function
US7524870B2 (en) * 2004-12-03 2009-04-28 Hoffmann-La Roche Inc. Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
GB0503053D0 (en) * 2005-02-14 2005-03-23 Smithkline Beecham Corp Chemical compounds
WO2006130690A2 (en) 2005-06-01 2006-12-07 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
CN102083969A (zh) * 2008-05-06 2011-06-01 乔斯林糖尿病中心股份有限公司 诱导褐色脂肪形成的方法和组合物
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US7947728B1 (en) 2009-11-11 2011-05-24 Hoffmann-La Roche Inc. Indole and indazole analogs as glycogen synthase activators
US20110112147A1 (en) * 2009-11-11 2011-05-12 David Robert Bolin Indazolone analogs as glycogen synthase activators
US20110112158A1 (en) 2009-11-11 2011-05-12 David Robert Bolin Benzisoxazole analogs as glycogen synthase activators
US8039495B2 (en) * 2009-11-16 2011-10-18 Hoffman-La Roche Inc. Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators
US20110118314A1 (en) * 2009-11-16 2011-05-19 Weiya Yun Piperidine analogs as glycogen synthase activators
US7939569B1 (en) 2009-12-01 2011-05-10 Hoffmann-La Roche Inc. Aniline analogs as glycogen synthase activators
US20110136792A1 (en) 2009-12-04 2011-06-09 David Robert Bolin Novel carboxylic acid analogs as glycogen synthase activators
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2655331A1 (en) 2010-12-23 2013-10-30 Pfizer Inc Glucagon receptor modulators
PT2673260T (pt) 2011-02-08 2016-10-24 Pfizer Modulador do recetor de glucagon
CN103476258B (zh) 2011-02-25 2017-04-26 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
CN103732578B (zh) 2011-07-22 2015-08-12 辉瑞大药厂 喹啉基胰高血糖素受体调节剂
JPWO2013065835A1 (ja) 2011-11-04 2015-04-02 味の素株式会社 糖尿病治療用医薬組成物
WO2013122028A1 (ja) * 2012-02-13 2013-08-22 武田薬品工業株式会社 芳香環化合物
EP2880028B1 (en) 2012-08-02 2020-09-30 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CA2898482A1 (en) 2013-02-22 2014-08-28 Linda L. Brockunier Antidiabetic bicyclic compounds
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
JP2016130214A (ja) 2013-05-01 2016-07-21 味の素株式会社 糖尿病治療用医薬組成物
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2016002853A1 (ja) * 2014-07-01 2016-01-07 味の素株式会社 糖尿病治療用医薬組成物
JP6699011B2 (ja) * 2014-07-04 2020-05-27 国立大学法人 東京大学 脂肪酸サロゲートを含むリゾホスファチジルセリン誘導体
EP3551176A4 (en) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. ANTIDIABETIC HETEROCYCLIC COMPOUNDS
EP3558298A4 (en) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. ANTIDIABETIC SPIROCHROMAN COMPOUNDS

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DE2842243A1 (de) 1978-09-28 1980-04-10 Hoechst Ag Furan- und thiophen-carbonsaeure-derivate und verfahren zu ihrer herstellung
DE4142514A1 (de) 1991-12-21 1993-06-24 Basf Ag Verfahren zur bekaempfung von pilzen
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Also Published As

Publication number Publication date
ES2298761T3 (es) 2008-05-16
WO2005000781A1 (en) 2005-01-06
NZ544150A (en) 2008-12-24
TWI302532B (en) 2008-11-01
NO20056010L (no) 2006-01-20
US20080255198A1 (en) 2008-10-16
EP1663936B1 (en) 2008-01-09
AU2004251846A1 (en) 2005-01-06
KR20060059910A (ko) 2006-06-02
US20080108662A1 (en) 2008-05-08
MY138708A (en) 2009-07-31
US7842825B2 (en) 2010-11-30
US7355049B2 (en) 2008-04-08
CA2529875A1 (en) 2005-01-06
ATE383329T1 (de) 2008-01-15
KR100809205B1 (ko) 2008-02-29
TW200517389A (en) 2005-06-01
DE602004011239D1 (de) 2008-02-21
AU2004251846B2 (en) 2010-02-04
AR044856A1 (es) 2005-10-05
US7700632B2 (en) 2010-04-20
PT1663936E (pt) 2008-02-04
PL1663936T3 (pl) 2008-06-30
MXPA05014082A (es) 2006-03-02
US20040266856A1 (en) 2004-12-30
BRPI0411906A (pt) 2006-08-08
HK1093724A1 (en) 2007-03-09
DK1663936T3 (da) 2008-03-31
EP1663936A1 (en) 2006-06-07
DE602004011239T2 (de) 2009-01-08
JP4471974B2 (ja) 2010-06-02
JP2007506666A (ja) 2007-03-22
TW200817350A (en) 2008-04-16
IL172617A0 (en) 2006-04-10

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