DE60306539D1 - Nicht-nukleosidische inhibitoren der reverse transkriptase - Google Patents

Nicht-nukleosidische inhibitoren der reverse transkriptase

Info

Publication number
DE60306539D1
DE60306539D1 DE60306539T DE60306539T DE60306539D1 DE 60306539 D1 DE60306539 D1 DE 60306539D1 DE 60306539 T DE60306539 T DE 60306539T DE 60306539 T DE60306539 T DE 60306539T DE 60306539 D1 DE60306539 D1 DE 60306539D1
Authority
DE
Germany
Prior art keywords
sub
sup
alkyl
reverse transcriptase
nucleoside inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60306539T
Other languages
English (en)
Other versions
DE60306539T2 (de
Inventor
Christiane Yoakim
Eric Malenfant
Bounkham Thavonekham
W Ogilvie
Robert Deziel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Boehringer Ingelheim Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd
Application granted granted Critical
Publication of DE60306539D1 publication Critical patent/DE60306539D1/de
Publication of DE60306539T2 publication Critical patent/DE60306539T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60306539T 2002-09-19 2003-09-15 Nicht-nukleosidische inhibitoren der reverse transkriptase Expired - Lifetime DE60306539T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41178502P 2002-09-19 2002-09-19
US411785P 2002-09-19
PCT/CA2003/001409 WO2004085437A1 (en) 2002-09-19 2003-09-15 Non-nucleoside reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
DE60306539D1 true DE60306539D1 (de) 2006-08-10
DE60306539T2 DE60306539T2 (de) 2007-07-19

Family

ID=33097881

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60306539T Expired - Lifetime DE60306539T2 (de) 2002-09-19 2003-09-15 Nicht-nukleosidische inhibitoren der reverse transkriptase

Country Status (9)

Country Link
US (1) US7105510B2 (de)
EP (1) EP1554276B1 (de)
JP (1) JP4391426B2 (de)
AT (1) ATE331716T1 (de)
AU (1) AU2003303944A1 (de)
CA (1) CA2495721C (de)
DE (1) DE60306539T2 (de)
ES (1) ES2268499T3 (de)
WO (1) WO2004085437A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050085681A (ko) * 2002-12-16 2005-08-29 베링거 인겔하임 인터내셔날 게엠베하 프로테아제 억제제와 같은 사이토크롬 ｐ450의 억제제와함께 비-뉴클레오시드 역전사효소 억제제(ｎｎｒｔｉ)를함유하는 배합물의 용도
GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
RS51660B (en) 2007-09-14 2011-10-31 Ortho-Mcneil-Janssen Pharmaceuticals Inc. 1`, 3`-DISUPSTITUATED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1`H- [1,4`] BIPYRIDINYL-2`-ONE
JP5433579B2 (ja) 2007-09-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン
CN101861316B (zh) 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
RU2510396C2 (ru) 2008-09-02 2014-03-27 Янссен Фармасьютикалз, Инк. 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов
US8697689B2 (en) 2008-10-16 2014-04-15 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
RU2512283C2 (ru) 2008-11-28 2014-04-10 Янссен Фармасьютикалз, Инк. Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153912A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ME01573B (me) 2009-05-12 2014-09-20 Addex Pharma Sa DERIVATI 1,2,4-TRIAZOLO[4,3-a]PIRIDINA I NJIHOVA UPOTREBA U TRETMANU ILI PREVENCIJI NEUROLOŠKIH I PSIHIJATRIJSKIH POREMEĆAJA
WO2012062759A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CA2814996C (en) 2010-11-08 2019-10-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR102502485B1 (ko) 2014-01-21 2023-02-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
UA121965C2 (uk) 2014-01-21 2020-08-25 Янссен Фармацевтика Нв Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705499A (en) * 1995-10-06 1998-01-06 Boehringer Ingelheim Pharmaceuticals, Inc. 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection
US6716836B2 (en) * 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US6673791B2 (en) * 2001-07-30 2004-01-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
CA2495721C (en) 2009-08-18
ES2268499T3 (es) 2007-03-16
US7105510B2 (en) 2006-09-12
JP2006515312A (ja) 2006-05-25
CA2495721A1 (en) 2004-10-07
US20040106791A1 (en) 2004-06-03
JP4391426B2 (ja) 2009-12-24
AU2003303944A1 (en) 2004-10-18
DE60306539T2 (de) 2007-07-19
ATE331716T1 (de) 2006-07-15
EP1554276B1 (de) 2006-06-28
WO2004085437A1 (en) 2004-10-07
EP1554276A1 (de) 2005-07-20

Similar Documents

Publication Publication Date Title
DE60306539D1 (de) Nicht-nukleosidische inhibitoren der reverse transkriptase
ECSP045359A (es) Isoxazolinas 5 metiloximetil sustituidas por 3-heteroarilo utilizadas con herbicidas
JP2016536363A5 (de)
ATE388146T1 (de) 1-isopropyl-2-oxo-1,2-dihydropyridin-3- carbonsäureamidderivate mit agonistischer wirkung am 5-ht4-rezeptor
EA200100755A1 (ru) 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
DE602005023343D1 (de) Pyrimidinderivate als gpcr-agonisten
JP2016536364A5 (de)
CO5640117A2 (es) Derivados de 2,4-diamonopirimidina
CR9690A (es) 3-acilaminobenzanilidas insecticidas
EA200601686A1 (ru) Замещенные производные морфолина и тиоморфолина
JO2791B1 (en) Acid secretion inhibitor
CO5640098A2 (es) Acidos biariloximetilaren-carboxilicos
WO2009109991A3 (en) Novel hydrazide containing tyrosine kinase inhibitors
NO20050871L (no) 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
DE60311869D1 (de) Kristalline cefdinirsalze
EA200201255A1 (ru) Ненуклеозидные ингибиторы обратной транскриптазы
DE60225019D1 (de) Nicht-nucleosidische inhibitoren der reverse transkriptase
EA200601176A1 (ru) 3-цианохинолиновые производные с антипролиферативной активностью
CY1113031T1 (el) Παραγωγα ν-αμινοϊμιδαζολιου που αναστελουν ηιv
MA27077A1 (fr) Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible
DE602005011177D1 (de) Pyridinketone mit herbizideffekt
EA200700179A1 (ru) Производные пиррола, их получение и их применение в терапии
NO20033131L (no) Anvendelse av 2-amino-4-pyridylmetyl-tiazolinderivater som inhibitorer forinduktibel NO-syntase
AU2010277350A8 (en) Herbicidally active heteroaryl-substituted cyclic diones or derivatives thereof
EA202190009A1 (ru) Производные бензимидазола и их применение в качестве ингибиторов idh1

Legal Events

Date Code Title Description
8364 No opposition during term of opposition