CY1113031T1 - Παραγωγα ν-αμινοϊμιδαζολιου που αναστελουν ηιv - Google Patents
Παραγωγα ν-αμινοϊμιδαζολιου που αναστελουν ηιvInfo
- Publication number
- CY1113031T1 CY1113031T1 CY20121100097T CY121100097T CY1113031T1 CY 1113031 T1 CY1113031 T1 CY 1113031T1 CY 20121100097 T CY20121100097 T CY 20121100097T CY 121100097 T CY121100097 T CY 121100097T CY 1113031 T1 CY1113031 T1 CY 1113031T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyrimidyl
- pyridyl
- naphthyl
- methyl
- ethyl
- Prior art date
Links
- -1 2-pyrimidyl Chemical group 0.000 abstract 6
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 2
- 239000004305 biphenyl Chemical group 0.000 abstract 2
- 235000010290 biphenyl Nutrition 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- FMXYWAWAIGUHRZ-UHFFFAOYSA-N 3-amino-1h-imidazole-2-thione Chemical class NN1C=CNC1=S FMXYWAWAIGUHRZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- MXZANEWAFZMPKW-UHFFFAOYSA-N imidazol-1-amine Chemical compound NN1C=CN=C1 MXZANEWAFZMPKW-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Παράγωγο Ν-αμινοϊμιδαζολίου ή Ν-αμινοϊμιδαζολοθειόνης, φαρμακευτικώς αποδεκτό άλας, ταυτομερές, ισομερές, εστέρας ή προϊόν γλυκοζυλίωσης αυτού, το εν λόγω δε παράγωγο αντιπροσωπεύεται από τον γενικό τύπο (Ι): όπου m = μηδέν ή 1, n = μηδέν ή 1, το R1 επιλέγεται από υδρογόνο, μεθύλ ή αιθύλ, το R2 επιλέγεται από υδρογόνο, SΗ ή -SR° όπου το R° είναι μεθύλ, βενζύλ ή υπόλειμμα γλυκόζης, το Q επιλέγεται από 1-ναφθύλ, 2-ναφθύλ, διφαινύλ, 2-πυριδύλ, 3-πυριδύλ, 4-πυριδύλ, 2-πυριμιδύλ, 4-πυριμιδύλ, 5-πυριμιδύλ, θειενύλ ή υποκατεστημένο ή μη υποκατεστημένο φαινύλ δακτύλιο, όπου η υποκατάσταση κατανοείται ότι είναι ένας ή δύο υποκαταστάτες που επιλέγονται από Η, F, CΙ, Βr, Ι, μεθύλ, αιθύλ ή ισοπροπύλ, το L επιλέγεται από 1-ναφθύλ, 2-ναφθύλ, διφαινύλ, 2-πυριδύλ, 3-πυριδύλ, 4-πυριδύλ, 2-πυριμιδύλ, 4-πυριμιδύλ, 5-πυριμιδύλ, θειενύλ ή υποκατεστημένο ή μη υποκατεστημένο φαινύλ δακτύλιο όπου η υποκατάσταση κατανοείται ότι είναι ένας ή δύο υποκαταστάτες που επιλέγονται από Η, F, CΙ, Βr, Ι, μεθύλ, αιθύλ ή ισοπροπύλ. Η εφεύρεση αυτή περαιτέρω αφορά την χρήση ενώσεων του τύπου (Ι) ως παράγοντες που έχουν βιολογική δραστικότητα, ειδικά έναντι ιικών μολύνσεων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01919343A EP1370539B1 (en) | 2001-02-23 | 2001-02-23 | Hiv inhibiting n-aminoimidazole derivatives |
PCT/EP2001/002140 WO2002068395A1 (en) | 2001-02-23 | 2001-02-23 | Hiv inhibiting n-aminoimidazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113031T1 true CY1113031T1 (el) | 2016-04-13 |
Family
ID=8164312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100097T CY1113031T1 (el) | 2001-02-23 | 2012-01-27 | Παραγωγα ν-αμινοϊμιδαζολιου που αναστελουν ηιv |
Country Status (22)
Country | Link |
---|---|
US (1) | US7049332B2 (el) |
EP (1) | EP1370539B1 (el) |
JP (1) | JP2004519477A (el) |
KR (1) | KR100732581B1 (el) |
CN (1) | CN1555365A (el) |
AT (1) | ATE532771T1 (el) |
AU (1) | AU2001246474B2 (el) |
BR (1) | BR0116938A (el) |
CA (1) | CA2439053A1 (el) |
CY (1) | CY1113031T1 (el) |
DK (1) | DK1370539T3 (el) |
EA (1) | EA006706B1 (el) |
ES (1) | ES2376998T3 (el) |
HU (1) | HUP0303238A3 (el) |
IL (1) | IL157453A0 (el) |
MX (1) | MXPA03007546A (el) |
NO (1) | NO20033660L (el) |
NZ (1) | NZ527640A (el) |
PL (1) | PL363100A1 (el) |
PT (1) | PT1370539E (el) |
TR (1) | TR200301890T2 (el) |
WO (1) | WO2002068395A1 (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011226950B9 (en) * | 2003-12-15 | 2013-04-11 | Laboratoire Theramex | 1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them |
CN1890221B (zh) * | 2003-12-15 | 2014-07-16 | 沙拉麦斯实验公司 | 1-n-苯基-氨基-1h-咪唑衍生物和含有它们的医药组合物 |
EP1544195A1 (en) * | 2003-12-15 | 2005-06-22 | Laboratoire Theramex | 1-N-phenyl-amino- 1H-imidazole derivatives and pharmaceutical compositions containing them |
GB0609252D0 (en) * | 2006-05-10 | 2006-06-21 | Leuven K U Res & Dev | Novel sytoprotective compounds |
US20140194473A1 (en) * | 2013-01-10 | 2014-07-10 | E I Du Pont De Nemours And Company | Imidazole fungicides |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW235963B (el) * | 1992-01-16 | 1994-12-11 | Shionogi & Co | |
JPH0810019A (ja) * | 1994-07-04 | 1996-01-16 | Taiyo Shinjiyu Kk | タグが取り付けられた連珠製品、及び、連珠製品へのタグ取り付け方法 |
DE69532245T2 (de) * | 1994-09-26 | 2004-09-16 | Shionogi & Co., Ltd. | Imidazolderivat |
-
2001
- 2001-02-23 MX MXPA03007546A patent/MXPA03007546A/es active IP Right Grant
- 2001-02-23 EP EP01919343A patent/EP1370539B1/en not_active Expired - Lifetime
- 2001-02-23 ES ES01919343T patent/ES2376998T3/es not_active Expired - Lifetime
- 2001-02-23 DK DK01919343.2T patent/DK1370539T3/da active
- 2001-02-23 IL IL15745301A patent/IL157453A0/xx unknown
- 2001-02-23 CA CA002439053A patent/CA2439053A1/en not_active Abandoned
- 2001-02-23 NZ NZ527640A patent/NZ527640A/en unknown
- 2001-02-23 JP JP2002567909A patent/JP2004519477A/ja active Pending
- 2001-02-23 EA EA200300920A patent/EA006706B1/ru not_active IP Right Cessation
- 2001-02-23 TR TR2003/01890T patent/TR200301890T2/xx unknown
- 2001-02-23 AU AU2001246474A patent/AU2001246474B2/en not_active Ceased
- 2001-02-23 CN CNA018231675A patent/CN1555365A/zh active Pending
- 2001-02-23 BR BR0116938-6A patent/BR0116938A/pt not_active IP Right Cessation
- 2001-02-23 PL PL01363100A patent/PL363100A1/xx not_active Application Discontinuation
- 2001-02-23 PT PT01919343T patent/PT1370539E/pt unknown
- 2001-02-23 HU HU0303238A patent/HUP0303238A3/hu unknown
- 2001-02-23 AT AT01919343T patent/ATE532771T1/de active
- 2001-02-23 WO PCT/EP2001/002140 patent/WO2002068395A1/en active IP Right Grant
- 2001-02-23 US US10/468,541 patent/US7049332B2/en not_active Expired - Fee Related
- 2001-02-23 KR KR1020037011071A patent/KR100732581B1/ko not_active IP Right Cessation
-
2003
- 2003-08-19 NO NO20033660A patent/NO20033660L/no not_active Application Discontinuation
-
2012
- 2012-01-27 CY CY20121100097T patent/CY1113031T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1370539A1 (en) | 2003-12-17 |
EA200300920A1 (ru) | 2004-02-26 |
NO20033660D0 (no) | 2003-08-19 |
CA2439053A1 (en) | 2002-09-06 |
CN1555365A (zh) | 2004-12-15 |
BR0116938A (pt) | 2005-01-18 |
AU2001246474B8 (en) | 2002-09-12 |
NZ527640A (en) | 2005-10-28 |
ATE532771T1 (de) | 2011-11-15 |
TR200301890T2 (tr) | 2004-12-21 |
HUP0303238A2 (hu) | 2004-01-28 |
JP2004519477A (ja) | 2004-07-02 |
HUP0303238A3 (en) | 2004-05-28 |
ES2376998T3 (es) | 2012-03-21 |
EP1370539B1 (en) | 2011-11-09 |
DK1370539T3 (da) | 2012-02-13 |
US7049332B2 (en) | 2006-05-23 |
KR20030086271A (ko) | 2003-11-07 |
PL363100A1 (en) | 2004-11-15 |
WO2002068395A1 (en) | 2002-09-06 |
PT1370539E (pt) | 2012-02-14 |
MXPA03007546A (es) | 2004-10-15 |
AU2001246474B2 (en) | 2007-07-05 |
EA006706B1 (ru) | 2006-02-24 |
KR100732581B1 (ko) | 2007-06-27 |
NO20033660L (no) | 2003-10-15 |
US20040122024A1 (en) | 2004-06-24 |
IL157453A0 (en) | 2004-03-28 |
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