BR0116938A - Derivados de n-aminoimidazol de inibição de hiv - Google Patents
Derivados de n-aminoimidazol de inibição de hivInfo
- Publication number
- BR0116938A BR0116938A BR0116938-6A BR0116938A BR0116938A BR 0116938 A BR0116938 A BR 0116938A BR 0116938 A BR0116938 A BR 0116938A BR 0116938 A BR0116938 A BR 0116938A
- Authority
- BR
- Brazil
- Prior art keywords
- pyrimidyl
- pyridyl
- methyl
- aminoimidazole
- naphthyl
- Prior art date
Links
- MXZANEWAFZMPKW-UHFFFAOYSA-N imidazol-1-amine Chemical class NN1C=CN=C1 MXZANEWAFZMPKW-UHFFFAOYSA-N 0.000 title abstract 4
- 230000005764 inhibitory process Effects 0.000 title 1
- -1 2-pyrimidyl Chemical group 0.000 abstract 6
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 2
- 239000004305 biphenyl Chemical group 0.000 abstract 2
- 235000010290 biphenyl Nutrition 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE N-AMINOIMIDAZOL DE INIBIçãO DE HIV". Um derivado de N-aminoimidazol ou N-aminoimidazoltiona, um sal farmaceuticamente aceitável, um tautómero, um isómero, um éster ou produto de glicosilação deste, sendo o referido derivado representado pela fórmula geral (I): na qual m = zero ou 1, n = zero ou 1, R^ 1^ é selecionado de hidrogênio, metila ou etila, R^ 2^ é selecionado de hidrogênio, SH ou -SR^ 0^ onde R^ 0^ é resíduo de glicose, benzila ou metila; Q é selecionado de 1naftila, 2-naftila, bifenila, 2-piridila, 3-piridila, 4-piridila, 2-pirimidila, 4pirimidila, 5-pirimidila, tienila, ou um anel fenila substituído ou não substituído, onde a substituição é entendida como sendo um ou dois substituintes selecionados de H, F, Cl, Br, l, metila, etila ou isopropila; L é selecionado de 1-naftila, 2-naftila, bifenila, 2-piridila, 3-piridila, 4-piridila, 2pirimidila, 4-pirimidila, 5-pirimidila, tienila, ou um anel fenila substituído ou não-substituído onde a substituição é entendida como sendo um ou dois substituintes selecionados de H, F, Cl, Br, l, metila, etila ou isopropila. Esta invenção também refere-se ao emprego de compostos de fórmula (I) como agentes tendo atividade biológica, especialmente contra infecções virais.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2001/002140 WO2002068395A1 (en) | 2001-02-23 | 2001-02-23 | Hiv inhibiting n-aminoimidazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0116938A true BR0116938A (pt) | 2005-01-18 |
Family
ID=8164312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0116938-6A BR0116938A (pt) | 2001-02-23 | 2001-02-23 | Derivados de n-aminoimidazol de inibição de hiv |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7049332B2 (pt) |
| EP (1) | EP1370539B1 (pt) |
| JP (1) | JP2004519477A (pt) |
| KR (1) | KR100732581B1 (pt) |
| CN (1) | CN1555365A (pt) |
| AT (1) | ATE532771T1 (pt) |
| AU (1) | AU2001246474B2 (pt) |
| BR (1) | BR0116938A (pt) |
| CA (1) | CA2439053A1 (pt) |
| CY (1) | CY1113031T1 (pt) |
| DK (1) | DK1370539T3 (pt) |
| EA (1) | EA006706B1 (pt) |
| ES (1) | ES2376998T3 (pt) |
| HU (1) | HUP0303238A3 (pt) |
| IL (1) | IL157453A0 (pt) |
| MX (1) | MXPA03007546A (pt) |
| NO (1) | NO20033660L (pt) |
| NZ (1) | NZ527640A (pt) |
| PL (1) | PL363100A1 (pt) |
| PT (1) | PT1370539E (pt) |
| TR (1) | TR200301890T2 (pt) |
| WO (1) | WO2002068395A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2549603A1 (en) * | 2003-12-15 | 2005-06-30 | Laboratoire Theramex | 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them |
| EP1544195A1 (en) * | 2003-12-15 | 2005-06-22 | Laboratoire Theramex | 1-N-phenyl-amino- 1H-imidazole derivatives and pharmaceutical compositions containing them |
| AU2011226950B9 (en) * | 2003-12-15 | 2013-04-11 | Laboratoire Theramex | 1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them |
| GB0609252D0 (en) * | 2006-05-10 | 2006-06-21 | Leuven K U Res & Dev | Novel sytoprotective compounds |
| US20140194473A1 (en) * | 2013-01-10 | 2014-07-10 | E I Du Pont De Nemours And Company | Imidazole fungicides |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW235963B (pt) | 1992-01-16 | 1994-12-11 | Shionogi & Co | |
| JPH0810019A (ja) * | 1994-07-04 | 1996-01-16 | Taiyo Shinjiyu Kk | タグが取り付けられた連珠製品、及び、連珠製品へのタグ取り付け方法 |
| CN1093535C (zh) * | 1994-09-26 | 2002-10-30 | 盐野义制药株式会社 | 咪唑衍生物 |
-
2001
- 2001-02-23 PT PT01919343T patent/PT1370539E/pt unknown
- 2001-02-23 KR KR1020037011071A patent/KR100732581B1/ko not_active IP Right Cessation
- 2001-02-23 DK DK01919343.2T patent/DK1370539T3/da active
- 2001-02-23 EA EA200300920A patent/EA006706B1/ru not_active IP Right Cessation
- 2001-02-23 HU HU0303238A patent/HUP0303238A3/hu unknown
- 2001-02-23 MX MXPA03007546A patent/MXPA03007546A/es active IP Right Grant
- 2001-02-23 BR BR0116938-6A patent/BR0116938A/pt not_active IP Right Cessation
- 2001-02-23 IL IL15745301A patent/IL157453A0/xx unknown
- 2001-02-23 TR TR2003/01890T patent/TR200301890T2/xx unknown
- 2001-02-23 ES ES01919343T patent/ES2376998T3/es not_active Expired - Lifetime
- 2001-02-23 AU AU2001246474A patent/AU2001246474B2/en not_active Ceased
- 2001-02-23 PL PL01363100A patent/PL363100A1/xx not_active Application Discontinuation
- 2001-02-23 CN CNA018231675A patent/CN1555365A/zh active Pending
- 2001-02-23 AT AT01919343T patent/ATE532771T1/de active
- 2001-02-23 EP EP01919343A patent/EP1370539B1/en not_active Expired - Lifetime
- 2001-02-23 JP JP2002567909A patent/JP2004519477A/ja active Pending
- 2001-02-23 CA CA002439053A patent/CA2439053A1/en not_active Abandoned
- 2001-02-23 WO PCT/EP2001/002140 patent/WO2002068395A1/en active IP Right Grant
- 2001-02-23 NZ NZ527640A patent/NZ527640A/en unknown
- 2001-02-23 US US10/468,541 patent/US7049332B2/en not_active Expired - Fee Related
-
2003
- 2003-08-19 NO NO20033660A patent/NO20033660L/no not_active Application Discontinuation
-
2012
- 2012-01-27 CY CY20121100097T patent/CY1113031T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1370539T3 (da) | 2012-02-13 |
| ATE532771T1 (de) | 2011-11-15 |
| TR200301890T2 (tr) | 2004-12-21 |
| EP1370539A1 (en) | 2003-12-17 |
| EP1370539B1 (en) | 2011-11-09 |
| MXPA03007546A (es) | 2004-10-15 |
| PL363100A1 (en) | 2004-11-15 |
| NO20033660D0 (no) | 2003-08-19 |
| JP2004519477A (ja) | 2004-07-02 |
| CN1555365A (zh) | 2004-12-15 |
| AU2001246474B2 (en) | 2007-07-05 |
| ES2376998T3 (es) | 2012-03-21 |
| AU2001246474B8 (en) | 2002-09-12 |
| PT1370539E (pt) | 2012-02-14 |
| CA2439053A1 (en) | 2002-09-06 |
| EA200300920A1 (ru) | 2004-02-26 |
| EA006706B1 (ru) | 2006-02-24 |
| NO20033660L (no) | 2003-10-15 |
| CY1113031T1 (el) | 2016-04-13 |
| HUP0303238A2 (hu) | 2004-01-28 |
| NZ527640A (en) | 2005-10-28 |
| US7049332B2 (en) | 2006-05-23 |
| HUP0303238A3 (en) | 2004-05-28 |
| IL157453A0 (en) | 2004-03-28 |
| US20040122024A1 (en) | 2004-06-24 |
| WO2002068395A1 (en) | 2002-09-06 |
| KR20030086271A (ko) | 2003-11-07 |
| KR100732581B1 (ko) | 2007-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 9A, 10E 11A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |