AR039522A1 - Microemulsiones polimericas - Google Patents
Microemulsiones polimericasInfo
- Publication number
- AR039522A1 AR039522A1 ARP030101540A ARP030101540A AR039522A1 AR 039522 A1 AR039522 A1 AR 039522A1 AR P030101540 A ARP030101540 A AR P030101540A AR P030101540 A ARP030101540 A AR P030101540A AR 039522 A1 AR039522 A1 AR 039522A1
- Authority
- AR
- Argentina
- Prior art keywords
- polymer
- block copolymer
- block
- liquid
- temperature below
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/46—Polyesters chemically modified by esterification
- C08G63/48—Polyesters chemically modified by esterification by unsaturated higher fatty oils or their acids; by resin acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
- C08G64/183—Block or graft polymers containing polyether sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
- C08G2261/10—Definition of the polymer structure
- C08G2261/12—Copolymers
- C08G2261/126—Copolymers block
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
- Polymerisation Methods In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Centrifugal Separators (AREA)
- Paper (AREA)
- Polyethers (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Abstract
Se provee nuevos copolímeros de dos bloques auto-emulsionantes y nuevas composiciones auto-emulsionantes que comprende un ingrediente activo y un copolímero de dos bloques caracterizado porque un copolímero de dos bloques es líquido a una temperatura por debajo de los 50 °C y la composición es no acuosa y líquida a una temperatura por debajo de los 50°C. Reivindicación 1: Un copolímero de dos bloques de fórmula A-B en el cual el bloque polimérico A representa un polímero hidrofílico lineal farmacéuticamente aceptable y el bloque polimérico B representa un polímero que comprende monómeros seleccionados entre ácido L-láctico, ácido D, L-láctico, ácido glicólico, propiolactona, gama-butirolactona, delta-valerolactona, gama-valerolactona, epsilon-caprolactona, carbonato de trimetileno, p-dioxanona, carbonato de tetrametileno, epsilon-lactona, 1,5-dioxepan-2-ona o mezclas de los mismos caracterizado porque el copolímero de dos bloques es líquido a una temperatura por debajo de los 50 °C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37790102P | 2002-05-03 | 2002-05-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR039522A1 true AR039522A1 (es) | 2005-02-23 |
Family
ID=29401581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030101540A AR039522A1 (es) | 2002-05-03 | 2003-05-02 | Microemulsiones polimericas |
Country Status (22)
Country | Link |
---|---|
US (3) | US20060034797A1 (es) |
EP (1) | EP1504047B1 (es) |
JP (1) | JP4300184B2 (es) |
KR (1) | KR20040111466A (es) |
CN (1) | CN1290893C (es) |
AR (1) | AR039522A1 (es) |
AT (1) | ATE380834T1 (es) |
AU (1) | AU2003222310B2 (es) |
BR (1) | BR0309688A (es) |
CA (1) | CA2483282C (es) |
DE (1) | DE60318035T2 (es) |
EA (1) | EA008244B1 (es) |
ES (1) | ES2298510T3 (es) |
IL (1) | IL164977A (es) |
MX (1) | MXPA04010778A (es) |
MY (1) | MY139066A (es) |
NO (1) | NO20045283L (es) |
NZ (1) | NZ536294A (es) |
PL (1) | PL220850B1 (es) |
TW (1) | TWI310388B (es) |
WO (1) | WO2003093344A1 (es) |
ZA (1) | ZA200408854B (es) |
Families Citing this family (44)
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US8101629B2 (en) * | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
US7638522B2 (en) * | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
BR0313545B1 (pt) * | 2002-08-09 | 2021-07-27 | Janssen Pharmaceutica Nv | processos para a preparação de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila |
JP4266926B2 (ja) * | 2002-10-21 | 2009-05-27 | ロレアル | 両親媒性ブロックコポリマーを用いた水溶液に脂質親和性化合物を溶解させる方法、及び化粧品用組成物 |
US7968115B2 (en) * | 2004-03-05 | 2011-06-28 | Board Of Regents, The University Of Texas System | Liposomal curcumin for treatment of cancer |
US8784881B2 (en) | 2004-03-05 | 2014-07-22 | Board Of Regents, The University Of Texas System | Liposomal curcumin for treatment of diseases |
JP4929567B2 (ja) * | 2004-08-05 | 2012-05-09 | コニカミノルタエムジー株式会社 | ポリマーミセル含有製剤の製造方法 |
NZ553804A (en) * | 2004-09-29 | 2010-07-30 | Bayer Schering Pharma Ag | Thermodynamically stable form of bay 43-9006 tosylate |
WO2006042215A1 (en) * | 2004-10-08 | 2006-04-20 | Janssen Pharmaceutica, N.V. | 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives |
US7202209B2 (en) * | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
EP1922310A2 (en) | 2005-09-07 | 2008-05-21 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
JP4892264B2 (ja) * | 2006-03-30 | 2012-03-07 | 高田製薬株式会社 | リスペリドン水性液剤 |
JPWO2007136134A1 (ja) * | 2006-05-23 | 2009-10-01 | ナノキャリア株式会社 | 疎水性薬物内包ポリマーミセルの製造方法 |
KR100795214B1 (ko) * | 2006-08-22 | 2008-01-21 | 이화여자대학교 산학협력단 | 온도 민감성 졸-젤 전이 폴리(에틸렌글리콜)/폴리(카보네이트) 블록 공중합체 및 이의 제조방법 |
AR062927A1 (es) * | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
EP2081902A1 (en) * | 2006-11-09 | 2009-07-29 | Bayer Schering Pharma Aktiengesellschaft | Polymorph iii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide |
CA2669158A1 (en) * | 2006-11-14 | 2008-05-22 | Bayer Schering Pharma Aktiengesellschaft | Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide |
US8012965B2 (en) | 2006-12-29 | 2011-09-06 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
PT2078010E (pt) | 2006-12-29 | 2014-05-07 | Rigel Pharmaceuticals Inc | Triazoles substituídos com heteroarilos policíclicos úteis como inibidores de axl |
CN101622248B (zh) | 2006-12-29 | 2013-04-17 | 里格尔制药公司 | 用作axl抑制剂的n3-杂芳基取代的三唑和n5-杂芳基取代的三唑 |
JP2010514810A (ja) | 2006-12-29 | 2010-05-06 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axlインヒビターとして有用な置換トリアゾール |
US7872000B2 (en) | 2006-12-29 | 2011-01-18 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as Axl inhibitors |
JP5501224B2 (ja) * | 2007-05-25 | 2014-05-21 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 治療薬の経口投与のための製剤および関連する方法 |
FR2919296A1 (fr) * | 2007-07-25 | 2009-01-30 | Rhodia Operations Sas | Ouverture de cycles epoxy par des carbenes. |
SI2205592T1 (sl) | 2007-10-26 | 2013-09-30 | Rigel Pharmaceuticals, Inc. | Triazoli substituirani s policikličnim arilom in triazoli substituirani s policikličnim heteroarilom uporabni kot Axl inhibitorji |
US8349838B2 (en) | 2008-07-09 | 2013-01-08 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors |
JP5613156B2 (ja) | 2008-07-09 | 2014-10-22 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axl阻害剤として有用な架橋二環ヘテロアリール置換トリアゾール |
SG172398A1 (en) | 2008-12-24 | 2011-07-28 | Tibotec Pharm Ltd | Implantable devices for treating hiv |
EP2201935B1 (en) * | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Polymeric micelle composition containing a poorly soluble drug and preparation method of the same |
CN101444510B (zh) * | 2008-12-31 | 2011-03-09 | 南京卡文迪许生物工程技术有限公司 | 含有伏立康唑的药物制剂及其制备方法 |
AU2010204578B2 (en) | 2009-01-16 | 2016-05-12 | Rigel Pharmaceuticals, Inc. | AXL inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
CN101531756B (zh) * | 2009-04-16 | 2011-06-15 | 山东大学 | 一种水溶性聚乙二醇/聚乳酸多嵌段聚碳酸酯的制备方法 |
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ES2742525T3 (es) | 2009-10-01 | 2020-02-14 | Adare Pharmaceuticals Us L P | Composiciones de corticosteroides administradas oralmente |
WO2011050457A1 (en) | 2009-10-26 | 2011-05-05 | The University Of British Columbia | Stabilized formulation for oral administration of therapeutic agents and related methods |
US9023897B2 (en) * | 2010-12-29 | 2015-05-05 | Medincell | Biodegradable drug delivery compositions |
EP2634179A1 (en) * | 2012-02-28 | 2013-09-04 | Sanofi | Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging |
ITTO20130431A1 (it) * | 2013-05-28 | 2014-11-29 | Fond Istituto Italiano Di Tecnologia | Copolimero e nanoparticelle da esso ottenute per la veicolazione di un farmaco |
WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
CN104523592B (zh) * | 2015-01-26 | 2017-03-15 | 湖北工业大学 | 甲泼尼龙醋酸酯注射用自微乳制剂及其制备方法 |
AU2016355236C1 (en) | 2015-11-16 | 2022-09-22 | Medincell | A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
EP4137323A1 (en) | 2021-08-18 | 2023-02-22 | Imertech | Hydraulic binder with low carbon footprint and high early strength |
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DE3779838T2 (de) * | 1986-09-05 | 1992-12-24 | American Cyanamid Co | Beschichtung fuer chirurgische faeden. |
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2003
- 2003-04-24 DE DE60318035T patent/DE60318035T2/de not_active Expired - Lifetime
- 2003-04-24 JP JP2004501483A patent/JP4300184B2/ja not_active Expired - Fee Related
- 2003-04-24 EP EP03717321A patent/EP1504047B1/en not_active Expired - Lifetime
- 2003-04-24 EA EA200401465A patent/EA008244B1/ru not_active IP Right Cessation
- 2003-04-24 CN CNB038095793A patent/CN1290893C/zh not_active Expired - Fee Related
- 2003-04-24 CA CA2483282A patent/CA2483282C/en not_active Expired - Fee Related
- 2003-04-24 AU AU2003222310A patent/AU2003222310B2/en not_active Ceased
- 2003-04-24 MX MXPA04010778A patent/MXPA04010778A/es active IP Right Grant
- 2003-04-24 KR KR10-2004-7015633A patent/KR20040111466A/ko not_active Application Discontinuation
- 2003-04-24 BR BR0309688-2A patent/BR0309688A/pt not_active IP Right Cessation
- 2003-04-24 AT AT03717321T patent/ATE380834T1/de not_active IP Right Cessation
- 2003-04-24 WO PCT/EP2003/004368 patent/WO2003093344A1/en active IP Right Grant
- 2003-04-24 ES ES03717321T patent/ES2298510T3/es not_active Expired - Lifetime
- 2003-04-24 PL PL371934A patent/PL220850B1/pl unknown
- 2003-04-24 NZ NZ536294A patent/NZ536294A/en unknown
- 2003-04-24 US US10/522,456 patent/US20060034797A1/en not_active Abandoned
- 2003-04-30 MY MYPI20031645A patent/MY139066A/en unknown
- 2003-05-02 AR ARP030101540A patent/AR039522A1/es unknown
- 2003-05-02 TW TW092112064A patent/TWI310388B/zh active
-
2004
- 2004-11-02 IL IL164977A patent/IL164977A/en active IP Right Grant
- 2004-11-02 ZA ZA200408854A patent/ZA200408854B/en unknown
- 2004-12-02 NO NO20045283A patent/NO20045283L/no not_active Application Discontinuation
-
2011
- 2011-01-06 US US12/985,608 patent/US20110112115A1/en not_active Abandoned
-
2014
- 2014-12-01 US US14/557,058 patent/US20150086504A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR0309688A (pt) | 2005-02-22 |
PL220850B1 (pl) | 2016-01-29 |
EP1504047B1 (en) | 2007-12-12 |
IL164977A0 (en) | 2005-12-18 |
JP4300184B2 (ja) | 2009-07-22 |
KR20040111466A (ko) | 2004-12-31 |
EA008244B1 (ru) | 2007-04-27 |
NZ536294A (en) | 2005-05-27 |
US20110112115A1 (en) | 2011-05-12 |
NO20045283L (no) | 2005-01-07 |
AU2003222310B2 (en) | 2009-04-09 |
JP2005524730A (ja) | 2005-08-18 |
ZA200408854B (en) | 2005-11-02 |
IL164977A (en) | 2007-12-03 |
MY139066A (en) | 2009-08-28 |
CN1290893C (zh) | 2006-12-20 |
US20060034797A1 (en) | 2006-02-16 |
CA2483282A1 (en) | 2003-11-13 |
DE60318035T2 (de) | 2008-12-11 |
CA2483282C (en) | 2012-05-29 |
EP1504047A1 (en) | 2005-02-09 |
TWI310388B (en) | 2009-06-01 |
MXPA04010778A (es) | 2005-03-07 |
TW200413434A (en) | 2004-08-01 |
ES2298510T3 (es) | 2008-05-16 |
AU2003222310A1 (en) | 2003-11-17 |
ATE380834T1 (de) | 2007-12-15 |
EA200401465A1 (ru) | 2005-04-28 |
PL371934A1 (en) | 2005-07-11 |
WO2003093344A1 (en) | 2003-11-13 |
CN1649932A (zh) | 2005-08-03 |
US20150086504A1 (en) | 2015-03-26 |
DE60318035D1 (de) | 2008-01-24 |
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