EA200401465A1 - Полимерные микроэмульсии - Google Patents

Полимерные микроэмульсии

Info

Publication number
EA200401465A1
EA200401465A1 EA200401465A EA200401465A EA200401465A1 EA 200401465 A1 EA200401465 A1 EA 200401465A1 EA 200401465 A EA200401465 A EA 200401465A EA 200401465 A EA200401465 A EA 200401465A EA 200401465 A1 EA200401465 A1 EA 200401465A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polymeric micro
micro emulsions
liquid
temperature below
new self
Prior art date
Application number
EA200401465A
Other languages
English (en)
Other versions
EA008244B1 (ru
Inventor
Альбертина Мария Эдуарда Ариэн
Маркус Эли Брюстер
Аруна Натан
Джоэль Розенблатт
Луиза Мирьям Уль-Уали
Вероник Преа
Original Assignee
Янссен Фармацевтика Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н. В. filed Critical Янссен Фармацевтика Н. В.
Publication of EA200401465A1 publication Critical patent/EA200401465A1/ru
Publication of EA008244B1 publication Critical patent/EA008244B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/46—Polyesters chemically modified by esterification
    • C08G63/48—Polyesters chemically modified by esterification by unsaturated higher fatty oils or their acids; by resin acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/18—Block or graft polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/18—Block or graft polymers
    • C08G64/183—Block or graft polymers containing polyether sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/12—Copolymers
    • C08G2261/126—Copolymers block
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polymerisation Methods In General (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Centrifugal Separators (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paper (AREA)

Abstract

В изобретении предлагаются новые самоэмульгирующиеся диблоксополимеры и новые самоэмульгирующиеся композиции, содержащие активный ингредиент и диблоксополимер, отличающиеся тем, что диблоксополимер является жидкостью при температуре ниже 50°C, а композиция является неводной и жидкой при температуре ниже 50°C.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401465A 2002-05-03 2003-04-24 Полимерные микроэмульсии EA008244B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37790102P 2002-05-03 2002-05-03
PCT/EP2003/004368 WO2003093344A1 (en) 2002-05-03 2003-04-24 Polymeric microemulsions

Publications (2)

Publication Number Publication Date
EA200401465A1 true EA200401465A1 (ru) 2005-04-28
EA008244B1 EA008244B1 (ru) 2007-04-27

Family

ID=29401581

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401465A EA008244B1 (ru) 2002-05-03 2003-04-24 Полимерные микроэмульсии

Country Status (22)

Country Link
US (3) US20060034797A1 (ru)
EP (1) EP1504047B1 (ru)
JP (1) JP4300184B2 (ru)
KR (1) KR20040111466A (ru)
CN (1) CN1290893C (ru)
AR (1) AR039522A1 (ru)
AT (1) ATE380834T1 (ru)
AU (1) AU2003222310B2 (ru)
BR (1) BR0309688A (ru)
CA (1) CA2483282C (ru)
DE (1) DE60318035T2 (ru)
EA (1) EA008244B1 (ru)
ES (1) ES2298510T3 (ru)
IL (1) IL164977A (ru)
MX (1) MXPA04010778A (ru)
MY (1) MY139066A (ru)
NO (1) NO20045283L (ru)
NZ (1) NZ536294A (ru)
PL (1) PL220850B1 (ru)
TW (1) TWI310388B (ru)
WO (1) WO2003093344A1 (ru)
ZA (1) ZA200408854B (ru)

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Also Published As

Publication number Publication date
BR0309688A (pt) 2005-02-22
MXPA04010778A (es) 2005-03-07
DE60318035T2 (de) 2008-12-11
ES2298510T3 (es) 2008-05-16
DE60318035D1 (de) 2008-01-24
NZ536294A (en) 2005-05-27
MY139066A (en) 2009-08-28
JP4300184B2 (ja) 2009-07-22
AR039522A1 (es) 2005-02-23
AU2003222310A1 (en) 2003-11-17
EA008244B1 (ru) 2007-04-27
AU2003222310B2 (en) 2009-04-09
US20060034797A1 (en) 2006-02-16
EP1504047A1 (en) 2005-02-09
KR20040111466A (ko) 2004-12-31
TWI310388B (en) 2009-06-01
PL220850B1 (pl) 2016-01-29
CA2483282C (en) 2012-05-29
ATE380834T1 (de) 2007-12-15
CN1649932A (zh) 2005-08-03
EP1504047B1 (en) 2007-12-12
IL164977A0 (en) 2005-12-18
IL164977A (en) 2007-12-03
US20150086504A1 (en) 2015-03-26
WO2003093344A1 (en) 2003-11-13
NO20045283L (no) 2005-01-07
ZA200408854B (en) 2005-11-02
PL371934A1 (en) 2005-07-11
TW200413434A (en) 2004-08-01
CA2483282A1 (en) 2003-11-13
CN1290893C (zh) 2006-12-20
US20110112115A1 (en) 2011-05-12
JP2005524730A (ja) 2005-08-18

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