AR038786A1 - Compuesto de urea, procedimiento para su preparacion, su uso para fabricar un medicamento y composicion farmaceutica que lo comprende - Google Patents

Compuesto de urea, procedimiento para su preparacion, su uso para fabricar un medicamento y composicion farmaceutica que lo comprende

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Publication number
AR038786A1
AR038786A1 ARP020103454A ARP020103454A AR038786A1 AR 038786 A1 AR038786 A1 AR 038786A1 AR P020103454 A ARP020103454 A AR P020103454A AR P020103454 A ARP020103454 A AR P020103454A AR 038786 A1 AR038786 A1 AR 038786A1
Authority
AR
Argentina
Prior art keywords
urea
pyrrolidin
methylphenyl
compound
fluorophenyl
Prior art date
Application number
ARP020103454A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0122156A external-priority patent/GB0122156D0/en
Priority claimed from GB0130503A external-priority patent/GB0130503D0/en
Priority claimed from GB0130505A external-priority patent/GB0130505D0/en
Priority claimed from GB0130547A external-priority patent/GB0130547D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR038786A1 publication Critical patent/AR038786A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compuesto de urea de fórmula (1) o sus sales farmacéuticamente aceptables, o sus solvatos, donde P y P' son independientemente arilo y heteroarilo; R1 y R2 son independientemente -H, halógeno, alquilo, alcoxi, cicloalquilo, aralquilo, aralcoxi, cicloalquilalquilo, cicloalquialcoxi, -CN, -NO2, -OH, -OCF3, -CF3, -NR4R5, -S(O)mR6, -S(O)2NR4R5, -OS(O)2R6, -OS(O)2CF3, -O(CH2)xNR4R5, -C(O)CF3, -C(O)alquilo, -C(O)cicloalquilo; -C(O)aralquilo, -C(O)Ar, -C(O)(CH2)xOR6, -C(O)(CH2)xNR4R5, -C(O)alcoxi, -C(O)NR4R5, -(CH2)xC(O)alcoxi, -(CH2)xOC(O)R6, -(CH2)xOR6, -(CH2)xR4R5, -(CH2)xC(O)NR4R5, -(CH2)xN(R4)C(O)R6, -(CH2)xS(O)2NR4R5, -(CH2)xN(R4)S(O)2R6, -ZAr, -(CH2)xS(O)2R6, -(OCH2)xS(O)2R6, -N(R4)s(O)2R6, -N(R4)C(O)R6, -(CH2)xN(R4)S(O)2R6, -(CH2)xN(R4)C(O)R6 o -(CH2)xC(O)alquilo; R4 y R5 pueden ser iguales o diferentes y representan H o alquilo, o R4 y R5 junto con los átomos a los que están unidos forman un anillo de azacicloalcano C 3-6, (2-oxo)azacicloalcano C3-6 o cadena de polimetileno C5-8 opcionalmente interrumpida por heteroátomos tales como O ó NR7; Z es O, S o NR7; R6 es alquilo o arilo; R7 es H, alquilo o arilo; m es 1 ó 2; n es 0, 1, 2 ó 3; p y q son independientemente 0, 1, 2, 3, ó 4; r es 1, 2, ó 3; s es 0, 1 ó 2; y x es 0, 1, 2, 3, 4, 5 ó 6; con la condición de que dicho compuesto de fórmula (1) no sea un compuesto seleccionado de 1-(1-fenil-3-pirrolidinil)-3-fenil-urea; 1-(1-fenil-3-pirrolidinil)-3-(4-metoxifenil)urea; N-(4-fluorofenil)-N'-[((R)-1-((3-metilfenil)pirrolidin-2-ilmetil)]urea; N-(2-bromofenil)-N'-[((R)-1-(-3-metilfenil)pirrolidin-3-il)]urea; N-(2-bromofenil)-N'-[((R)-1-(3-metilfenil)pirrolidin-2-ilmetil)]urea, N-(4-fluorofenil)-N'-[((S)-1-(3-metilfenil)pirrolidin-2-ilmetil)]urea; N-(2-bromofenil)-N'[((S)-1-(3-metilfenil)pirrolidin-2-ilmetil)]urea; N-(4-fluorometil)-N'-[((S)-1-(3-metilfenil)pirrolidin-3-il)]urea; N-(2-bromofenil)-N'-[((S)-1-(3-metilfenil)pirrolidin-3-il)]urea; N-(4-fluorofenil)-N'-[((R)-1-(3-metilfenil)pirrolidin-3-il)]urea, N-(4-fluorofenil)-N'-[((R)-1-(3-fluorofenil)]pirrolidin-3-il)]urea; N-(2-bromofenil)-N'-[((R)-1-(3-fluorofenil)pirrolidin-3-il)]urea; N-(1-naftil)-N'-[((R)-1-(3-metilfenil)pirrolidin-3-il)]urea; N-(2,3-diclorofenil)-N'[((R)-1-(3-metilfenil)pirrolidin-3-il)]urea; N-(2-bromofenil)-N'-[((S)-1-(3-fluorofenil)pirrolidin-3-il)]urea; N-(2-bromofenil)-N'-[((R)-1-(4-fluoro-3-metilfenil)pirrolidin-3-il)]urea; N-(2-bromofenil)-N'-[((R)-1-(3,4-difluorofenil)pirrolidin-3-il)]urea; N-(2-bromofenil)-N'-[((R)-1-(3-fluoro-4-metilfenil)pirrolidin-3-il)]urea; N-(3-cloro-2-metilfenil)-N'-[((R)-1-(3-metilfenil)pirrolidin-3-il)]urea; N-(2,3-diclorofenil)-N'-[((R)-1-(3-metilfenil)pirrolidin-3-il)]urea; N-(2,3-diclorofenil)-N'[((R)-1-(3-metilfenil)pirrolidin-3-il)]urea; N-(2,3-diclorofenil)-N'-[((R)-1-(3-fluorofenil)pirrolidin-3-il)]urea; N-(2,5-diclorofenil)-N'-[((R)-1-(3-fluorofenil)pirrolidin-3-il)]urea; N-(3-cloro-2-metilfenil)-N'-[((R)-1-(3-fluorofenil)pirrolidin-3-il)]urea; N-(3-cloro-2-metilfenil)-N'[((R)-1-(3,4-difluorofenil)pirrolidin-3-il)]urea; N-(2,3-diclorofenil)-N'-[((R)-1-(3,4-difuorofenil)pirrolidin-3-il)]urea; N-(2,5-diclorofenil)-N'-[((R)-1-(3,4-difluorofenil)pirrolidin-3-il)]urea; N-(3-cloro-2-metilfenil)-N'-[((R)-1-(3-fluoro-4-metilfenil)pirrolidin-3-il)]urea y N-(2,3-diclorofenil)-N'-[((R)-1-(3-fluoro-4-metilfenil)pirrolidin-3-il)]urea. Procedimiento para preparar dicho compuesto de fórmula (1) o sus sales. Uso de dicho compuesto para fabricar un medicamento útil para el tratamiento o profilaxis de trastornos o dolor asociado con ellos, en los que es beneficioso el antagonismo del receptor Vainilloide (VR1), composición farmacéutica que lo comprende. Se aplica en terapéutica activa de dolores, neuralgia, neuropatías, enfermedades pulmonares, trastornos inflamatorios, y otros por vía oral, parenteral, rectal o intravesical. Reivindicación 6: Un procedimiento para preparar un compuesto de fórmula (1) o una de sus sales farmacéuticamente aceptable, según la reivindicación 1, dicho procedimiento caracterizado porque comprende acoplar un compuesto de fórmula (2) en la que R1, P y p son como se han definido en la fórmula (1), con un compuesto de fórmula (3): en la que P', R2, n, q, r, y s son como se han definido en la fórmula (1), y A y B contienen grupos funcionales adecuados que son capaces de reaccionar entre sí para formar el resto urea; y después, cuando sea necesario, llevar a cabo una o más de las siguientes reacciones: (i) convertir un compuesto de fórmula (1) en otro compuesto de fórmula (1); (ii) separar cualquier protector; (iii) preparar una sal o un solvato del compuesto así formado.
ARP020103454A 2001-09-13 2002-09-12 Compuesto de urea, procedimiento para su preparacion, su uso para fabricar un medicamento y composicion farmaceutica que lo comprende AR038786A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0122156A GB0122156D0 (en) 2001-09-13 2001-09-13 Novel compounds
GB0130503A GB0130503D0 (en) 2001-12-20 2001-12-20 Novel compounds
GB0130505A GB0130505D0 (en) 2001-12-20 2001-12-20 Novel compounds
GB0130547A GB0130547D0 (en) 2001-12-20 2001-12-20 Novel compounds

Publications (1)

Publication Number Publication Date
AR038786A1 true AR038786A1 (es) 2005-01-26

Family

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Application Number Title Priority Date Filing Date
ARP020103454A AR038786A1 (es) 2001-09-13 2002-09-12 Compuesto de urea, procedimiento para su preparacion, su uso para fabricar un medicamento y composicion farmaceutica que lo comprende

Country Status (32)

Country Link
US (1) US8063078B2 (es)
EP (3) EP2036902A3 (es)
JP (2) JP4463552B2 (es)
KR (3) KR101063679B1 (es)
CN (1) CN1247568C (es)
AP (1) AP1818A (es)
AR (1) AR038786A1 (es)
AT (1) ATE420083T1 (es)
AU (1) AU2002329397B2 (es)
BR (1) BR0212468A (es)
CA (1) CA2458632C (es)
CY (1) CY1109449T1 (es)
DE (1) DE60230773D1 (es)
DK (1) DK1425277T3 (es)
EA (1) EA007731B1 (es)
ES (1) ES2316607T3 (es)
HK (1) HK1066534A1 (es)
HU (1) HUP0401923A3 (es)
IL (2) IL160755A0 (es)
MA (1) MA26216A1 (es)
MX (1) MXPA04002379A (es)
MY (1) MY138086A (es)
NO (3) NO327009B1 (es)
NZ (1) NZ531137A (es)
OA (1) OA12659A (es)
PE (1) PE20030417A1 (es)
PL (1) PL213639B1 (es)
PT (1) PT1425277E (es)
SI (1) SI1425277T1 (es)
TW (1) TWI283665B (es)
UY (1) UY27446A1 (es)
WO (1) WO2003022809A2 (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030417A1 (es) 2001-09-13 2003-08-06 Smithkline Beecham Plc Derivados de urea como antagonistas del receptor vainilloide
ES2345044T3 (es) 2002-02-01 2010-09-14 Euro-Celtique S.A. 2-piperazin-piridinas utiles para tratar el dolor.
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
WO2003070247A1 (en) * 2002-02-20 2003-08-28 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
US6974818B2 (en) 2002-03-01 2005-12-13 Euro-Celtique S.A. 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
RS114804A (en) 2002-06-28 2006-12-15 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
GB0221157D0 (en) * 2002-09-12 2002-10-23 Glaxo Group Ltd Novel treatment
AU2003270199A1 (en) * 2002-09-13 2004-04-30 Glaxo Group Limited Urea compounds active as vanilloid receptor antagonists for the treatment of pain
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
WO2004052846A1 (en) 2002-12-06 2004-06-24 Bayer Healthcare Ag Tetrahydro-naphthalene derivatives
GB0229808D0 (en) 2002-12-20 2003-01-29 Glaxo Group Ltd Novel compositions
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
ES2330107T3 (es) * 2003-03-06 2009-12-04 Glaxo Group Limited Derivados de urea heterociclicos para el tratamiento del dolor.
JP2006519806A (ja) * 2003-03-07 2006-08-31 グラクソ　グループ　リミテッド 尿素誘導体および疼痛治療におけるバニロイド受容体拮抗剤としてのそれらの使用。
GB0305426D0 (en) 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
SE0301446D0 (sv) 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
CA2526361C (en) 2003-05-20 2012-05-15 Ajinomoto Co., Inc. Amide derivative
EP1493438A1 (en) * 2003-07-03 2005-01-05 Bayer HealthCare AG Vanilloid receptor (VR) inhibitors for treatment of Human Immunodeficiency Virus (HIV)-mediated pain states
GB0319151D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
GB0319150D0 (en) 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
DE602004019294D1 (de) 2003-10-01 2009-03-19 Xention Ltd Tetrahydronaphthalin- und harnstoffderivate
EP1679296A4 (en) 2003-10-14 2007-12-26 Ajinomoto Kk DERIVE ETHERE
WO2005040100A1 (en) * 2003-10-15 2005-05-06 Bayer Healthcare Ag Tetrahydro-naphthalene and urea derivatives
CA2545109A1 (en) 2003-11-08 2005-05-19 Bayer Healthcare Ag Tetrahydro-quinolinylurea derivatives
EP1736465A4 (en) 2004-03-31 2009-06-17 Ajinomoto Kk ANILINE DERIVATIVES
CA2584502A1 (en) 2004-06-24 2006-01-05 Incyte Corporation 2-methylpropanamides and their use as pharmaceuticals
US7879866B2 (en) 2004-07-19 2011-02-01 Dorte Xenia Gram Inhibition of the activity of the capsaicin receptor in the treatment of obesity or obesity-related diseases and disorders
KR20060087386A (ko) 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
WO2006098554A1 (en) * 2005-03-16 2006-09-21 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
WO2007046867A2 (en) * 2005-05-19 2007-04-26 Xenon Pharmaceuticals Inc. Piperidine derivatives and their uses as therapeutic agents
TW200736227A (en) 2005-12-23 2007-10-01 Astrazeneca Ab New compounds III
EP1889830A1 (en) * 2006-07-10 2008-02-20 Pharmeste S.r.l. Biarylcarboxyarylamides as vanilloid-1 receptor modulators
EP1882687A1 (en) * 2006-07-27 2008-01-30 Amorepacific Corporation Heterocyclic compounds useful as vanilloid receptor antagonists and pharmaceutical compositions containing the same
KR101410318B1 (ko) * 2006-07-27 2014-06-27 (주)아모레퍼시픽 바닐로이드 수용체 길항제로서의 신규 화합물, 그의 이성질체, 또는 약제학적으로 허용가능한 그의 염, 및 이를함유하는 약제학적 조성물
TWI433839B (zh) 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290
MX2009002018A (es) 2006-08-25 2009-03-05 Abbott Lab Derivados de indazol que inhiben vanilloide-1 potencial de receptor pasajero (trpv1) y usos de los mismos.
EP2450346A1 (en) 2006-12-20 2012-05-09 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
EP2489660A1 (en) 2008-03-20 2012-08-22 Abbott Laboratories Methods for making central nervous system agents that are TRPV1 antagonists
JP5372138B2 (ja) 2008-04-18 2013-12-18 テウン ファーマシューティカル カンパニー，リミテッド 新規ベンゾオキサジンベンズイミダゾール誘導体、これを含む薬学組成物およびこの用途
ES2433008T3 (es) * 2008-05-07 2013-12-05 Dainippon Sumitomo Pharma Co., Ltd. Derivado de éster de ácido amino-1-carboxílico cíclico y composición farmacéutica que contiene el mismo
WO2010026128A1 (en) * 2008-09-02 2010-03-11 Glaxo Group Limited N-(3-methyl-5-isoquinolinyl)-n'-((3r)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl) urea for the treatment of rhinitis
JP2012501315A (ja) * 2008-09-02 2012-01-19 グラクソ グループ リミテッド 鼻炎を治療するためのｔｒｐｖｌアンタゴニストｓｂ−７０５４９８
JP2013028536A (ja) * 2009-11-11 2013-02-07 Dainippon Sumitomo Pharma Co Ltd 環状アミン−１−カルボン酸エステル誘導体およびそれを含有する医薬組成物
WO2012045729A1 (en) 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
KR101293384B1 (ko) 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
WO2012072512A1 (en) 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
GB201101517D0 (en) * 2011-01-28 2011-03-16 Proximagen Ltd Receptor antagonists
US8754101B2 (en) 2011-04-11 2014-06-17 Glaxo Group Limited N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3424761A (en) 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
US3424760A (en) * 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
GB1460389A (en) * 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants
DE68918991T2 (de) 1988-06-17 1995-04-27 Procter & Gamble Anwendung von Vanillin-Derivaten zur Herstellung eines Arzneimittels zur Behandlung von Herpes simplex-Infektion.
HU206082B (en) 1988-12-23 1992-08-28 Sandoz Ag Process for producing capsaicin derivatives and pharmaceutical compositions comprising such compounds
CA2017383A1 (en) 1989-06-08 1990-12-08 Raymond R. Martodam Use of vanilloids for the treatment of respiratory diseases or disorders
AU9079491A (en) 1990-11-27 1992-06-25 Procter & Gamble Company, The Combinations of vanilloid compounds and phosphonate antiviral compounds for treatment of herpes infections
US5149704A (en) 1991-05-03 1992-09-22 Abbott Laboratories Platelet activating antagonists
CA2197364A1 (en) 1996-02-15 1997-08-16 Toshikazu Suzuki Phenol compound and process for preparing the same
EP1014962A4 (en) * 1997-06-26 2007-06-27 Lilly Co Eli ANTITHROMBOTIC AGENTS
WO1999000128A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
JP2000080085A (ja) 1997-09-01 2000-03-21 Kyorin Pharmaceut Co Ltd ６，７−非対称ジ置換キノキサリンカルボン酸誘導体とその付加塩及びそれらの製造方法
CN1210254C (zh) 1999-02-22 2005-07-13 株式会社太平洋 作为有效的香草类受体激动剂和镇痛药的含有树脂毒素药效基团的香草类类似物,其组合物以及应用
EE04799B1 (et) 1999-03-12 2007-04-16 Boehringer Ingelheim Pharmaceuticals, Inc. Ühendid, mis on kasulikud põletikuvastaste vahenditena, nende ühendite valmistamise meetodid ja neid sisaldavad farmatseutilised kompositsioonid
US6608227B1 (en) * 1999-10-15 2003-08-19 Bristol-Myers Squibb Pharma Benzylcycloalkyl amines as modulators of chemokine receptor activity
NZ523526A (en) 2000-07-20 2004-10-29 Neurogen Corp Diaryl piperazines as capsaicin receptor ligands
WO2002016318A1 (en) 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
US20030153596A1 (en) 2000-08-21 2003-08-14 Suh Young Ger Novel thiourea derivatives and the pharmaceutical compositions containing the same
WO2002016317A1 (en) 2000-08-21 2002-02-28 Pacific Corporation Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same
JP2002080073A (ja) 2000-09-07 2002-03-19 Kyokuto Kobunshi Kk 電子レンジ用自動開孔袋
JP2002088073A (ja) * 2000-09-08 2002-03-27 Yamanouchi Pharmaceut Co Ltd 抗アンドロゲン剤
GB0110901D0 (en) 2001-05-02 2001-06-27 Smithkline Beecham Plc Novel Compounds
PE20030417A1 (es) 2001-09-13 2003-08-06 Smithkline Beecham Plc Derivados de urea como antagonistas del receptor vainilloide
JP2005537247A (ja) * 2002-06-27 2005-12-08 シエーリング アクチエンゲゼルシャフト 置換されたキノリンｃｃｒ５受容体アンタゴニスト
AU2003270199A1 (en) 2002-09-13 2004-04-30 Glaxo Group Limited Urea compounds active as vanilloid receptor antagonists for the treatment of pain
GB0229808D0 (en) 2002-12-20 2003-01-29 Glaxo Group Ltd Novel compositions
EP1740557A1 (en) 2004-04-20 2007-01-10 Bayer HealthCare AG Urea derivatives as antagonists of the vanilloid receptor (vr1)

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