AR038369A1 - Metodo para preparar dispersiones solidas amorfas de farmacos secadas por pulverizacion utilizando inyectores a presion y producto - Google Patents
Metodo para preparar dispersiones solidas amorfas de farmacos secadas por pulverizacion utilizando inyectores a presion y productoInfo
- Publication number
- AR038369A1 AR038369A1 ARP030100268A ARP030100268A AR038369A1 AR 038369 A1 AR038369 A1 AR 038369A1 AR P030100268 A ARP030100268 A AR P030100268A AR P030100268 A ARP030100268 A AR P030100268A AR 038369 A1 AR038369 A1 AR 038369A1
- Authority
- AR
- Argentina
- Prior art keywords
- trifluoromethyl
- drug
- microns
- benzyl
- drops
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Glanulating (AREA)
- Disintegrating Or Milling (AREA)
Abstract
Dispersiones sólidas amorfas homogéneas de fármacos en polímeros mejoradores de la concentración se preparan en tamanos de partícula más grandes adecuados con mínimo contenido de fines, utilizando un atomizador y condiciones de procedimiento capaces de producir gotas que tienen un diámetro medio de al menos 50 micrones y un D10 de al menos 10 micrones. Reivindicación 1: Un procedimiento para producir una composición farmacéutica, caracterizado porque comprende las etapas de: (a) formar una disolución de alimentación que comprende un fármaco, un polímero mejorador de la concentración y un disolvente; (b) dirigir dicha disolución de alimentación hacia un aparato de secado por pulverización que comprende una cámara de secado, medios de atomización para atomizar en gotas dicha disolución de alimentación en dicha cámara de secado, una fuente de gas de secado calentando para secar dichas gotas y medios de recogida del producto secado; (c) atomizar en gotas dicha disolución de alimentación en dicha cámara de secado mediante dichos medios de atomización, teniendo dichas gotas un diámetro medio de al menos 50 micrones y un D10 de al menos 10 micrones; (d) poner en contacto dichas gotas con dicho gas de secado calentado para preparar materiales en partículas de una dispersión sólida amorfa de dicho fármaco y dicho polímero mejorador de la concentración; y (e) recoger dichos materiales en partículas: en el que dicho polímero mejorador de la concentración está presente en dicha disolución en una cantidad suficiente, de manera que dicha dispersión sólida amorfa proporciona una mejora de la concentración de dicho fármaco en un medio de utilización con respecto a una composición testigo que consiste esencialmente en una cantidad equivalente de dicho fármaco solo. Reivindicación 9: El procedimiento según la reivindicación 1, caracterizado porque dicho fármaco se elige del grupo que consta [R-(R*S*)]-5-cloro-N-2-hidroxi-3-{metoximetilamino}-3-oxo-1-(fenilmetil)propil-1H-indol-2-carboxamida, [(1S)-bencil-(2R)-hidroxi-3-((3R,4S)-dihidroxi-pirrolidin-1-il)-3-oxipropil]amida del ácido 5-cloro-1H-indol-2-carboxílico, éster isopropílico del ácido [2R,4S]-4-[acetil(3,5-bis-trifluorometil-bencil)-amino]-2-etil-6-trifluorometil-3,4-dihidro-2H-quinolin-1-carboxílico, éster etílico del ácido [2R,4S]-4-(3,5-bis-trifluorometil-bencil)-metoxicarbonil-amino]-2-etil-6-trifluorometil-3,4-dihidro-2H-quinolin-1-carboxílico y éster isopropílico del ácido [2R,4S]-4-[(3,5-bis-trifluorometil-bencil)-metoxicarbonil-amino]-2-etil-6-trifluorometil-3,4-dihidro-2H-quinolin-1-carboxílico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35398602P | 2002-02-01 | 2002-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038369A1 true AR038369A1 (es) | 2005-01-12 |
Family
ID=27663274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100268A AR038369A1 (es) | 2002-02-01 | 2003-01-30 | Metodo para preparar dispersiones solidas amorfas de farmacos secadas por pulverizacion utilizando inyectores a presion y producto |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7780988B2 (es) |
| EP (1) | EP1469830A2 (es) |
| JP (1) | JP2005523260A (es) |
| KR (1) | KR100758045B1 (es) |
| CN (1) | CN1787808A (es) |
| AR (1) | AR038369A1 (es) |
| AU (1) | AU2003239463B2 (es) |
| BR (1) | BR0307515A (es) |
| CA (1) | CA2474958A1 (es) |
| GT (1) | GT200300024A (es) |
| MX (1) | MXPA04007435A (es) |
| PA (1) | PA8565401A1 (es) |
| PE (1) | PE20030804A1 (es) |
| PL (1) | PL371593A1 (es) |
| RS (1) | RS67304A (es) |
| RU (1) | RU2288703C2 (es) |
| TW (1) | TW200404576A (es) |
| UY (1) | UY27645A1 (es) |
| WO (1) | WO2003063821A2 (es) |
| ZA (1) | ZA200405971B (es) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| BR0307515A (pt) | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Método para fabricar dispersões de drogas amorfas sólidas secas por aspersão homogêneas usando bicos de pressão |
| BR0307333A (pt) | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Métodos para a preparação de dispersões homogéneas de fármacos sólidos amorfos atomizados utilizando um sistema de secagem por pulverização |
| CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| ES2339682T3 (es) | 2004-06-01 | 2010-05-24 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Procedimiento para la preparacion de la forma amorfa de un farmaco. |
| DK1773816T3 (en) | 2004-06-24 | 2015-01-26 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
| WO2006060614A1 (en) | 2004-12-01 | 2006-06-08 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Methods for preparing pimecrolimus |
| US9265731B2 (en) | 2005-01-28 | 2016-02-23 | Bend Research, Inc. | Drying of drug-containing particles |
| US20070026073A1 (en) | 2005-07-28 | 2007-02-01 | Doney John A | Amorphous efavirenz and the production thereof |
| EP1970370A4 (en) * | 2005-12-21 | 2010-11-10 | Eisai R&D Man Co Ltd | AMORPHOUS FORM OF 1,2-DIHYDROPYRIDINE COMPOUND |
| JP5409010B2 (ja) | 2005-12-28 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｎ−［２，４−ビス（１，１−ジメチルエチル）−５−ヒドロキシフェニル］−１，４−ジヒドロ−４−オキソキノリン−３−カルボキサミドの固体形態 |
| KR101418267B1 (ko) | 2006-02-09 | 2014-07-11 | 머크 샤프 앤드 돔 코포레이션 | Ｃｅｔｐ 억제제의 중합체 제형 |
| PT2029110E (pt) * | 2006-06-06 | 2011-11-23 | Tibotec Pharm Ltd | Processo para preparar formulações secas por atomização de tmc125 |
| WO2008012617A1 (en) | 2006-07-21 | 2008-01-31 | Pfizer Products Inc. | Drying of drug-containing particles |
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| EP2093225A1 (en) | 2007-05-01 | 2009-08-26 | Plus Chemicals B.V. | Process for preparing crystalline eletriptan hydrobromide form ß |
| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| EP2393827B1 (en) | 2009-02-05 | 2015-10-07 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| NZ624460A (en) | 2009-03-20 | 2015-12-24 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| WO2010111132A2 (en) | 2009-03-27 | 2010-09-30 | Bend Research, Inc. | Spray-drying process |
| CN104959087B (zh) | 2010-04-09 | 2017-08-15 | 帕西拉制药有限公司 | 用于配制大直径合成膜囊泡的方法 |
| MX2012014387A (es) | 2010-06-09 | 2013-05-01 | Abbvie Inc | Dispersiones solidas que contienen inhibidores de cinasa. |
| ES2676209T3 (es) * | 2010-06-23 | 2018-07-17 | Metabolex Inc. | Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina |
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| CN103429228B (zh) | 2011-01-05 | 2016-10-26 | 赫士睿股份有限公司 | 万古霉素的喷雾干燥 |
| TWI520732B (zh) * | 2011-01-18 | 2016-02-11 | 輝瑞有限公司 | 固體分子分散液 |
| PT106063B (pt) * | 2011-12-19 | 2017-05-30 | Inst Superior Técnico | Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono |
| CN104470518A (zh) | 2012-02-27 | 2015-03-25 | 沃泰克斯药物股份有限公司 | 药物组合物及其施用 |
| CN109078015A (zh) * | 2012-05-31 | 2018-12-25 | 默沙东公司 | 食欲素受体拮抗剂的固体剂量制剂 |
| WO2014043208A1 (en) * | 2012-09-11 | 2014-03-20 | Medivation Prostate Therapeutics, Inc. | Formulations of enzalutamide |
| ES2771458T3 (es) | 2013-01-31 | 2020-07-06 | Gilead Pharmasset Llc | Formulación de combinación de dos compuestos antivirales |
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| US9884067B2 (en) | 2013-03-14 | 2018-02-06 | University Of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
| CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
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| PL3650014T3 (pl) | 2013-08-27 | 2022-01-31 | Gilead Pharmasset Llc | Preparat złożony dwóch związków przeciwwirusowych |
| CN103694903B (zh) * | 2013-12-02 | 2015-07-01 | 南通瑞普埃尔生物工程有限公司 | 一种瞬干胶粘剂及其制备方法 |
| JP6505705B2 (ja) * | 2013-12-05 | 2019-04-24 | アルライズ バイオシステムズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 経口投与用製剤の製造方法 |
| US10406127B2 (en) | 2014-07-25 | 2019-09-10 | Laurent Pharmaceuticals | Solid oral formulation of fenretinide |
| AU2015292212B2 (en) | 2014-07-25 | 2019-03-14 | Laurent Pharmaceuticals | Solid oral formulation of fenretinide |
| CA2963945C (en) | 2014-10-07 | 2023-01-10 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| US11364203B2 (en) | 2014-10-31 | 2022-06-21 | Bend Reserch, Inc. | Process for forming active domains dispersed in a matrix |
| MA41107A (fr) * | 2014-12-05 | 2017-10-10 | Aragon Pharmaceuticals Inc | Compositions anti-cancéreuses |
| UA123538C2 (uk) | 2014-12-05 | 2021-04-21 | Араґон Фармасьютікалз, Інк. | Протиракові композиції |
| RU2585023C1 (ru) * | 2014-12-18 | 2016-05-27 | Общество с ограниченной ответственностью "Нанолек" | Способ гранулирования |
| JP2019511542A (ja) | 2016-04-15 | 2019-04-25 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | カプシド集合阻害剤を含む組み合わせ及び方法 |
| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
| US20180110760A1 (en) | 2016-10-21 | 2018-04-26 | Glialogix, Inc. | Compositions and methods for the treatmentof neurodegenerative and other diseases |
| AU2019235522A1 (en) | 2018-03-14 | 2020-09-03 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| TW202019416A (zh) | 2018-07-30 | 2020-06-01 | 日商中外製藥股份有限公司 | 乙內醯脲衍生物的固體分散體 |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
| IL293866A (en) | 2019-12-30 | 2022-08-01 | Deciphera Pharmaceuticals Llc | Compositions of amorphous kinase inhibitors and methods of using them |
| WO2021138483A1 (en) | 2019-12-30 | 2021-07-08 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
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|---|---|---|---|---|
| GB1131242A (en) | 1965-02-18 | 1968-10-23 | Gen Foods Ltd | Improvements in or relating to spray-drying apparatus |
| DE2201111A1 (de) | 1971-01-19 | 1972-07-27 | Niro Atomizer As | Zerstaeubungstrocknungsvorrichtung zur Herstellung von Pulver,z.B. Milchpulver |
| IT1025765B (it) | 1974-11-18 | 1978-08-30 | Gastaldi Francesco | Essiccatore perfezionato a spruzzo |
| DE2741196A1 (de) * | 1977-09-13 | 1979-03-15 | Bayer Ag | Verfahren zur herstellung von perlpolymeren |
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| US4702799A (en) | 1985-09-03 | 1987-10-27 | Nestec S.A. | Dryer and drying method |
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| US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
| DE19613691A1 (de) * | 1996-04-05 | 1997-10-09 | Boehringer Ingelheim Int | Arzneimittel für die Behandlung von Tumorerkrankungen |
| US5858409A (en) * | 1996-04-17 | 1999-01-12 | Fmc Corporation | Hydrolyzed cellulose granulations for pharmaceuticals |
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| BR0307515A (pt) | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Método para fabricar dispersões de drogas amorfas sólidas secas por aspersão homogêneas usando bicos de pressão |
-
2003
- 2003-01-20 BR BR0307515-0A patent/BR0307515A/pt not_active IP Right Cessation
- 2003-01-20 CN CNA038047640A patent/CN1787808A/zh active Pending
- 2003-01-20 PL PL03371593A patent/PL371593A1/xx not_active Application Discontinuation
- 2003-01-20 AU AU2003239463A patent/AU2003239463B2/en not_active Ceased
- 2003-01-20 MX MXPA04007435A patent/MXPA04007435A/es active IP Right Grant
- 2003-01-20 RU RU2004123639/04A patent/RU2288703C2/ru not_active IP Right Cessation
- 2003-01-20 WO PCT/IB2003/000120 patent/WO2003063821A2/en active Application Filing
- 2003-01-20 RS YU67304A patent/RS67304A/sr unknown
- 2003-01-20 EP EP20030700071 patent/EP1469830A2/en not_active Withdrawn
- 2003-01-20 CA CA002474958A patent/CA2474958A1/en not_active Abandoned
- 2003-01-20 JP JP2003563515A patent/JP2005523260A/ja active Pending
- 2003-01-20 KR KR1020047011807A patent/KR100758045B1/ko not_active IP Right Cessation
- 2003-01-24 US US10/351,568 patent/US7780988B2/en active Active
- 2003-01-28 TW TW092101817A patent/TW200404576A/zh unknown
- 2003-01-29 PE PE2003000096A patent/PE20030804A1/es not_active Application Discontinuation
- 2003-01-30 GT GT200300024A patent/GT200300024A/es unknown
- 2003-01-30 AR ARP030100268A patent/AR038369A1/es unknown
- 2003-01-31 UY UY27645A patent/UY27645A1/es not_active Application Discontinuation
- 2003-02-03 PA PA20038565401A patent/PA8565401A1/es unknown
-
2004
- 2004-07-27 ZA ZA200405971A patent/ZA200405971B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1787808A (zh) | 2006-06-14 |
| PA8565401A1 (es) | 2003-12-10 |
| KR100758045B1 (ko) | 2007-09-11 |
| ZA200405971B (en) | 2006-05-31 |
| RU2004123639A (ru) | 2005-04-20 |
| KR20040083491A (ko) | 2004-10-02 |
| CA2474958A1 (en) | 2003-08-07 |
| JP2005523260A (ja) | 2005-08-04 |
| PL371593A1 (en) | 2005-06-27 |
| GT200300024A (es) | 2003-09-22 |
| PE20030804A1 (es) | 2003-09-19 |
| MXPA04007435A (es) | 2004-10-11 |
| AU2003239463B2 (en) | 2007-10-18 |
| BR0307515A (pt) | 2004-12-07 |
| UY27645A1 (es) | 2003-09-30 |
| TW200404576A (en) | 2004-04-01 |
| RU2288703C2 (ru) | 2006-12-10 |
| US7780988B2 (en) | 2010-08-24 |
| EP1469830A2 (en) | 2004-10-27 |
| RS67304A (en) | 2006-10-27 |
| WO2003063821A2 (en) | 2003-08-07 |
| US20030185893A1 (en) | 2003-10-02 |
| WO2003063821A3 (en) | 2003-11-13 |
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