AR035011A1 - Compuestos inhibidores de vla-4 - Google Patents
Compuestos inhibidores de vla-4Info
- Publication number
- AR035011A1 AR035011A1 ARP000103363A ARP000103363A AR035011A1 AR 035011 A1 AR035011 A1 AR 035011A1 AR P000103363 A ARP000103363 A AR P000103363A AR P000103363 A ARP000103363 A AR P000103363A AR 035011 A1 AR035011 A1 AR 035011A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- formula
- alkyl
- aryl
- lower alkyl
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14160299P | 1999-06-30 | 1999-06-30 | |
US14169299P | 1999-06-30 | 1999-06-30 | |
US14160199P | 1999-06-30 | 1999-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR035011A1 true AR035011A1 (es) | 2004-04-14 |
Family
ID=27385682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000103363A AR035011A1 (es) | 1999-06-30 | 2000-06-30 | Compuestos inhibidores de vla-4 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1189612A4 (fr) |
JP (1) | JP2003503350A (fr) |
CN (1) | CN1391473A (fr) |
AR (1) | AR035011A1 (fr) |
AU (1) | AU781438B2 (fr) |
BR (1) | BR0012068A (fr) |
CA (1) | CA2369308A1 (fr) |
HK (1) | HK1043318A1 (fr) |
IL (1) | IL146288A0 (fr) |
MX (1) | MXPA01013406A (fr) |
NO (1) | NO324892B1 (fr) |
TW (1) | TWI283240B (fr) |
WO (1) | WO2001000206A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2299879C2 (ru) * | 2000-01-17 | 2007-05-27 | Байер Акциенгезелльшафт | Замещенные арилкетоны |
DE10006453A1 (de) * | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
EP1296949A2 (fr) | 2000-06-21 | 2003-04-02 | Bristol-Myers Squibb Pharma Company | Amides de piperidine utilises comme modulateurs de l'activite des recepteurs des chimiokines |
RU2290403C2 (ru) | 2000-12-28 | 2006-12-27 | Дайити Фармасьютикал Ко., Лтд. | Ингибиторы vla-4 |
DE60222667T2 (de) | 2001-06-27 | 2008-07-17 | Smithkline Beecham Corp. | Fluorpyrrolidine als dipeptidylpeptidaseinhibitoren |
GB0123765D0 (en) * | 2001-10-03 | 2001-11-21 | Bayer Ag | Para-amino benzoic acids |
ATE421500T1 (de) * | 2002-05-09 | 2009-02-15 | Baker Med Res Inst | Aminosäureanaloga |
CN1678311A (zh) | 2002-06-27 | 2005-10-05 | 诺沃挪第克公司 | 用作治疗剂的芳基羰基衍生物 |
CA2744893A1 (fr) * | 2002-06-27 | 2004-01-08 | Novo Nordisk A/S | Derives d'arylcarbonyle servant d'activateurs de glucokinase |
JP4691988B2 (ja) * | 2002-10-03 | 2011-06-01 | 小野薬品工業株式会社 | Lpa受容体拮抗剤 |
GB0225944D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
JPWO2004099136A1 (ja) | 2003-05-09 | 2006-07-13 | 第一製薬株式会社 | ピロリジン誘導体の製造方法 |
CA2770493A1 (fr) | 2003-07-24 | 2005-02-03 | Daiichi Pharmaceutical Co., Ltd. | Compose acide cyclohexanecarboxylique |
EP1680109A4 (fr) * | 2003-10-07 | 2009-05-06 | Renovis Inc | Derives d'amide utilises comme ligands du canal ionique et compositions pharmaceutiques et methodes d'utilisation de ces derives |
CA2551324C (fr) | 2004-01-06 | 2012-11-27 | Novo Nordisk A/S | Heteroaryl-urees et leur utilisation en tant qu'activateurs de glucokinase |
JP2005350417A (ja) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | 還元的エーテル化法を用いたピロリジン誘導体の製造法 |
KR20070044054A (ko) * | 2004-08-16 | 2007-04-26 | 머크 앤드 캄파니 인코포레이티드 | Vla-4 길항제 |
EP1961750B1 (fr) | 2005-12-13 | 2013-09-18 | Daiichi Sankyo Company, Limited | Médicament inhibiteur de vla-4 |
AR068875A1 (es) | 2007-10-16 | 2009-12-09 | Novartis Ag | Derivados de 4-5-dihidro-5-oxo-imidazol,composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos como inhibidores de receptores de npy y2 no peptidicos, para el tratamiento de trastornos de ansiedad , depresion, trastornos metabolicos y endocrinos. |
PL2260020T3 (pl) * | 2008-03-26 | 2015-01-30 | Novartis Ag | Hydroksamianowe inhibitory deacetylaz B |
EA020506B1 (ru) * | 2009-11-18 | 2014-11-28 | Сувен Лайф Сайенсиз Лимитед | БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ЛИГАНДОВ αβНИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА |
JP5976011B2 (ja) * | 2011-04-05 | 2016-08-23 | 武田薬品工業株式会社 | スルホンアミド誘導体およびその用途 |
AU2019287437A1 (en) | 2018-06-12 | 2020-09-10 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
CN112969700A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的咪唑并吡啶衍生物 |
JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4β7インテグリンの阻害のための化合物 |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
EP3873897A1 (fr) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Composés pour l'inhibition de l'intégrine alpha 4 bêta 7 |
WO2020173861A1 (fr) | 2019-02-26 | 2020-09-03 | Bayer Aktiengesellschaft | Dérivés hétérocycliques bicycliques condensés utilisés comme pesticides |
WO2021030438A1 (fr) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Composés pour l'inhibition de l'intégrine alpha 4 bêta 7 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
US6248713B1 (en) * | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
CA2291778A1 (fr) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Composes d'amide heterocycliques utilises en tant qu'inhibiteurs de l'adhesion cellulaire |
WO1999020272A1 (fr) * | 1997-10-21 | 1999-04-29 | Merck & Co., Inc. | Acides azapeptidiques utilises comme inhibiteurs de l'adhesion cellulaire |
AU748041B2 (en) * | 1997-10-31 | 2002-05-30 | Aventis Pharma Limited | Substituted anilides |
WO1999054321A1 (fr) * | 1998-04-21 | 1999-10-28 | Aventis Pharma Limited | Diamines substituees et leur utilisation en tant qu'inhibiteurs d'adhesion cellulaire |
OA11577A (en) * | 1998-06-30 | 2004-07-26 | Pfizer Prod Inc | Non-peptidyl inhibitors of VLA-4 dependent cell vinding useful in treating inflammatory, autoimmune,and respiratory diseases. |
-
2000
- 2000-06-30 BR BR0012068-5A patent/BR0012068A/pt not_active Application Discontinuation
- 2000-06-30 CA CA002369308A patent/CA2369308A1/fr not_active Abandoned
- 2000-06-30 IL IL14628800A patent/IL146288A0/xx not_active IP Right Cessation
- 2000-06-30 AR ARP000103363A patent/AR035011A1/es unknown
- 2000-06-30 WO PCT/US2000/018079 patent/WO2001000206A1/fr active IP Right Grant
- 2000-06-30 CN CN00809510A patent/CN1391473A/zh active Pending
- 2000-06-30 TW TW089112968A patent/TWI283240B/zh not_active IP Right Cessation
- 2000-06-30 EP EP00945035A patent/EP1189612A4/fr not_active Withdrawn
- 2000-06-30 MX MXPA01013406A patent/MXPA01013406A/es active IP Right Grant
- 2000-06-30 AU AU59031/00A patent/AU781438B2/en not_active Ceased
- 2000-06-30 JP JP2001505915A patent/JP2003503350A/ja active Pending
-
2001
- 2001-12-21 NO NO20016319A patent/NO324892B1/no unknown
-
2002
- 2002-07-09 HK HK02105102.2A patent/HK1043318A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
NO20016319D0 (no) | 2001-12-21 |
WO2001000206A1 (fr) | 2001-01-04 |
NO324892B1 (no) | 2007-12-27 |
BR0012068A (pt) | 2002-05-14 |
EP1189612A1 (fr) | 2002-03-27 |
CA2369308A1 (fr) | 2001-01-04 |
AU5903100A (en) | 2001-01-31 |
TWI283240B (en) | 2007-07-01 |
JP2003503350A (ja) | 2003-01-28 |
MXPA01013406A (es) | 2003-09-04 |
CN1391473A (zh) | 2003-01-15 |
NO20016319L (no) | 2002-02-28 |
IL146288A0 (en) | 2002-07-25 |
EP1189612A4 (fr) | 2005-02-16 |
HK1043318A1 (zh) | 2002-09-13 |
AU781438B2 (en) | 2005-05-26 |
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