EP1189612A4 - Composes inhibiteurs de vla-4 - Google Patents
Composes inhibiteurs de vla-4Info
- Publication number
- EP1189612A4 EP1189612A4 EP00945035A EP00945035A EP1189612A4 EP 1189612 A4 EP1189612 A4 EP 1189612A4 EP 00945035 A EP00945035 A EP 00945035A EP 00945035 A EP00945035 A EP 00945035A EP 1189612 A4 EP1189612 A4 EP 1189612A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- vla
- inhibitor compounds
- inhibitor
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A61P11/06—Antiasthmatics
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- General Health & Medical Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14169299P | 1999-06-30 | 1999-06-30 | |
US14160299P | 1999-06-30 | 1999-06-30 | |
US14160199P | 1999-06-30 | 1999-06-30 | |
US141601P | 1999-06-30 | ||
US141692P | 1999-06-30 | ||
US141602P | 1999-06-30 | ||
PCT/US2000/018079 WO2001000206A1 (fr) | 1999-06-30 | 2000-06-30 | Composes inhibiteurs de vla-4 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1189612A1 EP1189612A1 (fr) | 2002-03-27 |
EP1189612A4 true EP1189612A4 (fr) | 2005-02-16 |
Family
ID=27385682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00945035A Withdrawn EP1189612A4 (fr) | 1999-06-30 | 2000-06-30 | Composes inhibiteurs de vla-4 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1189612A4 (fr) |
JP (1) | JP2003503350A (fr) |
CN (1) | CN1391473A (fr) |
AR (1) | AR035011A1 (fr) |
AU (1) | AU781438B2 (fr) |
BR (1) | BR0012068A (fr) |
CA (1) | CA2369308A1 (fr) |
HK (1) | HK1043318A1 (fr) |
IL (1) | IL146288A0 (fr) |
MX (1) | MXPA01013406A (fr) |
NO (1) | NO324892B1 (fr) |
TW (1) | TWI283240B (fr) |
WO (1) | WO2001000206A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2001053275A2 (fr) * | 2000-01-17 | 2001-07-26 | Bayer Aktiengesellschaft | Arylcetones substituees |
DE10006453A1 (de) * | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
CA2413418A1 (fr) | 2000-06-21 | 2001-12-27 | Joseph B. Santella | Amides de piperidine utilises comme modulateurs de l'activite des recepteurs des chimiokines |
ATE524441T1 (de) | 2000-12-28 | 2011-09-15 | Daiichi Seiyaku Co | Vla-4-inhibitoren |
CN1990468A (zh) | 2001-06-27 | 2007-07-04 | 史密丝克莱恩比彻姆公司 | 作为二肽酶抑制剂的氟代吡咯烷 |
GB0123765D0 (en) * | 2001-10-03 | 2001-11-21 | Bayer Ag | Para-amino benzoic acids |
US7956219B2 (en) * | 2002-05-09 | 2011-06-07 | Baker IDI Heart and Diabetes | Amino acid analogues |
PL215132B1 (pl) * | 2002-06-27 | 2013-10-31 | Novo Nordisk As | Pochodna arylokarbonylowa jako srodek terapeutyczny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca |
KR101124245B1 (ko) | 2002-06-27 | 2012-07-02 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
TW200408393A (en) * | 2002-10-03 | 2004-06-01 | Ono Pharmaceutical Co | Antagonist of lysophosphatidine acid receptor |
GB0225944D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
EP1623975A4 (fr) | 2003-05-09 | 2008-07-02 | Daiichi Seiyaku Co | Procede de production de derives de pyrrolidine |
JP4676884B2 (ja) | 2003-07-24 | 2011-04-27 | 第一三共株式会社 | シクロヘキサンカルボン酸類 |
US7432281B2 (en) * | 2003-10-07 | 2008-10-07 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
KR101196313B1 (ko) | 2004-01-06 | 2012-11-07 | 노보 노르디스크 에이/에스 | 헤테로아릴-유리아 및 글루코키나아제 활성제로서의 그들의사용 |
JP2005350417A (ja) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | 還元的エーテル化法を用いたピロリジン誘導体の製造法 |
EP1781686B1 (fr) * | 2004-08-16 | 2009-05-06 | Merck & Co., Inc. | Antagonistes de vla-4 |
JP5107724B2 (ja) | 2005-12-13 | 2012-12-26 | 第一三共株式会社 | Vla−4阻害薬 |
CN101827826A (zh) | 2007-10-16 | 2010-09-08 | 诺瓦提斯公司 | 4-苯基-5-氧代-咪唑衍生物、其药物组合物及其应用 |
WO2009118305A1 (fr) * | 2008-03-26 | 2009-10-01 | Novartis Ag | Inhibiteurs de désacétylases b à base d'hydroxamate |
KR101376145B1 (ko) * | 2009-11-18 | 2014-03-19 | 수벤 라이프 사이언시스 리미티드 | α₄β₂ 니코틴성 아세틸콜린 수용체 리간드로서 비시클릭 화합물 |
WO2012137982A2 (fr) * | 2011-04-05 | 2012-10-11 | Takeda Pharmaceutical Company Limited | Dérivé de sulfonamide et son utilisation |
AU2019287437A1 (en) | 2018-06-12 | 2020-09-10 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
WO2020092401A1 (fr) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOSÉS POUR INHIBITION DE L'INTÉGRINE ALPHA 4β7 |
JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリンの阻害のための化合物 |
CA3114240C (fr) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Derives d'imidazopyridine utilises en tant qu'inhibiteurs de l'integrine alpha4beta7 |
CA3116769C (fr) | 2018-10-30 | 2023-08-22 | Gilead Sciences, Inc. | Derives de quinoleine utilises en tant qu'inhibiteurs de l'integrine alpha4beta7 |
JP7535532B2 (ja) | 2019-02-26 | 2024-08-16 | バイエル・アクチエンゲゼルシヤフト | 有害生物防除剤としての縮合二環式複素環式誘導体 |
EP4013499A1 (fr) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Composés pour l'inhibition de l'intégrine alpha 4 bêta 7 |
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WO1999020272A1 (fr) * | 1997-10-21 | 1999-04-29 | Merck & Co., Inc. | Acides azapeptidiques utilises comme inhibiteurs de l'adhesion cellulaire |
WO1999023063A1 (fr) * | 1997-10-31 | 1999-05-14 | Aventis Pharma Limited | Anilides substituees |
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US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
US6248713B1 (en) * | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
CA2291778A1 (fr) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Composes d'amide heterocycliques utilises en tant qu'inhibiteurs de l'adhesion cellulaire |
AU3716499A (en) * | 1998-04-21 | 1999-11-08 | Aventis Pharma Limited | Substituted diamines and their use as cell adhesion inhibitors |
TR200003848T2 (tr) * | 1998-06-30 | 2001-06-21 | Pfizer Products Inc. | VLA-4'e bağlı hücre bağlanmasının peptidil olmayan önleyicileri. |
-
2000
- 2000-06-30 CA CA002369308A patent/CA2369308A1/fr not_active Abandoned
- 2000-06-30 TW TW089112968A patent/TWI283240B/zh not_active IP Right Cessation
- 2000-06-30 JP JP2001505915A patent/JP2003503350A/ja active Pending
- 2000-06-30 AU AU59031/00A patent/AU781438B2/en not_active Ceased
- 2000-06-30 BR BR0012068-5A patent/BR0012068A/pt not_active Application Discontinuation
- 2000-06-30 WO PCT/US2000/018079 patent/WO2001000206A1/fr active IP Right Grant
- 2000-06-30 MX MXPA01013406A patent/MXPA01013406A/es active IP Right Grant
- 2000-06-30 CN CN00809510A patent/CN1391473A/zh active Pending
- 2000-06-30 IL IL14628800A patent/IL146288A0/xx not_active IP Right Cessation
- 2000-06-30 EP EP00945035A patent/EP1189612A4/fr not_active Withdrawn
- 2000-06-30 AR ARP000103363A patent/AR035011A1/es unknown
-
2001
- 2001-12-21 NO NO20016319A patent/NO324892B1/no unknown
-
2002
- 2002-07-09 HK HK02105102.2A patent/HK1043318A1/zh unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1999020272A1 (fr) * | 1997-10-21 | 1999-04-29 | Merck & Co., Inc. | Acides azapeptidiques utilises comme inhibiteurs de l'adhesion cellulaire |
WO1999023063A1 (fr) * | 1997-10-31 | 1999-05-14 | Aventis Pharma Limited | Anilides substituees |
Non-Patent Citations (1)
Title |
---|
See also references of WO0100206A1 * |
Also Published As
Publication number | Publication date |
---|---|
NO20016319L (no) | 2002-02-28 |
TWI283240B (en) | 2007-07-01 |
NO324892B1 (no) | 2007-12-27 |
CN1391473A (zh) | 2003-01-15 |
AU781438B2 (en) | 2005-05-26 |
CA2369308A1 (fr) | 2001-01-04 |
WO2001000206A1 (fr) | 2001-01-04 |
JP2003503350A (ja) | 2003-01-28 |
MXPA01013406A (es) | 2003-09-04 |
IL146288A0 (en) | 2002-07-25 |
AR035011A1 (es) | 2004-04-14 |
HK1043318A1 (zh) | 2002-09-13 |
AU5903100A (en) | 2001-01-31 |
NO20016319D0 (no) | 2001-12-21 |
BR0012068A (pt) | 2002-05-14 |
EP1189612A1 (fr) | 2002-03-27 |
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