EP1189612A4 - Composes inhibiteurs de vla-4 - Google Patents

Composes inhibiteurs de vla-4

Info

Publication number
EP1189612A4
EP1189612A4 EP00945035A EP00945035A EP1189612A4 EP 1189612 A4 EP1189612 A4 EP 1189612A4 EP 00945035 A EP00945035 A EP 00945035A EP 00945035 A EP00945035 A EP 00945035A EP 1189612 A4 EP1189612 A4 EP 1189612A4
Authority
EP
European Patent Office
Prior art keywords
vla
inhibitor compounds
inhibitor
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00945035A
Other languages
German (de)
English (en)
Other versions
EP1189612A1 (fr
Inventor
John J Baldwin
Edward Mcdonald
Kevin Joseph Moriarty
Christopher Ronald Sarko
Nobuo Machinaga
Atsushi Nakayama
Jun Chiba
Shin Iimura
Yoshiyuki Yoneda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Pharmacopeia Drug Discovery Inc
Original Assignee
Daiichi Pharmaceutical Co Ltd
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd, Pharmacopeia Inc filed Critical Daiichi Pharmaceutical Co Ltd
Publication of EP1189612A1 publication Critical patent/EP1189612A1/fr
Publication of EP1189612A4 publication Critical patent/EP1189612A4/fr
Withdrawn legal-status Critical Current

Links

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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EP00945035A 1999-06-30 2000-06-30 Composes inhibiteurs de vla-4 Withdrawn EP1189612A4 (fr)

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US14169299P 1999-06-30 1999-06-30
US14160299P 1999-06-30 1999-06-30
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US141601P 1999-06-30
US141692P 1999-06-30
US141602P 1999-06-30
PCT/US2000/018079 WO2001000206A1 (fr) 1999-06-30 2000-06-30 Composes inhibiteurs de vla-4

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CA2413418A1 (fr) 2000-06-21 2001-12-27 Joseph B. Santella Amides de piperidine utilises comme modulateurs de l'activite des recepteurs des chimiokines
ATE524441T1 (de) 2000-12-28 2011-09-15 Daiichi Seiyaku Co Vla-4-inhibitoren
CN1990468A (zh) 2001-06-27 2007-07-04 史密丝克莱恩比彻姆公司 作为二肽酶抑制剂的氟代吡咯烷
GB0123765D0 (en) * 2001-10-03 2001-11-21 Bayer Ag Para-amino benzoic acids
US7956219B2 (en) * 2002-05-09 2011-06-07 Baker IDI Heart and Diabetes Amino acid analogues
PL215132B1 (pl) * 2002-06-27 2013-10-31 Novo Nordisk As Pochodna arylokarbonylowa jako srodek terapeutyczny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca
KR101124245B1 (ko) 2002-06-27 2012-07-02 노보 노르디스크 에이/에스 치료제로서 아릴 카르보닐 유도체
TW200408393A (en) * 2002-10-03 2004-06-01 Ono Pharmaceutical Co Antagonist of lysophosphatidine acid receptor
GB0225944D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
EP1623975A4 (fr) 2003-05-09 2008-07-02 Daiichi Seiyaku Co Procede de production de derives de pyrrolidine
JP4676884B2 (ja) 2003-07-24 2011-04-27 第一三共株式会社 シクロヘキサンカルボン酸類
US7432281B2 (en) * 2003-10-07 2008-10-07 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
KR101196313B1 (ko) 2004-01-06 2012-11-07 노보 노르디스크 에이/에스 헤테로아릴-유리아 및 글루코키나아제 활성제로서의 그들의사용
JP2005350417A (ja) * 2004-06-11 2005-12-22 Dai Ichi Seiyaku Co Ltd 還元的エーテル化法を用いたピロリジン誘導体の製造法
EP1781686B1 (fr) * 2004-08-16 2009-05-06 Merck & Co., Inc. Antagonistes de vla-4
JP5107724B2 (ja) 2005-12-13 2012-12-26 第一三共株式会社 Ｖｌａ−４阻害薬
CN101827826A (zh) 2007-10-16 2010-09-08 诺瓦提斯公司 4-苯基-5-氧代-咪唑衍生物、其药物组合物及其应用
WO2009118305A1 (fr) * 2008-03-26 2009-10-01 Novartis Ag Inhibiteurs de désacétylases b à base d'hydroxamate
KR101376145B1 (ko) * 2009-11-18 2014-03-19 수벤 라이프 사이언시스 리미티드 α₄β₂ 니코틴성 아세틸콜린 수용체 리간드로서 비시클릭 화합물
WO2012137982A2 (fr) * 2011-04-05 2012-10-11 Takeda Pharmaceutical Company Limited Dérivé de sulfonamide et son utilisation
AU2019287437A1 (en) 2018-06-12 2020-09-10 Vtv Therapeutics Llc Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
WO2020092401A1 (fr) 2018-10-30 2020-05-07 Gilead Sciences, Inc. COMPOSÉS POUR INHIBITION DE L'INTÉGRINE ALPHA 4β7
JP7189368B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ， インコーポレイテッド アルファ４ベータ７インテグリンの阻害のための化合物
CA3114240C (fr) 2018-10-30 2023-09-05 Gilead Sciences, Inc. Derives d'imidazopyridine utilises en tant qu'inhibiteurs de l'integrine alpha4beta7
CA3116769C (fr) 2018-10-30 2023-08-22 Gilead Sciences, Inc. Derives de quinoleine utilises en tant qu'inhibiteurs de l'integrine alpha4beta7
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TWI283240B (en) 2007-07-01
NO324892B1 (no) 2007-12-27
CN1391473A (zh) 2003-01-15
AU781438B2 (en) 2005-05-26
CA2369308A1 (fr) 2001-01-04
WO2001000206A1 (fr) 2001-01-04
JP2003503350A (ja) 2003-01-28
MXPA01013406A (es) 2003-09-04
IL146288A0 (en) 2002-07-25
AR035011A1 (es) 2004-04-14
HK1043318A1 (zh) 2002-09-13
AU5903100A (en) 2001-01-31
NO20016319D0 (no) 2001-12-21
BR0012068A (pt) 2002-05-14
EP1189612A1 (fr) 2002-03-27

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