NO306399B1 - Kondenserte pyrrolkarboksyanilider - Google Patents

Kondenserte pyrrolkarboksyanilider

Info

Publication number
NO306399B1
NO306399B1 NO961655A NO961655A NO306399B1 NO 306399 B1 NO306399 B1 NO 306399B1 NO 961655 A NO961655 A NO 961655A NO 961655 A NO961655 A NO 961655A NO 306399 B1 NO306399 B1 NO 306399B1
Authority
NO
Norway
Prior art keywords
straight
carbon atoms
branched chain
chain lower
lower alkyl
Prior art date
Application number
NO961655A
Other languages
English (en)
Other versions
NO961655D0 (no
NO961655L (no
Inventor
Pamela Albaugh
Alan Hutchison
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of NO961655D0 publication Critical patent/NO961655D0/no
Publication of NO961655L publication Critical patent/NO961655L/no
Publication of NO306399B1 publication Critical patent/NO306399B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
NO961655A 1993-10-27 1996-04-25 Kondenserte pyrrolkarboksyanilider NO306399B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/144,138 US5484944A (en) 1993-10-27 1993-10-27 Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
PCT/US1994/012300 WO1995011885A1 (en) 1993-10-27 1994-10-26 Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands

Publications (3)

Publication Number Publication Date
NO961655D0 NO961655D0 (no) 1996-04-25
NO961655L NO961655L (no) 1996-06-10
NO306399B1 true NO306399B1 (no) 1999-11-01

Family

ID=22507244

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961655A NO306399B1 (no) 1993-10-27 1996-04-25 Kondenserte pyrrolkarboksyanilider

Country Status (21)

Country Link
US (2) US5484944A (no)
EP (2) EP0825193A1 (no)
JP (1) JP3542356B2 (no)
KR (1) KR0181383B1 (no)
CN (1) CN1099413C (no)
AT (1) ATE168673T1 (no)
AU (1) AU701151B2 (no)
CA (1) CA2175204C (no)
CZ (1) CZ288027B6 (no)
DE (1) DE69411939T2 (no)
DK (1) DK0725775T3 (no)
ES (1) ES2122504T3 (no)
FI (1) FI961776A (no)
HU (1) HU219715B (no)
NO (1) NO306399B1 (no)
NZ (2) NZ275968A (no)
PL (1) PL180027B1 (no)
RU (2) RU2125989C1 (no)
SE (2) SE9601563L (no)
SK (2) SK282817B6 (no)
WO (1) WO1995011885A1 (no)

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US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
AU717630B2 (en) * 1995-06-05 2000-03-30 Neurogen Corporation Novel substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
US6211365B1 (en) 1996-01-19 2001-04-03 Neurogen Corporation Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
WO1997034870A1 (en) * 1996-03-22 1997-09-25 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) * 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
GB9622370D0 (en) * 1996-10-28 1997-01-08 Merck Sharp & Dohme Therapeutic agents
KR100386722B1 (ko) * 1997-11-13 2003-06-09 화이자 프로덕츠 인코포레이티드 피롤 아미드의 합성 방법
GT199800179A (es) * 1997-11-13 2000-05-02 Procedimiento de sintesis de pirrol amidas.
CO4980854A1 (es) * 1998-02-10 2000-11-27 Novartis Ag Inhibidores de celulas b particularmente amidas, proceso par su produccion y composiciones farmaceuticas que los contiene
WO1999043681A1 (en) 1998-02-26 1999-09-02 Neurogen Corporation 4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands
GB9812038D0 (en) 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
GB9900222D0 (en) 1999-01-06 1999-02-24 Merck Sharp & Dohme Therapeutic compounds
WO2000058303A1 (en) * 1999-03-29 2000-10-05 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
WO2001016103A1 (en) * 1999-08-31 2001-03-08 Neurogen Corporation Fused pyrrolecarboxamides: gaba brain receptor ligands
US6310212B1 (en) 2000-03-28 2001-10-30 Neurogen Corporation 4-substituted quinoline derivatives
US6528649B2 (en) * 2000-05-30 2003-03-04 Neurogen Corporation Imidazoloisoquinolines
WO2002012189A1 (fr) * 2000-08-09 2002-02-14 Mitsubishi Pharma Corporation Composes amide bicycliques condenses et utilisations medicales associees
US6861529B2 (en) * 2001-07-06 2005-03-01 Pfizer Inc Cycloalkypyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives
EP1472252A1 (en) * 2002-02-07 2004-11-03 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
EP4101846B1 (en) * 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
MX2008001200A (es) * 2005-07-28 2008-03-18 Hoffmann La Roche Derivados de acido 2-hidroxi-propionico y derivados de 3-hidroxi-benzofura-2-ona con afinidad para el receptor gaba-b.
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CN101263139A (zh) 2005-09-19 2008-09-10 弗·哈夫曼-拉罗切有限公司 作为GABA Aα5逆激动剂的异唑衍生物
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20070244143A1 (en) * 2006-03-08 2007-10-18 Braincells, Inc Modulation of neurogenesis by nootropic agents
BRPI0710213A2 (pt) * 2006-03-30 2011-04-12 Ptc Therapeutics Inc métodos para produzir uma quantidade efetiva de uma proteìna de transleitura funcional codificada por uma sequência de ácido nucleico que compreende uma mutação não-sentido e para tratar, controlar e/ou prevenir uma doença
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
WO2008030651A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
CA2663347A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. Ppar mediated modulation of neurogenesis
US8293737B2 (en) 2006-10-16 2012-10-23 Bionomics Limited Anxiolytic compounds
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP2014510065A (ja) 2011-03-02 2014-04-24 バイオノミックス リミテッド 治療薬としての新規な小分子
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines
CN106455571A (zh) 2014-03-06 2017-02-22 Ptc医疗公司 1,2,4‑噁二唑苯甲酸的药物组合物和盐
KR20180081516A (ko) 2015-10-30 2018-07-16 피티씨 테라퓨틱스, 인크. 간질 치료 방법

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DE3029980A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3147276A1 (de) * 1981-11-28 1983-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole
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US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
AU701151B2 (en) 1999-01-21
EP0725775B1 (en) 1998-07-22
HUT76064A (en) 1997-06-30
SK282994B6 (sk) 2003-01-09
DE69411939T2 (de) 1999-03-25
EP0725775A1 (en) 1996-08-14
DK0725775T3 (da) 1999-04-26
CN1143953A (zh) 1997-02-26
CA2175204C (en) 1999-10-05
FI961776A0 (fi) 1996-04-25
JPH09506082A (ja) 1997-06-17
CZ288027B6 (cs) 2001-04-11
FI961776A (fi) 1996-06-14
CZ112996A3 (en) 1997-04-16
HU219715B (hu) 2001-06-28
SE9902648L (sv) 1999-07-09
ES2122504T3 (es) 1998-12-16
ATE168673T1 (de) 1998-08-15
JP3542356B2 (ja) 2004-07-14
PL314136A1 (en) 1996-08-19
KR0181383B1 (ko) 1999-03-20
EP0825193A1 (en) 1998-02-25
CA2175204A1 (en) 1995-05-11
SE9601563D0 (sv) 1996-04-24
NZ275968A (en) 1998-05-27
SE9902648D0 (sv) 1999-07-09
SK52496A3 (en) 1997-07-09
NZ330023A (en) 1999-11-29
RU2125989C1 (ru) 1999-02-10
RU2157367C2 (ru) 2000-10-10
PL180027B1 (pl) 2000-12-29
DE69411939D1 (de) 1998-08-27
AU8126594A (en) 1995-05-22
HU9601106D0 (en) 1996-07-29
NO961655D0 (no) 1996-04-25
CN1099413C (zh) 2003-01-22
SE9601563L (sv) 1996-05-22
US5484944A (en) 1996-01-16
KR960705812A (ko) 1996-11-08
NO961655L (no) 1996-06-10
SK282817B6 (sk) 2002-12-03
WO1995011885A1 (en) 1995-05-04
US5608079A (en) 1997-03-04

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