DE69329084D1 - Benzoxazepin-Derivate als Cholinesterase-Inhibitoren - Google Patents

Benzoxazepin-Derivate als Cholinesterase-Inhibitoren

Info

Publication number
DE69329084D1
DE69329084D1 DE69329084T DE69329084T DE69329084D1 DE 69329084 D1 DE69329084 D1 DE 69329084D1 DE 69329084 T DE69329084 T DE 69329084T DE 69329084 T DE69329084 T DE 69329084T DE 69329084 D1 DE69329084 D1 DE 69329084D1
Authority
DE
Germany
Prior art keywords
ring
optionally substituted
denotes
integer
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69329084T
Other languages
English (en)
Other versions
DE69329084T2 (de
Inventor
Giichi Goto
Masaomi Miyamoto
Yuji Ishihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69329084D1 publication Critical patent/DE69329084D1/de
Publication of DE69329084T2 publication Critical patent/DE69329084T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69329084T 1992-04-24 1993-04-21 Benzoxazepin-Derivate als Cholinesterase-Inhibitoren Expired - Fee Related DE69329084T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10678992 1992-04-24
JP20565092 1992-07-31
JP30987292 1992-11-19

Publications (2)

Publication Number Publication Date
DE69329084D1 true DE69329084D1 (de) 2000-08-31
DE69329084T2 DE69329084T2 (de) 2000-12-21

Family

ID=27310829

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329084T Expired - Fee Related DE69329084T2 (de) 1992-04-24 1993-04-21 Benzoxazepin-Derivate als Cholinesterase-Inhibitoren

Country Status (5)

Country Link
US (1) US6319916B1 (de)
EP (1) EP0567090B1 (de)
AT (1) ATE194982T1 (de)
CA (1) CA2094767A1 (de)
DE (1) DE69329084T2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2144013A1 (en) * 1994-03-09 1995-09-10 Yuzo Yagi Hexahydropyrano [3, 2-b][1,4]benzothiazine derivative
US5658909A (en) 1994-11-17 1997-08-19 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease
US5705501A (en) 1994-11-17 1998-01-06 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-morpholinopropanones to treat Alzheimer's Disease
AU6852898A (en) 1997-04-17 1998-11-11 Takeda Chemical Industries Ltd. Thermogenic composition and benzazepine thermogenics
KR100639543B1 (ko) 1998-09-30 2006-10-31 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
MXPA04006344A (es) 2001-12-28 2005-03-31 Takeda Pharmaceutical Preventivos/remedios para la perturbacion de miccion.
EP1472237A4 (de) * 2002-02-06 2006-01-11 Yissum Res Dev Co Catechinbioisostere
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
PE20070702A1 (es) * 2005-11-02 2007-07-20 Takeda Pharmaceutical COMPUESTOS DERIVADOS DE (TRIFLUOROMETOXI-FENIL)-ETILAMINO COMO INHIBIDORES DE LA ACETILCOLINESTERASA Y ANTAGONISTAS DEL RECEPTOR DE ADRENALINA alfa1
WO2008108445A1 (ja) 2007-03-07 2008-09-12 Takeda Pharmaceutical Company Limited ベンゾオキサゼピン誘導体およびその用途
DE102007047737A1 (de) 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
EP4329765A1 (de) * 2021-04-27 2024-03-06 Merck Sharp & Dohme LLC Phenylazepine als ripk1-inhibitoren und verfahren zur verwendung davon
CN113387955B (zh) * 2021-06-01 2023-03-10 兰州大学 一种1,2,3,4-四氢噌啉骨架类化合物及其合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2035749A1 (de) * 1969-02-06 1970-12-24 Bellon Labor Sa Roger
CA1041523A (en) * 1974-06-19 1978-10-31 Queen's University Preparation of 1-oxapenicillins and novel intermediates therefor
FR2332010A1 (fr) 1975-11-18 1977-06-17 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
FR2491066A1 (fr) * 1980-09-29 1982-04-02 Cerm Cent Europ Rech Mauvernay Benzoxazolinones substituees en 6 par une chaine aminoalcool ou aminocetone, leur preparation et leur application en therapeutique
JPS597185A (ja) 1982-07-02 1984-01-14 Mitsubishi Chem Ind Ltd １，５−ベンゾジオキセピン誘導体およびその酸付加塩
US4613598A (en) * 1984-03-13 1986-09-23 Mitsubishi Chemical Industries Limited Piperazine derivatives and their acid addition salts
DK623586A (da) 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2637286A1 (fr) * 1988-10-04 1990-04-06 Adir Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
TW197435B (de) 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
DE69329084T2 (de) 2000-12-21
EP0567090A3 (de) 1994-03-30
EP0567090B1 (de) 2000-07-26
EP0567090A2 (de) 1993-10-27
US6319916B1 (en) 2001-11-20
ATE194982T1 (de) 2000-08-15
CA2094767A1 (en) 1993-10-25

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP

8339 Ceased/non-payment of the annual fee