AR033659A1 - El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene - Google Patents

El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene

Info

Publication number
AR033659A1
AR033659A1 ARP000106217A ARP000106217A AR033659A1 AR 033659 A1 AR033659 A1 AR 033659A1 AR P000106217 A ARP000106217 A AR P000106217A AR P000106217 A ARP000106217 A AR P000106217A AR 033659 A1 AR033659 A1 AR 033659A1
Authority
AR
Argentina
Prior art keywords
compound
bis
phenyl
prepare
methyl
Prior art date
Application number
ARP000106217A
Other languages
English (en)
Spanish (es)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR033659A1 publication Critical patent/AR033659A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ARP000106217A 1999-11-29 2000-11-27 El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene AR033659A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
AR033659A1 true AR033659A1 (es) 2004-01-07

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106217A AR033659A1 (es) 1999-11-29 2000-11-27 El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene

Country Status (49)

Country Link
EP (1) EP1103545B1 (en:Method)
JP (1) JP3480835B2 (en:Method)
KR (1) KR100390117B1 (en:Method)
CN (1) CN1152016C (en:Method)
AR (1) AR033659A1 (en:Method)
AT (1) ATE253561T1 (en:Method)
AU (1) AU775292B2 (en:Method)
BG (1) BG64622B1 (en:Method)
BR (1) BRPI0005616B8 (en:Method)
CA (1) CA2326529C (en:Method)
CO (1) CO5251405A1 (en:Method)
CZ (1) CZ299286B6 (en:Method)
DE (2) DE60006340T2 (en:Method)
DK (1) DK1103545T3 (en:Method)
DO (1) DOP2000000106A (en:Method)
EA (1) EA004404B1 (en:Method)
ES (2) ES2208205T3 (en:Method)
FR (1) FR2801590A1 (en:Method)
GB (1) GB2356863A (en:Method)
GC (1) GC0000151A (en:Method)
GE (1) GEP20022763B (en:Method)
GT (1) GT200000197A (en:Method)
HR (1) HRP20000809A2 (en:Method)
HU (1) HU224703B1 (en:Method)
ID (1) ID28483A (en:Method)
IL (1) IL139868A (en:Method)
IS (1) IS2212B (en:Method)
IT (1) IT1320120B1 (en:Method)
JO (1) JO2298B1 (en:Method)
MA (1) MA26754A1 (en:Method)
MX (1) MXPA00011672A (en:Method)
MY (1) MY127426A (en:Method)
NO (1) NO317264B1 (en:Method)
NZ (1) NZ508386A (en:Method)
OA (1) OA11513A (en:Method)
PA (1) PA8507201A1 (en:Method)
PE (1) PE20010901A1 (en:Method)
PL (1) PL195957B1 (en:Method)
PT (1) PT1103545E (en:Method)
SG (1) SG97171A1 (en:Method)
SI (1) SI1103545T1 (en:Method)
SK (1) SK285373B6 (en:Method)
SV (1) SV2002000227A (en:Method)
TN (1) TNSN00226A1 (en:Method)
TR (1) TR200302077T4 (en:Method)
UA (1) UA70326C2 (en:Method)
UY (1) UY26458A1 (en:Method)
YU (1) YU73400A (en:Method)
ZA (1) ZA200006964B (en:Method)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1394150E (pt) * 1999-02-24 2011-02-17 Hoffmann La Roche Derivados de 4-fenilpiridina e a sua utilização como antagonistas dos receptores de nc-1
TR200102490T2 (tr) * 1999-02-24 2001-12-21 F.Hoffmann-La Roche Ag Fenil ve piridinil türevleri
EP1303490B1 (en) * 2000-07-14 2008-07-09 F. Hoffmann-La Roche Ag N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
JP2005515788A (ja) * 2002-01-31 2005-06-02 エフ．ホフマン−ラ　ロシュ　アーゲー プレプロタキキニン遺伝子における遺伝子多型
DK1643998T3 (da) 2003-07-03 2007-12-27 Hoffmann La Roche NK1/NK3-antagonister til behandling af skizofreni
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
DE602005026669D1 (de) 2004-07-06 2011-04-14 Hoffmann La Roche Herstellungsverfahren für carboxamid-pyridin-derivate als zwischenprodukte bei der synthese von nk-1-rezeptor-antagonisten
KR20070094666A (ko) 2005-02-25 2007-09-20 에프. 호프만-라 로슈 아게 약제 물질 분산성이 향상된 정제
BRPI0609699A2 (pt) 2005-03-23 2010-04-20 Hoffmann La Roche metabolitos para antatonistas de nk-1 para êmese
DE602006011485D1 (de) 2005-09-23 2010-02-11 Hoffmann La Roche Neue dosierformulierung
WO2008090117A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
AP2015008722A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EP3067349B1 (en) 2013-11-08 2018-02-28 Kissei Pharmaceutical Co., Ltd. Carboxymethyl piperidine derivative
CN114181194A (zh) 2014-02-07 2022-03-15 全球血液疗法股份有限公司 一种化合物的结晶多晶型物
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체
KR102328682B1 (ko) 2018-08-27 2021-11-18 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0533280T4 (da) * 1991-09-20 2005-02-28 Glaxo Group Ltd Ny medicinsk anvendelse af tachykininantagonister
CA2099233A1 (en) * 1992-06-29 1993-12-30 Conrad P. Dorn Morpholine and thiomorpholine tachykinin receptor antagonists
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
CA2178219C (en) * 1993-12-29 2005-03-22 Raymond Baker Substituted morpholine derivatives and their use as therapeutic agents
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
DE69628484T2 (de) * 1995-03-24 2004-05-19 Takeda Chemical Industries, Ltd. Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
PT1394150E (pt) * 1999-02-24 2011-02-17 Hoffmann La Roche Derivados de 4-fenilpiridina e a sua utilização como antagonistas dos receptores de nc-1
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
EP1303490B1 (en) * 2000-07-14 2008-07-09 F. Hoffmann-La Roche Ag N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
NZ508386A (en) 2003-02-28
CN1152016C (zh) 2004-06-02
ID28483A (id) 2001-05-31
YU73400A (sh) 2003-02-28
PE20010901A1 (es) 2001-09-20
EP1103545A1 (en) 2001-05-30
MA26754A1 (fr) 2004-12-20
GT200000197A (es) 2002-05-22
UY26458A1 (es) 2001-05-31
DE60006340D1 (de) 2003-12-11
DE60006340T2 (de) 2004-09-09
GC0000151A (en) 2005-06-29
SG97171A1 (en) 2003-07-18
EA200001114A2 (ru) 2001-08-27
GB0028566D0 (en) 2001-01-10
ES2208205T3 (es) 2004-06-16
ITMI20002575A1 (it) 2002-05-29
PT1103545E (pt) 2004-03-31
HK1036759A1 (en) 2002-01-18
DE10058310A1 (de) 2001-05-31
CO5251405A1 (es) 2003-02-28
JP3480835B2 (ja) 2003-12-22
HU224703B1 (en) 2006-01-30
JP2001151754A (ja) 2001-06-05
SV2002000227A (es) 2002-02-05
MXPA00011672A (es) 2002-08-20
TR200302077T4 (tr) 2004-01-21
ES2171134A1 (es) 2002-08-16
HU0004725D0 (en:Method) 2001-02-28
IL139868A0 (en) 2002-02-10
SI1103545T1 (en) 2004-02-29
GB2356863A (en) 2001-06-06
DOP2000000106A (es) 2002-07-30
BR0005616A (pt) 2001-07-17
KR20010051983A (ko) 2001-06-25
FR2801590A1 (fr) 2001-06-01
JO2298B1 (en) 2005-09-12
HUP0004725A2 (hu) 2002-04-29
IT1320120B1 (it) 2003-11-18
BG104992A (en) 2001-11-30
OA11513A (fr) 2004-02-03
UA70326C2 (en) 2004-10-15
IS5725A (is) 2001-05-29
GEP20022763B (en) 2002-08-26
ZA200006964B (en) 2001-06-05
CA2326529A1 (en) 2001-05-29
AU7178700A (en) 2001-05-31
SK17932000A3 (sk) 2001-11-06
EP1103545B1 (en) 2003-11-05
CZ299286B6 (cs) 2008-06-04
SK285373B6 (sk) 2006-12-07
NO20006012L (no) 2001-05-30
TNSN00226A1 (fr) 2002-05-30
CN1297888A (zh) 2001-06-06
PA8507201A1 (es) 2002-02-21
KR100390117B1 (ko) 2003-07-04
PL344147A1 (en) 2001-06-04
IL139868A (en) 2009-09-01
HRP20000809A2 (en) 2001-12-31
NO20006012D0 (no) 2000-11-28
BRPI0005616B8 (pt) 2021-07-06
BG64622B1 (bg) 2005-09-30
CZ20004399A3 (cs) 2001-07-11
EA200001114A3 (ru) 2001-12-24
BRPI0005616B1 (pt) 2017-12-12
IS2212B (is) 2007-02-15
CA2326529C (en) 2009-12-22
AU775292B2 (en) 2004-07-29
EA004404B1 (ru) 2004-04-29
NO317264B1 (no) 2004-09-27
DK1103545T3 (da) 2004-03-15
MY127426A (en) 2006-11-30
ATE253561T1 (de) 2003-11-15
PL195957B1 (pl) 2007-11-30

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