AR032175A1 - Proceso para la fabricacion de acidos n-aril-antranilicos y sus derivados - Google Patents
Proceso para la fabricacion de acidos n-aril-antranilicos y sus derivadosInfo
- Publication number
- AR032175A1 AR032175A1 ARP010104047A ARP010104047A AR032175A1 AR 032175 A1 AR032175 A1 AR 032175A1 AR P010104047 A ARP010104047 A AR P010104047A AR P010104047 A ARP010104047 A AR P010104047A AR 032175 A1 AR032175 A1 AR 032175A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- aryl
- alkyl
- hydrogen
- metal cation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22820600P | 2000-08-25 | 2000-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032175A1 true AR032175A1 (es) | 2003-10-29 |
Family
ID=22856235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104047A AR032175A1 (es) | 2000-08-25 | 2001-08-24 | Proceso para la fabricacion de acidos n-aril-antranilicos y sus derivados |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1313694A1 (bg) |
| JP (1) | JP2004507518A (bg) |
| KR (1) | KR20030059115A (bg) |
| CN (1) | CN1458921A (bg) |
| AP (1) | AP2001002249A0 (bg) |
| AR (1) | AR032175A1 (bg) |
| AU (1) | AU2001277044A1 (bg) |
| BG (1) | BG107635A (bg) |
| BR (1) | BR0113520A (bg) |
| CA (1) | CA2420003A1 (bg) |
| CZ (1) | CZ2003477A3 (bg) |
| DO (1) | DOP2001000238A (bg) |
| EA (1) | EA200300187A1 (bg) |
| GT (1) | GT200100174A (bg) |
| HN (1) | HN2001000216A (bg) |
| HU (1) | HUP0300828A2 (bg) |
| IL (1) | IL154507A0 (bg) |
| IS (1) | IS6724A (bg) |
| MA (1) | MA26949A1 (bg) |
| MX (1) | MXPA03001654A (bg) |
| NO (1) | NO20030844L (bg) |
| PA (1) | PA8526501A1 (bg) |
| PE (1) | PE20020393A1 (bg) |
| PL (1) | PL360699A1 (bg) |
| SK (1) | SK2072003A3 (bg) |
| SV (1) | SV2002000601A (bg) |
| TN (1) | TNSN01127A1 (bg) |
| UY (1) | UY26908A1 (bg) |
| WO (1) | WO2002018319A1 (bg) |
| YU (1) | YU14303A (bg) |
| ZA (1) | ZA200301182B (bg) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI350285B (en) | 2002-03-13 | 2011-10-11 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
| BRPI0415710A (pt) | 2003-10-21 | 2006-12-19 | Warner Lambert Co | formas polimórficas de n-[(r)-2,3-dihidróxi-propóxi]-3,4-diflúor-2-(2-flúor-4-io dofenilamino)-benzamida |
| US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
| US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| PL1689387T3 (pl) | 2003-11-19 | 2012-02-29 | Array Biopharma Inc | Bicykliczne inhibitory MEK i sposoby ich otrzymywania |
| RU2006121990A (ru) | 2003-11-21 | 2007-12-27 | Эррэй Биофарма Инк. (Us) | Ингибиторы протеинкиназ акт |
| UA89035C2 (ru) * | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
| EP2332909B1 (en) | 2005-04-13 | 2014-10-15 | Astex Therapeutics Limited | Hydroxybenzamide derivatives and their use as inhibitors of hsp90 |
| EP2361905B1 (en) | 2005-05-18 | 2013-03-06 | Array Biopharma Inc. | Heterocyclic Inhibitors of MEK and methods of use thereof |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| CN101516891B (zh) | 2006-07-06 | 2013-06-05 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的二氢噻吩并嘧啶 |
| SI2049500T1 (sl) | 2006-07-06 | 2012-01-31 | Array Biopharma Inc | Ciklopenta (d) pirimidini kot AKT protein kinazni inhibitorji |
| CA2656566C (en) | 2006-07-06 | 2014-06-17 | Array Biopharma Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2073804B1 (en) | 2006-10-12 | 2017-09-13 | Astex Therapeutics Limited | Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain |
| WO2008044027A2 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical compounds having hsp90 inhibitory or modulating activity |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2073802A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| WO2009006569A1 (en) | 2007-07-05 | 2009-01-08 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| KR20150089099A (ko) | 2007-07-05 | 2015-08-04 | 어레이 바이오파마 인크. | Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄 |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| CN101932564B (zh) | 2008-01-09 | 2012-12-26 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷类 |
| ES2401685T3 (es) | 2008-01-09 | 2013-04-23 | Array Biopharma, Inc. | Pirimidil ciclopentano hidroxilado como inhibidor de la proteína quinasa AKT |
| GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| CN101985428B (zh) * | 2009-07-29 | 2014-02-12 | 杭州民生药业有限公司 | 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途 |
| CA2789373A1 (en) * | 2010-02-19 | 2011-08-25 | Centre National De La Recherche Scientifique | Process for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group |
| CA2789361A1 (en) * | 2010-02-19 | 2011-08-25 | Jacques Mortier | Method for preparing chemical compounds of interest by aromatic nucleophilic substitution |
| EP2694073B1 (en) | 2011-04-01 | 2018-08-08 | Genentech, Inc. | Combinations of akt and mek inhibitors for treating cancer |
| KR102021157B1 (ko) | 2011-04-01 | 2019-09-11 | 제넨테크, 인크. | Ａｋｔ 억제제 화합물 및 아비라테론의 조합물, 및 사용 방법 |
| MX2015004660A (es) * | 2012-10-12 | 2015-08-07 | Exelixis Inc | Proceso novedoso para la elaboración de compuestos para su uso en el tratamiento del cáncer. |
| CN112745237B (zh) * | 2019-10-29 | 2023-06-20 | 中国科学院上海药物研究所 | 2-芳基胺类化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3138636A (en) * | 1960-06-23 | 1964-06-23 | Parke Davis & Co | Anthranilic acid derivatives |
| US6251943B1 (en) * | 1997-02-28 | 2001-06-26 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a MEK inhibitor |
| DE69836378T2 (de) * | 1997-07-01 | 2007-10-11 | Warner-Lambert Co. Llc | Benzoesäure- und Benzamid-Derivate von Anthranilsäure und ihre Anwendung als MEK-Inhibitoren |
| ES2229515T3 (es) * | 1997-07-01 | 2005-04-16 | Warner-Lambert Company Llc | Derivados 4-bromo o 4-yodo del acido fenilamino benzhidroxamico y su uso como inhibidores de la mek. |
| CA2348236A1 (en) * | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors |
| CN1213997C (zh) * | 1999-04-21 | 2005-08-10 | 沃尼尔·朗伯公司 | 制备－2－(n－苯基氨基)苯甲酸衍生物的方法 |
-
2001
- 2001-07-20 CA CA002420003A patent/CA2420003A1/en not_active Abandoned
- 2001-07-20 MX MXPA03001654A patent/MXPA03001654A/es unknown
- 2001-07-20 KR KR10-2003-7002675A patent/KR20030059115A/ko not_active Application Discontinuation
- 2001-07-20 AU AU2001277044A patent/AU2001277044A1/en not_active Abandoned
- 2001-07-20 CZ CZ2003477A patent/CZ2003477A3/cs unknown
- 2001-07-20 EA EA200300187A patent/EA200300187A1/ru unknown
- 2001-07-20 IL IL15450701A patent/IL154507A0/xx unknown
- 2001-07-20 JP JP2002523437A patent/JP2004507518A/ja active Pending
- 2001-07-20 SK SK207-2003A patent/SK2072003A3/sk unknown
- 2001-07-20 BR BR0113520-1A patent/BR0113520A/pt not_active Application Discontinuation
- 2001-07-20 YU YU14303A patent/YU14303A/sh unknown
- 2001-07-20 PL PL36069901A patent/PL360699A1/xx unknown
- 2001-07-20 CN CN01815869A patent/CN1458921A/zh active Pending
- 2001-07-20 WO PCT/US2001/022948 patent/WO2002018319A1/en not_active Application Discontinuation
- 2001-07-20 EP EP01954824A patent/EP1313694A1/en not_active Withdrawn
- 2001-07-20 HU HU0300828A patent/HUP0300828A2/hu unknown
- 2001-07-20 AP APAP/P/2001/002249A patent/AP2001002249A0/en unknown
- 2001-08-15 SV SV2001000601A patent/SV2002000601A/es not_active Application Discontinuation
- 2001-08-22 TN TNTNSN01127A patent/TNSN01127A1/en unknown
- 2001-08-23 PA PA20018526501A patent/PA8526501A1/es unknown
- 2001-08-24 AR ARP010104047A patent/AR032175A1/es unknown
- 2001-08-24 DO DO2001000238A patent/DOP2001000238A/es unknown
- 2001-08-24 PE PE2001000853A patent/PE20020393A1/es not_active Application Discontinuation
- 2001-08-24 UY UY26908A patent/UY26908A1/es not_active Application Discontinuation
- 2001-08-24 GT GT200100174A patent/GT200100174A/es unknown
- 2001-09-26 HN HN2001000216A patent/HN2001000216A/es unknown
-
2003
- 2003-02-12 ZA ZA200301182A patent/ZA200301182B/en unknown
- 2003-02-20 IS IS6724A patent/IS6724A/is unknown
- 2003-02-24 NO NO20030844A patent/NO20030844L/no not_active Application Discontinuation
- 2003-03-13 BG BG107635A patent/BG107635A/bg unknown
- 2003-03-14 MA MA27069A patent/MA26949A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG107635A (bg) | 2004-09-30 |
| MA26949A1 (fr) | 2004-12-20 |
| PE20020393A1 (es) | 2002-05-09 |
| KR20030059115A (ko) | 2003-07-07 |
| CZ2003477A3 (cs) | 2003-10-15 |
| SV2002000601A (es) | 2002-04-03 |
| DOP2001000238A (es) | 2003-01-31 |
| MXPA03001654A (es) | 2004-09-10 |
| CN1458921A (zh) | 2003-11-26 |
| PA8526501A1 (es) | 2002-07-30 |
| PL360699A1 (en) | 2004-09-20 |
| IL154507A0 (en) | 2003-09-17 |
| TNSN01127A1 (en) | 2005-11-10 |
| NO20030844L (no) | 2003-02-25 |
| NO20030844D0 (no) | 2003-02-24 |
| UY26908A1 (es) | 2001-11-30 |
| IS6724A (is) | 2003-02-20 |
| YU14303A (sh) | 2006-08-17 |
| AP2001002249A0 (en) | 2001-09-30 |
| AU2001277044A1 (en) | 2002-03-13 |
| JP2004507518A (ja) | 2004-03-11 |
| CA2420003A1 (en) | 2002-03-07 |
| HUP0300828A2 (hu) | 2003-09-29 |
| EP1313694A1 (en) | 2003-05-28 |
| SK2072003A3 (en) | 2004-01-08 |
| GT200100174A (es) | 2002-07-18 |
| ZA200301182B (en) | 2004-05-12 |
| BR0113520A (pt) | 2003-06-24 |
| EA200300187A1 (ru) | 2003-08-28 |
| WO2002018319A1 (en) | 2002-03-07 |
| HN2001000216A (es) | 2002-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |