JP2004507518A - Ｎ−アリール−アントラニル酸及びその誘導体の製造法 - Google Patents

Ｎ−アリール−アントラニル酸及びその誘導体の製造法 Download PDF

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Publication number
JP2004507518A
JP2004507518A JP2002523437A JP2002523437A JP2004507518A JP 2004507518 A JP2004507518 A JP 2004507518A JP 2002523437 A JP2002523437 A JP 2002523437A JP 2002523437 A JP2002523437 A JP 2002523437A JP 2004507518 A JP2004507518 A JP 2004507518A
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JP
Japan
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alkyl
formula
compound
hydrogen
group
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JP2002523437A
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English (en)
Japanese (ja)
Inventor
マイクル・フワイ・グー・チェン
エドワード・マーク・デイヴィス
ハビエル・マガーノ
トマス・ノーマン・ナニンガ
デリク・デイル・ウィンクル
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ワーナー−ランバート・カンパニー・エルエルシー
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Publication of JP2004507518A publication Critical patent/JP2004507518A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
JP2002523437A 2000-08-25 2001-07-20 Ｎ−アリール−アントラニル酸及びその誘導体の製造法 Pending JP2004507518A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25
PCT/US2001/022948 WO2002018319A1 (en) 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives

Publications (1)

Publication Number Publication Date
JP2004507518A true JP2004507518A (ja) 2004-03-11

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002523437A Pending JP2004507518A (ja) 2000-08-25 2001-07-20 Ｎ−アリール−アントラニル酸及びその誘導体の製造法

Country Status (31)

Country Link
EP (1) EP1313694A1 (bg)
JP (1) JP2004507518A (bg)
KR (1) KR20030059115A (bg)
CN (1) CN1458921A (bg)
AP (1) AP2001002249A0 (bg)
AR (1) AR032175A1 (bg)
AU (1) AU2001277044A1 (bg)
BG (1) BG107635A (bg)
BR (1) BR0113520A (bg)
CA (1) CA2420003A1 (bg)
CZ (1) CZ2003477A3 (bg)
DO (1) DOP2001000238A (bg)
EA (1) EA200300187A1 (bg)
GT (1) GT200100174A (bg)
HN (1) HN2001000216A (bg)
HU (1) HUP0300828A2 (bg)
IL (1) IL154507A0 (bg)
IS (1) IS6724A (bg)
MA (1) MA26949A1 (bg)
MX (1) MXPA03001654A (bg)
NO (1) NO20030844L (bg)
PA (1) PA8526501A1 (bg)
PE (1) PE20020393A1 (bg)
PL (1) PL360699A1 (bg)
SK (1) SK2072003A3 (bg)
SV (1) SV2002000601A (bg)
TN (1) TNSN01127A1 (bg)
UY (1) UY26908A1 (bg)
WO (1) WO2002018319A1 (bg)
YU (1) YU14303A (bg)
ZA (1) ZA200301182B (bg)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013519715A (ja) * 2010-02-19 2013-05-30 センター ナショナル デ ラ リシェルシェ サイエンティフィック 少なくとも１つの電子求引性基を有する芳香族カルボン酸誘導体の芳香族求核置換による目的の化学化合物の調製方法
JP2013519714A (ja) * 2010-02-19 2013-05-30 センター ナショナル デ ラ リシェルシェ サイエンティフィック 芳香族求核置換によって目的の化学化合物を調製するための方法
JP2015533175A (ja) * 2012-10-12 2015-11-19 エグゼリクシス， インコーポレイテッド 癌の処置に使用するための化合物の製造方法

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US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
PT3000810T (pt) 2002-03-13 2017-10-25 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
AU2004283148A1 (en) 2003-10-21 2005-05-06 Warner-Lambert Company Llc Polymorphic form of N-[(R)-2,3-Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
PT1682138E (pt) 2003-11-19 2011-02-28 Array Biopharma Inc Inibidores heterocíclicos de mek
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
WO2005051304A2 (en) 2003-11-21 2005-06-09 Array Biopharma Inc. Akt protein kinase inhibitors
UA89035C2 (ru) 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
CA2604042C (en) 2005-04-13 2016-06-21 Astex Therapeutics Limited Pharmaceutical compounds
EP1922307B1 (en) 2005-05-18 2011-12-28 Array Biopharma, Inc. Heterocyclic inhibitors of mek and methods of use thereof
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2008006025A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
SI2054418T1 (sl) 2006-07-06 2012-02-29 Array Biopharma Inc Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji
CN103288753A (zh) 2006-07-06 2013-09-11 阵列生物制药公司 作为akt蛋白激酶抑制剂的环戊二烯并[d]嘧啶
WO2008044029A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
JP5410285B2 (ja) 2006-10-12 2014-02-05 アステックス、セラピューティックス、リミテッド 医薬化合物
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US8377937B2 (en) 2007-07-05 2013-02-19 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
WO2009006567A2 (en) 2007-07-05 2009-01-08 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
NZ586720A (en) 2008-01-09 2012-11-30 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
AU2009204025B2 (en) 2008-01-09 2014-02-20 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
PT2694072T (pt) 2011-04-01 2018-02-26 Genentech Inc Combinação de composto inibidor de akt e abiraterona para utilização em tratamentos terapêuticos
US9682082B2 (en) 2011-04-01 2017-06-20 Genentech, Inc. Combinations of AKT and MEK inhibitor compounds, and methods of use
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

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US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
AU5610398A (en) * 1997-02-28 1998-09-18 Warner-Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
NZ501277A (en) * 1997-07-01 2002-12-20 Warner Lambert Co -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
CN1163475C (zh) * 1997-07-01 2004-08-25 沃尼尔·朗伯公司 4-溴或4-碘苯基氨基苯氧肟酸衍生物及其作为mek抑制剂的用途
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
TR200103015T2 (tr) * 1999-04-21 2002-01-21 Warner-Lambert Company 2-(N-Fenilamino) benzoik asitler üretmek için yöntemler.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013519715A (ja) * 2010-02-19 2013-05-30 センター ナショナル デ ラ リシェルシェ サイエンティフィック 少なくとも１つの電子求引性基を有する芳香族カルボン酸誘導体の芳香族求核置換による目的の化学化合物の調製方法
JP2013519714A (ja) * 2010-02-19 2013-05-30 センター ナショナル デ ラ リシェルシェ サイエンティフィック 芳香族求核置換によって目的の化学化合物を調製するための方法
JP2015533175A (ja) * 2012-10-12 2015-11-19 エグゼリクシス， インコーポレイテッド 癌の処置に使用するための化合物の製造方法

Also Published As

Publication number Publication date
SK2072003A3 (en) 2004-01-08
MA26949A1 (fr) 2004-12-20
EP1313694A1 (en) 2003-05-28
HUP0300828A2 (hu) 2003-09-29
PA8526501A1 (es) 2002-07-30
PL360699A1 (en) 2004-09-20
EA200300187A1 (ru) 2003-08-28
PE20020393A1 (es) 2002-05-09
UY26908A1 (es) 2001-11-30
DOP2001000238A (es) 2003-01-31
MXPA03001654A (es) 2004-09-10
TNSN01127A1 (en) 2005-11-10
WO2002018319A1 (en) 2002-03-07
KR20030059115A (ko) 2003-07-07
NO20030844D0 (no) 2003-02-24
BR0113520A (pt) 2003-06-24
AP2001002249A0 (en) 2001-09-30
ZA200301182B (en) 2004-05-12
HN2001000216A (es) 2002-05-22
IL154507A0 (en) 2003-09-17
CA2420003A1 (en) 2002-03-07
GT200100174A (es) 2002-07-18
AR032175A1 (es) 2003-10-29
SV2002000601A (es) 2002-04-03
CN1458921A (zh) 2003-11-26
NO20030844L (no) 2003-02-25
BG107635A (bg) 2004-09-30
IS6724A (is) 2003-02-20
CZ2003477A3 (cs) 2003-10-15
AU2001277044A1 (en) 2002-03-13
YU14303A (sh) 2006-08-17

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