AR029775A1 - Derivados de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2-sustituidas, procedimiento para su preparacion, formas cristalinas de los mismos y metodo de tratamiento de la aterosclerosis que lo utiliza - Google Patents
Derivados de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2-sustituidas, procedimiento para su preparacion, formas cristalinas de los mismos y metodo de tratamiento de la aterosclerosis que lo utilizaInfo
- Publication number
- AR029775A1 AR029775A1 ARP000106287A ARP000106287A AR029775A1 AR 029775 A1 AR029775 A1 AR 029775A1 AR P000106287 A ARP000106287 A AR P000106287A AR P000106287 A ARP000106287 A AR P000106287A AR 029775 A1 AR029775 A1 AR 029775A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- crystalline forms
- tetrahydrochinolines
- carboxyamin
- aterosclerosis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 201000001320 Atherosclerosis Diseases 0.000 abstract 2
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 abstract 2
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16796799P | 1999-11-30 | 1999-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029775A1 true AR029775A1 (es) | 2003-07-16 |
Family
ID=22609556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000106287A AR029775A1 (es) | 1999-11-30 | 2000-11-29 | Derivados de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2-sustituidas, procedimiento para su preparacion, formas cristalinas de los mismos y metodo de tratamiento de la aterosclerosis que lo utiliza |
Country Status (44)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
| WO2003053359A2 (en) | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders |
| BR0215240A (pt) * | 2001-12-19 | 2004-10-26 | Atherogenics Inc | Derivados de calcona e seu uso no tratamento de doenças |
| ATE410521T1 (de) * | 2002-04-11 | 2008-10-15 | Roar Holding Llc | Ex-vivo-verfahren zur bestimmung der cetp- aktivität und der wirksamkeit der behandlung von herzerkrankungen |
| EA011385B1 (ru) * | 2002-10-04 | 2009-02-27 | Миллениум Фармасьютикалз, Инк. | Антагонисты рецептора pgd2 для лечения воспалительных заболеваний |
| US7504508B2 (en) * | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
| US20090181966A1 (en) * | 2002-10-04 | 2009-07-16 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
| US7223870B2 (en) | 2002-11-01 | 2007-05-29 | Pfizer Inc. | Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction |
| WO2004056727A2 (en) * | 2002-12-19 | 2004-07-08 | Atherogenics, Inc. | Process of making chalcone derivatives |
| US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
| CA2508840A1 (en) | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
| WO2004078730A2 (en) * | 2003-03-04 | 2004-09-16 | Takasago International Corporation | Method for producing optically active amines |
| ATE534381T1 (de) * | 2003-03-17 | 2011-12-15 | Japan Tobacco Inc | Pharmazeutische cetp-inhibitor-zusammensetzungen |
| JP2006520810A (ja) * | 2003-03-17 | 2006-09-14 | 日本たばこ産業株式会社 | Ｓ−［２−（［［１−（２−エチルブチル）シクロヘキシル］カルボニル］アミノ）フェニル］２−メチルプロパンチオエートの経口吸収性を増加させる方法 |
| TWI393560B (zh) * | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合 |
| ES2332051T3 (es) * | 2003-10-08 | 2010-01-25 | Eli Lilly And Company | Compuestos y procedimientos para tratar dislipidemia. |
| UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| JP2008504266A (ja) * | 2004-06-24 | 2008-02-14 | イーライ リリー アンド カンパニー | 異脂肪血症を治療するための化合物及び方法 |
| DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| WO2006033001A1 (en) * | 2004-09-23 | 2006-03-30 | Pfizer Products Inc. | Quinoline compounds |
| WO2006069162A1 (en) * | 2004-12-20 | 2006-06-29 | Reddy Us Therapeutics, Inc. | Novel heterocyclic compounds and their pharmaceutical compositions |
| EP1861372A1 (en) * | 2005-02-24 | 2007-12-05 | Millennium Pharmaceuticals, Inc. | Pgd2 receptor antagonists for the treatment of inflammatory diseases |
| TW200808731A (en) | 2006-03-30 | 2008-02-16 | Tanabe Seiyaku Co | A process for preparing tetrahydroquinoline derivatives |
| CL2008000684A1 (es) | 2007-03-09 | 2008-08-01 | Indigene Pharmaceuticals Inc | Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de reductasa hmg-coa; formulacion de dosis unitaria; y uso en el tratamiento de una complicacion diabetica. |
| CN101429160B (zh) * | 2007-11-06 | 2011-10-19 | 上海药明康德新药开发有限公司 | 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法 |
| AR077208A1 (es) | 2009-06-30 | 2011-08-10 | Lilly Co Eli | Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam |
| EP4551567A1 (en) | 2022-07-05 | 2025-05-14 | NewAmsterdam Pharma B.V. | Salts of obicetrapib and processes for their manufacture and intermediates thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7870M (enExample) * | 1968-11-08 | 1970-04-27 | ||
| US3971789A (en) | 1972-10-21 | 1976-07-27 | John Wyeth & Brother Limited | O-(4-Quinolylamino)benzamides |
| GB8432091D0 (en) | 1984-12-19 | 1985-01-30 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
| US4839368A (en) | 1986-05-02 | 1989-06-13 | Mochida Pharmaceutical Co., Ltd. | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives |
| GB8804444D0 (en) | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
| US5231102A (en) | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US6140342A (en) | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
| US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| US6147089A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
| HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
-
2000
- 2000-09-14 HN HN2000000203A patent/HN2000000203A/es unknown
- 2000-09-27 PA PA20008503801A patent/PA8503801A1/es unknown
- 2000-09-29 OA OA1200000268A patent/OA11494A/en unknown
- 2000-10-10 US US09/684,830 patent/US6313142B1/en not_active Expired - Fee Related
- 2000-11-03 GT GT200000190A patent/GT200000190A/es unknown
- 2000-11-09 CO CO00085289A patent/CO5261552A1/es not_active Application Discontinuation
- 2000-11-13 EP EP00310064A patent/EP1125929B1/en not_active Expired - Lifetime
- 2000-11-13 ES ES00310064T patent/ES2254109T3/es not_active Expired - Lifetime
- 2000-11-13 DK DK00310064T patent/DK1125929T3/da active
- 2000-11-13 AT AT00310064T patent/ATE315028T1/de not_active IP Right Cessation
- 2000-11-13 DE DE60025317T patent/DE60025317T2/de not_active Expired - Fee Related
- 2000-11-16 YU YU71500A patent/YU71500A/sh unknown
- 2000-11-17 IS IS5715A patent/IS5715A/is unknown
- 2000-11-22 HR HR20000804A patent/HRP20000804A2/hr not_active Application Discontinuation
- 2000-11-23 IL IL139849A patent/IL139849A/en not_active IP Right Cessation
- 2000-11-23 AU AU71789/00A patent/AU784694B2/en not_active Ceased
- 2000-11-24 TW TW089125066A patent/TW591016B/zh not_active IP Right Cessation
- 2000-11-24 SK SK1779-2000A patent/SK17792000A3/sk unknown
- 2000-11-27 ZA ZA200006947A patent/ZA200006947B/xx unknown
- 2000-11-27 UY UY26451A patent/UY26451A1/es not_active Application Discontinuation
- 2000-11-27 ID IDP20001022D patent/ID28489A/id unknown
- 2000-11-27 CZ CZ20004407A patent/CZ20004407A3/cs unknown
- 2000-11-28 UA UA2000116782A patent/UA65615C2/uk unknown
- 2000-11-28 PE PE2000001266A patent/PE20010913A1/es not_active Application Discontinuation
- 2000-11-28 CN CNB001283820A patent/CN1173953C/zh not_active Expired - Fee Related
- 2000-11-28 CA CA002327029A patent/CA2327029C/en not_active Expired - Fee Related
- 2000-11-28 SG SG200006869A patent/SG102603A1/en unknown
- 2000-11-29 NO NO20006039A patent/NO20006039L/no not_active Application Discontinuation
- 2000-11-29 EA EA200001129A patent/EA003668B1/ru not_active IP Right Cessation
- 2000-11-29 NZ NZ508509A patent/NZ508509A/en unknown
- 2000-11-29 TN TNTNSN00230A patent/TNSN00230A1/fr unknown
- 2000-11-29 HU HU0004747A patent/HUP0004747A3/hu unknown
- 2000-11-29 AR ARP000106287A patent/AR029775A1/es unknown
- 2000-11-29 KR KR10-2000-0071527A patent/KR100408177B1/ko not_active Expired - Fee Related
- 2000-11-29 MA MA26112A patent/MA25223A1/fr unknown
- 2000-11-29 DZ DZ000153A patent/DZ3079A1/xx active
- 2000-11-29 JP JP2000362153A patent/JP3579345B2/ja not_active Expired - Fee Related
- 2000-11-30 PL PL00344208A patent/PL344208A1/xx not_active Application Discontinuation
- 2000-11-30 AP APAP/P/2000/002011A patent/AP2000002011A0/en unknown
- 2000-11-30 BG BG105009A patent/BG105009A/xx unknown
- 2000-11-30 GE GEAP20005651A patent/GEP20022798B/en unknown
- 2000-11-30 EE EEP200000659A patent/EE200000659A/xx unknown
- 2000-11-30 BR BR0005636-7A patent/BR0005636A/pt not_active Application Discontinuation
-
2006
- 2006-03-01 CY CY20061100287T patent/CY1104989T1/el unknown
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| FB | Suspension of granting procedure |