GEP20022798B - Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline - Google Patents

Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline

Info

Publication number
GEP20022798B
GEP20022798B GEAP20005651A GEAP2000005651A GEP20022798B GE P20022798 B GEP20022798 B GE P20022798B GE AP20005651 A GEAP20005651 A GE AP20005651A GE AP2000005651 A GEAP2000005651 A GE AP2000005651A GE P20022798 B GEP20022798 B GE P20022798B
Authority
GE
Georgia
Prior art keywords
carboxyamino
tetrahydroquinoline
substituted
producing
cetp
Prior art date
Application number
GEAP20005651A
Other languages
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of GEP20022798B publication Critical patent/GEP20022798B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GEAP20005651A 1999-11-30 2000-11-30 Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline GEP20022798B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
GEP20022798B true GEP20022798B (en) 2002-09-25

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP20005651A GEP20022798B (en) 1999-11-30 2000-11-30 Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline

Country Status (44)

Country Link
US (1) US6313142B1 (enExample)
EP (1) EP1125929B1 (enExample)
JP (1) JP3579345B2 (enExample)
KR (1) KR100408177B1 (enExample)
CN (1) CN1173953C (enExample)
AP (1) AP2000002011A0 (enExample)
AR (1) AR029775A1 (enExample)
AT (1) ATE315028T1 (enExample)
AU (1) AU784694B2 (enExample)
BG (1) BG105009A (enExample)
BR (1) BR0005636A (enExample)
CA (1) CA2327029C (enExample)
CO (1) CO5261552A1 (enExample)
CY (1) CY1104989T1 (enExample)
CZ (1) CZ20004407A3 (enExample)
DE (1) DE60025317T2 (enExample)
DK (1) DK1125929T3 (enExample)
DZ (1) DZ3079A1 (enExample)
EA (1) EA003668B1 (enExample)
EE (1) EE200000659A (enExample)
ES (1) ES2254109T3 (enExample)
GE (1) GEP20022798B (enExample)
GT (1) GT200000190A (enExample)
HN (1) HN2000000203A (enExample)
HR (1) HRP20000804A2 (enExample)
HU (1) HUP0004747A3 (enExample)
ID (1) ID28489A (enExample)
IL (1) IL139849A (enExample)
IS (1) IS5715A (enExample)
MA (1) MA25223A1 (enExample)
NO (1) NO20006039L (enExample)
NZ (1) NZ508509A (enExample)
OA (1) OA11494A (enExample)
PA (1) PA8503801A1 (enExample)
PE (1) PE20010913A1 (enExample)
PL (1) PL344208A1 (enExample)
SG (1) SG102603A1 (enExample)
SK (1) SK17792000A3 (enExample)
TN (1) TNSN00230A1 (enExample)
TW (1) TW591016B (enExample)
UA (1) UA65615C2 (enExample)
UY (1) UY26451A1 (enExample)
YU (1) YU71500A (enExample)
ZA (1) ZA200006947B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
IL162533A0 (en) * 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
WO2003053359A2 (en) 2001-12-19 2003-07-03 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
ATE410521T1 (de) * 2002-04-11 2008-10-15 Roar Holding Llc Ex-vivo-verfahren zur bestimmung der cetp- aktivität und der wirksamkeit der behandlung von herzerkrankungen
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
PL376156A1 (en) * 2002-10-04 2005-12-27 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
EP1961419B1 (en) 2002-12-20 2010-03-24 Pfizer Products Inc. Dosage forms comprising a CETP inhibitor and an HMG-CoA reductase inhibitor
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
EP1601655A2 (en) * 2003-03-04 2005-12-07 Takasago International Corporation Method for producing optically active amines
AU2004222436A1 (en) * 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of S-(2-(((1- (2-ethylbutyl) cyclohexyl)carbonyl) amino) phenyl)-2-methylpropanethioate
PT1603553E (pt) * 2003-03-17 2012-02-03 Japan Tobacco Inc Composições farmacêuticas de inibidores de cetp
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
PL1670768T3 (pl) * 2003-10-08 2010-01-29 Lilly Co Eli Związki i sposoby leczenia dyslipidemii
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
JP2008504266A (ja) * 2004-06-24 2008-02-14 イーライ リリー アンド カンパニー 異脂肪血症を治療するための化合物及び方法
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
BRPI0608553A2 (pt) * 2005-02-24 2010-01-12 Millennium Pharm Inc antagonistas de receptor de pgd2 para o tratamento de doenças inflamatórias
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
TW200901959A (en) 2007-03-09 2009-01-16 Indigene Pharmaceuticals Inc Combination of metformin R-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
PE20251749A1 (es) 2022-07-05 2025-07-09 Newamsterdam Pharma B V Sales de obicetrapib y procesos para su fabricacion y productos intermedios de estos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7870M (enExample) * 1968-11-08 1970-04-27
US3971789A (en) 1972-10-21 1976-07-27 John Wyeth & Brother Limited O-(4-Quinolylamino)benzamides
GB8432091D0 (en) 1984-12-19 1985-01-30 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
GB8804444D0 (en) 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5231102A (en) 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
PE20010913A1 (es) 2001-09-10
DZ3079A1 (fr) 2004-10-24
CA2327029A1 (en) 2001-05-30
HUP0004747A2 (hu) 2001-10-28
EA200001129A3 (ru) 2001-10-22
EE200000659A (et) 2001-08-15
IL139849A0 (en) 2002-02-10
YU71500A (sh) 2003-02-28
DE60025317T2 (de) 2006-08-03
PL344208A1 (en) 2001-06-04
MA25223A1 (fr) 2001-07-02
EP1125929B1 (en) 2006-01-04
UA65615C2 (uk) 2004-04-15
JP3579345B2 (ja) 2004-10-20
NO20006039D0 (no) 2000-11-29
EA003668B1 (ru) 2003-08-28
DK1125929T3 (da) 2006-04-03
HN2000000203A (es) 2001-06-13
JP2001163859A (ja) 2001-06-19
CO5261552A1 (es) 2003-03-31
ES2254109T3 (es) 2006-06-16
CZ20004407A3 (cs) 2002-06-12
US6313142B1 (en) 2001-11-06
ID28489A (id) 2001-05-31
SK17792000A3 (sk) 2002-10-08
AP2000002011A0 (en) 2000-12-31
KR20010052012A (ko) 2001-06-25
OA11494A (en) 2004-05-07
ATE315028T1 (de) 2006-02-15
AR029775A1 (es) 2003-07-16
CA2327029C (en) 2005-08-09
AU784694B2 (en) 2006-06-01
ZA200006947B (en) 2002-05-27
HUP0004747A3 (en) 2002-12-28
SG102603A1 (en) 2004-03-26
HU0004747D0 (enExample) 2001-02-28
NO20006039L (no) 2001-05-31
DE60025317D1 (de) 2006-03-30
BR0005636A (pt) 2001-07-17
EP1125929A1 (en) 2001-08-22
CN1173953C (zh) 2004-11-03
PA8503801A1 (es) 2002-07-30
TNSN00230A1 (fr) 2005-11-10
CY1104989T1 (el) 2010-03-03
HRP20000804A2 (en) 2001-06-30
GT200000190A (es) 2002-04-27
NZ508509A (en) 2001-06-29
KR100408177B1 (ko) 2003-12-01
IL139849A (en) 2006-10-31
TW591016B (en) 2004-06-11
UY26451A1 (es) 2001-06-29
IS5715A (is) 2001-05-31
HK1038007A1 (en) 2002-03-01
BG105009A (en) 2001-11-30
AU7178900A (en) 2001-05-31
CN1302800A (zh) 2001-07-11
EA200001129A2 (ru) 2001-06-25

Similar Documents

Publication Publication Date Title
YU71500A (sh) Metod za dobijanje 4-karboksiamino-2-supstituisanog -1,2,3,4-tetrahidrohinolina
HUP0201219A2 (en) Quinoline derivatives as inhibitors of mek enzymes, process for producing them, use of them and pharmaceutical compositions containing them
GEP20053602B (en) Aripiprazole for Oral Administration
AU641460B2 (en) Process for the production and extraction of antioxidants from a micro-organism culture and photobioreactor for performing this process
DE60025328D1 (de) Verfahren zur herstellung von mehrfach vernetzten hyaluronsäurederivaten
AU5027200A (en) Method and apparatus for access to, and delivery of, multimedia information
AU2001269742A1 (en) Method of treating gastrointestinal diseases associated with species of genus clostridium
DE69733657D1 (de) System zur vermeidung intradialytischer symptomatologie
AU3655995A (en) Method for removal of hexenuronic acid groups in cellulose pulp by heat treatment
AU2002363345A1 (en) Method for the production of fuel from acid fats and system for carrying out said method
AU7051500A (en) Method of and system for displaying cards
AU6213800A (en) Method for production of tetanus toxin using media substantially free of animal products
ZA200006161B (en) Method for production of acrylic acid and apparatus for production of acrylic acid.
FI940203A7 (fi) Geeni, joka koodaa eikosapeutaanihappoa syntetisoivia entsyymejä, ja m enetelmä eikospentaanihapon valmistamiseksi
AU2003202470A1 (en) Process for producing 6,6,6-trifluoro-3,5-dioxohexanoic acid ester and tautomer thereof
AU7118200A (en) Method and system for non-random selection of plant and tissue products
ZA200000738B (en) Method for production of (METH)acrylic acid and/or (METH)acrylic esters.
HUT50338A (en) Process for producing new 4-thiazolidinecarboxylic acid derivative and pharmaceutical compositions comprising same as active ingredient
AU1060397A (en) High efficiency tissue specific compound delivery system using streptavidin-protein a fusion protein
AU5995100A (en) Microorganism culture method and apparatus
EP1385993B8 (en) Method of detecting and treating tuberous sclerosis complex associated disorders
AU4037299A (en) Genetically-modified fibroblasts and the use thereof
AU4174496A (en) Silylation process
PT744951E (pt) Processo para a producao de um gel de prednisolona esteril
BR0009636B1 (pt) processo para a preparação de insulina madura ou um derivado de insulina madura.