AR023629A1 - Compuestos derivados de 3,4-difenil-biciclo[4.3.0]nonilo, procedimiento para su elaboracion, medicamento que los comprende y utilizacion de los mismos - Google Patents
Compuestos derivados de 3,4-difenil-biciclo[4.3.0]nonilo, procedimiento para su elaboracion, medicamento que los comprende y utilizacion de los mismosInfo
- Publication number
- AR023629A1 AR023629A1 ARP990102729A ARP990102729A AR023629A1 AR 023629 A1 AR023629 A1 AR 023629A1 AR P990102729 A ARP990102729 A AR P990102729A AR P990102729 A ARP990102729 A AR P990102729A AR 023629 A1 AR023629 A1 AR 023629A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- given
- cases
- group
- given cases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Compuestos derivados de 3,4-difenil-biciclo [4.3.0]nonilo o que responden a la formula general (1) donde R1 representa un alcanoilo C1-20, en casos dados,sustituido, un alquilo C1-20, en casos dados sustituido, un aralquilo C7-20, en casos dadosusti tuido, un aroilo C7-15, en casos dados, sustituido, un grupoPG1 o un átomo de hidrogeno, R2 representa un alcanoilo C1-20, en casos dados sustituido, un alquilo C1-20 en casos dados sustituido, un aralquilo C7-20, encasos dados sustituido, unaroilo C7-15, en casos dados sustituido, un grupo PG2 o un átomo de hidrogeno, PG1, PG2 representan, iguales o distintos, un grupoprotector PG, A-A-D-D representa un grupo -CH2-C(OH)-C=CH-, -CH=C-C(OH)-CH2, -CH-C-C=CH-CH2-C=C-CH2-,CH2-C(OH)-CH-CH2-, CH2-CH -C(OH)-CH2-,-CH2-C(OH)-C(OH)-CH2- o CH2-epoxi-CH2-(hidroxi=alfa o beta; epoxi = alfa o beta), X representa un enlace, un átomo de oxígeno, un átomo de azufre, SO, SO2, Erepresenta un grupo alquileno, alquenileno, oalquinileno con hasta 15 átomos de carbono, lineal o ramificado, Y representa un halogeno (F, Cl, Br, I), unsustituyente R4, un resto arilo o heteroarilo, n casos dados, sustituido, un grupo NR4aR4b, SO2NR4aR4b, NR4a(CH2)p-Q-G-,NR5(CHR6-CHR7)-(CH2)t-Q-G-,SO2NR4a(CH2)p-Q-G-, O-G-, S-G -, SO-G-, SO2-G-,R4 representa un átomo de hidrogeno, un alquilo C1-20, parcial- o totalmente fluorado, un alcanoilo C1-20. en casos dadosun arilo, en casos dados, sustituido, un heteroarilo,en casos dados sustituidos, un aralquilo C7-20, en casos d ados sustituido, un aroiloC7-15, en casos dados, sustituido, Q representa un átomo de oxígeno, an átomo de azufre, SO o SO2, G representa -(CH2)nR3, n representa 0 o 10, p representa 1a 10,t representa 0,1 o 2, R3 representa un átomo de hidrogeno, u n grupo alquilo, alquenilo o alquinilo con hasta 10 átomos de carbono, lineal o ramificado,un grupo alquilo o alquenilo con hasta 10 átomos de carbono, lineal o ramificado, parcial-ototalmente fluorado, un cicloalquilo C4-8, en casos dados,sustituid o, un grupo arilo, en casos dados sustituido, un grupo aralquilo C7-20, en casos dados, sustituido,o en caso de que n > 0, también un grupo hidroxilo
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19826213A DE19826213A1 (de) | 1998-06-09 | 1998-06-09 | Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023629A1 true AR023629A1 (es) | 2002-09-04 |
Family
ID=7870694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102729A AR023629A1 (es) | 1998-06-09 | 1999-06-09 | Compuestos derivados de 3,4-difenil-biciclo[4.3.0]nonilo, procedimiento para su elaboracion, medicamento que los comprende y utilizacion de los mismos |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6166075A (es) |
| EP (1) | EP1086077B1 (es) |
| JP (1) | JP2002517482A (es) |
| KR (1) | KR20010052688A (es) |
| CN (1) | CN1305457A (es) |
| AR (1) | AR023629A1 (es) |
| AT (1) | ATE263755T1 (es) |
| AU (1) | AU759942B2 (es) |
| BR (1) | BR9911103A (es) |
| CA (1) | CA2334780A1 (es) |
| CO (1) | CO5050355A1 (es) |
| DE (2) | DE19826213A1 (es) |
| DK (1) | DK1086077T3 (es) |
| ES (1) | ES2220072T3 (es) |
| HU (1) | HUP0102211A3 (es) |
| IL (1) | IL139863A0 (es) |
| PE (1) | PE20000541A1 (es) |
| PL (1) | PL344309A1 (es) |
| PT (1) | PT1086077E (es) |
| WO (1) | WO1999064393A1 (es) |
| ZA (1) | ZA200100201B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19826213A1 (de) * | 1998-06-09 | 1999-12-16 | Schering Ag | Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| US6525069B1 (en) | 1998-12-18 | 2003-02-25 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| DE10039199A1 (de) * | 2000-08-10 | 2002-02-21 | Schering Ag | Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen |
| DE60230017D1 (de) * | 2001-02-15 | 2009-01-08 | Janssen Pharmaceutica Nv | Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen |
| DE10142881A1 (de) * | 2001-09-03 | 2003-04-03 | Jomed Gmbh | Implantate mit Combretastatin A-4 (CA4) |
| CN1798721A (zh) * | 2003-05-31 | 2006-07-05 | 詹森药业有限公司 | 作为选择性的雌激素受体蛋白调节剂的环己基衍生物 |
| US7750631B2 (en) * | 2007-06-22 | 2010-07-06 | Morpho Detection, Inc. | Passenger inspection system and methods for using the same |
| CA2653189A1 (en) | 2008-02-04 | 2009-08-04 | University Of Ottawa | Estrogenic compounds, process for their production and pharmaceutical uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| FR2685332A1 (fr) * | 1991-12-20 | 1993-06-25 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| FR2744445B1 (fr) * | 1996-02-01 | 1998-10-02 | Roussel Uclaf | Composes biphenyles nouveaux et/ou a titre de medicament, compositions pharmaceutiques les contenant, leur procede de preparation et les intermediaires de ce procede |
| DE19826213A1 (de) * | 1998-06-09 | 1999-12-16 | Schering Ag | Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
-
1998
- 1998-06-09 DE DE19826213A patent/DE19826213A1/de not_active Withdrawn
-
1999
- 1999-06-07 PE PE1999000482A patent/PE20000541A1/es not_active Application Discontinuation
- 1999-06-08 CO CO99035556A patent/CO5050355A1/es unknown
- 1999-06-09 WO PCT/EP1999/004049 patent/WO1999064393A1/de not_active Application Discontinuation
- 1999-06-09 PL PL99344309A patent/PL344309A1/xx not_active Application Discontinuation
- 1999-06-09 KR KR1020007013943A patent/KR20010052688A/ko not_active Application Discontinuation
- 1999-06-09 PT PT99931059T patent/PT1086077E/pt unknown
- 1999-06-09 DK DK99931059T patent/DK1086077T3/da active
- 1999-06-09 AU AU47716/99A patent/AU759942B2/en not_active Ceased
- 1999-06-09 DE DE59909123T patent/DE59909123D1/de not_active Expired - Fee Related
- 1999-06-09 AT AT99931059T patent/ATE263755T1/de not_active IP Right Cessation
- 1999-06-09 CN CN99807191A patent/CN1305457A/zh active Pending
- 1999-06-09 IL IL13986399A patent/IL139863A0/xx unknown
- 1999-06-09 ES ES99931059T patent/ES2220072T3/es not_active Expired - Lifetime
- 1999-06-09 HU HU0102211A patent/HUP0102211A3/hu unknown
- 1999-06-09 JP JP2000553403A patent/JP2002517482A/ja active Pending
- 1999-06-09 US US09/328,451 patent/US6166075A/en not_active Expired - Fee Related
- 1999-06-09 EP EP99931059A patent/EP1086077B1/de not_active Expired - Lifetime
- 1999-06-09 AR ARP990102729A patent/AR023629A1/es not_active Application Discontinuation
- 1999-06-09 BR BR9911103-9A patent/BR9911103A/pt not_active IP Right Cessation
- 1999-06-09 CA CA002334780A patent/CA2334780A1/en not_active Abandoned
-
2000
- 2000-11-07 US US09/706,806 patent/US6559181B1/en not_active Expired - Fee Related
-
2001
- 2001-01-08 ZA ZA200100201A patent/ZA200100201B/en unknown
-
2003
- 2003-02-21 US US10/369,577 patent/US7074829B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2334780A1 (en) | 1999-12-16 |
| US6166075A (en) | 2000-12-26 |
| CN1305457A (zh) | 2001-07-25 |
| WO1999064393A1 (de) | 1999-12-16 |
| PL344309A1 (en) | 2001-10-22 |
| PT1086077E (pt) | 2004-08-31 |
| BR9911103A (pt) | 2001-03-06 |
| CO5050355A1 (es) | 2001-06-27 |
| ES2220072T3 (es) | 2004-12-01 |
| AU759942B2 (en) | 2003-05-01 |
| HUP0102211A2 (hu) | 2002-03-28 |
| IL139863A0 (en) | 2002-02-10 |
| DE59909123D1 (de) | 2004-05-13 |
| KR20010052688A (ko) | 2001-06-25 |
| JP2002517482A (ja) | 2002-06-18 |
| US6559181B1 (en) | 2003-05-06 |
| US7074829B2 (en) | 2006-07-11 |
| EP1086077A1 (de) | 2001-03-28 |
| DE19826213A1 (de) | 1999-12-16 |
| HUP0102211A3 (en) | 2002-12-28 |
| ATE263755T1 (de) | 2004-04-15 |
| ZA200100201B (en) | 2002-01-08 |
| DK1086077T3 (da) | 2004-08-02 |
| EP1086077B1 (de) | 2004-04-07 |
| PE20000541A1 (es) | 2000-08-10 |
| AU4771699A (en) | 1999-12-30 |
| US20030162830A1 (en) | 2003-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |