CO5050355A1 - Compuestos derivados de 3,4-difenil-biciclo[4.3.0] nonilo, procedimiento para su elaboracion, medicamento que los comprende y utilizacion de los mismos - Google Patents

Compuestos derivados de 3,4-difenil-biciclo[4.3.0] nonilo, procedimiento para su elaboracion, medicamento que los comprende y utilizacion de los mismos

Info

Publication number
CO5050355A1
CO5050355A1 CO99035556A CO99035556A CO5050355A1 CO 5050355 A1 CO5050355 A1 CO 5050355A1 CO 99035556 A CO99035556 A CO 99035556A CO 99035556 A CO99035556 A CO 99035556A CO 5050355 A1 CO5050355 A1 CO 5050355A1
Authority
CO
Colombia
Prior art keywords
difenyl
understands
nonyl
medication
bicycle
Prior art date
Application number
CO99035556A
Other languages
English (en)
Inventor
Ulrich Klar
Rolf Bohlmann
Parczyk Karsten
Karl Heinz Fritzemeier
Monika Lessl
Lichtner Rossmarie
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CO5050355A1 publication Critical patent/CO5050355A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nuevos antiestrógenos que responden a la fórmula generalen la que los sustituyentes poseen los significados expresados con mayor detalle en la descripción.Tales nuevos compuestos se tratan de a) antiestrógenos puros o de b) antiestrógenos con subacción estrógena (estrógeno selector de tejidos).Como consecuencia de estas propiedades, los nuevos compuestos se adecuan para la elaboración de medicamentos; en el caso a), por ejemplo, para el tratamiento del carcinoma de mama, en el caso b), por ejemplo, en la terapia sustitutiva de hormonas.
CO99035556A 1998-06-09 1999-06-08 Compuestos derivados de 3,4-difenil-biciclo[4.3.0] nonilo, procedimiento para su elaboracion, medicamento que los comprende y utilizacion de los mismos CO5050355A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19826213A DE19826213A1 (de) 1998-06-09 1998-06-09 Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung

Publications (1)

Publication Number Publication Date
CO5050355A1 true CO5050355A1 (es) 2001-06-27

Family

ID=7870694

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99035556A CO5050355A1 (es) 1998-06-09 1999-06-08 Compuestos derivados de 3,4-difenil-biciclo[4.3.0] nonilo, procedimiento para su elaboracion, medicamento que los comprende y utilizacion de los mismos

Country Status (21)

Country Link
US (3) US6166075A (es)
EP (1) EP1086077B1 (es)
JP (1) JP2002517482A (es)
KR (1) KR20010052688A (es)
CN (1) CN1305457A (es)
AR (1) AR023629A1 (es)
AT (1) ATE263755T1 (es)
AU (1) AU759942B2 (es)
BR (1) BR9911103A (es)
CA (1) CA2334780A1 (es)
CO (1) CO5050355A1 (es)
DE (2) DE19826213A1 (es)
DK (1) DK1086077T3 (es)
ES (1) ES2220072T3 (es)
HU (1) HUP0102211A3 (es)
IL (1) IL139863A0 (es)
PE (1) PE20000541A1 (es)
PL (1) PL344309A1 (es)
PT (1) PT1086077E (es)
WO (1) WO1999064393A1 (es)
ZA (1) ZA200100201B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
DE10039199A1 (de) * 2000-08-10 2002-02-21 Schering Ag Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
US20040110769A1 (en) * 2001-02-15 2004-06-10 End David William Farnesyl protein transferase inhibitor combinations with antiestrogen agents
DE10142881A1 (de) * 2001-09-03 2003-04-03 Jomed Gmbh Implantate mit Combretastatin A-4 (CA4)
CN1798721A (zh) * 2003-05-31 2006-07-05 詹森药业有限公司 作为选择性的雌激素受体蛋白调节剂的环己基衍生物
US7750631B2 (en) * 2007-06-22 2010-07-06 Morpho Detection, Inc. Passenger inspection system and methods for using the same
CA2653189A1 (en) 2008-02-04 2009-08-04 University Of Ottawa Estrogenic compounds, process for their production and pharmaceutical uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
FR2744445B1 (fr) * 1996-02-01 1998-10-02 Roussel Uclaf Composes biphenyles nouveaux et/ou a titre de medicament, compositions pharmaceutiques les contenant, leur procede de preparation et les intermediaires de ce procede
DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung

Also Published As

Publication number Publication date
JP2002517482A (ja) 2002-06-18
US20030162830A1 (en) 2003-08-28
ZA200100201B (en) 2002-01-08
PL344309A1 (en) 2001-10-22
US7074829B2 (en) 2006-07-11
US6559181B1 (en) 2003-05-06
EP1086077A1 (de) 2001-03-28
ES2220072T3 (es) 2004-12-01
WO1999064393A1 (de) 1999-12-16
CN1305457A (zh) 2001-07-25
PE20000541A1 (es) 2000-08-10
CA2334780A1 (en) 1999-12-16
KR20010052688A (ko) 2001-06-25
DE19826213A1 (de) 1999-12-16
BR9911103A (pt) 2001-03-06
HUP0102211A2 (hu) 2002-03-28
IL139863A0 (en) 2002-02-10
PT1086077E (pt) 2004-08-31
HUP0102211A3 (en) 2002-12-28
DE59909123D1 (de) 2004-05-13
EP1086077B1 (de) 2004-04-07
AU4771699A (en) 1999-12-30
ATE263755T1 (de) 2004-04-15
AU759942B2 (en) 2003-05-01
DK1086077T3 (da) 2004-08-02
US6166075A (en) 2000-12-26
AR023629A1 (es) 2002-09-04

Similar Documents

Publication Publication Date Title
AR020019A1 (es) Composicion farmaceutica para la prevencion o el tratamiento de cancer de mama
SV1999000149A (es) 1,2,3,4 - tetrahidroquinolinas - 2 - metil - 4 - carboxiamino ref. pc10024/82736/bb
ES2194468T3 (es) Uso de derivados del bisindol indigoide para la fabricacion de un medicamento para inhibir quinasas dependientes de ciclinas.
ES2179351T3 (es) Amidas acidas de piridil alqueno y piridil alquino como citoestaticos e inmunosupresores.
BR0113235A (pt) Composições e métodos para a terapia e a diagnose de malignidades associadas com her-2/neu
PA8493701A1 (es) Compuestos para tratar la obesidad
CO5050355A1 (es) Compuestos derivados de 3,4-difenil-biciclo[4.3.0] nonilo, procedimiento para su elaboracion, medicamento que los comprende y utilizacion de los mismos
GEP20043375B (en) APRIL-Receptor (BCMA) and Use Thereof
ATE522220T1 (de) Triterpenzusammensetzungen und deren verwendungsmethoden
DK398587A (da) Antitumorvirksomt laegemiddel
UY26058A1 (es) Compuestos utiles como antiinflamatorios ley 17.164 art. 127
BR0110961A (pt) Derivados de triazol
PA8537201A1 (es) Agonistas de ppar
DK0533703T3 (da) Anvendelse af steroider til hæmning af angiogenese
ES2189768T3 (es) Sintesis regioselectiva de derivados de rapamicina.
RS52651B (en) PHARMACEUTICAL COMPOSITION CONTAINING GESTAGENS AND / OR ESTROGENS AND 5-METHYL- (6S) -TETRAHYDROPHOLATE
PL356699A1 (en) Novel derivatives of flavones, xanthones and coumarins
ES2127532T3 (es) Preparacion de nalbufina con niveles bajos del epimero beta.
ES2172937T3 (es) 21-hidroxi-6,19-oxidoprogesterona(21oh-6op) como medicamento para tratar el exceso de glucocorticoides.
AR018201A1 (es) Compuesto de mesilato de n-(3-etinilfenil)-6,7-bis-(2-metoxietoxi)-4-quinazolinamina, composiciones que los contienen y su uso de dichos compuestos para la preparacion de medicamentos.
BR0113165A (pt) Derivados de 4-pirimidinamina, composições farmacêuticas e métodos relacionados
PE20031047A1 (es) Tratamiento de padecimientos post-menopausicos en pacientes con cancer de mama
ES2177671T3 (es) Benzamida enterocinetica.
ES2190201T3 (es) Medicamento para la profilaxis y/o el tratamiento del carcinoma de mama que contiene un inhibidor esteroideo de la aromatasa.
ES2039314T1 (es) Complejos de sulfato de condoitrina con actividad antiflamatoria, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.