PE20000541A1 - Compuestos derivados de 3,4-difenil-biciclo[4.3.0]nonilo, procedimiento para su elaboracion y medicamento que los comprende - Google Patents

Compuestos derivados de 3,4-difenil-biciclo[4.3.0]nonilo, procedimiento para su elaboracion y medicamento que los comprende

Info

Publication number
PE20000541A1
PE20000541A1 PE1999000482A PE00048299A PE20000541A1 PE 20000541 A1 PE20000541 A1 PE 20000541A1 PE 1999000482 A PE1999000482 A PE 1999000482A PE 00048299 A PE00048299 A PE 00048299A PE 20000541 A1 PE20000541 A1 PE 20000541A1
Authority
PE
Peru
Prior art keywords
alkylene
alkyl
bicycle
nonyl
diphenyl
Prior art date
Application number
PE1999000482A
Other languages
English (en)
Inventor
Rolf Bohlmann
Karl-Heinrich Fritzemeier
Monika Lessl
Karsten Parczyk
Ulrich Klar
Rosemarie Lichtner
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20000541A1 publication Critical patent/PE20000541A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A DERIVADOS DE 3,4-DIFENIL-BICICLO[4.3.0]NONILO DE FORMULA I, DONDE R1 ES ALCANOILO C1-C20, ALQUILO C1-C20, ARALQUILO C7-C20, AROILO C7-C15, PG1; R2 ES ALCANOILO C1-C20, ALQUILO C1-C20, ARALQUILO C7-C20, AROILO C7-C15, PG2; PG1 Y PG2 SON GRUPOS PROTECTORES; A`-A-D-D' ES -CH2-COH-C=CH-, -CH=C-COH-CH2, -CH2-COH-CH-CH2-, ENTRE OTROS; X ES UN ENLACE, O, S, SO, SO2; E ES ALQUILENO, ALQUENILENO, ALQUINILENO; Y ES HALOGENO, R4, ARILO, HETEROARILO OPCIONALMENTE SUSTITUIDO CON NR4aR4b, NR4a(CH2)p-Q-G-, NR5(CHR6-CHR7)-(CH2)t-Q-G-, SO2NR4a(CH2)p-Q-G-, ENTRE OTROS; R4 ES H, ALQUILO C1-C20, ALCANOILO C1-C20, ENTRE OTROS; Q ES 0, S, SO, SO2; G ES -(CH2)n-R3; n ES 0-10; t ES 0-2, p ES 1-10; R3 ES H, ALQUILO, ALQUENILO, ALQUINILO; R4a, R4b SON ALQUILENO C3-C15; R5 ES H, ALQUILO C1-C5; R6 o R7 ES H o R5 Y R6 SON ALQUILENO-(CH2)d-; d ES 2-5; Y R7 ES H; o R5 Y R7 SON ALQUILENO-(CH2)e-; e ES 2-4 Y R6 ES H; Z ES H, HALOGENO, OH, N3, ENTRE OTROS. UN COMPUESTO PREFERIDO ES (1S,3S,4R,6S,9S)-9-HIDROXI-4-(4-HIDROXIFENIL)-1-METIL-3-[4-(10,10,11,11,11-PENTAFLUOR-6-TIA-UNDECILOXI)FENIL]-BICICLO[4.3.0]NONANO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN ANTIESTROGENO, ANTIESTROGENO CON SUBACCION ESTROGENA Y PUEDE SER UTIL PARA TRATAR CANCER DE MAMA, TERAPIA SUSTITUTIVA DE HORMONAS
PE1999000482A 1998-06-09 1999-06-07 Compuestos derivados de 3,4-difenil-biciclo[4.3.0]nonilo, procedimiento para su elaboracion y medicamento que los comprende PE20000541A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19826213A DE19826213A1 (de) 1998-06-09 1998-06-09 Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung

Publications (1)

Publication Number Publication Date
PE20000541A1 true PE20000541A1 (es) 2000-08-10

Family

ID=7870694

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000482A PE20000541A1 (es) 1998-06-09 1999-06-07 Compuestos derivados de 3,4-difenil-biciclo[4.3.0]nonilo, procedimiento para su elaboracion y medicamento que los comprende

Country Status (21)

Country Link
US (3) US6166075A (es)
EP (1) EP1086077B1 (es)
JP (1) JP2002517482A (es)
KR (1) KR20010052688A (es)
CN (1) CN1305457A (es)
AR (1) AR023629A1 (es)
AT (1) ATE263755T1 (es)
AU (1) AU759942B2 (es)
BR (1) BR9911103A (es)
CA (1) CA2334780A1 (es)
CO (1) CO5050355A1 (es)
DE (2) DE19826213A1 (es)
DK (1) DK1086077T3 (es)
ES (1) ES2220072T3 (es)
HU (1) HUP0102211A3 (es)
IL (1) IL139863A0 (es)
PE (1) PE20000541A1 (es)
PL (1) PL344309A1 (es)
PT (1) PT1086077E (es)
WO (1) WO1999064393A1 (es)
ZA (1) ZA200100201B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
DE10039199A1 (de) * 2000-08-10 2002-02-21 Schering Ag Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
US20040110769A1 (en) * 2001-02-15 2004-06-10 End David William Farnesyl protein transferase inhibitor combinations with antiestrogen agents
DE10142881A1 (de) * 2001-09-03 2003-04-03 Jomed Gmbh Implantate mit Combretastatin A-4 (CA4)
CN1798721A (zh) * 2003-05-31 2006-07-05 詹森药业有限公司 作为选择性的雌激素受体蛋白调节剂的环己基衍生物
US7750631B2 (en) * 2007-06-22 2010-07-06 Morpho Detection, Inc. Passenger inspection system and methods for using the same
CA2653189A1 (en) 2008-02-04 2009-08-04 University Of Ottawa Estrogenic compounds, process for their production and pharmaceutical uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
FR2744445B1 (fr) * 1996-02-01 1998-10-02 Roussel Uclaf Composes biphenyles nouveaux et/ou a titre de medicament, compositions pharmaceutiques les contenant, leur procede de preparation et les intermediaires de ce procede
DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung

Also Published As

Publication number Publication date
JP2002517482A (ja) 2002-06-18
CO5050355A1 (es) 2001-06-27
US20030162830A1 (en) 2003-08-28
ZA200100201B (en) 2002-01-08
PL344309A1 (en) 2001-10-22
US7074829B2 (en) 2006-07-11
US6559181B1 (en) 2003-05-06
EP1086077A1 (de) 2001-03-28
ES2220072T3 (es) 2004-12-01
WO1999064393A1 (de) 1999-12-16
CN1305457A (zh) 2001-07-25
CA2334780A1 (en) 1999-12-16
KR20010052688A (ko) 2001-06-25
DE19826213A1 (de) 1999-12-16
BR9911103A (pt) 2001-03-06
HUP0102211A2 (hu) 2002-03-28
IL139863A0 (en) 2002-02-10
PT1086077E (pt) 2004-08-31
HUP0102211A3 (en) 2002-12-28
DE59909123D1 (de) 2004-05-13
EP1086077B1 (de) 2004-04-07
AU4771699A (en) 1999-12-30
ATE263755T1 (de) 2004-04-15
AU759942B2 (en) 2003-05-01
DK1086077T3 (da) 2004-08-02
US6166075A (en) 2000-12-26
AR023629A1 (es) 2002-09-04

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FD Application declared void or lapsed