ES2102478T3 - Complejos de vanadio, su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Complejos de vanadio, su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2102478T3
ES2102478T3 ES92401883T ES92401883T ES2102478T3 ES 2102478 T3 ES2102478 T3 ES 2102478T3 ES 92401883 T ES92401883 T ES 92401883T ES 92401883 T ES92401883 T ES 92401883T ES 2102478 T3 ES2102478 T3 ES 2102478T3
Authority
ES
Spain
Prior art keywords
alkyl
chemical structure
hydroxyl
formula
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92401883T
Other languages
English (en)
Inventor
Jean-Michel Lacoste
Jacques Duhault
Denis Ravel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2102478T3 publication Critical patent/ES2102478T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/005—Compounds of elements of Group 5 of the Periodic System without metal-carbon linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

COMPUESTOS DE FORMULA (I): EN LA QUE: R1 O R4, IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALKILO, R2 REPRESENTA UN ATOMO, UN GRUPO ALKILO, HIDROXIMETILO, CH2OPO(OH)2 O --CH2OPO(ONA)2, R3 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALKILO, HIDROXI O UNO CUALQUIERA DE LOS SIGUIENTES GRUPOS: EN LOS QUE: T REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE, N REPRESENTA UN NUMERO ENTERO COMPRENDIDO ENTRE 1 Y 4, R5 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALKILO, X REPRESENTA UN ATOMO DE NITROGENO, UN RADICAL CH O UN RADICAL CR''3 (EN EL QUE R''3 TIENE LA MISMA SIGNIFICACION QUE R3 SALVO EN EL CASO EN QUE R3 REPRESENTA UN GRUPO HIDROXI), A REPRESENTA UN RADICAL ALKILENO DE FORMULA -(CH2)P RO ENTERO COMPRENDIDO ENTRE 2 Y 4, EVENTUALMENTE SUSTITUIDO POR UNO O VARIOS GRUPOS ALKILOS (C1-C4) LINEALES O RAMIFICADOS, O UNO CUALQUIERA DE LOS SIGUIENTES RADICALES: Y Y Z FORMAN JUNTOS UN ATOMO DE OXIGENO, O REPRESENTAN SIMULTANEAMENTE DOS GRUPOS HIDROXI Y EN ESTE CASO EL COMPUESTO DE FORMULA (I) ESTA CARGADO POSITIVAMENTE, SUS ISOMEROS ASI COMO SUS SALES DE ADICION DE UN ACIDO O DE UNA BASE FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
ES92401883T 1991-07-03 1992-07-02 Complejos de vanadio, su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2102478T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR919108253A FR2678622B1 (fr) 1991-07-03 1991-07-03 Nouveaux complexes de vanadium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2102478T3 true ES2102478T3 (es) 1997-08-01

Family

ID=9414615

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92401883T Expired - Lifetime ES2102478T3 (es) 1991-07-03 1992-07-02 Complejos de vanadio, su preparacion y composiciones farmaceuticas que los contienen.

Country Status (14)

Country Link
US (2) US5266565A (es)
EP (1) EP0521787B1 (es)
JP (1) JPH0742302B2 (es)
AT (1) ATE152113T1 (es)
AU (1) AU649849B2 (es)
CA (1) CA2072938A1 (es)
DE (1) DE69219221T2 (es)
DK (1) DK0521787T3 (es)
ES (1) ES2102478T3 (es)
FR (1) FR2678622B1 (es)
GR (1) GR3023940T3 (es)
IE (1) IE922160A1 (es)
NZ (1) NZ243418A (es)
ZA (1) ZA924966B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637739A (en) * 1990-03-21 1997-06-10 Research Corporation Technologies, Inc. Chiral catalysts and catalytic epoxidation catalyzed thereby
ATE263770T1 (de) * 1994-02-04 2004-04-15 Smithkline Beecham Plc Verfahren zum epoxidieren prochiral olefine
US6211107B1 (en) 1994-02-04 2001-04-03 Smithkline Beecham P.L.C. Process for expoxidizing prochiral olefins and a catalyst therefor and intermediates for making the catalyst
US20020132326A1 (en) * 1995-12-15 2002-09-19 Hemmings Brian A. Process for activating a kinase
US20050053594A1 (en) * 1995-11-16 2005-03-10 Dario Alessi RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK
GB9525703D0 (en) * 1995-12-15 1996-02-14 Ciba Geigy Ag Screening method
US5955111A (en) * 1996-10-08 1999-09-21 Hartford Hospital Methods and compositions for inducing production of stress proteins
US5986136A (en) * 1997-04-15 1999-11-16 President And Fellows Of Harvard College Photolabeling reagent
EP0984971A1 (en) * 1997-04-24 2000-03-15 Angiotech Pharmaceuticals, Inc. Vanadium complexes and derivatives thereof and methods related thereto
US6232340B1 (en) 1997-04-24 2001-05-15 Angiotech Pharmaceuticals, Inc. Vanadium complexes and derivatives thereof and methods related thereto
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
WO2000024730A1 (en) * 1998-10-28 2000-05-04 The University Of British Columbia Organic vanadium(iii) complexes and their use
US6339085B1 (en) 1999-03-08 2002-01-15 The University Of Manitoba Therapeutics for cardiovascular and related diseases
US6489345B1 (en) 1999-07-13 2002-12-03 Medicure, Inc. Treatment of diabetes and related pathologies
EP1872797A3 (en) * 1999-08-24 2008-04-02 Medicure International Inc. Treatment of cardiovascular and related pathologies
ITMI991894A1 (it) * 1999-09-09 2001-03-09 Carlo Ghisalberti Acido linoleico coniugato e trigliceride nuovi metodi di sintesi e d'uso
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
JP2003525303A (ja) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド 心臓保護ホスホン酸塩およびマロン酸塩
EP1278526A2 (en) 2000-03-28 2003-01-29 Medicure International Inc. Treatment of cerebrovascular disease
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
ATE364595T1 (de) 2000-07-07 2007-07-15 Medicure Int Inc Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
US6957781B2 (en) * 2003-09-15 2005-10-25 Kraft Food Holdings, Inc. Cleaning attachment for fluid dispenser nozzles and fluid dispensers using same
EP1773370A1 (en) * 2004-07-07 2007-04-18 Medicure International Inc. Combination therapies employing platelet aggregation drugs
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
WO2006050598A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
WO2007059631A1 (en) * 2005-11-28 2007-05-31 Medicure International Inc. Selected dosage for the treatment of cardiovascular and related pathologies
KR100722795B1 (ko) 2005-12-26 2007-05-30 한국조폐공사 초근적외선을 흡수하는 이소인돌린 비대칭 사량체환 화합물및 이를 이용한 제품
GB0607096D0 (en) * 2006-04-07 2006-05-17 Imp Innovations Ltd Compound
PL231079B1 (pl) 2012-11-07 2019-01-31 Univ Jagiellonski Kompleksy wanadu z hydrazydohydrazonami, preparaty farmaceutyczne oraz zastosowanie kompleksów wanadu z hydrazydohydrazonami
JP6735163B2 (ja) * 2016-06-22 2020-08-05 株式会社Adeka バナジウム化合物、薄膜形成用原料及び薄膜の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2619382B1 (fr) * 1987-08-11 1990-05-04 Lazaro Rene Compose organo-mineral de vanadyle, procede d'obtention d'un tel compose, composition pharmaceutique contenant ce compose organo-mineral

Also Published As

Publication number Publication date
AU1941392A (en) 1993-01-07
JPH0742302B2 (ja) 1995-05-10
ATE152113T1 (de) 1997-05-15
GR3023940T3 (en) 1997-09-30
DK0521787T3 (da) 1997-10-27
DE69219221D1 (de) 1997-05-28
DE69219221T2 (de) 1997-11-20
CA2072938A1 (fr) 1993-01-04
US5278154A (en) 1994-01-11
AU649849B2 (en) 1994-06-02
US5266565A (en) 1993-11-30
NZ243418A (en) 1994-04-27
JPH05186481A (ja) 1993-07-27
IE922160A1 (en) 1993-01-13
EP0521787B1 (fr) 1997-04-23
ZA924966B (en) 1993-03-31
FR2678622B1 (fr) 1994-11-18
FR2678622A1 (fr) 1993-01-08
EP0521787A1 (fr) 1993-01-07

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