AR012594A1 - Imidazoles sustituidos, composicion farmaceutica que los comprende, el uso de los mismos en la manufactura de un medicamento y procedimiento para supreparacion e intermediario - Google Patents

Imidazoles sustituidos, composicion farmaceutica que los comprende, el uso de los mismos en la manufactura de un medicamento y procedimiento para supreparacion e intermediario

Info

Publication number
AR012594A1
AR012594A1 ARP980101886A ARP980101886A AR012594A1 AR 012594 A1 AR012594 A1 AR 012594A1 AR P980101886 A ARP980101886 A AR P980101886A AR P980101886 A ARP980101886 A AR P980101886A AR 012594 A1 AR012594 A1 AR 012594A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
substituted
5alkyl
substituents
Prior art date
Application number
ARP980101886A
Other languages
English (en)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of AR012594A1 publication Critical patent/AR012594A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Imidazoles sustituidos de la formula (I), en la cual R1 es fenilo, fenilo sustituido (donde los sustituyentes son seleccionados entre el grupo queconsiste en alquilo C1-5, halogeno, nitro trifluorometilo y nitrilo), o heteroarilo, donde elheteroarilo contiene de 5 a 6 átomos en el anillo; R2es fenilo, fenilo sustituido (donde los sustituyentes son seleccionados entre el grupo que consiste en alquilo C1-5, halogeno, nitro, triflurometilo ynitrilo), o heteroarilo, donde elheteroarilo contiene de 5 a 6 átmos en el anillo y está optativamente sustituido con alquilo C1-4; R3 es hidrogeno, SEM,alcoxicarbonilo C1-5, ariloxicarbonilo, arilalquiloxicarbonilo C1-5, arilalquilo C1-5, arilalquilo C1-5 sustituido(donde los sustituyentes ariloson independientemente seleccionados entre uno o más miembros del grupo que consiste en alquilo C1-5, halogeno, amino, alquilamino C1-5 y dialquilaminoC1-5), ftalimidoalquilo C1-5, aminoalquilo C1-5, diaminoalquiloC1-5, succinimidoalquilo C1-5, alquilcarbonilo C1-5, arilcarbonilo, alquilcarboniloC1-5 alquilo C1-5, ariloxicarbonilalquilo C1-5, heteroarilalquilo C1-5 , donde el heteroarilo contiene 5 o 6 átomos en el anillo; R4 es (A)-(CH2)q-X donde: Aesvinileno , etinileno o formula (II), donde R5 es seleccionado entre el grupo que consiste en hidrogeno, alquilo C1-5, fenilo y fenilalquilo C1-5; q es 0-9;X es seleccionado entre el grupo que consiste en hidrogeno, hidroxi, vinilo, vinilosustituido (dond e uno o más sustituyentes son seleccionados entre elgrupo que consiste en fluor, bromo, cloro y yodo), etinilo, etinilo sustituido (donde los sustituyentes son seleccionados entre uno o más del grupo queconsiste en fluor, bromo,cloro y yodo), alqui lo C1-5; alquilo C1-5 sustituido (donde los sustituyentes alquilo son seleccionados entre el grupo que consiste
ARP980101886A 1997-04-24 1998-04-23 Imidazoles sustituidos, composicion farmaceutica que los comprende, el uso de los mismos en la manufactura de un medicamento y procedimiento para supreparacion e intermediario AR012594A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4425297P 1997-04-24 1997-04-24

Publications (1)

Publication Number Publication Date
AR012594A1 true AR012594A1 (es) 2000-11-08

Family

ID=21931339

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980101886A AR012594A1 (es) 1997-04-24 1998-04-23 Imidazoles sustituidos, composicion farmaceutica que los comprende, el uso de los mismos en la manufactura de un medicamento y procedimiento para supreparacion e intermediario

Country Status (24)

Country Link
US (3) US5965583A (es)
EP (1) EP1028954B1 (es)
JP (1) JP2001522357A (es)
KR (1) KR100568438B1 (es)
CN (1) CN1211381C (es)
AR (1) AR012594A1 (es)
AT (1) ATE244234T1 (es)
AU (1) AU7138298A (es)
BR (1) BR9808998A (es)
CA (1) CA2297176A1 (es)
DE (1) DE69816109T2 (es)
DK (1) DK1028954T3 (es)
ES (1) ES2202840T3 (es)
HU (1) HUP0002842A3 (es)
IL (1) IL132318A0 (es)
NO (1) NO318937B1 (es)
NZ (1) NZ500447A (es)
PL (1) PL191111B1 (es)
PT (1) PT1028954E (es)
RU (1) RU2222534C2 (es)
TR (1) TR199902622T2 (es)
UA (1) UA65572C2 (es)
WO (1) WO1998047892A1 (es)
ZA (1) ZA983451B (es)

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EP1028954B1 (en) 2003-07-02
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UA65572C2 (en) 2004-04-15
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US5965583A (en) 1999-10-12
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