HUP0002842A3 - Substituted imidazoles, process for producing them, pharmaceutical compositions containing them, their use and their intermediates - Google Patents
Substituted imidazoles, process for producing them, pharmaceutical compositions containing them, their use and their intermediatesInfo
- Publication number
- HUP0002842A3 HUP0002842A3 HU0002842A HUP0002842A HUP0002842A3 HU P0002842 A3 HUP0002842 A3 HU P0002842A3 HU 0002842 A HU0002842 A HU 0002842A HU P0002842 A HUP0002842 A HU P0002842A HU P0002842 A3 HUP0002842 A3 HU P0002842A3
- Authority
- HU
- Hungary
- Prior art keywords
- intermediates
- producing
- pharmaceutical compositions
- compositions containing
- substituted imidazoles
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4425297P | 1997-04-24 | 1997-04-24 | |
| PCT/US1998/007910 WO1998047892A1 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles useful in the treatment of inflammatory diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002842A2 HUP0002842A2 (hu) | 2001-06-28 |
| HUP0002842A3 true HUP0002842A3 (en) | 2002-01-28 |
Family
ID=21931339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002842A HUP0002842A3 (en) | 1997-04-24 | 1998-04-17 | Substituted imidazoles, process for producing them, pharmaceutical compositions containing them, their use and their intermediates |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US5965583A (hu) |
| EP (1) | EP1028954B1 (hu) |
| JP (1) | JP2001522357A (hu) |
| KR (1) | KR100568438B1 (hu) |
| CN (1) | CN1211381C (hu) |
| AR (1) | AR012594A1 (hu) |
| AT (1) | ATE244234T1 (hu) |
| AU (1) | AU7138298A (hu) |
| BR (1) | BR9808998A (hu) |
| CA (1) | CA2297176A1 (hu) |
| DE (1) | DE69816109T2 (hu) |
| DK (1) | DK1028954T3 (hu) |
| ES (1) | ES2202840T3 (hu) |
| HU (1) | HUP0002842A3 (hu) |
| IL (1) | IL132318A0 (hu) |
| NO (1) | NO318937B1 (hu) |
| NZ (1) | NZ500447A (hu) |
| PL (1) | PL191111B1 (hu) |
| PT (1) | PT1028954E (hu) |
| RU (1) | RU2222534C2 (hu) |
| TR (1) | TR199902622T2 (hu) |
| UA (1) | UA65572C2 (hu) |
| WO (1) | WO1998047892A1 (hu) |
| ZA (1) | ZA983451B (hu) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
| WO1998007425A1 (en) | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| UA65572C2 (en) | 1997-04-24 | 2004-04-15 | Ortho Mcneil Pharm Inc | Substituted imidazoles, intermediate compounds for the preparation thereof, a method for the preparation of substituted imidazoles and a method for the treatment of inflammatory diseases |
| JP2002504909A (ja) | 1997-06-13 | 2002-02-12 | スミスクライン・ビーチャム・コーポレイション | 新規な置換ピラゾールおよびピラゾリン化合物 |
| EP0994870A4 (en) | 1997-06-19 | 2002-10-23 | Smithkline Beecham | NEW IMIDAZOLE COMPOUNDS SUBSTITUTED BY AN ARYLOXYREST |
| GB9713726D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| US6489325B1 (en) | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| WO1999001452A1 (en) | 1997-07-02 | 1999-01-14 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
| US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6362193B1 (en) | 1997-10-08 | 2002-03-26 | Smithkline Beecham Corporation | Cycloalkenyl substituted compounds |
| US6436966B1 (en) * | 1997-10-27 | 2002-08-20 | Takeda Chemical Ind., Ltd. | Adenosine A3 receptor antagonists |
| WO1999032121A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
| TR200003472T2 (tr) | 1998-05-22 | 2001-09-21 | Smithkline Beecham Corporation | Yeni 2-alkil ikameli imidazol bileşikler |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6207687B1 (en) | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
| CA2346665A1 (en) | 1998-10-07 | 2000-04-13 | Smithkline Beecham Corporation | Novel treatment for stroke management |
| AU1909200A (en) | 1998-11-04 | 2000-05-22 | Smithkline Beecham Corporation | Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines |
| ATE374026T1 (de) * | 1999-03-25 | 2007-10-15 | Mitsubishi Pharma Corp | Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose |
| US6291457B1 (en) * | 1999-07-01 | 2001-09-18 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| DE60111417T2 (de) * | 2000-10-18 | 2006-03-16 | Ortho-Mcneil Pharmaceutical, Inc. | Substituierte imidazole, die sich für die behandlung entzündlicher krankheiten eignen |
| AU2002224417A1 (en) * | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| MXPA03008727A (es) * | 2001-03-26 | 2004-07-30 | Johnson & Johnson | Procedimiento para la preparacion de derivados de imidazol tetrasubstituidos y estructuras cristalinas novedosas de los mismos. |
| EP1508569A3 (en) * | 2001-03-26 | 2005-09-14 | Ortho-McNeil Pharmaceutical, Inc. | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof |
| GB0112348D0 (en) * | 2001-05-19 | 2001-07-11 | Smithkline Beecham Plc | Compounds |
| CA2451955C (en) | 2001-06-26 | 2015-09-29 | Abgenix, Inc. | Antibodies to opgl |
| AU2002324625B2 (en) * | 2001-08-07 | 2008-05-08 | Immunex Corporation | Interleukin-1 receptors in the treatment of diseases |
| KR20020009532A (ko) * | 2001-11-13 | 2002-02-01 | (주)쎌믹스 | 류코트리엔 합성 억제용 조성물 |
| AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| HRP20020453A2 (en) | 2002-05-23 | 2003-12-31 | Pliva D D | 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
| WO2004004725A2 (en) | 2002-07-09 | 2004-01-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| CN101899006B (zh) * | 2002-08-19 | 2013-11-06 | 劳洛斯治疗公司 | 2，4，5-三取代的咪唑及其作为抗菌剂的用途 |
| DK2213685T3 (en) | 2002-09-06 | 2014-03-03 | Medarex Llc | Therapeutic anti-IL-1R1 monoclonal antibody |
| UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
| CL2004000234A1 (es) * | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| JP4617299B2 (ja) * | 2003-03-03 | 2011-01-19 | アレイ バイオファーマ、インコーポレイテッド | ｐ３８阻害剤及びその使用法 |
| US7429378B2 (en) * | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
| US7553827B2 (en) * | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
| US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
| US20040229878A1 (en) * | 2003-05-13 | 2004-11-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of P38 kinase |
| US7344716B2 (en) * | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
| WO2005000405A2 (en) * | 2003-06-06 | 2005-01-06 | The Trustees Of The University Of Pennsylvania | P38 kinase inhibitor compositions and methods of use |
| US8361467B2 (en) * | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
| US8969372B2 (en) * | 2003-11-14 | 2015-03-03 | Aptose Boisciences Inc. | Aryl imidazoles and their use as anti-cancer agents |
| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| WO2005063716A1 (en) | 2003-12-22 | 2005-07-14 | Janssen Pharmaceutica, N.V. | Imidazoles and their use cck-1 receptor modulators |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| US20080119498A1 (en) * | 2004-12-06 | 2008-05-22 | Masatomo Kato | Therapeutic Agent for Pruritus Comprising P38 Map Kinase Inhibitor as the Active Ingredient |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
| AU2006250809B2 (en) * | 2005-05-25 | 2011-05-12 | Lorus Therapeutics Inc. | 2-indolyl imidazo(4,5-D)phenanthroline derivatives and their use in the treatment of cancer |
| CN101484575B (zh) | 2005-06-08 | 2013-10-02 | 森托科尔公司 | 用于眼变性的细胞疗法 |
| JP5131990B2 (ja) * | 2006-01-31 | 2013-01-30 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害剤およびその使用方法 |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CN101952415B (zh) | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| CN107574142B (zh) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| US8986696B2 (en) * | 2007-12-21 | 2015-03-24 | Depuy Mitek, Inc. | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints |
| US20090162351A1 (en) * | 2007-12-21 | 2009-06-25 | Depuy Spine, Inc. | Transdiscal administration of inhibitors of p38 MAP kinase |
| WO2009105570A2 (en) | 2008-02-21 | 2009-08-27 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| EP2111861A1 (en) | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
| US8623648B2 (en) * | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| JP5734183B2 (ja) | 2008-06-30 | 2015-06-17 | ヤンセン バイオテツク，インコーポレーテツド | 多能性幹細胞の分化 |
| BRPI0919885A2 (pt) | 2008-10-31 | 2015-08-11 | Centocor Ortho Biotech Inc | Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática |
| CA2742267C (en) | 2008-10-31 | 2019-06-04 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| RU2555538C2 (ru) | 2008-11-20 | 2015-07-10 | Сентокор Орто Байотек Инк. | Культура плюрипотентных стволовых клеток на микроносителях |
| AU2009316583B2 (en) | 2008-11-20 | 2016-04-21 | Janssen Biotech, Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
| US8334287B2 (en) * | 2009-07-17 | 2012-12-18 | Hoffmann-La Roche Inc. | Imidazoles |
| EP2456862A4 (en) | 2009-07-20 | 2013-02-27 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS |
| GB2485113B (en) | 2009-07-20 | 2016-12-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage |
| RU2540021C2 (ru) | 2009-07-20 | 2015-01-27 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека |
| RU2586506C2 (ru) | 2009-12-23 | 2016-06-10 | Янссен Байотек, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
| CN102741395B (zh) | 2009-12-23 | 2016-03-16 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| AU2011223900A1 (en) | 2010-03-01 | 2012-09-13 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
| MX351515B (es) | 2010-05-12 | 2017-10-17 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
| US9528090B2 (en) | 2010-08-31 | 2016-12-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| CA2809305C (en) | 2010-08-31 | 2019-06-11 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| AU2011296381B2 (en) | 2010-08-31 | 2016-03-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| AU2012355698B2 (en) | 2011-12-22 | 2018-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| EP2799537B1 (en) | 2011-12-28 | 2021-09-22 | Kyoto Prefectural Public University Corporation | Normalization of culture of corneal endothelial cells |
| KR20140131999A (ko) | 2012-03-07 | 2014-11-14 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포의 증폭 및 유지를 위한 한정 배지 |
| CN108103006A (zh) | 2012-06-08 | 2018-06-01 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌细胞的分化 |
| JP6529440B2 (ja) | 2012-12-31 | 2019-06-12 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞への分化のためのヒト多能性細胞の懸濁及びクラスタリング |
| KR102084561B1 (ko) | 2012-12-31 | 2020-03-04 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양 |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| KR102036780B1 (ko) | 2012-12-31 | 2019-10-25 | 얀센 바이오테크 인코포레이티드 | Hb9 조절제를 사용하는 인간 배아 줄기세포의 췌장 내분비 세포로의 분화 |
| CA2903866A1 (en) | 2013-03-20 | 2014-09-25 | Aptose Biosciences Inc. | 2-substituted imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer |
| US20150104392A1 (en) | 2013-10-04 | 2015-04-16 | Aptose Biosciences Inc. | Compositions, biomarkers and their use in the treatment of cancer |
| US10813920B2 (en) | 2013-11-14 | 2020-10-27 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
| CA2949056A1 (en) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| EP3708156A1 (en) | 2014-05-16 | 2020-09-16 | Atriva Therapeutics GmbH | Novel anti-infective strategy against influenza virus and s. aureus coinfections |
| US20170266173A1 (en) * | 2014-08-25 | 2017-09-21 | Bing Hui Wang | Mapk inhibitors |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CA3128468A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
| CA3081261A1 (en) | 2017-10-30 | 2019-05-09 | Aptose Biosciences Inc. | Aryl imidazoles for the treatment of cancer |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| BR112023001007A2 (pt) | 2020-07-20 | 2023-03-28 | Annexon Inc | Inibidores de fatores do complemento e usos dos mesmos |
| WO2023280911A1 (en) | 2021-07-06 | 2023-01-12 | Westfälische Wilhelms-Universität Münster | P38-inhibitors for the treatment of coronavirus infections and/or covid-19 cytokine storm |
| WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0004648B1 (de) * | 1978-04-11 | 1982-08-25 | Ciba-Geigy Ag | Neue Mercaptoimidazolderivate, Verfahren zu deren Herstellung, Mercaptoimidazolderivate zur Behandlung entzündlicher Erkrankungen und diese enthaltende pharmazeutische Präparate |
| GR75287B (hu) * | 1980-07-25 | 1984-07-13 | Ciba Geigy Ag | |
| US4503065A (en) * | 1982-08-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl 1-2-halo imidazoles |
| US5656762A (en) * | 1990-12-28 | 1997-08-12 | Neurogen Corporation | 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, dopamine receptor subtype specific ligands |
| IL104369A0 (en) * | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
| US5593992A (en) | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| UA65572C2 (en) | 1997-04-24 | 2004-04-15 | Ortho Mcneil Pharm Inc | Substituted imidazoles, intermediate compounds for the preparation thereof, a method for the preparation of substituted imidazoles and a method for the treatment of inflammatory diseases |
-
1998
- 1998-04-17 UA UA99105811A patent/UA65572C2/uk unknown
- 1998-04-17 DE DE69816109T patent/DE69816109T2/de not_active Expired - Fee Related
- 1998-04-17 RU RU99122164/04A patent/RU2222534C2/ru not_active IP Right Cessation
- 1998-04-17 CN CNB988045230A patent/CN1211381C/zh not_active Expired - Fee Related
- 1998-04-17 TR TR1999/02622T patent/TR199902622T2/xx unknown
- 1998-04-17 HU HU0002842A patent/HUP0002842A3/hu unknown
- 1998-04-17 JP JP54623198A patent/JP2001522357A/ja not_active Withdrawn
- 1998-04-17 CA CA002297176A patent/CA2297176A1/en not_active Abandoned
- 1998-04-17 AU AU71382/98A patent/AU7138298A/en not_active Abandoned
- 1998-04-17 PT PT98918463T patent/PT1028954E/pt unknown
- 1998-04-17 BR BR9808998-6A patent/BR9808998A/pt not_active Application Discontinuation
- 1998-04-17 ES ES98918463T patent/ES2202840T3/es not_active Expired - Lifetime
- 1998-04-17 WO PCT/US1998/007910 patent/WO1998047892A1/en not_active Application Discontinuation
- 1998-04-17 DK DK98918463T patent/DK1028954T3/da active
- 1998-04-17 AT AT98918463T patent/ATE244234T1/de not_active IP Right Cessation
- 1998-04-17 EP EP98918463A patent/EP1028954B1/en not_active Expired - Lifetime
- 1998-04-17 KR KR1019997009785A patent/KR100568438B1/ko not_active IP Right Cessation
- 1998-04-17 NZ NZ500447A patent/NZ500447A/en unknown
- 1998-04-17 IL IL13231898A patent/IL132318A0/xx not_active IP Right Cessation
- 1998-04-17 PL PL336758A patent/PL191111B1/pl not_active IP Right Cessation
- 1998-04-17 US US09/062,304 patent/US5965583A/en not_active Expired - Lifetime
- 1998-04-23 ZA ZA9803451A patent/ZA983451B/xx unknown
- 1998-04-23 AR ARP980101886A patent/AR012594A1/es not_active Application Discontinuation
-
1999
- 1999-04-20 US US09/295,156 patent/US6214830B1/en not_active Expired - Lifetime
- 1999-10-19 NO NO19995095A patent/NO318937B1/no unknown
-
2000
- 2000-11-03 US US09/705,508 patent/US6521655B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| TR199902622T2 (xx) | 2000-05-22 |
| EP1028954B1 (en) | 2003-07-02 |
| RU2222534C2 (ru) | 2004-01-27 |
| UA65572C2 (en) | 2004-04-15 |
| KR100568438B1 (ko) | 2006-04-07 |
| NO995095L (no) | 1999-12-09 |
| DK1028954T3 (da) | 2003-10-27 |
| US6521655B1 (en) | 2003-02-18 |
| PL191111B1 (pl) | 2006-03-31 |
| US5965583A (en) | 1999-10-12 |
| NO318937B1 (no) | 2005-05-30 |
| AU7138298A (en) | 1998-11-13 |
| ZA983451B (en) | 1999-10-25 |
| JP2001522357A (ja) | 2001-11-13 |
| PT1028954E (pt) | 2003-11-28 |
| WO1998047892A1 (en) | 1998-10-29 |
| EP1028954A1 (en) | 2000-08-23 |
| CN1253558A (zh) | 2000-05-17 |
| ES2202840T3 (es) | 2004-04-01 |
| AR012594A1 (es) | 2000-11-08 |
| NZ500447A (en) | 2001-09-28 |
| PL336758A1 (en) | 2000-07-17 |
| BR9808998A (pt) | 2000-08-08 |
| DE69816109D1 (de) | 2003-08-07 |
| CN1211381C (zh) | 2005-07-20 |
| ATE244234T1 (de) | 2003-07-15 |
| NO995095D0 (no) | 1999-10-19 |
| KR20010020204A (ko) | 2001-03-15 |
| CA2297176A1 (en) | 1998-10-29 |
| HUP0002842A2 (hu) | 2001-06-28 |
| DE69816109T2 (de) | 2004-04-22 |
| IL132318A0 (en) | 2001-03-19 |
| US6214830B1 (en) | 2001-04-10 |
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| FD9A | Lapse of provisional protection due to non-payment of fees |