AR002702A1 - Formulación farmacéutica oral estable conteniendo un compuesto de bencimidazol labil en medio ácido su procedimiento de obtención y sus formulaciones galenicas - Google Patents
Formulación farmacéutica oral estable conteniendo un compuesto de bencimidazol labil en medio ácido su procedimiento de obtención y sus formulaciones galenicasInfo
- Publication number
 - AR002702A1 AR002702A1 AR10105196A AR10105196A AR002702A1 AR 002702 A1 AR002702 A1 AR 002702A1 AR 10105196 A AR10105196 A AR 10105196A AR 10105196 A AR10105196 A AR 10105196A AR 002702 A1 AR002702 A1 AR 002702A1
 - Authority
 - AR
 - Argentina
 - Prior art keywords
 - formulation containing
 - acidic medium
 - benzimidazole compound
 - stable oral
 - obtaining procedure
 - Prior art date
 
Links
- 230000002378 acidificating effect Effects 0.000 title 1
 - -1 benzimidazole compound Chemical class 0.000 title 1
 - 238000000034 method Methods 0.000 title 1
 - 239000008203 oral pharmaceutical composition Substances 0.000 title 1
 - 239000008194 pharmaceutical composition Substances 0.000 title 1
 
Classifications
- 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
 - A61K31/00—Medicinal preparations containing organic active ingredients
 - A61K31/33—Heterocyclic compounds
 - A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
 - A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
 - A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
 - A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
 - A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
 - A61K31/00—Medicinal preparations containing organic active ingredients
 - A61K31/33—Heterocyclic compounds
 - A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
 - A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
 - A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
 - A61K9/00—Medicinal preparations characterised by special physical form
 - A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
 - A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
 - A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
 - A61K9/00—Medicinal preparations characterised by special physical form
 - A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
 - A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
 - A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
 - A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
 - A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
 - A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
 - A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
 - A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
 - A61P31/04—Antibacterial agents
 
 
Landscapes
- Health & Medical Sciences (AREA)
 - Engineering & Computer Science (AREA)
 - Medicinal Chemistry (AREA)
 - Pharmacology & Pharmacy (AREA)
 - Bioinformatics & Cheminformatics (AREA)
 - Life Sciences & Earth Sciences (AREA)
 - Animal Behavior & Ethology (AREA)
 - General Health & Medical Sciences (AREA)
 - Public Health (AREA)
 - Chemical & Material Sciences (AREA)
 - Veterinary Medicine (AREA)
 - Epidemiology (AREA)
 - General Chemical & Material Sciences (AREA)
 - Chemical Kinetics & Catalysis (AREA)
 - Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
 - Organic Chemistry (AREA)
 - Communicable Diseases (AREA)
 - Oncology (AREA)
 - Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
 - Medicinal Preparation (AREA)
 - Plural Heterocyclic Compounds (AREA)
 
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| ES09500181A ES2094694B1 (es) | 1995-02-01 | 1995-02-01 | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. | 
Publications (1)
| Publication Number | Publication Date | 
|---|---|
| AR002702A1 true AR002702A1 (es) | 1998-04-29 | 
Family
ID=8289322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| AR10105196A AR002702A1 (es) | 1995-02-01 | 1996-01-17 | Formulación farmacéutica oral estable conteniendo un compuesto de bencimidazol labil en medio ácido su procedimiento de obtención y sus formulaciones galenicas | 
Country Status (20)
| Country | Link | 
|---|---|
| US (1) | US5626875A (instruction) | 
| EP (2) | EP0773025B1 (instruction) | 
| JP (1) | JP4183746B2 (instruction) | 
| KR (1) | KR100331290B1 (instruction) | 
| AR (1) | AR002702A1 (instruction) | 
| AT (2) | ATE193649T1 (instruction) | 
| AU (1) | AU4540396A (instruction) | 
| CA (1) | CA2184842C (instruction) | 
| DE (3) | DE69608767D1 (instruction) | 
| DK (2) | DK0773025T3 (instruction) | 
| ES (3) | ES2094694B1 (instruction) | 
| FI (1) | FI121730B (instruction) | 
| HU (1) | HU229219B1 (instruction) | 
| IL (1) | IL116673A (instruction) | 
| IN (1) | IN186596B (instruction) | 
| PT (2) | PT773025E (instruction) | 
| SI (2) | SI0773025T1 (instruction) | 
| TW (1) | TW503115B (instruction) | 
| WO (1) | WO1996023500A1 (instruction) | 
| ZA (1) | ZA96683B (instruction) | 
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process | 
| ES2236628T3 (es) | 1995-09-21 | 2005-07-16 | Pharma Pass Ii Llc | Composicion farmaceutica que contiene un omeprazol labil de acido, y procedimiento para su preparacion. | 
| SI9700186B (sl) | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin | 
| ES2137862B1 (es) * | 1997-07-31 | 2000-09-16 | Intexim S A | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. | 
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects | 
| US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds | 
| US6559158B1 (en) | 1997-11-03 | 2003-05-06 | Ur Labs, Inc. | Use of methylnaltrexone and related compounds to treat chronic opioid use side affects | 
| FR2774288B1 (fr) † | 1998-01-30 | 2001-09-07 | Ethypharm Sa | Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques | 
| DK173431B1 (da) | 1998-03-20 | 2000-10-23 | Gea Farmaceutisk Fabrik As | Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs | 
| ATE526022T1 (de) * | 1998-04-20 | 2011-10-15 | Eisai R&D Man Co Ltd | Stabilisierte zusammenstellungen die benzimidazole enthalten | 
| ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. | 
| WO2000009092A1 (en) * | 1998-08-12 | 2000-02-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1h-benzimidazoles | 
| FR2793688B1 (fr) * | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques | 
| ES2168043B1 (es) | 1999-09-13 | 2003-04-01 | Esteve Labor Dr | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. | 
| TWI268779B (en) | 1999-10-20 | 2006-12-21 | Eisai Co Ltd | Method for stabilizing benzimidazole-based compounds | 
| DE19959419A1 (de) * | 1999-12-09 | 2001-06-21 | Ratiopharm Gmbh | Stabile galenische Zubereitungen umfassend ein Benzimidazol und Verfahren zu ihrer Herstellung | 
| DK1108425T3 (da) * | 1999-12-16 | 2005-09-26 | Medinfar Produtos Farmaceutico | Nye, stabile flerenhedspræparater, der indeholder substituerede benzimidazoler | 
| US6419956B1 (en) | 1999-12-30 | 2002-07-16 | Ancile Pharmaceuticals | Odor-masking coating for a pharmaceutical preparation | 
| US20020064555A1 (en) * | 2000-09-29 | 2002-05-30 | Dan Cullen | Proton pump inhibitor formulation | 
| KR20030051794A (ko) * | 2000-11-10 | 2003-06-25 | 에프. 호프만-라 로슈 아게 | 가수분해에 불안정한 조성물 | 
| CA2449175A1 (en) * | 2001-06-05 | 2002-12-12 | University Of Chicago | Use of methylnaltrexone to treat immune suppression | 
| KR100914175B1 (ko) | 2001-07-16 | 2009-08-27 | 얀센 파마슈티카 엔.브이. | 벤즈이미다졸-타입 화합물의 개선된 제조 방법 | 
| EP1438030A2 (en) * | 2001-09-28 | 2004-07-21 | McNEIL-PPC, INC. | Modified release dosage forms | 
| US20040170689A1 (en) * | 2001-11-09 | 2004-09-02 | Odink Debra Alida | Stabilized formulations comprising hydrolytically unstable compositions | 
| ES2198195B1 (es) | 2001-12-18 | 2004-10-01 | Laboratorios Del Dr. Esteve, S.A. | Forma de dosificacion farmaceutica oral comprimida, con recubrimiento enterico, que contiene un compuesto de bencimidazol labil en medio acido. | 
| ES2299710T3 (es) * | 2002-08-02 | 2008-06-01 | Ratiopharm Gmbh | Preparacion farmaceutica que contiene un compuesto de bencimidazol mezclado con celulosa microcristalina y un metodo para su preparacion. | 
| US20040028737A1 (en) * | 2002-08-12 | 2004-02-12 | Kopran Research Laboratories Limited | Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same | 
| WO2004066982A1 (en) * | 2003-01-31 | 2004-08-12 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and processes for their preparation | 
| MXPA05010819A (es) * | 2003-04-08 | 2006-03-30 | Progenics Pharm Inc | Uso de antagonistas de opioide perifericos, especialmente metilnaltrexona para tratar sindrome de intestino irritable. | 
| US20040259899A1 (en) * | 2003-04-08 | 2004-12-23 | Sanghvi Suketu P. | Combination therapy for constipation | 
| HRP20150037T4 (hr) * | 2003-04-08 | 2022-09-02 | Progenics Pharmaceuticals, Inc. | Farmaceutske formulacije koje sadrže metilnaltrekson | 
| ES2234393B2 (es) * | 2003-04-29 | 2006-09-01 | Laboratorios Belmac, S.A. | "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido". | 
| AU2003245033A1 (en) * | 2003-05-08 | 2004-11-26 | Podili Khadgapathi | An improved and stable pharmaceutical composition containing substituted benzimidazoles and a process for its preparation | 
| WO2005011637A1 (ja) * | 2003-08-04 | 2005-02-10 | Eisai Co., Ltd. | 用時分散型製剤 | 
| TWI372066B (en) | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations | 
| WO2005034924A1 (en) * | 2003-10-14 | 2005-04-21 | Natco Pharma Limited | Enteric coated pellets comprising esomeprazole, hard gelatin capsule containing them, and method of preparation | 
| GB0400781D0 (en) * | 2004-01-14 | 2004-02-18 | Novartis Ag | Organic compounds | 
| US20050214372A1 (en) * | 2004-03-03 | 2005-09-29 | Simona Di Capua | Stable pharmaceutical composition comprising an acid labile drug | 
| PL1746980T3 (pl) | 2004-05-07 | 2012-03-30 | Nycomed Gmbh | Farmaceutyczna postać dawkowania zawierająca peletki i sposób jej wytwarzania | 
| US20050281876A1 (en) * | 2004-06-18 | 2005-12-22 | Shun-Por Li | Solid dosage form for acid-labile active ingredient | 
| EP1830823A2 (en) | 2004-12-23 | 2007-09-12 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and process of preparation thereof | 
| WO2006066932A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Stable pharmaceutical composition comprising an active substance in the form of solid solution | 
| MX2007008141A (es) * | 2005-01-03 | 2007-12-10 | Lupin Ltd | Composicion farmaceutica de sustancias labiles en medio acido. | 
| CN101137378A (zh) * | 2005-01-20 | 2008-03-05 | 普罗热尼奇制药公司 | 甲基纳曲酮和相关化合物治疗术后胃肠功能障碍的用途 | 
| WO2006087613A2 (en) * | 2005-02-02 | 2006-08-24 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions prepared by non-aqueous layering process | 
| EP1861096B1 (en) | 2005-03-07 | 2018-12-26 | The University of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration | 
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration | 
| US8524731B2 (en) * | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration | 
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists | 
| US8673352B2 (en) * | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form | 
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion | 
| US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion | 
| AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos | 
| AR057035A1 (es) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS | 
| US20080194611A1 (en) * | 2005-06-03 | 2008-08-14 | Alverdy John C | Modulation of Cell Barrier Dysfunction | 
| EP1785135A1 (en) * | 2005-11-10 | 2007-05-16 | Laboratorios Del Dr. Esteve, S.A. | New stabilized galenic formulations comprising lansoprazole and their preparation | 
| CA2633825A1 (en) * | 2005-12-20 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Lansoprazole orally disintegrating tablets | 
| EP1813275A1 (en) * | 2005-12-20 | 2007-08-01 | Teva Pharmaceutical Industries Ltd | Lansoprazole orally disintegrating tablets | 
| US7579476B2 (en) * | 2006-02-24 | 2009-08-25 | Praktikatalyst Pharma, Llc | Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals | 
| ITMI20061024A1 (it) * | 2006-05-25 | 2007-11-26 | Eurand Pharmaceuticals Ltd | Pellet a base di acido lipoico | 
| ES2511792T3 (es) * | 2006-07-25 | 2014-10-23 | Vecta Ltd. | Composiciones y métodos para la inhibición de la secreción de ácido gástrico usando derivados de pequeños ácidos dicarboxílicos en combinación con IBP | 
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 | 
| TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof | 
| WO2008121860A1 (en) * | 2007-03-29 | 2008-10-09 | Wyeth | Peripheral opioid receptor and antagonists and uses thereof | 
| EP3064503A1 (en) * | 2007-03-29 | 2016-09-07 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof | 
| CN101801979A (zh) | 2007-03-29 | 2010-08-11 | 普罗热尼奇制药公司 | (r)-n-溴化甲基纳曲酮的晶体形式及其用途 | 
| US8471022B2 (en) * | 2008-02-06 | 2013-06-25 | Progenics Pharmaceuticals, Inc. | Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone | 
| US8911787B2 (en) | 2008-02-26 | 2014-12-16 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and process of preparation thereof | 
| CA2719134C (en) | 2008-03-21 | 2015-06-30 | The University Of Chicago | Treatment with opioid antagonists and mtor inhibitors | 
| US20110250278A1 (en) | 2008-07-01 | 2011-10-13 | University Of Chicago | Particles containing an opioid receptor antagonist and methods of use | 
| CA2733299A1 (en) * | 2008-08-11 | 2010-02-18 | Mepha Gmbh | Oral pharmaceutical formulation for omeprazole comprising a specific separation layer | 
| CH699302B1 (de) * | 2008-08-11 | 2012-03-15 | Mepha Gmbh | Orale pharmazeutische Formulierung für Omeprazol, enthaltend eine spezifische Trennschicht. | 
| CA2676881C (en) * | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof | 
| WO2010117756A2 (en) * | 2009-03-31 | 2010-10-14 | Dr. Reddy's Laboratories Ltd | Substituted benzimidazole pharmaceutical formulations | 
| US20130202688A1 (en) | 2010-05-04 | 2013-08-08 | Sunilendu Bhushan Roy | Delayed release oral disintegrating pharmaceutical compositions of lansoprazole | 
| BR112014009580B1 (pt) * | 2011-11-02 | 2022-03-29 | Esteve Pharmaceuticals, S.A | Composição farmacêutica de omeprazol | 
| GB2513172A (en) * | 2013-04-18 | 2014-10-22 | Nupharm Lab Ltd | Liquid dosage form and delivery system | 
| WO2016061531A1 (en) | 2014-10-17 | 2016-04-21 | Salix Pharmaceuticals, Inc. | Use of methylnaltrexone to attenuate tumor progression | 
| US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions | 
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions | 
| EP3292862A1 (en) | 2016-09-07 | 2018-03-14 | Sandoz Ag | Omeprazole formulations | 
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| GB829055A (en) * | 1958-02-07 | 1960-02-24 | Charles E Frosst And Company | Improvements in or relating to pharmaceutical preparations | 
| US4150111A (en) * | 1974-05-28 | 1979-04-17 | Allister Warren | Enteric coated magnesium chloride | 
| JPS5837285B2 (ja) * | 1975-05-29 | 1983-08-15 | カブシキガイシヤ ミドリジユウジ | チヨウナイカンセンシヨウチリヨウザイノセイゾウホウホウ | 
| JPS5598120A (en) * | 1979-01-16 | 1980-07-25 | Shin Etsu Chem Co Ltd | Preparation of drug having enteric coating | 
| US4470980A (en) * | 1980-03-07 | 1984-09-11 | Interx Research Corp. | Method of increasing oral absorption of β-lactam antibiotics | 
| US4377568A (en) * | 1981-08-12 | 1983-03-22 | Merck Sharp & Dohme (I.A.) Corp. | Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same | 
| JPS58208155A (ja) * | 1982-05-28 | 1983-12-03 | Sumitomo Electric Ind Ltd | 光伝送用ガラスフアイバの製造方法 | 
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| GB2189698A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets | 
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| YU48263B (sh) * | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola | 
| ATE156707T1 (de) * | 1991-06-21 | 1997-08-15 | Ilsan Ilac Ve Hammaddeleri San | Neues galenisches verfahren für omeprazol enthaltende pellets | 
| FR2692146B1 (fr) * | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. | 
| WO1994002140A1 (en) * | 1992-07-17 | 1994-02-03 | Astra Aktiebolag | Pharmaceutical composition containing antiulcer agent | 
| SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation | 
| SE9500478D0 (sv) | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process | 
- 
        1995
        
- 1995-02-01 ES ES09500181A patent/ES2094694B1/es not_active Expired - Fee Related
 - 1995-04-27 US US08/429,689 patent/US5626875A/en not_active Expired - Lifetime
 
 - 
        1996
        
- 1996-01-04 IL IL11667396A patent/IL116673A/xx not_active IP Right Cessation
 - 1996-01-17 AR AR10105196A patent/AR002702A1/es not_active Application Discontinuation
 - 1996-01-22 IN IN104CA1996 patent/IN186596B/en unknown
 - 1996-01-26 DE DE69608767T patent/DE69608767D1/de not_active Revoked
 - 1996-01-26 DK DK96901349T patent/DK0773025T3/da active
 - 1996-01-26 ES ES99116334T patent/ES2238796T3/es not_active Expired - Lifetime
 - 1996-01-26 AT AT96901349T patent/ATE193649T1/de not_active IP Right Cessation
 - 1996-01-26 KR KR1019960704702A patent/KR100331290B1/ko not_active Expired - Fee Related
 - 1996-01-26 AU AU45403/96A patent/AU4540396A/en not_active Abandoned
 - 1996-01-26 DK DK99116334T patent/DK0993830T3/da active
 - 1996-01-26 HU HU9603014A patent/HU229219B1/hu not_active IP Right Cessation
 - 1996-01-26 AT AT99116334T patent/ATE292967T1/de not_active IP Right Cessation
 - 1996-01-26 SI SI9630226T patent/SI0773025T1/xx unknown
 - 1996-01-26 TW TW085100946A patent/TW503115B/zh not_active IP Right Cessation
 - 1996-01-26 WO PCT/ES1996/000013 patent/WO1996023500A1/es not_active Application Discontinuation
 - 1996-01-26 ES ES96901349T patent/ES2148725T3/es not_active Expired - Lifetime
 - 1996-01-26 DE DE69634613T patent/DE69634613T2/de not_active Revoked
 - 1996-01-26 CA CA002184842A patent/CA2184842C/en not_active Expired - Fee Related
 - 1996-01-26 EP EP96901349A patent/EP0773025B1/en not_active Revoked
 - 1996-01-26 EP EP99116334A patent/EP0993830B1/en not_active Revoked
 - 1996-01-26 JP JP52327896A patent/JP4183746B2/ja not_active Expired - Fee Related
 - 1996-01-26 PT PT96901349T patent/PT773025E/pt unknown
 - 1996-01-26 DE DE29623938U patent/DE29623938U1/de not_active Expired - Lifetime
 - 1996-01-26 PT PT99116334T patent/PT993830E/pt unknown
 - 1996-01-26 SI SI9630710T patent/SI0993830T1/xx unknown
 - 1996-01-30 ZA ZA96683A patent/ZA96683B/xx unknown
 - 1996-09-30 FI FI963916A patent/FI121730B/fi not_active IP Right Cessation
 
 
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