AP910A - Indazole bioisostere replacement of catechol in therapeutically active compounds. - Google Patents

Indazole bioisostere replacement of catechol in therapeutically active compounds. Download PDF

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Publication number
AP910A
AP910A APAP/P/1998/001375A AP9801375A AP910A AP 910 A AP910 A AP 910A AP 9801375 A AP9801375 A AP 9801375A AP 910 A AP910 A AP 910A
Authority
AP
ARIPO
Prior art keywords
catechol
indazole
replacement
activity
compounds
Prior art date
Application number
APAP/P/1998/001375A
Other languages
English (en)
Other versions
AP9801375A0 (en
Inventor
Anthony Mafrat
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP9801375A0 publication Critical patent/AP9801375A0/xx
Application granted granted Critical
Publication of AP910A publication Critical patent/AP910A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
APAP/P/1998/001375A 1997-11-04 1998-10-29 Indazole bioisostere replacement of catechol in therapeutically active compounds. AP910A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6422997P 1997-11-04 1997-11-04
US6402497P 1997-11-04 1997-11-04
US6422897P 1997-11-04 1997-11-04
US6418797P 1997-11-04 1997-11-04
US6419897P 1997-11-04 1997-11-04

Publications (2)

Publication Number Publication Date
AP9801375A0 AP9801375A0 (en) 1998-12-31
AP910A true AP910A (en) 2000-12-05

Family

ID=27535645

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1998/001375A AP910A (en) 1997-11-04 1998-10-29 Indazole bioisostere replacement of catechol in therapeutically active compounds.

Country Status (29)

Country Link
US (1) US6391872B1 (hu)
EP (1) EP1028946A1 (hu)
JP (1) JP2001521926A (hu)
CN (1) CN1284948A (hu)
AP (1) AP910A (hu)
AR (1) AR013746A1 (hu)
AU (1) AU754734B2 (hu)
BG (1) BG104450A (hu)
BR (1) BR9813926A (hu)
CA (1) CA2309150A1 (hu)
CZ (1) CZ20001621A3 (hu)
DZ (1) DZ2640A1 (hu)
EA (1) EA200000488A1 (hu)
HR (1) HRP20000253A2 (hu)
HU (1) HUP0004150A3 (hu)
ID (1) ID23921A (hu)
IL (1) IL135900A0 (hu)
IS (1) IS5465A (hu)
MA (1) MA26563A1 (hu)
NO (1) NO20002129L (hu)
NZ (1) NZ503918A (hu)
OA (1) OA11354A (hu)
PE (1) PE129199A1 (hu)
PL (1) PL340753A1 (hu)
SK (1) SK6252000A3 (hu)
TN (1) TNSN98200A1 (hu)
TR (1) TR200001234T2 (hu)
WO (1) WO1999023077A1 (hu)
YU (1) YU25000A (hu)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0100330A3 (en) * 1997-11-04 2002-03-28 Pfizer Prod Inc Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors, compositions containing them and their use
UA71971C2 (en) 1999-06-04 2005-01-17 Agoron Pharmaceuticals Inc Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US7141581B2 (en) 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
JP2001031549A (ja) * 1999-07-14 2001-02-06 Pola Chem Ind Inc 真皮コラーゲン線維束再構築剤及びそれを含有する化粧料
US6432979B1 (en) 1999-08-12 2002-08-13 American Cyanamid Company Method of treating or inhibiting colonic polyps and colorectal cancer
WO2001012227A1 (en) * 1999-08-12 2001-02-22 American Cyanamid Company Nsaid and efgr kinase inhibitor containing composition for the treatment or inhibition of colonic polyps and colorectal cancer
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
WO2001079198A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinase
EP1380576B1 (en) 2001-04-16 2009-11-25 Eisai R&D Management Co., Ltd. 1h-indazole compounds inhibiting jnk
MXPA04002562A (es) 2001-09-19 2004-05-31 Altana Pharma Ag Combinacion de un pde-4 y nsaid.
WO2003024456A1 (en) * 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating and preventing migraines
EP1479138A2 (en) * 2002-02-13 2004-11-24 Koninklijke Philips Electronics N.V. Integrated semiconductor optical device, method and apparatus for manufacturing such a device
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
JP4723239B2 (ja) * 2002-04-30 2011-07-13 ユニジェン・インコーポレーテッド 治療剤としての遊離−ｂ−環フラボノイド類とフラバン類との混合物の製剤
CA2507074A1 (en) 2002-12-02 2004-06-17 F. Hoffmann-La Roche Ag Indazole derivatives as crf antagonists
NZ541699A (en) 2003-02-14 2009-01-31 Wyeth Corp Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
WO2004089392A1 (en) * 2003-04-04 2004-10-21 Unigen Pharmaceuticals, Inc. Formulation of dual cycloxygenase (cox) and lipoxygenase (lox) inhibitors for mammal skin care
US6984652B2 (en) * 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
CA2557575A1 (en) 2004-02-27 2005-09-15 F. Hoffmann-La Roche Ag Fused derivatives of pyrazole
WO2005085206A1 (en) 2004-02-27 2005-09-15 F. Hoffmann-La Roche Ag Indazole derivatives and pharmaceutical compositions containing them
AU2005219517A1 (en) 2004-02-27 2005-09-15 F.Hoffmann-La Roche Ag Heteroaryl-fused pyrazolo derivatives
US7844309B2 (en) * 2004-02-27 2010-11-30 Nokia Corporation Exchangeable keymat
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
WO2006056873A2 (en) * 2004-11-29 2006-06-01 Warner-Lambert Company Llc Therapeutic pyrazolo[3,4-b] pyridines and indazoles
RU2008103700A (ru) * 2005-08-15 2009-09-27 Вайет (Us) Производные азинил-3-сульфонилиндазола в качестве лиганд 5ов 5-гидрокситриптамина-6
BRPI0614343A2 (pt) * 2005-08-15 2011-03-22 Wyeth Corp derivados de 3-sulfonilindazol substituìdo como ligantes de 5-hidroxitriptamina-6
JP2009506007A (ja) 2005-08-25 2009-02-12 エフ．ホフマン−ラ ロシュ アーゲー ｐ３８ＭＡＰキナーゼ阻害剤及びその使用方法
WO2007029077A1 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-iv
WO2007031838A1 (en) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
EP1960353B1 (en) * 2005-11-03 2014-03-12 Allergan, Inc. Prostaglandins and analogues as agents for lowering intraocular pressure
KR20080114688A (ko) 2006-01-13 2008-12-31 와이어쓰 5-히드록시트립타민 수용체에 대한 리간드로서의 술포닐 치환된 1ｈ-인돌
RU2442777C2 (ru) 2006-01-31 2012-02-20 Эррэй Биофарма Инк. Ингибиторы киназ и способы их применения
ES2462240T3 (es) 2006-02-28 2014-05-22 Dart Neuroscience (Cayman) Ltd Piperazinas terapéuticas como inhibidores de PDE4
WO2007120523A2 (en) * 2006-03-31 2007-10-25 Vitae Pharmaceuticals, Inc. 6-(aminoalkyl)indazoles
JP2009532471A (ja) * 2006-04-05 2009-09-10 ワイス ５−ヒドロキシトリプタミン−６リガンドとしてのスルホニル−３−ヘテロシクリルインダゾール誘導体
WO2007120596A1 (en) * 2006-04-12 2007-10-25 Wyeth DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
US8012886B2 (en) * 2007-03-07 2011-09-06 Asm Assembly Materials Ltd Leadframe treatment for enhancing adhesion of encapsulant thereto
CA2680625C (en) 2007-03-14 2016-02-23 Ranbaxy Laboratories Limited Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
CN102648284B (zh) * 2009-09-18 2014-09-24 株式会社里维松 多酚衍生物及其制造方法
WO2011143430A1 (en) 2010-05-12 2011-11-17 Abbott Laboratories Indazole inhibitors of kinase
CN103709146B (zh) * 2014-01-15 2015-11-25 中国药科大学 一类含苯并咪唑结构的喹啉-4-胺衍生物、其制法及医药用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338087A1 (en) * 1987-10-13 1989-10-25 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds, process for their preparation, and their medicinal use
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006520A (en) * 1987-10-13 1991-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds and pharmaceutical use thereof
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
IL128642A0 (en) * 1996-09-04 2000-01-31 Pfizer Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338087A1 (en) * 1987-10-13 1989-10-25 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds, process for their preparation, and their medicinal use
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors

Also Published As

Publication number Publication date
HUP0004150A2 (hu) 2001-05-28
DZ2640A1 (fr) 2003-03-08
IS5465A (is) 2000-04-19
AU754734B2 (en) 2002-11-21
CA2309150A1 (en) 1999-05-14
YU25000A (sh) 2003-12-31
SK6252000A3 (en) 2001-11-06
IL135900A0 (en) 2001-05-20
BG104450A (en) 2000-12-29
AU9455298A (en) 1999-05-24
WO1999023077A1 (en) 1999-05-14
TNSN98200A1 (fr) 2005-03-15
OA11354A (en) 2003-12-23
CZ20001621A3 (cs) 2001-08-15
EP1028946A1 (en) 2000-08-23
US6391872B1 (en) 2002-05-21
HUP0004150A3 (en) 2001-08-28
EA200000488A1 (ru) 2000-10-30
AR013746A1 (es) 2001-01-10
PL340753A1 (en) 2001-02-26
NO20002129L (no) 2000-07-03
PE129199A1 (es) 1999-12-16
BR9813926A (pt) 2000-09-19
NO20002129D0 (no) 2000-04-26
NZ503918A (en) 2002-03-28
AP9801375A0 (en) 1998-12-31
HRP20000253A2 (en) 2001-06-30
ID23921A (id) 2000-05-25
MA26563A1 (fr) 2004-12-20
JP2001521926A (ja) 2001-11-13
CN1284948A (zh) 2001-02-21
TR200001234T2 (tr) 2000-08-21

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