YU25000A - Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima - Google Patents

Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima

Info

Publication number
YU25000A
YU25000A YU25000A YU25000A YU25000A YU 25000 A YU25000 A YU 25000A YU 25000 A YU25000 A YU 25000A YU 25000 A YU25000 A YU 25000A YU 25000 A YU25000 A YU 25000A
Authority
YU
Yugoslavia
Prior art keywords
catechol
activity
replacement
indazole
same
Prior art date
Application number
YU25000A
Other languages
English (en)
Inventor
Anthony Marfat
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of YU25000A publication Critical patent/YU25000A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

Terapeutski aktivni preparati i clanovi njihovih vrsta su opisani koji sadrze jedinjenja koja sadrze indazol, gde pomenuta jedinjenja i njihova terapeutska aktivnost rezultiraju direktno iz bioizoster zamene indazol-za-katehol jedinjenja koje sadrzi katehol koje ima pomenutu terapeutsku aktivnost, gde su ne-katehol supstituenti isti iil homologni pre i posle zamene, gde pomenuti preparati sadrze jedinjenje formule (I1) i (I2), ili njihove farmaceutski prihvatljive soli, gde u pozeljnoj realizaciji Rc je vodonik; RA je cikloheksil; i RB je etil, Ra i Rb su svaki pojedinacno i nezavisno vodonik ili ne-katehol supstituenti pomenutih jedinjenja rezultirajuci direktno od bioizoster zamene indazol-za-katehol pomenutog jedinjenja koje sadrzi katehol koje ima pomenutu terapeutsku aktivnost, gde su pomenuti ne-katehol supstituenti isti ili homologni pre i posle pomenute zamene, pod uslovom da oba Ra i Rb ne mogu da budu vodonik u isto vreme. Ukljucena terapeutska aktivnost moze da ouhvata i inhibitorsku aktivnost holinesteraze, aktivnost adrenergijskog α1-antagonista i ß1-agonista, inhibitornu aktivnost kanala kalcijuma, antineoplasticnu aktivnost, i inhibitornu aktivnost fosfodiesteraze tipa IV.
YU25000A 1997-11-04 1998-10-26 Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima YU25000A (sh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6419897P 1997-11-04 1997-11-04
US6418797P 1997-11-04 1997-11-04
US6422997P 1997-11-04 1997-11-04
US6422897P 1997-11-04 1997-11-04
US6402497P 1997-11-04 1997-11-04

Publications (1)

Publication Number Publication Date
YU25000A true YU25000A (sh) 2003-12-31

Family

ID=27535645

Family Applications (1)

Application Number Title Priority Date Filing Date
YU25000A YU25000A (sh) 1997-11-04 1998-10-26 Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima

Country Status (29)

Country Link
US (1) US6391872B1 (sh)
EP (1) EP1028946A1 (sh)
JP (1) JP2001521926A (sh)
CN (1) CN1284948A (sh)
AP (1) AP910A (sh)
AR (1) AR013746A1 (sh)
AU (1) AU754734B2 (sh)
BG (1) BG104450A (sh)
BR (1) BR9813926A (sh)
CA (1) CA2309150A1 (sh)
CZ (1) CZ20001621A3 (sh)
DZ (1) DZ2640A1 (sh)
EA (1) EA200000488A1 (sh)
HR (1) HRP20000253A2 (sh)
HU (1) HUP0004150A3 (sh)
ID (1) ID23921A (sh)
IL (1) IL135900A0 (sh)
IS (1) IS5465A (sh)
MA (1) MA26563A1 (sh)
NO (1) NO20002129L (sh)
NZ (1) NZ503918A (sh)
OA (1) OA11354A (sh)
PE (1) PE129199A1 (sh)
PL (1) PL340753A1 (sh)
SK (1) SK6252000A3 (sh)
TN (1) TNSN98200A1 (sh)
TR (1) TR200001234T2 (sh)
WO (1) WO1999023077A1 (sh)
YU (1) YU25000A (sh)

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US7141581B2 (en) 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
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HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
WO2001079198A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinase
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WO2003024456A1 (en) * 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating and preventing migraines
KR20040085179A (ko) * 2002-02-13 2004-10-07 코닌클리케 필립스 일렉트로닉스 엔.브이. 통합된 반도체 광학 디바이스, 이러한 디바이스를제조하는 방법 및 장치
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US7514469B2 (en) 2002-04-30 2009-04-07 Unigen Pharmaceuticals, Inc. Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
BR0316950A (pt) 2002-12-02 2006-01-17 Hoffmann La Roche Derivados de indazol como antagonistas de crf
WO2004074243A2 (en) * 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
CA2521429A1 (en) * 2003-04-04 2004-10-21 Unigen Pharmaceuticals, Inc. Formulation of dual cycloxygenase (cox) and lipoxygenase (lox) inhibitors for mammal skin care
US6984652B2 (en) 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
KR100843526B1 (ko) 2004-02-27 2008-07-03 에프. 호프만-라 로슈 아게 피라졸의 접합 유도체
WO2005085248A1 (en) 2004-02-27 2005-09-15 F.Hoffmann-La Roche Ag Heteroaryl-fused pyrazolo derivatives
EP1747202A1 (en) 2004-02-27 2007-01-31 F.Hoffmann-La Roche Ag Indazole derivatives and pharmaceutical compositions containing them
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CA2628413C (en) * 2005-11-03 2014-09-23 Allergan, Inc. Prostaglandins and analogues as agents for lowering intraocular pressure
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Also Published As

Publication number Publication date
CA2309150A1 (en) 1999-05-14
NO20002129L (no) 2000-07-03
PL340753A1 (en) 2001-02-26
HRP20000253A2 (en) 2001-06-30
CN1284948A (zh) 2001-02-21
ID23921A (id) 2000-05-25
DZ2640A1 (fr) 2003-03-08
EP1028946A1 (en) 2000-08-23
AU754734B2 (en) 2002-11-21
BR9813926A (pt) 2000-09-19
CZ20001621A3 (cs) 2001-08-15
HUP0004150A3 (en) 2001-08-28
OA11354A (en) 2003-12-23
AP9801375A0 (en) 1998-12-31
SK6252000A3 (en) 2001-11-06
WO1999023077A1 (en) 1999-05-14
NZ503918A (en) 2002-03-28
PE129199A1 (es) 1999-12-16
AP910A (en) 2000-12-05
TR200001234T2 (tr) 2000-08-21
MA26563A1 (fr) 2004-12-20
JP2001521926A (ja) 2001-11-13
IS5465A (is) 2000-04-19
TNSN98200A1 (fr) 2005-03-15
HUP0004150A2 (hu) 2001-05-28
AU9455298A (en) 1999-05-24
EA200000488A1 (ru) 2000-10-30
AR013746A1 (es) 2001-01-10
IL135900A0 (en) 2001-05-20
US6391872B1 (en) 2002-05-21
NO20002129D0 (no) 2000-04-26
BG104450A (en) 2000-12-29

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