YU25000A - Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima - Google Patents

Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima

Info

Publication number
YU25000A
YU25000A YU25000A YU25000A YU25000A YU 25000 A YU25000 A YU 25000A YU 25000 A YU25000 A YU 25000A YU 25000 A YU25000 A YU 25000A YU 25000 A YU25000 A YU 25000A
Authority
YU
Yugoslavia
Prior art keywords
catechol
activity
replacement
indazole
same
Prior art date
Application number
YU25000A
Other languages
English (en)
Inventor
Anthony Marfat
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of YU25000A publication Critical patent/YU25000A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Terapeutski aktivni preparati i clanovi njihovih vrsta su opisani koji sadrze jedinjenja koja sadrze indazol, gde pomenuta jedinjenja i njihova terapeutska aktivnost rezultiraju direktno iz bioizoster zamene indazol-za-katehol jedinjenja koje sadrzi katehol koje ima pomenutu terapeutsku aktivnost, gde su ne-katehol supstituenti isti iil homologni pre i posle zamene, gde pomenuti preparati sadrze jedinjenje formule (I1) i (I2), ili njihove farmaceutski prihvatljive soli, gde u pozeljnoj realizaciji Rc je vodonik; RA je cikloheksil; i RB je etil, Ra i Rb su svaki pojedinacno i nezavisno vodonik ili ne-katehol supstituenti pomenutih jedinjenja rezultirajuci direktno od bioizoster zamene indazol-za-katehol pomenutog jedinjenja koje sadrzi katehol koje ima pomenutu terapeutsku aktivnost, gde su pomenuti ne-katehol supstituenti isti ili homologni pre i posle pomenute zamene, pod uslovom da oba Ra i Rb ne mogu da budu vodonik u isto vreme. Ukljucena terapeutska aktivnost moze da ouhvata i inhibitorsku aktivnost holinesteraze, aktivnost adrenergijskog α1-antagonista i ß1-agonista, inhibitornu aktivnost kanala kalcijuma, antineoplasticnu aktivnost, i inhibitornu aktivnost fosfodiesteraze tipa IV.
YU25000A 1997-11-04 1998-10-26 Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima YU25000A (sh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6419897P 1997-11-04 1997-11-04
US6402497P 1997-11-04 1997-11-04
US6422997P 1997-11-04 1997-11-04
US6422897P 1997-11-04 1997-11-04
US6418797P 1997-11-04 1997-11-04

Publications (1)

Publication Number Publication Date
YU25000A true YU25000A (sh) 2003-12-31

Family

ID=27535645

Family Applications (1)

Application Number Title Priority Date Filing Date
YU25000A YU25000A (sh) 1997-11-04 1998-10-26 Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima

Country Status (29)

Country Link
US (1) US6391872B1 (sh)
EP (1) EP1028946A1 (sh)
JP (1) JP2001521926A (sh)
CN (1) CN1284948A (sh)
AP (1) AP910A (sh)
AR (1) AR013746A1 (sh)
AU (1) AU754734B2 (sh)
BG (1) BG104450A (sh)
BR (1) BR9813926A (sh)
CA (1) CA2309150A1 (sh)
CZ (1) CZ20001621A3 (sh)
DZ (1) DZ2640A1 (sh)
EA (1) EA200000488A1 (sh)
HR (1) HRP20000253A2 (sh)
HU (1) HUP0004150A3 (sh)
ID (1) ID23921A (sh)
IL (1) IL135900A0 (sh)
IS (1) IS5465A (sh)
MA (1) MA26563A1 (sh)
NO (1) NO20002129L (sh)
NZ (1) NZ503918A (sh)
OA (1) OA11354A (sh)
PE (1) PE129199A1 (sh)
PL (1) PL340753A1 (sh)
SK (1) SK6252000A3 (sh)
TN (1) TNSN98200A1 (sh)
TR (1) TR200001234T2 (sh)
WO (1) WO1999023077A1 (sh)
YU (1) YU25000A (sh)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9813938A (pt) * 1997-11-04 2000-09-26 Pfizer Prod Inc Compostos terapeuticamente ativos baseados na substituição bioisóstera de indazol por catecol em inibidores de pde4
UA71971C2 (en) 1999-06-04 2005-01-17 Agoron Pharmaceuticals Inc Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
US7141581B2 (en) 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
JP2001031549A (ja) * 1999-07-14 2001-02-06 Pola Chem Ind Inc 真皮コラーゲン線維束再構築剤及びそれを含有する化粧料
US6432979B1 (en) 1999-08-12 2002-08-13 American Cyanamid Company Method of treating or inhibiting colonic polyps and colorectal cancer
WO2001012227A1 (en) * 1999-08-12 2001-02-22 American Cyanamid Company Nsaid and efgr kinase inhibitor containing composition for the treatment or inhibition of colonic polyps and colorectal cancer
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
BR0110302A (pt) 2000-04-18 2003-01-14 Agouron Pharma Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase
US6982274B2 (en) 2001-04-16 2006-01-03 Eisai Co., Ltd. 1H-indazole compound
HU229442B1 (hu) 2001-09-19 2013-12-30 Takeda Gmbh Nem-szteroid gyulladásgátlók és PDE4 inhibitorok kombinációi és alkalmazásuk
WO2003024456A1 (en) * 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating and preventing migraines
CN1701477A (zh) * 2002-02-13 2005-11-23 皇家飞利浦电子股份有限公司 集成半导体光学设备以及制造该设备的方法和装置
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
CA2703698C (en) 2002-04-30 2016-11-22 Unigen Pharmaceuticals, Inc. Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent
CA2507074A1 (en) 2002-12-02 2004-06-17 F. Hoffmann-La Roche Ag Indazole derivatives as crf antagonists
CN100422171C (zh) * 2003-02-14 2008-10-01 惠氏公司 作为5-羟色胺-6配体的杂环-3-磺酰基吲唑
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
CN1798568B (zh) * 2003-04-04 2011-05-11 尤尼根制药公司 用于哺乳动物皮肤护理的双重环氧合酶(cox)以及脂氧合酶(lox)抑制剂的组合物
US6984652B2 (en) 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
MXPA06009462A (es) 2004-02-27 2007-03-15 Hoffmann La Roche Derivados pirazolo heteroaril fusionados.
KR100843526B1 (ko) 2004-02-27 2008-07-03 에프. 호프만-라 로슈 아게 피라졸의 접합 유도체
US7844309B2 (en) * 2004-02-27 2010-11-30 Nokia Corporation Exchangeable keymat
AU2005219518A1 (en) 2004-02-27 2005-09-15 F. Hoffmann-La Roche Ag Indazole derivatives and pharmaceutical compositions containing them
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
DK1828182T3 (da) * 2004-11-29 2010-05-10 Warner Lambert Co Terapeutiske pyrazol[3,4-B]pyridiner og indazoler
CN101282938A (zh) * 2005-08-15 2008-10-08 惠氏公司 作为5-羟色胺-6配体的经取代3-磺酰基吲唑衍生物
CN101291913A (zh) * 2005-08-15 2008-10-22 惠氏公司 作为5-羟色胺-6配体的吖嗪基-3-磺酰基吲唑衍生物
CN101243088B (zh) 2005-08-25 2011-06-29 霍夫曼-拉罗奇有限公司 p38 MAP激酶抑制剂及使用它的方法
EP1928866A1 (en) * 2005-09-05 2008-06-11 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-iv
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
WO2007056087A1 (en) * 2005-11-03 2007-05-18 Allergan, Inc. Prostaglandins and analogues as agents for lowering intraocular pressure
US7645752B2 (en) 2006-01-13 2010-01-12 Wyeth Llc Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors
SG175599A1 (en) 2006-01-31 2011-11-28 Array Biopharma Inc Kinase inhibitors and methods of use thereof
SG171635A1 (en) 2006-02-28 2011-06-29 Helicon Therapeutics Inc Therapeutic piperazines as pde4 inhibitors
WO2007120523A2 (en) * 2006-03-31 2007-10-25 Vitae Pharmaceuticals, Inc. 6-(aminoalkyl)indazoles
JP2009532471A (ja) * 2006-04-05 2009-09-10 ワイス ５−ヒドロキシトリプタミン−６リガンドとしてのスルホニル−３−ヘテロシクリルインダゾール誘導体
WO2007120596A1 (en) * 2006-04-12 2007-10-25 Wyeth DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
US8012886B2 (en) * 2007-03-07 2011-09-06 Asm Assembly Materials Ltd Leadframe treatment for enhancing adhesion of encapsulant thereto
NZ579645A (en) 2007-03-14 2012-01-12 Ranbaxy Lab Ltd Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
JP5641494B2 (ja) * 2009-09-18 2014-12-17 株式会社Ｒｉｖｅｒｓｏｎ ポリフェノール誘導体及びそれの産生方法
WO2011143430A1 (en) 2010-05-12 2011-11-17 Abbott Laboratories Indazole inhibitors of kinase
CN103709146B (zh) * 2014-01-15 2015-11-25 中国药科大学 一类含苯并咪唑结构的喹啉-4-胺衍生物、其制法及医药用途
US20240109865A1 (en) 2020-12-30 2024-04-04 Tyra Biosciences, Inc. Indazole compounds as kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003385A1 (en) * 1987-10-13 1989-04-20 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds, process for their preparation, and their medicinal use
EP0338087A4 (en) * 1987-10-13 1991-07-24 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds, process for their preparation, and their medicinal use
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
AP2001002304A0 (en) * 1996-05-03 2001-12-31 Pfizer Substituted indazole derivatives and related compounds
BR9712782A (pt) * 1996-06-25 1999-12-07 Pfizer Derivados de indazol substituìdo e seu uso como inibidores de fosfodiesterose (pde) e fator de necrose de tumor (tnf)
DE69709493T2 (de) * 1996-06-27 2002-10-31 Pfizer Inc., New York Substituierte Indazolderivate
PL332187A1 (en) * 1996-09-04 1999-08-30 Pfizer Substitution derivatives of indazole and their application as inhibitors of phosphodiesterase (pde) of iv type and tumor necrosis factor (tnf)
BR9813938A (pt) * 1997-11-04 2000-09-26 Pfizer Prod Inc Compostos terapeuticamente ativos baseados na substituição bioisóstera de indazol por catecol em inibidores de pde4

Also Published As

Publication number Publication date
BR9813926A (pt) 2000-09-19
WO1999023077A1 (en) 1999-05-14
BG104450A (en) 2000-12-29
JP2001521926A (ja) 2001-11-13
EP1028946A1 (en) 2000-08-23
DZ2640A1 (fr) 2003-03-08
CA2309150A1 (en) 1999-05-14
MA26563A1 (fr) 2004-12-20
AU9455298A (en) 1999-05-24
US6391872B1 (en) 2002-05-21
NO20002129L (no) 2000-07-03
NO20002129D0 (no) 2000-04-26
AP9801375A0 (en) 1998-12-31
ID23921A (id) 2000-05-25
AU754734B2 (en) 2002-11-21
AR013746A1 (es) 2001-01-10
CN1284948A (zh) 2001-02-21
SK6252000A3 (en) 2001-11-06
NZ503918A (en) 2002-03-28
TNSN98200A1 (fr) 2005-03-15
OA11354A (en) 2003-12-23
IL135900A0 (en) 2001-05-20
CZ20001621A3 (cs) 2001-08-15
PL340753A1 (en) 2001-02-26
PE129199A1 (es) 1999-12-16
HUP0004150A3 (en) 2001-08-28
IS5465A (is) 2000-04-19
HRP20000253A2 (en) 2001-06-30
EA200000488A1 (ru) 2000-10-30
TR200001234T2 (tr) 2000-08-21
AP910A (en) 2000-12-05
HUP0004150A2 (hu) 2001-05-28

Similar Documents

Publication Publication Date Title
YU25000A (sh) Indazol bioizoster zamena katehola u terapeutski aktivnim jedinjenjima
BG106586A (en) Pyrazolopyramidines as therapeutic agents
AU2001256834A1 (en) Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cellproliferation
TR200002191T2 (tr) Potasyum kanal önleyicileri
MY141661A (en) 17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
GEP20084357B (en) Pyrimidine derivatives for the treatment of abnormal cell growth
GEP20064005B (en) Use of novel benzoimidazole derivatives as antiproliferative agents
MXPA04000069A (es) Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas, y metodos para su utilizacion.
AU3850600A (en) Dalda analogs and their use
AU8736798A (en) Use of cholinesterase inhibitors for treating attention deficit disorders
KR20000005379A (en) Isatin derivatives as acetylcholinesterase inhibitors and analgesics
EP1109560A4 (en) COMPOUNDS USEFUL AS AICARFT INHIBITORS
EP1019047A4 (en) ANTITHROMBOTIC AGENTS
EP1027051A4 (en) ANTITHROMBOTIC AGENTS
AU8438798A (en) Use of draflazine-analogues for treating pain
IL112695A0 (en) Pyridazinone derivatives and pharmaceutical compositions containing the same
HK1041000B (zh) 新型嘧啶衍生物及其製備方法
AU7467694A (en) Pyridazinone derivatives or their salts, processes for theirproduction, and anti-shock agents containing them
CA2242571A1 (en) Amino compounds and angiotensin iv receptor agonists
CO5280247A1 (es) Sustitucion biosisterica de catecol por indazol en compues- tos terapeuticamente activos
ECSP982722A (es) Sustitucion bioisosterica de catecol por indazol en compuestos terapeuticamente activos
EP1202628A4 (en) HYPOXANTHIN AND THIOHYPXANTHIN COMPOUNDS
SI0937075T1 (en) New Imidazo- and Oxazolopyridines as Phosphodiesterase Inhibitors.
DE69824410D1 (en) Antithrombosemittel
AU1434201A (en) Antithrombotic agents