MXPA04000069A - Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas, y metodos para su utilizacion. - Google Patents
Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas, y metodos para su utilizacion.Info
- Publication number
- MXPA04000069A MXPA04000069A MXPA04000069A MXPA04000069A MXPA04000069A MX PA04000069 A MXPA04000069 A MX PA04000069A MX PA04000069 A MXPA04000069 A MX PA04000069A MX PA04000069 A MXPA04000069 A MX PA04000069A MX PA04000069 A MXPA04000069 A MX PA04000069A
- Authority
- MX
- Mexico
- Prior art keywords
- cell proliferation
- thiazole
- methods
- pharmaceutical compositions
- inhibiting cell
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
Los compuestos aminotiazol con benzamida mono-di/substituidos estan representados por la Formula (l), (ver formula) y se describen sus sales farmaceuticamente aceptables, pro-drogas farmaceuticamente aceptables, metabolitos farmaceuticamente activos, y sales farmaceuticamente aceptables de dichos metabolitos; estos agentes modulan y/o inhiben la proliferacion de celula y la actividad de las quinasas de proteina y son utiles como farmaceuticos para tratar malignidades y otros desordenes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30367901P | 2001-07-06 | 2001-07-06 | |
US30527401P | 2001-07-13 | 2001-07-13 | |
PCT/US2002/021280 WO2003004467A2 (en) | 2001-07-06 | 2002-07-05 | Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04000069A true MXPA04000069A (es) | 2004-05-21 |
Family
ID=26973595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04000069A MXPA04000069A (es) | 2001-07-06 | 2002-07-05 | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas, y metodos para su utilizacion. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6720346B2 (es) |
EP (1) | EP1438046A4 (es) |
JP (1) | JP2005521631A (es) |
AU (1) | AU2002354801A1 (es) |
BR (1) | BR0210874A (es) |
CA (1) | CA2452609A1 (es) |
HN (1) | HN2002000156A (es) |
MX (1) | MXPA04000069A (es) |
PA (1) | PA8550101A1 (es) |
PE (1) | PE20030269A1 (es) |
SV (1) | SV2003001148A (es) |
UY (1) | UY27370A1 (es) |
WO (1) | WO2003004467A2 (es) |
Families Citing this family (33)
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US6495550B2 (en) * | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
JP2003506387A (ja) | 1999-08-04 | 2003-02-18 | アイカゲン インコーポレイテッド | カリウムチャンネルオープナーとしてのベンズアニリド |
AU2002322280A1 (en) | 2001-06-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
WO2004014904A1 (en) * | 2002-08-09 | 2004-02-19 | Pfizer Inc. | Antiproliferative 2-(heteroaryl)-aminothiazole compounds, pharmaceutical compositions and methods for their use |
US7169771B2 (en) * | 2003-02-06 | 2007-01-30 | Bristol-Myers Squibb Company | Thiazolyl-based compounds useful as kinase inhibitors |
WO2004072068A1 (en) | 2003-02-10 | 2004-08-26 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
CA2515728A1 (en) * | 2003-02-12 | 2004-08-26 | Pfizer Inc. | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives |
ATE439837T1 (de) | 2003-06-03 | 2009-09-15 | Novartis Ag | 5-gliedrige heterocyclische p-38 inhibitoren |
TWI452035B (zh) | 2003-06-26 | 2014-09-11 | Novartis Ag | 以5員雜環為主之p38激酶抑制劑 |
US20050026966A1 (en) * | 2003-07-30 | 2005-02-03 | Agouron Pharmaceuticals, Inc. | Process and chiral amine intermediates useful for preparation of antiproliferative 2,4-diaminothiazole amide compounds |
US20050164300A1 (en) * | 2003-09-15 | 2005-07-28 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
WO2005073225A1 (en) * | 2004-01-30 | 2005-08-11 | Ab Science | 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors |
AU2005230846A1 (en) * | 2004-03-31 | 2005-10-20 | Lexicon Pharmaceuticals, Inc. | 2-aminomethylthiazole-5-carboxamides as protein kinase modulators |
WO2005102326A2 (en) * | 2004-04-23 | 2005-11-03 | Ab Science | Use of c-kit inhibitors for treating renal diseases |
US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
US7423053B2 (en) * | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 4-Aminothiazole derivatives |
JP4652079B2 (ja) * | 2005-02-15 | 2011-03-16 | 花王株式会社 | 2,2−二置換エチレンジアミン誘導体の製造方法 |
AU2006227833A1 (en) | 2005-03-18 | 2006-09-28 | The Regents Of The University Of California | Compounds having activity in correcting mutant-CFTR processing and uses thereof |
UA92746C2 (en) | 2005-05-09 | 2010-12-10 | Акилайон Фармасьютикалз, Инк. | Thiazole compounds and methods of use |
BRPI0709612A2 (pt) | 2006-03-15 | 2011-07-19 | Wyeth Corp | composto de fórmula i; método para o tratamento de um distúrbio no sistema nervoso central relacionado ou afetado pelo receptor histamina-3 em um paciente que necessita deste tratamento; método para a inibição do receptor h3; composição farmacêutica; e processo para a preparação de um composto de fórmula i |
CN101432261A (zh) * | 2006-05-19 | 2009-05-13 | 惠氏公司 | 作为组织胺-3拮抗剂的n-苯甲酰基-吡咯烷-3-基胺和n-苄基-吡咯烷-3-基胺 |
PE20081152A1 (es) | 2006-10-06 | 2008-08-10 | Wyeth Corp | Azaciclilaminas n-sustituidas como antagonistas de histamina-3 |
EP2084150B1 (en) * | 2006-11-23 | 2012-08-08 | Basf Se | Process for the preparation of tertiary n-allyl sterically hindered amines |
EP2124873B1 (en) * | 2007-01-31 | 2016-01-06 | Basf Se | Cationic dyes |
GB0705656D0 (en) * | 2007-03-23 | 2007-05-02 | Addex Pharmaceuticals Sa | Novel compounds E1 |
CA2693138A1 (en) | 2007-07-16 | 2009-01-22 | Wyeth Llc | Aminoalkylazole derivatives as histamine-3 antagonists |
US9066951B2 (en) * | 2008-05-29 | 2015-06-30 | Wisconsin Alumni Research Foundation | Drugs to treat HPV infection |
EP2789618B1 (en) | 2008-12-03 | 2016-07-27 | The Scripps Research Institute | Stem cell cultures |
JP5212656B2 (ja) * | 2009-09-02 | 2013-06-19 | 日産化学工業株式会社 | イソチオシアナト化合物の製造方法 |
WO2012073314A1 (ja) | 2010-11-29 | 2012-06-07 | 日産化学工業株式会社 | イソチオシアナト化合物の製造方法 |
WO2013089689A1 (en) * | 2011-12-13 | 2013-06-20 | Kneller Bruce W | Constituent of desmodium elegans and methods of use |
WO2015199206A1 (ja) * | 2014-06-27 | 2015-12-30 | 塩野義製薬株式会社 | Trpv4阻害活性を有する6員環誘導体 |
EP3601250A4 (en) * | 2017-03-27 | 2020-11-25 | Pharmakea, Inc. | APOPTOSIS SIGNAL REGULATION KINASE 1 (ASK 1) INHIBITOR COMPOUNDS |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2203517A1 (en) | 1994-11-10 | 1996-05-23 | Alan M. Laibelman | Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases |
EP0816362A4 (en) | 1995-03-22 | 1998-07-08 | Taisho Pharmaceutical Co Ltd | THIAZOLE DERIVATIVES |
WO1997034876A1 (en) | 1996-03-15 | 1997-09-25 | Zeneca Limited | Cinnoline derivatives and use as medicine |
TW513418B (en) | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
YU22400A (sh) * | 1997-10-27 | 2003-08-29 | Agouron Pharmaceuticals Inc. | Supstituisana 4-amino-tiazol-2-i jedinjenja kao cdks inhibitori |
IL135176A0 (en) | 1997-11-10 | 2001-05-20 | Bristol Myers Squibb Co | Benzothiazole derivatives and pharmaceutical compositions containing the same |
US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
FR2780058B1 (fr) | 1998-06-17 | 2001-03-09 | Rhodia Chimie Sa | Emulsion aqueuse de silane pour l'hydrofugation de materiaux de construction |
JP2002526482A (ja) | 1998-09-18 | 2002-08-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | p38のインヒビター |
GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
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2002
- 2002-06-26 HN HN2002000156A patent/HN2002000156A/es unknown
- 2002-07-02 PE PE2002000595A patent/PE20030269A1/es not_active Application Discontinuation
- 2002-07-04 SV SV2002001148A patent/SV2003001148A/es not_active Application Discontinuation
- 2002-07-04 UY UY27370A patent/UY27370A1/es not_active Application Discontinuation
- 2002-07-05 AU AU2002354801A patent/AU2002354801A1/en not_active Abandoned
- 2002-07-05 EP EP02782499A patent/EP1438046A4/en not_active Withdrawn
- 2002-07-05 MX MXPA04000069A patent/MXPA04000069A/es unknown
- 2002-07-05 CA CA002452609A patent/CA2452609A1/en not_active Abandoned
- 2002-07-05 US US10/190,219 patent/US6720346B2/en not_active Expired - Fee Related
- 2002-07-05 JP JP2003510635A patent/JP2005521631A/ja not_active Withdrawn
- 2002-07-05 BR BRPI0210874-7A patent/BR0210874A/pt not_active IP Right Cessation
- 2002-07-05 WO PCT/US2002/021280 patent/WO2003004467A2/en active Application Filing
- 2002-07-08 PA PA20028550101A patent/PA8550101A1/es unknown
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EP1438046A2 (en) | 2004-07-21 |
SV2003001148A (es) | 2003-03-18 |
BR0210874A (pt) | 2006-10-24 |
PE20030269A1 (es) | 2003-04-16 |
JP2005521631A (ja) | 2005-07-21 |
PA8550101A1 (es) | 2003-09-05 |
WO2003004467A2 (en) | 2003-01-16 |
US6720346B2 (en) | 2004-04-13 |
UY27370A1 (es) | 2003-04-30 |
CA2452609A1 (en) | 2003-01-16 |
US20030225147A1 (en) | 2003-12-04 |
EP1438046A4 (en) | 2004-10-20 |
AU2002354801A1 (en) | 2003-01-21 |
WO2003004467A3 (en) | 2004-05-06 |
HN2002000156A (es) | 2003-11-27 |
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